Cochrane Priority Reviews List: December 2016 Update

Cochrane-wide prioritisation remains an important project, with over 140 priority reviews or updates have been published since it began in January 2015.The December 2016 revision of the Cochrane Priority Reviews List includes new titles from the Cochrane Airways, Anaesthesia, Dementia&Cognitive Improvement, ENT, Epilepsy, Gynaecological, Neuro-oncology and Orphan Cancers, Gynaecology&Fertility, Haematological Malignancies, Heart, Incontinence, Kidney&Transplant, Lung Cancer, Neuromuscular Disease, Oral Health, Skin, Stroke, and Urology Groups.The following titles on the list are open to new authors:Long-acting beta2-agonists and long-acting muscarinic antagonists in a combined inhaler versus either agent alone or placebo for chronic obstructive pulmonary diseaseProstacyclin for pulmonary hypertension in adultsWeight loss intervention through lifestyle modification or pharmacotherapy for obstructive sleep apnoea in adultsOutpatient treatment of diverticulitisPrevention of recurrent diverticulitisProphylactic antibiotics for preventing recurrent symptomatic episodes of acute diverticulitisAntibiotics for trachomaBiomarkers for predicting outcomes in endometrial cancerDiagnostic test accuracy of sentinel LN node sampling in endometrial cancerInterventions to improve insulin resistance for the prevention of endometrial cancerInterventions to promote early referral for women with symptoms of endometrial cancerImmunomodulatory treatment for amyotrophic lateral sclerosis...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news

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Publication date: Available online 19 April 2019Source: The American Journal of SurgeryAuthor(s): Tammy Ju, Lisbi Rivas, Kyle Kurland, Sheena Chen, Andrew Sparks, Paul P. Lin, Khashayar VaziriAbstractBackgroundTo identify trends in total and subtotal gastrectomy for middle and distal third gastric adenocarcinoma in the U.S.MethodsNCDB was queried for patients with stage 0-III middle or distal gastric adenocarcinoma treated with total or subtotal gastrectomy. Statistical analysis including cox proportional hazards model was performed to examine overall survival by stage.Results1,628(85%) underwent subtotal gastrectomy and 2...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Abstract The goal of this study was to identify neurostructural frontal lobe correlates of cognitive and speaking rate changes in amyotrophic lateral sclerosis (ALS). 17 patients diagnosed with ALS and 12 matched controls underwent clinical, bulbar, and neuropsychological assessment and structural neuroimaging. Neuropsychological testing was performed via a novel computerized frontal battery (ALS-CFB), based on a validated theoretical model of frontal lobe functions, and focused on testing energization, executive function, emotion processing, theory of mind, and behavioral inhibition via antisaccades. The measure ...
Source: Behavioural Neurology - Category: Neurology Authors: Tags: Behav Neurol Source Type: research
CANCER symptoms vary depending on which part of the body is affected by a tumour. You may be at risk of a deadly tumour if you have this painful sign in your chest. Should you see a doctor?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
AbstractIntroductionDespite the numerous studies investigating drug-induced anaphylaxis (DIA), understanding and quantitative data analysis in developing countries remain limited. The aim of our study is to describe and quantify DIA using the National Pharmacovigilance Database of Vietnam (NPDV).MethodsSpontaneous reporting of adverse drug reactions (ADRs) recorded between 2010 and 2016 were retrospectively analysed to identify DIA reports. The trend and characteristics of DIA cases were described. Multivariate disproportionality analysis was used for signal generation.ResultsOverall, 4873 DIA cases (13.2% of total ADRs) w...
Source: Drug Safety - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 19 April 2019Source: Canadian Journal of CardiologyAuthor(s): Pierluigi Costanzo, Vladimír DžavíkAbstractPatients with chronic kidney disease (CKD) have an increased risk of obstructive coronary artery disease (CAD), while patients with end stage renal disease (ESRD) on hemodialysis represent a population at particularly high risk of developing cardiac ischemic events. Patients with CKD and acute coronary syndromes (ACS) should be treated the same way as ACS patients without kidney dysfunction. The benefit of revascularization in patients with advanced kidney failure and CA...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 19 April 2019Source: Seminars in Cancer BiologyAuthor(s): Lingzhi Li, Zhuoyu Bi, Priya Wadgaonkar, Yongju Lu, Qian Zhang, Yao Fu, Chitra Thakur, Li Wang, Fei ChenAbstractAt present, the belief that genetic mutations control every aspect of tumorigenesis is still very popular. Even for the highly debated “bad luck” theory of cancers, it ascertained that random mutation of genes during the self-renewal of somatic stem cells is responsible for cancer initiation. Logically, most of the new therapeutic strategies so far, from molecular targeting to precision medicine or personalize...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 16 April 2019Source: Seminars in Cancer BiologyAuthor(s): Samanta Salvi, Massimiliano Bonafè, Sara BravacciniAbstractThe possibility that a receptor for androgen is expressed in Breast Cancer (BC) is fascinating given that the tumor is predominantly estrogen-dependent.The androgen receptor (AR) is emerging as a new marker and a potential new therapeutic target in the treatment of BC patients. The recent availability of selective AR inhibitors (e.g. bicalutamide, enzalutamide, apalutamide) approved for the treatment of prostate cancer has opened up the possibility to use them in BC ...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
ConclusionsThe study highlights increasing incidence of colon cancer in younger subjects and a decrease in incidence rates for rectal cancer in females.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Authors: Erejuwa OO, Gan SH, Romani AMP, Kamal MA, Nammi S PMID: 31001431 [PubMed]
Source: International Journal of Hypertension - Category: Cardiology Tags: Int J Hypertens Source Type: research
In this study we reprogrammed fibroblasts from a 30-year-old male patient with DDE carrying a point mutation (c.890G > A, p.Arg297Gln) in KCNA2 to induced pluripotent stem cells. Pluripotency state of the cells was verified by the capability to differentiate into all three germ layers and the expression of several pluripotency markers on RNA and protein levels.
Source: Stem Cell Research - Category: Stem Cells Source Type: research
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