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Condition: Epilepsy

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Total 2623 results found since Jan 2013.

The role of genetic risk factors in arterial ischemic stroke in pediatric and adult patients: a critical review.
Abstract The incidence of arterial ischemic stroke (AIS) in childhood (about 2-13 per 100,000 children a year) is much lower than the incidence in the adult population. Still, adverse outcomes of acute brain ischemia in childhood include death (10 % of AIS children), neurological sequel, epileptic seizures (over 50 %) and recurrence (over 20 %). The knowledge of childhood stroke etiopathogenesis is still insufficient and the diagnostic and therapeutic procedures-controversial. Risk factors for childhood stroke differ from those observed in adults due to differing exposure to external risk factors. The most freq...
Source: Molecular Biology Reports - March 1, 2014 Category: Molecular Biology Authors: Kopyta I, Sarecka-Hujar B, Sordyl J, Sordyl R Tags: Mol Biol Rep Source Type: research

Development of epilepsy after ischaemic stroke
Publication date: Available online 17 November 2015 Source:The Lancet Neurology Author(s): Asla Pitkänen, Reina Roivainen, Katarzyna Lukasiuk For about 30% of patients with epilepsy the cause is unknown. Even in patients with a known risk factor for epilepsy, such as ischaemic stroke, only a subpopulation of patients develops epilepsy. Factors that contribute to the risk for epileptogenesis in a given individual generally remain unknown. Studies in the past decade on epilepsy in patients with ischaemic stroke suggest that, in addition to the primary ischaemic injury, existing difficult-to-detect microscale changes in...
Source: The Lancet Neurology - November 17, 2015 Category: Neurology Source Type: research

The Progress of Epilepsy after Stroke.
Abstract Epilepsy is the second most common disease caused by multiple factors and characterized by an excessive discharge of certain neurons in the nervous system. Cerebrovascular disease, including stroke, is viewed as the most common cause of epilepsy in the elderly population, accounting for 30%-50% of the newly diagnosed cases of epilepsy cases in this age group. Depending on the underlying cerebrovascular disease, 3%-30% of patients after stroke may develop post-stroke epilepsy (PSE), which has a negative effect on stroke prognosis and the quality of life. In this review, we will describe new aspects emergin...
Source: Current Neuropharmacology - June 12, 2017 Category: Drugs & Pharmacology Authors: Zhao Y, Li X, Zhang K, Tong T, Cui R Tags: Curr Neuropharmacol Source Type: research

Risk factors for post-stroke seizure recurrence after the first episode
Conclusions In patients with post-stroke seizure, status epilepticus and younger age were the predictors of recurrence after early and late seizure, respectively.
Source: Seizure - September 14, 2017 Category: Neurology Source Type: research

Outcome and predictive factors in post-stroke seizures: A retrospective case-control study
Every year, more than 795,000 people in the United States have a stroke [1]. Stroke is the fifth leading cause of death for Americans [1]. Stroke is a commonly identified cause of epilepsy in patients older than 35, and the most common cause of seizures in the elderly [2,3]. From stroke registry data, 5-20% of all patients who have suffered stroke will develop seizures[4]. Frequency is variable due to different study methodologies[4]. In a multicenter, prospective study, seizures occurred in 8.9% of 1897 patients with stroke [4,5].
Source: Seizure: European Journal of Epilepsy - September 14, 2018 Category: Neurology Authors: Ramiro Castro-Apolo, Josephine F. Huang, Myrian Vinan-Vega, William O. Tatum Source Type: research

Chorea-ballism as a dominant clinical manifestation in heteroplasmic mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes syndrome with A3251G mutation in mitochondrial genome: a case report
ConclusionThe dominance of hyperkinetic movements in the clinical scenario and the finding of a point mutation A3251G inMT-TL1 gene make this a rare presentation.
Source: Journal of Medical Case Reports - March 5, 2019 Category: General Medicine Source Type: research

Incidence, Implications, and Management of Seizures Following Ischemic and Hemorrhagic Stroke.
Abstract PURPOSE OF REVIEW: In this review, we summarize the recent literature regarding the incidence and treatment of seizures arising after ischemic and hemorrhagic strokes. Additionally, we identify open questions in guidelines and standard clinical care to aid future studies aiming to improve management of seizures in post-stroke patients. RECENT FINDINGS: Studies demonstrate an increasing prevalence of seizures following strokes, probably a consequence of advances in post-stroke management and expanding use of continuous EEG monitoring. Post-stroke seizures are associated with longer hospitalization and...
Source: Epilepsy Curr - May 26, 2019 Category: Neurology Authors: Doria JW, Forgacs PB Tags: Curr Neurol Neurosci Rep Source Type: research

Poststroke seizures as stroke mimics: Clinical assessment and management.
This article is part of the Special Issue "Seizures & Stroke". PMID: 31303444 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - July 10, 2019 Category: Neurology Authors: Brigo F, Lattanzi S Tags: Epilepsy Behav Source Type: research

