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Specialty: Rheumatology

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Total 576 results found since Jan 2013.

A case of PRES in an active lupus nephritis patient after treatment of corticosteroid and cyclophosphamide
Abstract Posterior reversible encephalopathy syndrome (PRES) is primarily a radiological diagnosis. The syndrome is characterized by headache, altered mental status, seizures, and bilateral posterior white matter edema in a nonvascular distribution on neuroimaging with resolution of findings usually in 7–14 days (Casey et al. in AJNR Am J Neuroradiol 21:1199–1206, 2000). In most cases, computed tomography of the brain will show hypodense lesions in the parieto-occipital lobe. Although this syndrome is uncommon, prompt and accurate recognition allows early treatment, which has been shown to produce favorable o...
Source: Rheumatology International - November 12, 2014 Category: Rheumatology Source Type: research

The role of central sensitization in shoulder pain: A systematic literature review
Hyperexcitability of the central nervous system has been suggested to play an important role in pain experienced by patients with unilateral shoulder pain. A systematic literature review following the PRISMA guidelines was performed to evaluate the existing evidence related to the presence of central sensitization in patients with unilateral shoulder pain of different etiologies including those with chronic subacromial impingement syndrome. Studies addressing neuropathic pain (e.g. post-stroke shoulder pain) were not considered.
Source: Seminars in Arthritis and Rheumatism - November 13, 2014 Category: Rheumatology Authors: M.N. Sanchis, E. Lluch, J. Nijs, F. Struyf, M. Kangasperko Source Type: research

Cardiovascular events in ankylosing spondylitis: An updated meta-analysis
This study aims to assess the risk of myocardial infarction (MI) and stroke in AS patients.
Source: Seminars in Arthritis and Rheumatism - October 17, 2014 Category: Rheumatology Authors: Sylvain Mathieu, Bruno Pereira, Martin Soubrier Source Type: research

Delayed Positivization of Cerebral Angiography in Reversible Cerebral Vasoconstriction Syndrome (RCVS) Presenting with Recurrent Subarachnoid Haemorrhage.
We describe a case of RCVS presenting with a subarachnoid haemorrhage (SAH), with rebleeding and onset of hydrocephalus during the first week, and, notably, delayed evidence of typical angiographic features after two negative prior exams. Normalization of the angiographic vasculitic-like lesions was documented at month +6. Repeated cerebral angiograms are mandatory to exclude this kind of disease, and the uncommon presentation of this case reinforces this concept. PMID: 22870164 [PubMed]
Source: Open Rheumatology Journal - December 2, 2014 Category: Rheumatology Tags: Open Rheumatol J Source Type: research

Late‐onset primary antiphospholipid syndrome in the elderly: a report of seven cases
ConclusionIn this report, we report on primary APS in the elderly, to discuss its prevalence and the clinical significance of positive antiphospholipid antibodies in subjects over the age of 65 years.
Source: APLAR Journal of Rheumatology - December 20, 2014 Category: Rheumatology Authors: Yosra Cherif, Moez Jallouli, Hela Hriz, Radhouane Gouiaa, Sameh Marzouk, Mouna Snoussi, Faten Frikha, Hatem Masmoudi, Zouhir Bahloul Tags: Original Article Source Type: research

Bilateral scalp necrosis as a rare but devastating complication of giant cell arteritis
We report a case of a man who presented with a 4-week history of bilateral scalp necrosis associated with headache, jaw claudication, temporal artery tenderness, and raised inflammatory markers. He did not have any visual loss. A diagnosis of GCA was made and he was started on high-dose steroids immediately. The scalp lesions did improve and his symptoms resolved without any visual loss but, sadly he died due to severe sepsis. This case report is important as it describes a rare but severe complication of a common large vessel vasculitis seen by both primary care physicians and rheumatologists. Prompt recognition and early...
Source: Clinical Rheumatology - January 1, 2015 Category: Rheumatology Source Type: research

Psoriasis, psoriatic arthritis and cardiovascular risk: are we closer to a clinical recommendation?
The issue of vascular risk in chronic arthropathies and especially the magnitude of such risk and its clinical implications in daily practice are of considerable current importance. Similarly, the relative risk across distinct arthropathies and other chronic inflammatory conditions is debated. Ogdie et al1 report associations between psoriasis, psoriatic arthritis (PsA), rheumatoid arthritis (RA) and an increased risk of major adverse cardiovascular events (MACE—myocardial infarction, stroke and cardiovascular death) in data derived from the UK primary care registry. Results are stratified by use of disease-modifying...
Source: Annals of the Rheumatic Diseases - January 7, 2015 Category: Rheumatology Authors: Kristensen, S. L., McInnes, I. B., Sattar, N. Tags: Immunology (including allergy), Inflammation, Biological agents, Connective tissue disease, Degenerative joint disease, Drugs: musculoskeletal and joint diseases, Musculoskeletal syndromes, Rheumatoid arthritis, Epidemiology Editorials Source Type: research

