Flinders Sensitive Line rats are resistant to infarction following transient occlusion of the middle cerebral artery.

CONCLUSIONS: Our study suggests that the rat strain does not influence infarct volumes following MCAo. PMID: 32194078 [PubMed - as supplied by publisher]
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research

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This article discusses how neurological know-how could be integrated in academic geriatric medicine to improve care of neurogeriatric patients, to foster neurogeriatric research and training concepts and to provide innovative care concepts for geriatric patients with predominant neurological conditions and disabilities. PMID: 32430766 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Gerontologie und Geriatrie - Category: Geriatrics Authors: Tags: Z Gerontol Geriatr Source Type: research
When it comes to health concerns, the COVID-19 pandemic is top of mind for most people right now. And that’s for good reason. But there is some very good non-COVID health news that may not be getting the attention it deserves. According to the CDC, the rates of six of the top 10 causes of death in this country, which account for about three-quarters of all deaths, have been declining. That’s remarkable. And these improvements are occurring despite an aging population and an obesity epidemic that affects several health conditions. Six positive health trends Let’s look at the trends in these conditions...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Cancer Health Health trends Heart Health Source Type: blogs
The outcome of ischemic stroke varies across socioeconomic strata, even among countries with universal health care. Emerging evidence suggests that psychosocial aspects of low socioeconomic status such as social isolation and social defeat stress interact with, and contribute to, stroke pathophysiology. However, experimental investigations of stroke rarely account for such socioeconomic influences. Social isolation in stroke survivors is associated with increased infarction volume, increased risk of post-stroke depression, and worse long-term functional outcome. Social defeat is thought to contribute significantly to chron...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Authors: Hillis AE Abstract Introduction: Stroke is among the most common causes of disability worldwide. Nonmotor symptoms of stroke are common and disabling. Many are treatable, and intervention improves the quality of life for stroke survivors.Areas covered: Here the author summarizes evidence-based treatment of depression and other mood disorders, aphasia, hemispatial neglect, impairments of emotional communication and empathy, deficits in memory and other cognitive functions, sleep disorders, pain, fatigue, (1)and seizures resulting from stroke. The author focuses on treatments supported by randomized controlled ...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
Conclusions: Successful improvements in one-year functioning in both country-regions may result from optimising long-term rehabilitation services to address cognitive, emotional, and social functioning. Stroke-Specific Quality of Life one-year post-stroke could be explained by individual factors, such as pre-stroke dependency and mental health, rather than differences in the organisation of subacute rehabilitation services.IMPLICATIONS FOR REHABILITATIONThe stroke-specific health related quality of life (SS-QOL) assessment tool captures multidimensional effects of a stroke from the perspective of the patient, which is clin...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
AbstractTo describe sexual functioning/satisfaction and relational satisfaction of patients with stroke who received sexual counselling during their rehabilitation 1 –5 years thereafter. All adult patients with stroke admitted to one Dutch Rehabilitation Centre between January 2010 and January 2014 with at least two consultations with a sexologist were invited to participate in this cross-sectional survey study. Patients were asked to complete a questionnaire on sexual functioning, relational satisfaction (Maudsley Marital Questionnaire, 0–80; low–high dissatisfaction), health-related quality of life...
Source: Sexuality and Disability - Category: Disability Source Type: research
Abstract Stroke remains a leading cause of disability in the United States. Despite recent advances, interventions to reduce damage and enhance recovery after stroke are lacking. P2X4R, a receptor for adenosine triphosphate (ATP), regulates activation of myeloid immune cells (infiltrating monocytes/macrophages and brain-resident microglia) after stroke injury. However, over-stimulation of P2X4Rs due to excessive ATP release from dying or damaged neuronal cells can contribute to ischemic injury. Therefore, we pharmacologically inhibited P2X4R to limit the over-stimulated myeloid cell immune response and improve bot...
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research
Depression occurs in about 25% of stroke survivors and contributes to persistent disability and increased mortality.1 Poststroke depression is a heterogeneous syndrome; mood symptoms span the range of minor to major depression, and patients may also experience emotionally liability or blunting, restlessness, decreased insight, and cognitive impairment. These symptoms may in turn impair recovery and contribute to greater subsequent disability. In this issue of the Journal, Kanellopoulos et al. characterize dimensions of poststroke depression in 135 older adults with comorbid major depression by conducting a factor analysis ...
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Editorial Source Type: research
Depression occurs in about 25% of stroke survivors and contributes to persistent disability and increased mortality.1 Post-stroke depression is a heterogeneous syndrome; mood symptoms span the range of minor to major depression, and patients may also experience emotionally lability or blunting, restlessness, decreased insight, and cognitive impairment. These symptoms may in turn impair recovery and contribute to greater subsequent disability. In this issue of the Journal, Kanellopoulos et al. characterize dimensions of post-stroke depression in 135 older adults with comorbid major depression by conducting a factor analysis...
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Editorial Source Type: research
Conclusion: The Chinese version of the Fatigue Assessment Scale is reliable and valid for assessing fatigue. The level of physical fatigue was higher than that of mental fatigue. Participants with depressive symptoms had higher fatigue scores than those without.Implications for rehabilitationThe Fatigue Assessment Scale has been translated and culturally adapted into Chinese. It is reliable and valid for evaluating fatigue in stroke survivors in both clinical and research settings.The Chinese version of the Fatigue Assessment Scale significantly correlated with the Mental Fatigue Scale, Fatigue Severity Scale, Epworth Slee...
Source: Disability and Rehabilitation - Category: Rehabilitation Authors: Tags: Disabil Rehabil Source Type: research
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