Efficacy of Statin Therapy in Post-Stroke Seizure Prophylaxis: Clues from an Observational Study of Routine Secondary Prevention Treatment
Stroke is a common cause of epilepsy in the elderly population. The abnormal neuronal discharges of post-stroke seizures (PSS) can cause damage to neurons and worsen the outcome of stroke. Numerous studies have focused on the clinical epidemiology of PSS; and the reported incidence varies from 2% to 20%, depending on the study population, stroke subtype, and the seizure onset time after the stroke [1 –4]. Patients with early-onset seizures (ES) have a high risk of disability and mortality [1,5], whereas those with late-onset seizures (LS) and post-stroke epilepsy (PSE) tend to end up with poorer outcomes [6].
Source: Seizure: European Journal of Epilepsy - July 23, 2019 Category: Neurology Authors: Yuxiang Li, Bei Zhang, Lu Zhang, Dandan Xie, Yi Li Source Type: research

Incidence of early poststroke seizures during reperfusion therapies in patients with acute ischemic stroke: An observational prospective study: (TESI study: “Trombolisi/Trombectomia e crisi Epilettiche precoci nello Stroke Ischemico”)
ConclusionThe incidence of early poststroke seizures was overall rare, and no significant differences emerged between patients receiving and those not receiving reperfusion therapies.This article is part of the Special Issue “Seizures and Stroke”.
Source: Epilepsy and Behavior - August 18, 2019 Category: Neurology Source Type: research

Vagus nerve stimulation as a promising adjunctive treatment for ischemic stroke
Publication date: Available online 21 August 2019Source: Neurochemistry InternationalAuthor(s): Jingxi Ma, Peifeng Qiao, Qin Li, Yangyang Wang, Lan Zhang, Liang-Jun Yan, Zhiyou CaiAbstractThe Food and Drug Administration has approved vagus-nerve stimulation (VNS) for the treatment of patients with epilepsy, depression, and headache. By targeting diverse neuroprotective and neuroplasticity pathways, VNS has the potential to be expanded as a treatment for ischemic stroke. VNS has been found to attenuate infarct volume, reduce neurological deficits, and improve memory and cognition in rats with stroke injuries. Some pilot stu...
Source: Neurochemistry International - August 22, 2019 Category: Neuroscience Source Type: research

Younger age at stroke onset but not thrombolytic treatment predicts poststroke epilepsy: An updated meta-analysis.
CONCLUSION: Despite limitations due to the uneven quality and design of the studies, the present meta-analysis confirms that cortical involvement, hemorrhagic component, and ES are associated with a higher risk of PSE. In this update, younger age at stroke onset but not thrombolytic treatment seems to increase the risk for PSE. This article is part of the Special Issue "Seizures & Stroke". PMID: 31677999 [PubMed - as supplied by publisher]
Source: Epilepsy and Behaviour - October 29, 2019 Category: Neurology Authors: Gasparini S, Ascoli M, Brigo F, Cianci V, Branca D, Arcudi L, Aguglia U, Belcastro V, Ferlazzo E Tags: Epilepsy Behav Source Type: research

Seizures and Epilepsy After Stroke: Epidemiology, Biomarkers and Management
AbstractStroke is the leading cause of seizures and epilepsy in older adults. Patients who have larger and more severe strokes involving the cortex, are younger, and have acute symptomatic seizures and intracerebral haemorrhage are at highest risk of developing post-stroke epilepsy. Prognostic models, including the SeLECT and CAVE scores, help gauge the risk of epileptogenesis. Early electroencephalogram and blood-based biomarkers can provide information additional to the clinical risk factors of post-stroke epilepsy. The management of acute versus remote symptomatic seizures after stroke is markedly different. The choice ...
Source: Drugs and Aging - February 23, 2021 Category: Geriatrics Source Type: research

Childhood Stroke: Long-Term Outcomes and Health-Related Quality of Life with a Special Focus on the Development of Epilepsy
Conclusion One important finding in our study is that in the long-term course 39% of patients developed epilepsy after a childhood stroke. It occurred as late as 13 years after the acute episode and affected the QoL especially in cognitively less handicapped patients. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Neuropediatrics - July 12, 2021 Category: Neurology Authors: von St ülpnagel, C. Kutschker, Sebastian Sperl, Wolfgang Berweck, Steffen Staudt, Martin Berndt, Markus Kluger, G. Tags: Original Article Source Type: research

Functional seizures are associated with cerebrovascular disease and functional stroke is more common in patients with functional seizures than epileptic seizures
CONCLUSION: Our results confirm the initial observation of increased CVD in patients with FSe and further suggest that patients with FSe may be predisposed to developing another functional neurological disorder (FND) (i.e., functional stroke). We speculate that this may be due to shared risk factors and pathophysiological processes that are common to various manifestations of FND.PMID:35123242 | DOI:10.1016/j.yebeh.2022.108582
Source: Epilepsy and Behaviour - February 5, 2022 Category: Neurology Authors: Jonah Fox Slavina B Goleva Kevin F Haas Lea K Davis Source Type: research