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Total 498 results found since Jan 2013.
Down-regulation of NOX4 by betulinic acid protects against cerebral ischemia-reperfusion in mice
SummaryIschemic stroke leads to high potentiality of mortality and disability. The current treatment for ischemic stroke is mainly focused on intravenous thrombolytic therapy. However, ischemia/ reperfusion induces neuronal damage, which significantly influences the outcome of patients with ischemic stroke, and the exact mechanism implicated in ischemia/reperfusion injury remains unclear, although evidence shows that oxidative stress is likely to be involved. Betulinic acid is mainly known for its anti-tumor and anti-inflammatory activities. Our previous study showed that betulinic acid could decrease the reactive oxygen s...
Source: Journal of Huazhong University of Science and Technology -- Medical Sciences -- - October 1, 2017 Category: Research Source Type: research
Improvement of memory and neurological deficit with Ocimum basilicum L. extract after ischemia reperfusion induced cerebral injury in mice
AbstractOxidative stress is strongly implicated in the pathogenesis of stroke. Strategies using antioxidants to improve neurological functions after stroke have, thus, gained significant attention.Ocimum basilicum L. is used traditionally to treat CNS disorders. Its antioxidant capacity is well established. Our laboratory has reported protective effects of pre-treatment withO. basilicum in experimental stroke, but its curative (post-treatment) effects in ischemic stroke have not been documented. Hence, the present study was aimed to evaluate the effect ofO. basilicum leaf extract (OBLE) on functional outcomes following cer...
Source: Metabolic Brain Disease - March 15, 2018 Category: Neurology Source Type: research
Genistein attenuates brain damage induced by transient cerebral ischemia through up-regulation of Nrf2 expression in ovariectomized rats.
In this study, ovariectomized rats were treated with genistein (10 mg/kg) or vehicle daily for two weeks before they received middle cerebral artery occlusion (MCAO) and reperfusion. After 72 hours of reperfusion, the neurological function was evaluated by Garcia test, infarct volume was detected by 2,3,5-triphenyltetrazolium chloride staining, and neuronal damage was detected by Nissl staining. In addition, ROS production and the expression of Nrf2, NQO1 and cleaved-Caspase3 in the ischemic penumbra were detected.
RESULTS: The results showed that genistein treatment significantly improved the neurological outcome, red...
Source: Neurological Research - April 26, 2018 Category: Neurology Tags: Neurol Res Source Type: research
Neurophysiological Analysis of Intermanual Transfer in Motor Learning
In this study, MEPs were induced during the subject’s imaged kinesthetic MI. This involves recalling muscle contraction based on a muscle sensory image and was reported to indicate the activity of brain regions similar to those involved in actual muscle contraction (Ruby and Decety, 2001). In the transfer training group, the muscle sensory image evaluation correlated to the actual task execution with the right hand. As a result, it was easy to recall the kinesthetic MI for the training task, thus affecting MI of the non-trained limbs so that MEP changes occurred in the left hand’s MI. In addition, brain exc...
Source: Frontiers in Human Neuroscience - April 17, 2019 Category: Neuroscience Source Type: research
Interleukin-11 treatment protected against cerebral ischemia/reperfusion injury
In this study, we investigated the effects of IL-11 on cerebral ischemia-reperfusion injury in a model of focal cerebral ischemia.MethodsMice were randomly divided into five groups the vehicle group, the middle cerebral artery occlusion (MCAO) group, the MCAO plus adenosine monophosphate-activated protein kinase (AMPK) inhibitor compound C group, the MCAO plus IL-11 treatment group, and the MCAO plus IL-11 treatment and compound C group. Focal cerebral ischemia was induced by occluding the left middle cerebral artery, and reperfusion was achieved by withdrawing the suture 2 h after ischemia. The protein expression levels...
Source: Biomedicine and Pharmacotherapy - May 15, 2019 Category: Drugs & Pharmacology Source Type: research
Interleukin-11 treatment protected against cerebral ischemia/reperfusion injury.
In this study, we investigated the effects of IL-11 on cerebral ischemia-reperfusion injury in a model of focal cerebral ischemia.
METHODS: Mice were randomly divided into five groups the vehicle group, the middle cerebral artery occlusion (MCAO) group, the MCAO plus adenosine monophosphate-activated protein kinase (AMPK) inhibitor compound C group, the MCAO plus IL-11 treatment group, and the MCAO plus IL-11 treatment and compound C group. Focal cerebral ischemia was induced by occluding the left middle cerebral artery, and reperfusion was achieved by withdrawing the suture 2 h after ischemia. The protein expressio...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 12, 2019 Category: Drugs & Pharmacology Authors: Zhang B, Zhang HX, Shi ST, Bai YL, Zhe X, Zhang SJ, Li YJ Tags: Biomed Pharmacother Source Type: research
Electro-acupuncture treatment ameliorates intestinal inflammatory injury in cerebral ischemia-reperfusion rats via regulating the balance of Treg / γδ T cells
Brain Res. 2023 Jan 6:148233. doi: 10.1016/j.brainres.2023.148233. Online ahead of print.ABSTRACTElectro-acupuncture (EA) has an anti-inflammatory role in ischemic stroke, but whether the protective effect of EA involves the regulation of the intestine barrier and Treg/ γδ T cells is unclear. Cerebral ischemia-reperfusion (I/R) injury was induced by middle cerebral artery occlusion(MCAO) for 2 hours followed by reperfusion for 24 hours. The rats have treated with EA at the "Baihui" acupoint(GV20). Triphenyl tetrazolium chloride (TTC) staining and Longa neurologic score were performed to evaluate the outcomes after ischem...
