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Total 689 results found since Jan 2013.

A Network Pharmacology-Based Identification Study on the Mechanism of Xiao-Xu-Ming Decoction for Cerebral Ischemic Stroke.
Conclusion: This study initially clarified the main targets and pathways of XXMD in the treatment of CIS, which can lay the foundation for further research on its pharmacological effects. PMID: 33133212 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - November 3, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Multimodal Magnetic Resonance Imaging and Therapeutic Intervention With Yi-nao-jie-yu Decoction in a Rat Model of Post-stroke Depression
Post-stroke depression (PSD) is the most common neuropsychiatric complication after a stroke, though its neuropathological characteristics have not been fully elucidated. Comprehensive and non-invasive magnetic resonance (MR) assessment techniques are urgently needed for current research, as diffusion tensor imaging (DTI), arterial spin labeling (ASL), and magnetic resonance spectroscopy (MRS) can allow for a comprehensive assessment of neuropathological changes in the brain. These techniques can provide information about microscopic tissue integrity, cerebral perfusion, and cerebral metabolism, and can serve as powerful t...
Source: Frontiers in Psychiatry - November 4, 2020 Category: Psychiatry Source Type: research

Therapeutic effect of Chinese herbal medicines for post-stroke depression: A meta-analysis of randomized controlled trials
This study aimed to assess the efficacy and safety of combination of CHM with routine western medicines versus routine western medicines alone in patients with post-stroke depression (PSD). Methods: Electronic databases such as PubMed, EmBase, Cochrane library, and China National Knowledge Infrastructure were systematically searched from inception till October 2019. Studies designed as randomized controlled trials (RCTs) and that investigated the therapeutic effects of CHM plus routine western medicines (CHM group) versus routine western medicines alone (control group) in PSD patients were eligible. The relative ris...
Source: Medicine - January 8, 2021 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Chinese Herbal Medicine Xingnaojing Injection for Acute Ischemic Stroke: An Overview of Systematic Reviews and Meta-Analyses
Conclusion: XNJ appears to be effective and safe for acute IS in improving the neurological deficits, but the evidence is not robust enough. However, whether administering XNJ immediately after or within 24 h of IS is best remains unknown due to the lack of data. Well-designed large-scale randomized controlled trials with measurable outcomes are required in future studies.
Source: Frontiers in Pharmacology - May 18, 2021 Category: Drugs & Pharmacology Source Type: research

Herbal medicine for post-stroke insomnia: A protocol for systematic review and meta-analysis
Conclusion: This study will provide evidence regarding the efficacy and safety of HM for the treatment of PSI. Ethics and dissemination: No ethical approval will be needed because data from previously published studies in which informed consent was obtained by primary investigators will be retrieved and analyzed. We will publish this systematic review in a peer-reviewed journal. OSF registration DOI: 10.17605/OSF.IO/PEHQZ.
Source: Medicine - June 4, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research

Intravenous Thrombolysis for a Stroke Mimic Patient
The authors present the case of a young woman on phentermine and herbal supplements who presented as an acute stroke alert with right-sided facial droop and numbness. She was treated acutely with intravenous tissue plasminogen activator (tPA). However, the workup did not reveal any evidence of cerebrovascular disease or cerebral infarct. The authors discuss plausible stroke mimics and the safety of administering tPA to such patients.Case Rep Neurol 2021;13:704 –709
Source: Case Reports in Neurology - October 25, 2021 Category: Neurology Source Type: research

Suppressing NK Cells by Astragaloside IV Protects Against Acute Ischemic Stroke in Mice Via Inhibiting STAT3
In conclusion, ASIV inhibits post-ischemic brain infiltration and activation of NK cells through STAT3 suppression, and this inhibitory effect of ASIV on NK cells plays a key role in its protection against acute ischemic brain injury. Our findings suggest that ASIV is a promising therapeutic candidate in NK cell-based immunotherapy for the treatment of acute ischemic stroke and pave the way for potential clinical trials.
Source: Frontiers in Pharmacology - February 3, 2022 Category: Drugs & Pharmacology Source Type: research

Hydroxysafflor Yellow A Alleviates Ischemic Stroke in Rats via HIF-1Formula: see text, BNIP3, and Notch1-Mediated Inhibition of Autophagy
In conclusion, HSYA inhibits post-IS autophagy induction in the brain, possibly by suppressing HIF-1[Formula: see text], BNIP3 and Notch1. HSYA may have utility as a post-IS neuroprotective agent.PMID:35300568 | DOI:10.1142/S0192415X22500331
Source: The American Journal of Chinese Medicine - March 18, 2022 Category: Complementary Medicine Authors: Yuliang Zhang Yi Liu Qian Cui Zitong Fu Haoyu Yu Ao Liu Jingjing Liu Xiude Qin Shaoqin Ge Guowei Zhang Source Type: research

Interaction of compounds derived from the Chinese medicinal formula Huangqi Guizhi Wuwu Tang with stroke-related numbness and weakness targets: An in-silico docking and molecular dynamics study
This study aims to investigate the molecular mechanisms of components from HGWT targeting specific proteins related to numbness and weakness through computational docking and molecular dynamics (MD) simulations. A total of 786 compounds from HGWT were retrieved from a herbal compound database and docked against a candidate SRNW target protein, with the asernestioside B (HQ068)-mitogen-activated protein kinase 3 (MAPK3) complex predicted to exhibit the highest binding affinity (-10.4 kcal/mol) and number of ligand-receptor contacts. Subsequent molecular dynamics (MD) simulations were performed in triplicate on the apo-MAPK3...
Source: Molecular Medicine - May 4, 2022 Category: Molecular Biology Authors: Sanghyun Lee Ann Rann Wong Angela Wei Hong Yang Andrew Hung Source Type: research

Letter to the Editor: PNF and Gait Post-Stroke
We read with interest the article by Gunning et al. (The Effectiveness of the Proprioceptive Neuromuscular Facilitation (PNF) Method on Gait Parameters in Patients with Stroke: A Systematic Review)1 and were moved to comment on the authors ’ conclusions. The abstract of this article stated “current research suggests that PNF is an effective treatment for the improvement of gait parameters in patients with stroke”. Publication of such a statement led us to review the articles cited. We do not concur that these articles provide su fficient evidence that PNF is an effective treatment for improving gait parameters in patients with stroke.
Source: Archives of Physical Medicine and Rehabilitation - July 18, 2022 Category: Rehabilitation Authors: Herb Karpatkin, Heather Hayes, Lauren Snowdon, Parminder K. Padgett, Laura Doyle, Jennifer Lotter, Ryan Knight, Hallie Zeleznik, T. George Hornby Source Type: research