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Total 689 results found since Jan 2013.

Mechanistic understanding of the effect of Dengzhan Shengmai capsule on the pharmacokinetics of clopidogrel in rats
Conclusions DZSM significantly affects the pharmacokinetics of clopidogrel and its active metabolite by inhibiting the P-gp-mediated efflux transport and CYP450-mediated metabolism of clopidogrel. Thus, caution is needed when DZSM is co-administered with clopidogrel in the clinic because the interaction of these drugs may result in altered plasma concentrations of clopidogrel and its active metabolite. Graphical abstract
Source: Journal of Ethnopharmacology - August 7, 2016 Category: Drugs & Pharmacology Source Type: research

Voodoo Medicine: Time To Stop
The world's most celebrated athlete standing on the podium in Rio in honor of receiving yet another gold medal has something important in common with your lazy uncle throwing back a cold one in his Barcalounger. Yes, swimming powerhouse Michael Phelps, purple-spotted from cupping therapy, and your slovenly relative with a beer gut both share a bond -- a weakness in succumbing to the allure of voodoo medicine. Modern-day snake oil salesmen hawking quick cures and TV doctors peddling the latest diet miracle with blatantly ridiculous claims are everywhere on the tube, social media, the supermarket and old-fashioned billboards...
Source: Science - The Huffington Post - August 12, 2016 Category: Science Source Type: news

Anti-Inflammatory Effects of Traditional Chinese Medicines against Ischemic Injury in In Vivo Models of Cerebral Ischemia.
Authors: Cheng CY, Lee YC Abstract Inflammation plays a crucial role in the pathophysiology of acute ischemic stroke. In the ischemic cascade, resident microglia are rapidly activated in the brain parenchyma and subsequently trigger inflammatory mediator release, which facilitates leukocyte-endothelial cell interactions in inflammation. Activated leukocytes invade the endothelial cell junctions and destroy the blood-brain barrier integrity, leading to brain edema. Toll-like receptors (TLRs) stimulation in microglia/macrophages through the activation of intercellular signaling pathways secretes various proinflammato...
Source: Evidence-based Complementary and Alternative Medicine - October 7, 2016 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Breviscapine confers a neuroprotective efficacy against transient focal cerebral ischemia by attenuating neuronal and astrocytic autophagy in the penumbra
Publication date: June 2017 Source:Biomedicine & Pharmacotherapy, Volume 90 Author(s): Zhang Pengyue, Guo Tao, He Hongyun, Yang Liqiang, Deng Yihao Breviscapine is a flavonoid derived from a traditional Chinese herb Erigerin breviscapus (Vant.) Hand-Mazz, and has been extensively used in clinical treatment for cerebral stroke in China, but the underlying pharmacological mechanisms are still unclear. In present study, we investigated whether breviscapine could confer a neuroprotection against cerebral ischemia injury by targeting autophagy mechanisms. A cerebral stroke model in Sprague-Dawley rats was prepared by m...
Source: Biomedicine and Pharmacotherapy - March 24, 2017 Category: Drugs & Pharmacology Source Type: research

Breviscapine confers a neuroprotective efficacy against transient focal cerebral ischemia by attenuating neuronal and astrocytic autophagy in the penumbra.
Abstract Breviscapine is a flavonoid derived from a traditional Chinese herb Erigerin breviscapus (Vant.) Hand-Mazz, and has been extensively used in clinical treatment for cerebral stroke in China, but the underlying pharmacological mechanisms are still unclear. In present study, we investigated whether breviscapine could confer a neuroprotection against cerebral ischemia injury by targeting autophagy mechanisms. A cerebral stroke model in Sprague-Dawley rats was prepared by middle cerebral artery occlusion (MCAO), rats were then randomly divided into 5 groups: MCAO+Bre group, rats were treated with breviscapine;...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 23, 2017 Category: Drugs & Pharmacology Authors: Pengyue Z, Tao G, Hongyun H, Liqiang Y, Yihao D Tags: Biomed Pharmacother Source Type: research

Hyperforin protects against acute cerebral ischemic injury through inhibition of interleukin-17A-mediated microglial activation.
In conclusion, our results clearly showed that hyperforin could protect against acute cerebral ischemic injury through inhibition of interleukin-17A-mediated microglial activation and polarization of microglia to M2 phenotype. PMID: 28870826 [PubMed - as supplied by publisher]
Source: Brain Research - September 1, 2017 Category: Neurology Authors: Ma L, Pan X, Zhou F, Liu K, Wang L Tags: Brain Res Source Type: research

Patchouli Alcohol protects against Ischemia/Reperfusion-induced brain injury via inhibiting neuroinflammation in normal and obese mice.
In conclusion, we demonstrated for the first time that PA could protect against cerebral I/R injury not only in normal mice but also in obese mice via inhibiting inflammation, suggesting that PA can be a potential drug for clinical treatment of ischemic stroke. PMID: 29291393 [PubMed - as supplied by publisher]
Source: Brain Research - December 29, 2017 Category: Neurology Authors: Wei LL, Chen Y, Yu QY, Wang Y, Liu G Tags: Brain Res Source Type: research

