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Condition: Epilepsy
Procedure: Transplants

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Total 24 results found since Jan 2013.

Stroke versus non-stroke neurological complications after cardiac transplant (P4.299)
Conclusions:Neurological complications after CT in our population reach nearly a quarter of patients, similar to or even lower than in previous studies.4.3% of patients developed stroke, ischemic subtype.Pre- and perioperative variables do not differ between both groups, except from ischemic cardiomyopathy as the cause of heart failure being it more frequent in the stroke group.Disclosure: Dr. Vazquez has nothing to disclose. Dr. Thomson has nothing to disclose. Dr. Molina Melendres has nothing to disclose. Dr. Nadile has nothing to disclose. Dr. Gonzalez Toledo has nothing to disclose. Dr. Claverie has nothing to disclose...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Vazquez, G., Thomson, A., Melendres, J. M., Nadile, D., Toledo, M. E. G., Claverie, C. S., Thomson, A., Peradejordi, M., Couto, B., Favaloro, L. E., Favaloro, R., Bertolotti, A., Klein, F. Tags: In-Hospital Stroke Care Source Type: research

Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression
Conclusions Stroke comprises ischemic stroke and ICH. The immuno-inflammatory process is involved in neural plasticity following events such as a hemorrhage or ischemic stroke. After ischemia, astrocytes, microglia, and MDMs play important roles during rehabilitation with the modulation of cytokines or chemokines, such as TNF-α and IL-1. Moreover, MiRNAs are also important posttranscriptional regulators in these glial mitochondrial responses to cerebral ischemia. ICH involves processes similar and different to those seen in ischemia, including neuronal injury, astrocytic and microglial/macrophage activation, and n...
Source: Frontiers in Psychiatry - April 10, 2019 Category: Psychiatry Source Type: research

Cryptotanshinone Attenuates Oxygen-Glucose Deprivation/ Recovery-Induced Injury in an in vitro Model of Neurovascular Unit
Conclusions Despite the above limitations, we indicate that the protective mechanism of CTs against OGD/R damage might exert via inhibiting neuron apoptosis and attenuating BBB disruption. Furthermore, we also clarified that CTs inhibited neuronal apoptosis possibly by blocking the activation of MAPK signaling pathways, and CTs alleviating BBB disruption may associated with the regulation of TJPs and MMP-9 in our experiment. Accordingly, CTs will represent a novel and potent candidate for the treatment of CIRI in the future. Ethics Statement This study was carried out in accordance with the recommendations of China�...
Source: Frontiers in Neurology - April 17, 2019 Category: Neurology Source Type: research

Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

Management of Neurologic Manifestations in Patients with Liver Disease
Opinion statement Liver disease, both in its acute and chronic forms, can be associated with a wide spectrum of neurologic manifestations, both central and peripheral, ranging in severity from subclinical changes to neurocritical conditions. Neurologists are frequently consulted to participate in their management. In this review, we present an overview of management strategies for patients with hepatic disease whose clinical course is complicated by neurologic manifestations. Type A hepatic encephalopathy (HE), which occurs in acute liver failure, is a neurologic emergency, and multiple measures should be taken t...
Source: Current Treatment Options in Neurology - June 16, 2016 Category: Neurology Source Type: research

Management of Neurologic Manifestations in Patients with Liver Disease.
Abstract OPINION STATEMENT: Liver disease, both in its acute and chronic forms, can be associated with a wide spectrum of neurologic manifestations, both central and peripheral, ranging in severity from subclinical changes to neurocritical conditions. Neurologists are frequently consulted to participate in their management. In this review, we present an overview of management strategies for patients with hepatic disease whose clinical course is complicated by neurologic manifestations. Type A hepatic encephalopathy (HE), which occurs in acute liver failure, is a neurologic emergency, and multiple measures should b...
Source: Epilepsy Curr - June 19, 2016 Category: Neurology Authors: Ferro JM, Viana P, Santos P Tags: Curr Treat Options Neurol Source Type: research

Fecal Microbiota Transplantation in Neurological Disorders
Conclusions: Preliminary literature suggests that FMT may be a promising treatment option for several neurological disorders. However, available evidence is still scanty and some contrasting results were observed. A limited number of studies in humans have been performed or are ongoing, while for some disorders only animal experiments have been conducted. Large double-blinded randomized controlled trials are needed to further elucidate the effect of FMT in neurological disorders.
Source: Frontiers in cellular and infection microbiology - March 23, 2020 Category: Microbiology Source Type: research

Experimental and clinical factors influencing long-term stable in vitro expansion of multipotent neural cells from human adult temporal lobes.
Abstract Autologous adult human neural stem cells may be used for regenerative cell therapies bypass potential ethical problems. However, stable in vitro expansion protocols and experimental/clinical factors influencing primary cultures need to be further elucidated for clinically applicable techniques. To address these issues, we obtained biopsy specimens from 23 temporal lobe epilepsy patients and adult human multipotent neural cells (ahMNCs) were primarily cultured in a defined attachment culture condition. When the success of primary cultures was defined as stable expansion of cells (>ten in vitro passages)...
Source: Experimental Neurology - November 29, 2012 Category: Neurology Authors: Joo KM, Kang BG, Yeon JY, Cho YJ, An JY, Song HS, Won JH, Kim SJ, Hong SC, Nam DH Tags: Exp Neurol Source Type: research