Racial and ethnic differences in mortality and cardiovascular events among patients with end‐stage renal disease due to lupus nephritis
Conclusion: Among patients with LN ESRD, Asians and Hispanics experienced lower mortality and CV event risks, while African Americans had higher mortality and CV event risks compared to Whites. This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - January 1, 2015 Category: Rheumatology Authors: Jose A. Gómez‐Puerta, Candace H. Feldman, Graciela S. Alarcón, Hongshu Guan, Wolfgang C. Winkelmayer, Karen H. Costenbader Tags: Original Article Source Type: research

Procoagulant microparticles are increased in patients with Behçet’s disease but do not define a specific subset of clinical manifestations
Abstract Microparticles (MP) are considered a key component in the haemostatic response. Beyond their in vitro procoagulant properties, a number of pieces of evidence points to procoagulant MP as efficient effectors in the haemostatic response and as pathogenic markers of thrombotic disorders and vascular damage. The aim of the present study was to analyze the procoagulant activity of MP and its correlation with clinical manifestations focusing on vascular involvement in patients with Behçet’s disease (BD). We analyzed 55 BD patients in inactive phase of the disease (26 men; mean age, 35 ± 15 years) of wh...
Source: Clinical Rheumatology - February 26, 2015 Category: Rheumatology Source Type: research

Disability and not osteoarthritis predicts cardiovascular disease: a prospective population-based cohort study
Conclusions In this large population-based study, participants with OA were not at increased risk of CVD. The close relation between disability and osteoarthritis may explain previous findings. Further studies are required in order to clarify whether OA patients need more intensive treatment of their cardiovascular risk factors.
Source: Annals of the Rheumatic Diseases - March 5, 2015 Category: Rheumatology Authors: Hoeven, T. A., Leening, M. J. G., Bindels, P. J., Castano-Betancourt, M., van Meurs, J. B., Franco, O. H., Kavousi, M., Hofman, A., Ikram, M. A., Witteman, J. C. M., Bierma-Zeinstra, S. M. Tags: Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis, Epidemiology Clinical and epidemiological research Source Type: research

Development and initial validation of a damage index (DIAPS) in patients with thrombotic antiphospholipid syndrome (APS).
CONCLUSION: This study demonstrates content, criterion and construct validity of a new physician-reported instrument to assess the DIAPS. In addition, the DIAPS correlated with the EuroQol. PMID: 25767071 [PubMed - as supplied by publisher]
Source: Lupus - March 11, 2015 Category: Rheumatology Authors: Amigo MC, Goycochea-Robles MV, Espinosa-Cuervo G, Medina G, Barragán-Garfias JA, Vargas A, Jara LJ Tags: Lupus Source Type: research

Hip osteoarthritis and the risk of all‐cause and disease‐specific mortality in older women: Population‐based cohort study
Conclusion RHOA was associated with an increased risk of all‐cause and CVD mortality among older white women followed for 16 years. Dissemination of evidence‐based physical activity and self‐management interventions for hip OA in community and clinical settings can improve physical function and might also contribute to lower mortality. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - March 16, 2015 Category: Rheumatology Authors: Kamil E. Barbour, Li‐Yung Lui, Michael C. Nevitt, Louise B. Murphy, Charles G. Helmick, Kristina A. Theis, Marc C. Hochberg, Nancy E. Lane, Jennifer M. Hootman, Jane A. Cauley, Tags: Full Length Source Type: research

Disease activity in rheumatoid arthritis and the risk of cardiovascular events
Conclusions: Reduced time‐averaged disease activity in RA is associated with fewer CV events. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - March 16, 2015 Category: Rheumatology Authors: D.H. Solomon, G Reed, J.M. Kremer, J.R. Curtis, M.E. Farkouh, L.R. Harrold, M.C. Hochberg, P Tsao, J Greenberg Tags: Full Length Source Type: research

Prevalence and risk factors of arthritis in a middle-aged and older Chinese population: the China Health and Retirement Longitudinal Study
Conclusion. Middle-aged and older Chinese adults had a high prevalence of arthritis. Cardiovascular disease is a novel risk factor for arthritis in this population.
Source: Rheumatology - March 24, 2015 Category: Rheumatology Authors: Li, C., Liu, T., Sun, W., Wu, L., Zou, Z.-Y. Tags: Rheumatoid Arthritis CLINICAL SCIENCE Source Type: research

Using New Oral Anticoagulants in Patients Undergoing Major Orthopedic Surgery
Abstract Four new oral anticoagulants (NOAC), apixaban, rivaroxaban, edoxaban, and dabigatran, are now available in the USA; however, only apixaban and rivaroxaban are FDA approved for the prevention of venous thromboembolism following orthopedic surgery. Apixaban, rivaroxaban, and edoxaban’s anticoagulant activity can be measured using a chromogenic anti-factor Xa assay but there is no widely available means of measuring dabigatran blood levels. None of the NOAC has an antidote. Dabigatran is 80 % renally excreted, and patients with atrial fibrillation taking dabigatran for stroke prevention should stop the d...
Source: Current Rheumatology Reports - April 8, 2015 Category: Rheumatology Source Type: research