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Total 498 results found since Jan 2013.

Overexpression of Egr2 and Egr4 protects rat brains against ischemic stroke by downregulating JNK signaling pathway.
CONCLUSION: Upregulation of Egr2 and Egr4 could demote the activation of JNK/c-JUN pathway and the expression of pro-inflammatory cytokines in MCAO rats, so that Egr2 and Egr4 might be potential targets for ischemic stroke in future. PMID: 29580816 [PubMed - as supplied by publisher]
Source: Biochimie - March 23, 2018 Category: Biochemistry Authors: Niu RN, Shang XP, Teng JF Tags: Biochimie Source Type: research

Shengui Sansheng San extraction is an angiogenic switch via regulations of AKT/mTOR, ERK1/2 and Notch1 signal pathways after ischemic stroke
Conclusion Our study firstly demonstrates that SSS extraction is an angiogenic switch. Due to suppressed VEGFR2/Notch1 cascades and activated AKT/mTOR and ERK1/2 signals in BMECs, a feedback loop of angiogenic homeostasis is established. Furthermore, the comprehensive mediations of SDF-1α/CXCR4 axis, AKT/mTOR/HIF-α, ERK1/2 and Notch1 pathways in penumbra contribute to the improvements of neurological function, survival rate and infarct volume post-stroke. Graphical abstract
Source: Phytomedicine - April 10, 2018 Category: Drugs & Pharmacology Source Type: research

L-3-n-Butylphthalide reduces ischemic stroke injury and increases M2 microglial polarization
In conclusion, our results clearly show that NBP treatment significantly mitigates ischemic brain damage and promotes recovery of neurological function in early phase after ischemic stroke, probably by skewing M1 microglia/macrophages polarization towards M2 phenotype. Thus, our study provides new evidence that NBP might be a promising candidate for ameliorating injury caused by ischemic stroke.
Source: Metabolic Brain Disease - August 16, 2018 Category: Neurology Source Type: research

Inhibition of soluble epoxide hydrolase regulates monocyte/macrophage polarization and improves neurological outcome in a rat model of ischemic stroke
This study aimed to evaluate whether a selective sEH inhibitor, 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA), can regulate monocyte/macrophage polarization and improve motor function in the rats with ischemic stroke induced by middle cerebral artery occlusion. We measured the infarct volume with 2,3,5-triphenyltetrazolium chloride staining and used the rotarod test to assess motor performance in rats. The monocyte/macrophage activation and mRNA expression of proinflammatory mediators were measured by flow cytometry and reverse-transcription quantitative PCR, respectively. Our results showed better neurological funct...
Source: NeuroReport - April 27, 2019 Category: Neurology Tags: DEGENERATION AND REPAIR Source Type: research

MiR-130a exerts neuroprotective effects against ischemic stroke through PTEN/PI3K/AKT pathway
ConclusionsOur data demonstrated that miR-130a prevented cerebral I/R damage by mediating the PTEN/PI3K/AKT axis. These preliminarily findings furthered our understanding of this mechanism and identified new potential therapeutic targets for ischemic stroke.
Source: Biomedicine and Pharmacotherapy - June 19, 2019 Category: Drugs & Pharmacology Source Type: research

Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke RESEARCH ARTICLE
ABSTRACT A dopamine D2 receptor agonist, pramipexole, has been found to elicit neuroprotection in patients with Parkinson’s disease and restless leg syndrome. Recent evidence has shown that pramipexole mediates its neuroprotection through mitochondria. Considering this, we examined the possible mitochondrial role of pramipexole in promoting neuroprotection following an ischemic stroke of rat. Male Wistar rats underwent transient middle cerebral artery occlusion (tMCAO) and then received pramipexole (0.25 mg and 1 mg/kg body weight) at 1, 6, 12 and 18 h post-occlusion. A panel of neurological tests and ...
Source: DMM Disease Models and Mechanisms - August 28, 2019 Category: Biomedical Science Authors: Andrabi, S. S., Ali, M., Tabassum, H., Parveen, S., Parvez, S. Tags: Rat as a Disease Model RESEARCH ARTICLE Source Type: research

Anti-embolic effect of Taorenchengqi Tang in rats with embolic stroke induced by occluding middle cerebral artery.
CONCLUSION: Either TRCQT alone or TRCQT plus aspirin exhibits potent neuroprotective effect by reducing infarct volume without changing the status of SAH, ICH and gastric bleeding possibly via inhibiting the platelet activation and increasing bleeding time. PMID: 31682375 [PubMed]
Source: Journal of Traditional Chinese Medicine - May 31, 2017 Category: Complementary Medicine Authors: Li J, Chang T, Chang N, Li J, Thanasekaran J, Chang CC Tags: J Tradit Chin Med Source Type: research