Media advisory: Brain cell injections may quiet epileptic seizures
(NIH/National Institute of Neurological Disorders and Stroke) NIH-funded researchers at the University of California at San Francisco used a mouse model of epilepsy to show that transplanting new born inhibitory nerve cells can quiet seizures.
Source: EurekAlert! - Medicine and Health - May 5, 2013 Category: Global & Universal Source Type: news

Quality of Life in Liver Transplant Patients with Neurologic Complications. (P4.031)
Conclusions: Our analysis shows that neurological complications worsen the quality of life of liver transplant patients. Especially regarding perception of health, ability to function independently due to physical and mental health limitations. Pain is a limiting condition in this group. Transplant patients who suffer neurological complications should be carefully followed up to reduce the impact on quality of life, in order to promote the ultimate goal of transplant.Disclosure: Dr. Gonzalez Toledo has nothing to disclose. Dr. Calle has received personal compensation for activities with UCB Pharma. Dr. Pagani Cassara has n...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Gonzalez Toledo, M., Calle, A., Pagani Cassara, F., Tamargo, A., Thomson, A., Nadile, D., Gruz, F., Sinay, V. Tags: General Neurology III Source Type: research

Transthyretin-type cerebral amyloid angiopathy: a serious complication in post-transplant patients with familial amyloid polyneuropathy
Liver transplantation is a well-established treatment for transthyretin (TTR)-type familial amyloid polyneuropathy (TTR-FAP).1 According to data in the Familial Amyloidotic Polyneuropathy World Transplant Registry (http://www.fapwtr.org/ram_fap.htm), more than 2000 liver transplantations have been performed to date in 19 countries. Transplantation replaces the variant TTR gene with the wild-type gene in the liver, the main source of serum circulating TTR. The serum concentration of variant TTR decreases rapidly, reaching almost zero after the operation. The effects of liver transplantation on neuropathy are evident as its ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 14, 2015 Category: Neurosurgery Authors: Sekijima, Y. Tags: Genetics, Immunology (including allergy), Drugs: CNS (not psychiatric), Epilepsy and seizures, Neuromuscular disease, Peripheral nerve disease, Stroke, Ophthalmology Editorial commentaries Source Type: research

Post-transplant Acute Symptomatic Seizures. Long Term Recurrence and Development of Epilepsy. (P7.027)
CONCLUSIONS:Even though our population is small, these results show that most transplanted patients that suffered ASSz do not have a higher risk of recurrence in the long run. The use of CalInh that lower the convulsive threshold doesn’t seem to increase the risk of recurrence, enabling us to taper AED. Further studies are needed to support our hypothesis. Study Supported by: Disclosure: Dr. Gonzalez Toledo has nothing to disclose. Dr. Calle has received personal compensation for activities with UCB Pharma as a scientific advisory board member. Dr. Fontela has received personal compensation for activities with Quinti...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Gonzalez Toledo, M., Calle, A., Fontela, M. E., Tamargo, A., Nadile, D., Pagani Cassara, F., Thomson, A., Thomson, A. Tags: Epilepsy/Clinical Neurophysiology (EEG): Clinical Epilepsy Source Type: research

Cortical laminar necrosis due to refractory status epilepticus in a kidney transplant patient with cryptococcal meningitis
Publication date: Available online 17 November 2015 Source:Indian Journal of Transplantation Author(s): Zaheer Virani, Prashant Rajput, Pankaj Agarwal, Rashmi Badhe A 56-year-old diabetic male underwent kidney transplant in 2010. He was brought to the hospital with complaints of vomiting and altered sensorium of 10 days duration. Lumbar puncture revealed cryptococcal meningitis. He was promptly initiated on liposomal amphotericin B and flucytosine. Immunosuppressive agents tacrolimus and mycophenolate mofetil were discontinued. There was an initial improvement in his sensorium but a few days later, he developed super...
Source: Indian Journal of Transplantation - November 17, 2015 Category: Transplant Surgery Source Type: research

Cochrane Priority Reviews List: December 2016 Update
Cochrane-wide prioritisation remains an important project, with over 140 priority reviews or updates have been published since it began in January 2015.The December 2016 revision of the Cochrane Priority Reviews List includes new titles from the Cochrane Airways, Anaesthesia, Dementia& Cognitive Improvement, ENT, Epilepsy, Gynaecological, Neuro-oncology and Orphan Cancers, Gynaecology& Fertility, Haematological Malignancies, Heart, Incontinence, Kidney& Transplant, Lung Cancer, Neuromuscular Disease, Oral Health, Skin, Stroke, and Urology Groups.The following titles on the list are open to new authors:Long-acti...
Source: Cochrane News and Events - December 14, 2016 Category: Information Technology Authors: mumoquit at cochrane.org Source Type: news

Neurologic emergencies in HIV-negative immunosuppressed patients.
This article reviews the role of neuroimaging in HIV-negative immunodepressed patients with a neurologic complication that requires urgent management. PMID: 28012729 [PubMed - as supplied by publisher]
Source: Radiologia - December 20, 2016 Category: Radiology Authors: Guzmán-De-Villoria JA, Fernández-García P, Borrego-Ruiz PJ Tags: Radiologia Source Type: research