Banhabaekchulchunma-tang and chongsanggeontong-tang (herbal medicine) effect on migraine: A protocol for a systematic review of controlled trials
Conclusion:we propose the current protocol to evaluate the effectiveness and safety of BBT or CGT for migraine systematically.Ethics and dissemination:This systematic review will not need ethical approval, because it does not involve human beings. We will publish this systematic review electronically in a peer-reviewed journal.Systematic review registration:PROSPERO CRD42018076171 for BBT and CRD42018085130 for CGT Background: Migraine is a common disease of primary headache, which it causes many kinds of secondary diseases or symptoms. The treatment drugs have sometimes shown side effects such as overuse headache, str...
Source: Medicine - March 1, 2018 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Xueshuantong Injection (Lyophilized) Attenuates Cerebral Ischemia/Reperfusion Injury by the Activation of Nrf2-VEGF Pathway.
In conclusion, administered XST for 7 days after stroke could significantly improve functional recovery and promote angiogenesis, that might be related to Nrf2 signaling pathway. These findings could provide scientific evidence for the use of XST in cerebral ischemic diseases and provide theoretical support for further studies. PMID: 29633164 [PubMed - as supplied by publisher]
Source: Neurochemical Research - April 9, 2018 Category: Neuroscience Authors: Guo H, Adah D, James PB, Liu Q, Li G, Ahmadu P, Chai L, Wang S, Liu Y, Hu L Tags: Neurochem Res Source Type: research

Clinical benefits and pharmacology of Scutellarin: A comprehensive review
Publication date: Available online 6 May 2018 Source:Pharmacology & Therapeutics Author(s): Liping Wang, Qiang Ma Stroke and myocardial infarction are among the most common causes of mortality and disability in the world. The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. The current drug therapy of choice is to timely resupply the blood to the ischemic ti...
Source: Pharmacology and Therapeutics - May 6, 2018 Category: Drugs & Pharmacology Source Type: research

Long-Zhi Decoction Medicated Serum Promotes Angiogenesis in Human Umbilical Vein Endothelial Cells Based on Autophagy.
Authors: He Q, Liu Q, Chen Y, Meng J, Zou L Abstract Ischemic stroke (IS) is a fatal subtype of stroke that lacks effective treatments. Angiogenesis following IS is an effective response that mediates brain recovery and repair. Our previous study demonstrated that long-zhi decoction (LZD), a Chinese herbal formula, promoted angiogenesis in rats of IS model. To further investigate the association between the proangiogenic mechanism of an LZD-medicated serum and cellular autophagy, we evaluated its promotional effect on angiogenesis in human umbilical vein endothelial cells (HUVECs) in vitro. We used HUVECs subjected...
Source: Evidence-based Complementary and Alternative Medicine - June 3, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Hookah smoking raises cardiovascular risk comparable to traditional cigarette smoking, study finds
This study is believed to be the first to investigate the effects of hookah smoking on stiffening of the arteries. Studies have shown that as cigarette use continues to decline, hookah smoking is rising, especially among youth and particularly among college students.“We know that flavored tobacco products are frequently the first kind of tobacco product used by youth,” Rezk-Hanna said. “One of the major issues with hookah is the fact that the tobacco is flavored with fruit, candy and alcohol flavors, making hookah the most popular flavored tobacco produc t among this audience.”According to the Food and Drug Admini...
Source: UCLA Newsroom: Health Sciences - August 2, 2018 Category: Universities & Medical Training Source Type: news

Neuroprotective effect of Paeoniae Radix Rubra on hippocampal CA1 region of mice induced by transient focal cerebral ischemia via anti-gliosis and anti-oxidant activity
ConclusionPRR improved neuronal injuries that were induced by transient cerebral ischemia via inhibiting gliosis and elevating antioxidants.
Source: Chinese Herbal Medicines - November 15, 2018 Category: Complementary Medicine Source Type: research

< b > < i > Panax notoginseng < /i > < /b > Saponins Ameliorate Leukocyte Adherence and Cerebrovascular Endothelial Barrier Breakdown upon Ischemia-Reperfusion in Mice
Panax notoginseng saponins (PNS) are known as clinical anti-stroke herbal medicines. The aim of this study is to describe the impact of PNS on ischemia-reperfusion-induced cerebral microvasculature barrier dysfunction which has not been investigated yet. Mice were subjected to transient middle cerebral artery occlusion and PNS were administrated to mice 3 days before and 2 days after surgery. Leukocyte adhesion, albumin leakage, tight junctions and other parameters in the cortex were measured. The PNS 45 mg/kg intervention alleviated leukocyte adhesion, inhibited endothelial barrier alterations evidenced by reduced albumin...
Source: Journal of Vascular Research - February 14, 2019 Category: Research Source Type: research

Preventable Cases of Oral Anticoagulant-Induced Bleeding: Data From the Spontaneous Reporting System
Conclusion: Our findings describe the most reported risk factors for preventability of oral anticoagulant-induced bleedings. These factors may be useful for targeting interventions to improve pharmacovigilance activities in our regional territory and to reduce the burden of medication errors and inappropriate prescription. Introduction Oral anticoagulant therapy is widely used for the prevention of stroke and systemic embolism in patients with atrial fibrillation, or for the prevention and treatment of deep vein thrombosis and pulmonary embolism (Raj et al., 1994; Monaco et al., 2017). Oral anticoagulants can be di...
Source: Frontiers in Pharmacology - April 29, 2019 Category: Drugs & Pharmacology Source Type: research