Interleukin-18 from neurons and microglia mediates depressive behaviors in mice with post-stroke depression.
In this study, we demonstrate that in IL-18 level in the ischemic brain significantly increased in mice with depression-like behaviors that caused by the combined use of chronic spatial restraint stress and middle cerebral artery occlusion. Interestingly, IL-18 expression was mainly found in neurons at early phase and in microglia in late phase. Injection of exogenous IL-18 in to the amygdala, but not the hippocampus or the striatum, caused severe depression-like behaviors. On the contrary, the blockage of endogenous IL-18 by IL-18 binding protein, a specific antagonist of IL-18, rescued depressive phenotypes in SIR mice. ...
Source: Brain, Behavior, and Immunity - April 5, 2020 Category: Neurology Authors: Wu D, Zhang G, Zhao C, Yang Y, Miao Z, Xu X Tags: Brain Behav Immun Source Type: research

Waggle needling wields preferable neuroprotective and anti-spastic effects on post-stroke spasticity rats by attenuating γ-aminobutyric acid transaminase and enhancing γ-aminobutyric acid.
This study was designed to compare the anti-spastic effect of waggle needling to the routine needling and to explore its underlying mechanism. We established post-stroke spasticity model based on ischemia stroke operation (middle cerebral artery occlusion). Rats were divided into six groups: normal control group, sham-operated control group, ischemia stroke model group, waggle needling group, routine needling group and baclofen group. Neurological function and muscle tone were assessed by the Zea Longa score and modified Ashworth scale, respectively. Indirect muscle tone was testified with electrophysiological recording. C...
Source: NeuroReport - June 9, 2020 Category: Neurology Tags: Degeneration and Repair Source Type: research

S-oxiracetam Facilitates Cognitive Restoration after Ischemic Stroke by Activating α7nAChR and the PI3K-Mediated Pathway.
In conclusion, α7nAChR and PI3K are key molecules that mediated the signaling pathway leading to S-ORC-induced cognitive restoration after MCAO/R. PMID: 33481205 [PubMed - as supplied by publisher]
Source: Neurochemical Research - January 22, 2021 Category: Neuroscience Authors: Fan W, Zhang Y, Li X, Xu C Tags: Neurochem Res Source Type: research

Intracarotid Transplantation of Skin-Derived Precursor Schwann Cells Promotes Functional Recovery After Acute Ischemic Stroke in Rats
Conclusions: Intracarotid transplantation of SKP-SCs promoted functional recovery in the rat AIS model and possesses the potential to be further developed as a novel therapy to treat ischemic stroke in humans.
Source: Frontiers in Neurology - February 4, 2021 Category: Neurology Source Type: research

Transcription Factor HEY1 Improves Brain Vascular Endothelial Cell Function and Alleviates Ischemic Stroke by Upregulating NOTCH3
Neurochem Res. 2022 Mar 22. doi: 10.1007/s11064-022-03544-w. Online ahead of print.ABSTRACTTo investigate the function of hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) and Notch receptor 3 (NOTCH3) in ischemic stroke. Stroke models were established by middle cerebral artery occlusion (MCAO) and oxygen glucose deprivation (OGD) in rats and rat brain microvascular endothelial cells (BMVECs), respectively. Neurological deficit evaluation and 2,3,5-triphenyltetrazolium chloride staining were used to assess cerebral injury. The expression of HEY1 and NOTCH3 was manipulated using gain and loss of function appr...
Source: Neurochemical Research - March 22, 2022 Category: Neuroscience Authors: Tingting Zhu Hongxi Chen Cuihong He Xiaojuan Liu Source Type: research

β2-Microglobulin exacerbates neuroinflammation, brain damage, and cognitive impairment after stroke in rats
In this study, we established a rat model of focal cerebral ischemia by occlusion of the middle cerebral artery. We found that β2M levels in the cerebral spinal fluid, serum, and brain tissue were significantly increased in the acute period but gradually decreased during the recovery period. RNA interference was used to inhibit β2M expression in the acute period of cerebral stroke. Tissue staining with 2,3,5-triphenyltetrazolium chloride and evaluation of cognitive function using the Morris water maze test demonstrated that decreased β2M expression in the ischemic penumbra reduced infarct volume and alleviated cognitive...
Source: Cell Research - August 26, 2022 Category: Cytology Authors: Feng Chen Jing Liu Fa-Qiang Li Shuai-Shuai Wang Yan-Yan Zhang Yun-Yun Lu Fang-Fang Hu Rui-Qin Yao Source Type: research