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Specialty: Rheumatology

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Total 576 results found since Jan 2013.

Epidemiology of inpatient gout in Australia and New Zealand: temporal trends, comorbidities and gout flare site
ConclusionThe number of gout admissions rose in Australia numerically and as a proportion of the total population and total admissions. Gout is an increasing problem affecting individuals and the community as a whole in Australia.
Source: APLAR Journal of Rheumatology - July 25, 2016 Category: Rheumatology Authors: Philip C. Robinson, Sarina Kempe, Ian Tebbutt, Lynden Roberts Tags: Original Article Source Type: research

Patterns and consequences of multimorbidity in the general population: There is no chronic disease management without rheumatic disease management
Conclusion: Our study emphasizes RMDs as a major presence in multimorbidity in the general population. All multimorbidity patterns were associated with a wide set of adverse health outcomes. Management strategies for the patient with chronic cardiometabolic, respiratory or depressive conditions should also target RMDs. This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - August 1, 2016 Category: Rheumatology Authors: Daniela Sim ões, Fábio A. Araújo, Milton Severo, Teresa Monjardino, Ivo Cruz, Loreto Carmona, Raquel Lucas Tags: Original Article Source Type: research

Response to: 'Biologic agents for giant cell arteritis: treat to target by Moiseev et al
We thank Moiseev et al for their interest in our study of ustekinumab in giant cell arteritis (GCA).1 2 Our pilot study reported promising initial results from the use of ustekinumab in GCA.1 GCA is a potentially devastating disease with cranial ischaemic complications such as blindness and stroke occurring in 20%–25% of patients.3 While corticosteroids are effective in reducing the risk of cranial ischaemic complications, they do not fully extinguish the vascular inflammation in patients with GCA4–6 with consequent risk of disease relapse and longer-term consequences such as aortic aneurysms.7 8 Furthermore, c...
Source: Annals of the Rheumatic Diseases - August 9, 2016 Category: Rheumatology Authors: Conway, R., Molloy, E. S. Tags: Electronic pages Source Type: research

Effects of colchicine on risk of cardiovascular events and mortality among patients with gout: a cohort study using electronic medical records linked with Medicare claims
Conclusions Colchicine use was associated with a reduced risk of a CV event among patients with gout.
Source: Annals of the Rheumatic Diseases - August 9, 2016 Category: Rheumatology Authors: Solomon, D. H., Liu, C.-C., Kuo, I.-H., Zak, A., Kim, S. C. Tags: Genetics, Degenerative joint disease, Musculoskeletal syndromes, Epidemiology Clinical and epidemiological research Source Type: research

Incidence and predictors for cardiovascular events in patients with psoriatic arthritis
Conclusion A significant proportion of patients with PsA develop cardiovascular events during the course of their disease. Increased cardiovascular risk is associated with a combination of traditional cardiovascular risk factors and disease activity.
Source: Annals of the Rheumatic Diseases - August 9, 2016 Category: Rheumatology Authors: Eder, L., Wu, Y., Chandran, V., Cook, R., Gladman, D. D. Tags: Degenerative joint disease, Musculoskeletal syndromes Clinical and epidemiological research Source Type: research

Intracerebral hemorrhage with a favorable outcome in a patient with childhood primary angiitis of the central nervous system
We present the case of a boy with cPACNS that previously suffered an ischemic stroke. At the age of 7 years and 10 months, he presented a sudden and severe headache, vomiting and reduction in consciousness level (Glasgow coma scale 7), requiring prompt tracheal intubation. Brain computed tomography demonstrated intraparenchymal hematoma in the right parieto-occipital lobe and a small focus of bleeding in the right frontal lobe, vasogenic edema, herniation of the uncus and a 10 mm deviation to the left from the midline. C-reactive protein (9.2 mg/dL) and von Willebrand factor (vWF) antigen (202%) were elevated. Decompressiv...
Source: Revista Brasileira de Reumatologia - August 22, 2016 Category: Rheumatology Source Type: research

Comorbidities in patients with Primary Sj ögren's Syndrome and Systemic Lupus Erythematosus: A comparative registries‐based study
Conclusions: pSS patients have consistently less serious CV comorbidity burden and a lower prevalence of severe infection than those with SLE. In contrast, their risk of lymphoma was greater. This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - August 25, 2016 Category: Rheumatology Authors: I ñigo Rúa‐Figueroa, Mónica Fernández de Castro, José L. Andreu, Carlos Sanchez‐Piedra, Víctor Martínez‐Taboada, Alejandro Olivé, Javier López‐Longo, José Rosas, María Galindo, Jaime Calvo‐Alén, Antonio Fernández‐Nebro, Fernando A Tags: Original Article Source Type: research