Source: Cell Research - January 9, 2023 Category: Cytology Authors: Ya-Ling Wang Ling-Ling Meng Yong-Lin Chen Ling OuYang Bu-Fan Wu Rou Peng Sheng-Feng Lu Qing Liu Tao Zhang Xiao-Xiao Li Xin-Yue Jing Bin Xu Shu-Ping Fu Source Type: research
A Novel Rat Model of Embolic Cerebral Ischemia Using a Cell-Implantable Radiopaque Hydrogel Microfiber
We present a novel rat model of focal infarct restricted to the middle cerebral artery territory using a radiopaque hydrogel microfiber positioned under fluoroscopic guidance. By comparing the use of stem cell-containing versus non-containing fibers in this stroke model, it would be possible to determine the efficacy of "pure" cell transplantation in treating stroke.PMID:36867349 | DOI:10.1007/s12975-023-01144-6
Source: Cell Research - March 3, 2023 Category: Cytology Authors: Teppei Komatsu Hiroki Ohta Naoki Takakura Junichi Hata Tomomichi Kitagawa Yuta Kurashina Hiroaki Onoe Hirotaka James Okano Yasuyuki Iguchi Source Type: research
IMM-H004 therapy for permanent focal ischemic cerebral injury via CKLF1/CCR4-mediated NLRP3 inflammasome activation.
This study aims to investigate the effects of IMM-H004 on ischemia stroke injury and further elucidate the molecular mechanisms. The standard pMCAO model of focal ischemia was used in this paper. Drugs were administered at 6 hours after ischemia, and behavioral assessment, euthanasia, and outcome measures were evaluated at 9 hours after ischemia. The effects of IMM-H004 on ischemic stroke injury were determined using 2,3,5-triphenyltetrazolium chloride (TTC) staining, behavioral tests, enzyme-linked immunosorbent assay (ELISA), and Nissl staining. Immunohistologic staining, immunofluorescence staining, quantitative RT-PCR ...
Source: Translational Research : the journal of laboratory and clinical medicine - May 29, 2019 Category: Laboratory Medicine Authors: Ai QD, Chen C, Chu S, Zhang Z, Luo Y, Guan F, Lin M, Liu D, Wang S, Chen N Tags: Transl Res Source Type: research
Agomelatine protects against permanent cerebral ischaemia via the Nrf2-HO-1 pathway.
In this study, we focused on the effect of agomelatine on permanent cerebral ischaemia in a rat model. Male Wistar rats were randomly divided into the following four groups (n = 6/group): sham operating group, permanent ischaemic model group, permanent ischaemic model plus agomelatine (40 mg/kg, i.p) group and permanent ischaemic model plus melatonin (10 mg/kg, i.p) group. Twenty-four h after ischaemic onset, we investigated the neurological deficits and infarct volume using neurological deficit scores, 2,3,5-triphenyltetrazolium chloride (TTC) and transmission electron microscopy (Kochanski et al.). Moreover, we a...
Source: European Journal of Pharmacology - February 17, 2020 Category: Drugs & Pharmacology Authors: Chumboatong W, Khamchai S, Tocharus C, Govitrapong P, Tocharus J Tags: Eur J Pharmacol Source Type: research
Flinders Sensitive Line rats are resistant to infarction following transient occlusion of the middle cerebral artery.
CONCLUSIONS: Our study suggests that the rat strain does not influence infarct volumes following MCAo.
PMID: 32194078 [PubMed - as supplied by publisher]
Source: Brain Research - March 15, 2020 Category: Neurology Authors: Bay V, Happ DF, Ardalan M, Quist A, Oggiano F, Chumak T, Hansen K, Ding M, Mallard C, Andrew Tasker R, Wegener G Tags: Brain Res Source Type: research
Genes Induced by Panax Notoginseng in a Rodent Model of Ischemia-Reperfusion Injury.
In this study, middle cerebral artery occlusion (MCAO) was induced in rats with thrombi generated by thread and subsequently treated with PN. After that, staining with 2,3,5-triphenyltetrazolium chloride was employed to evaluate the infarcted area, and electron microscopy was used to assess ultrastructural changes of the neurovascular unit. RNA-Seq was performed to determine the differential expressed genes (DEGs) which were then verified by qPCR. In total, 817 DEGs were identified to be related to the therapeutic effect of PN on stroke recovery. Further analysis by Gene Oncology analysis and Kyoto Encyclopedia of Genes an...
Source: Journal of Immunology Research - December 11, 2020 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
The neuroprotective effects of Insulin-Like Growth Factor 1 via the Hippo/YAP signaling pathway are mediated by the PI3K/AKT cascade following cerebral ischemia/reperfusion injury
Brain Res Bull. 2021 Oct 27:S0361-9230(21)00309-9. doi: 10.1016/j.brainresbull.2021.10.017. Online ahead of print.ABSTRACTInsulin-like growth factor 1 (IGF-1) has neuroprotective actions, including vasodilatory, anti-inflammatory, and antithrombotic effects, following ischemic stroke. However, the molecular mechanisms underlying the neuroprotective effects of IGF-1 following ischemic stroke remain unknown. Therefore, in the present study, we investigated whether IGF-1 exerted its neuroprotective effects by regulating the Hippo/YAP signaling pathway, potentially via activation of the PI3K/AKT cascade, following ischemic str...
Source: Brain Research Bulletin - October 31, 2021 Category: Neurology Authors: Pian Gong Yichun Zou Wei Zhang Qi Tian Shoumeng Han Zhou Xu Qianxue Chen Xin Wang Mingchang Li Source Type: research
