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Specialty: Rheumatology

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Total 576 results found since Jan 2013.

Clinical Features and Outcomes of Takayasu Arteritis with Neurological Symptoms in China: A Retrospective Study.
CONCLUSION: Neurological features in patients with TA were variable, and correlated with the number of arteries and the site of artery involvement. Resistant hypertension was one of the most important risk factors for hemorrhagic stroke in patients with TA. PMID: 26233498 [PubMed - as supplied by publisher]
Source: J Rheumatol - August 1, 2015 Category: Rheumatology Authors: Yang L, Zhang H, Jiang X, Song L, Qin F, Zou Y, Wu H, Bian J, Zhou X, Hui R, Zheng D Tags: J Rheumatol Source Type: research

The burden of co‐morbidity in Systemic Lupus Erythematosus in the United Kingdom 1999‐2012
Conclusions: People with SLE in the UK have a greater burden of co‐morbidity and are more likely to develop CVD, stroke, ESRF, cancer, osteoporosis and infection than people of the same age and gender. This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - October 16, 2015 Category: Rheumatology Authors: Frances Rees, Michael Doherty, Matthew Grainge, Peter Lanyon, Graham Davenport, Weiya Zhang Tags: Original Article Source Type: research

Burden of Comorbidity in Systemic Lupus Erythematosus in the UK, 1999–2012
ConclusionPeople with SLE in the UK have a greater burden of comorbidity and are more likely to develop CVD, stroke, ESRF, cancer, osteoporosis, and infection than people of the same age and sex.
Source: Arthritis Care and Research - May 25, 2016 Category: Rheumatology Authors: Frances Rees, Michael Doherty, Matthew Grainge, Peter Lanyon, Graham Davenport, Weiya Zhang Tags: Systemic Lupus Erythematosus Source Type: research

Lupus patients 'at higher risk of developing other health conditions'
People with lupus are at a greater risk of developing other health conditions than members of the general population.This is according to a new study conducted by the University of Nottingham and the Arthritis Research UK Primary Care Centre at Keele University, which examined the frequency of comorbidities associated with systemic lupus erythematosus in the UK between 1999 and 2012.A broad UK study Published in the medical journal Arthritis Care & Research, the study drew upon data from the UK Clinical Practice Research Datalink, identifying cases of lupus and matching each one by age, gender and practice to four heal...
Source: Arthritis Research UK - May 26, 2016 Category: Rheumatology Source Type: news

Relationship between cerebrovascular and valvular manifestations in a Serbian cohort of patients with antiphospholipid syndrome.
CONCLUSIONS: In this cross-section analysis of a large cohort of Serbian APS patients, there was a strong relationship between valvular and cerebrovascular manifestations, suggesting a more cautious approach regarding neurological symptoms, especially in PAPS patients with valvular vegetations present. PMID: 29846156 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Rheumatology - June 4, 2018 Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

Cardiovascular risk and mortality in rheumatoid arthritis compared with diabetes mellitus and the general population
ConclusionThis study demonstrates that RA is associated with an increased risk of HF, MI, stroke and coronary revascularization than found in the GP but without reaching the risk levels observed in DM patients.
Source: Rheumatology - September 27, 2020 Category: Rheumatology Source Type: research

Combined brain/heart magnetic resonance imaging in antiphospholipid syndrome-two sides of the same coin
AbstractAntiphospholipid syndrome (APS) is an autoimmune disorder characterized by arterial, venous, and/or small vessel thrombosis, pregnancy morbidity, and persistently elevated levels of antiphospholipid antibodies (aPL). Cardiovascular disease (CVD) in APS can present as heart valvular disease (HVD), macro-micro-coronary artery disease (CAD), myocardial dysfunction, cardiac thrombi, or pulmonary hypertension. Brain disease presents as stroke or transient ischemic attack (TIA) and less frequently as cerebral venous thrombosis, seizures, cognitive dysfunction, multiple sclerosis (MS) −like syndrome, or chorea. Infarcts...
Source: Clinical Rheumatology - June 10, 2021 Category: Rheumatology Source Type: research

Inpatient complications in patients with giant cell arteritis: decreased mortality and increased risk of thromboembolism, delirium and adrenal insufficiency
Conclusion: Hospitalized GCA patients have lower mortality compared with the general inpatient population but greater risk of venous thromboembolism, delirium and adrenal insufficiency.
Source: Rheumatology - July 14, 2015 Category: Rheumatology Authors: Unizony, S., Menendez, M. E., Rastalsky, N., Stone, J. H. Tags: Vasculitis CLINICAL SCIENCE Source Type: research