Rivaroxaban 'could be a safe treatment option for antiphospholipid syndrome'
The drug rivaroxaban could be an effective means of treating some patients with thromboticantiphospholipid syndrome, according to a new study. Led by University College London and funded byArthritis Research UK, the research has suggested that the drug - which works by inhibiting the formation of blood clots - could be a useful tool in the treatment of those with this serious condition, which affects approximately 15 per cent of patients withlupus and may also occur on its own. The danger of antiphospholipid syndrome Thrombotic antiphospholipid syndrome is classified as a rare condition, but is probably underdiagnosed. It ...
Source: Arthritis Research UK - August 29, 2016 Category: Rheumatology Source Type: news

Most patients who reach disease remission following anti-TNF therapy continue to report fatigue: results from the British Society for Rheumatology Biologics Register for Rheumatoid Arthritis
Conclusion. Despite achieving clinical remission, many RA patients do not achieve complete remission of their fatigue. Therefore, despite being important in overall disease control, reductions in disease activity are not always sufficient to ameliorate fatigue, so other symptom-specific management approaches must be considered for those for whom fatigue does not resolve.
Source: Rheumatology - September 22, 2016 Category: Rheumatology Authors: Druce, K. L., Bhattacharya, Y., Jones, G. T., Macfarlane, G. J., Basu, N. Tags: Rheumatoid Arthritis CLINICAL SCIENCE Source Type: research

Disease Outcomes and Care Fragmentation among Patients with Systemic Lupus Erythematosus
Conclusion: In this cross‐site cohort of SLE patients, care fragmentation is associated with increased risk of severe infection and comorbidities. These results suggest that improved health information exchange could positively impact outcomes for SLE patients. This article is protected by copyright. All rights reserved.
Source: Arthritis Care and Research - November 30, 2016 Category: Rheumatology Authors: Theresa L. Walunas, Kathryn L. Jackson, Anh H. Chung, Karen A. Mancera ‐Cuevas, Daniel L. Erickson, Rosalind Ramsey‐Goldman, Abel Kho Tags: Original Article Source Type: research

Disease Activity and Increased Risk of Cardiovascular Death among Patients with Psoriatic Arthritis.
CONCLUSION: Patients with PsA had a small but significant increase in SMR for death due to diseases of the circulatory system compared with the general population. Among patients, death was associated with DAI, as well as axial involvement in combination with peripheral disease, indicating more aggressive disease phenotypes. PMID: 27909142 [PubMed - in process]
Source: J Rheumatol - November 30, 2016 Category: Rheumatology Authors: Juneblad K, Rantapää-Dahlqvist S, Alenius GM Tags: J Rheumatol Source Type: research

Clinical characteristics and laboratory findings of 252 Chinese patients with anti-phospholipid syndrome: comparison with Euro-Phospholipid cohort
This study aims to characterize the Chinese Han patients with anti-phospholipid syndrome (APS) and compare the data with those of the Euro-Phospholipid cohort. We conducted a single center study consisting of 252 patients with definite APS from 2000 to 2015. We analyzed the clinical and laboratory characteristics of our cohort and compared the data with those of the Euro-Phospholipid cohort. Our cohort consisted of 216 females and 36 males, with a mean age at entry into this study of 41  years (range 11–74 years). Of these patients, 69 (27.4%) patients had primary APS, and 183 (72.6%) had secondary APS (SAPS), includin...
Source: Clinical Rheumatology - January 26, 2017 Category: Rheumatology Source Type: research

Can we target CCR2 to treat osteoarthritis? The trick is in the timing!
C-C motif chemokines, including CCL2, CCL7, and CCL12, affect cells that express the C-C chemokine receptor type 2, CCR2, a seven-transmembrane domain G-protein coupled receptor (GPCR) [1]. Signaling through CCR2 has been implicated in many pathologies, including autoimmune disorders, tumor metastasis, atherosclerosis, stroke, neurodegenerative disorders, and neurological complications of HIV [2]. As a GPCR, CCR2 is eminently druggable and many small-molecule antagonists have been tested in clinical trials for different conditions [2, 3].
Source: Osteoarthritis and Cartilage - February 7, 2017 Category: Rheumatology Authors: Rachel E. Miller, Anne-Marie Malfait Source Type: research

Cardiovascular Safety of Tocilizumab versus Tumor Necrosis Factor Inhibitors in Patients with Rheumatoid Arthritis – a Multi‐database Cohort Study
Conclusion: This multi‐database population‐based cohort study found no evidence of an increased CV risk among RA patients who switched from a different biologic drug or tofacitinib to TCZ versus to a TNFi. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - February 27, 2017 Category: Rheumatology Authors: Seoyoung C. Kim, Daniel H. Solomon, James R. Rogers, Sara Gale, Micki Klearman, Khaled Sarsour, Sebastian Schneeweiss Tags: Full Length Source Type: research

Primary Prevention of Myocardial Infarction in Rheumatoid Arthritis Using Aspirin: A Case-crossover Study and a Propensity Score-matched Cohort Study.
CONCLUSION: We did not find a protective effect of ASA on MI in patients with RA when used as primary prophylaxis. PMID: 28250138 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - March 3, 2017 Category: Rheumatology Tags: J Rheumatol Source Type: research