Phenotypic variability in patients with ADA2 deficiency due to identical homozygous R169Q mutations
Conclusion. This case series revealed large phenotypic variability in patients with ADA2 deficiency though they were homozygous for the same R169Q mutation in CECR1. Disease modifiers, including epigenetic and environmental factors, thus seem important in determining the phenotype. Furthermore, haematopoietic cell transplantation appears promising for those patients with a severe clinical phenotype.
Source: Rheumatology - April 13, 2016 Category: Rheumatology Authors: Van Montfrans, J. M., Hartman, E. A. R., Braun, K. P. J., Hennekam, E. A. M., Hak, E. A., Nederkoorn, P. J., Westendorp, W. F., Bredius, R. G. M., Kollen, W. J. W., Schölvinck, E. H., Legger, G. E., Meyts, I., Liston, A., Lichtenbelt, K. D., Gilta Tags: Immunogenetics CLINICAL SCIENCE Source Type: research

Risk-benefit profile of statin therapy 'may be more positive than expected'
This study showed that providing an effective low-cost statin therapy to 10,000 patients for five years would prevent major cardiovascular events such as heart attacks, strokes and coronary artery bypasses in 1,000 people with preexisting vascular disease, as well as 500 people who are at increased risk but have not yet had a vascular event. By contrast, only 50 to 100 cases of symptomatic adverse events would be expected over the same period, as well as 50 to 100 new cases of diabetes, five cases of myopathy and between five and ten haemorrhagic strokes. Should statins be more widely used? Currently, about six million peo...
Source: Arthritis Research UK - September 8, 2016 Category: Rheumatology Source Type: news

Is ankylosing spondylitis a risk factor for cardiovascular disease, and how do these risks compare with those in rheumatoid arthritis?
Conclusions Prevalent patients with AS are at a 30%–50% increased risk of incident CV events. When compared with patients with RA, this level of increase was similar for stroke, but only half as high for ACS and thrombotic events.
Source: Annals of the Rheumatic Diseases - January 9, 2017 Category: Rheumatology Authors: Eriksson, J. K., Jacobsson, L., Bengtsson, K., Askling, J. Tags: Immunology (including allergy), Ankylosing spondylitis, Connective tissue disease, Degenerative joint disease, Musculoskeletal syndromes, Rheumatoid arthritis, Calcium and bone Clinical and epidemiological research Source Type: research

Race/Ethnicity and Cardiovascular Events among Patients with Systemic Lupus Erythematosus
Conclusion: Among SLE patients enrolled in Medicaid, MI risk was lower among Hispanics and Asians, while stroke risk was elevated among Blacks and Hispanics compared to Whites. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - June 1, 2017 Category: Rheumatology Authors: Medha Barbhaiya, Candace H. Feldman, Hongshu Guan, Jose A. G ómez‐Puerta, Michael A. Fischer, Daniel H. Solomon, Brendan Everett, Karen H. Costenbader Tags: Full Length Source Type: research

Cerebrovascular Events in Systemic Lupus Erythematosus
ConclusionCerVEs, the fourth most frequent NP event in SLE, are usually attributable to lupus. In contrast to good physician reported outcomes, patients report a sustained reduction in health‐related quality of life following CerVEs.This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - January 5, 2018 Category: Rheumatology Authors: John G. Hanly, Qiuju Li, Li Su, Murray B. Urowitz, Caroline Gordon, Sang ‐Cheol Bae, Juanita Romero‐Diaz, Jorge Sanchez‐Guerrero, Sasha Bernatsky, Ann E. Clarke, Daniel J Wallace, David A. Isenberg, Anisur Rahman, Joan T. Merrill, Paul Fortin, Dafna Tags: Original Article Source Type: research

Transcranial Doppler findings in antiphospholipid syndrome.
CONCLUSIONS: Patients with APS had a higher frequency of RLS than healthy controls. This finding alerts to the importance of cardiac investigation in patients with stroke and APS, because further therapies such as RLS occlusion might eventually add protection. The higher frequency of MES in patients with SLE could suggest an effect of anticoagulant therapy on MES prevention, more frequently used in patients with APS. PMID: 30755144 [PubMed - as supplied by publisher]
Source: Lupus - February 12, 2019 Category: Rheumatology Authors: Ricarte IF, Dutra LA, Barsottini OGP, Souza AWS, Andrade DCO, Mangueira C, Silva GS Tags: Lupus Source Type: research

Factors Associated with Relapse and Dependence to Glucocorticoids in Giant-Cell Arteritis.
CONCLUSION: In this study, LVV was an independent predictor of relapse and GC dependence. Further prospective studies are needed to confirm these findings and determine if patients with LVV require a different treatment approach. PMID: 30877210 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - March 17, 2019 Category: Rheumatology Tags: J Rheumatol Source Type: research