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Total 290 results found since Jan 2013.

Iron promotes neurological function recovery in mice with ischemic stroke through endogenous repair mechanisms
In this study, we first observed that changes in iron metabolism occured during neurological function recovery in the mice with distal middle cerebral artery occlusion (dMCAO). Our data showed that plasticity changes due to endogenous repair mechanisms resulted in improvements in cerebral cortex function. These changes involved gliosis, synaptic function reconstruction, remyelination, and activation of neural stem cells. In order to examine the potential role of iron, we synthesized liposomal-encapsulated deferoxamine (DFO) nanoparticles to further explore the effect and the mechanism of iron on the recovery of neurologica...
Source: Free Radical Biology and Medicine - February 24, 2022 Category: Biology Authors: Xin Guo Xiaofang Jin Kang Han Shaomeng Kang Siyu Tian Xin Lv Mudi Feng Huiwen Zheng Yong Zuo Guodong Xu Ming Hu Jing Xu Peiyuan Lv Yan-Zhong Chang Source Type: research

The mechanism of ferroptosis regulating oxidative stress in ischemic stroke and the regulation mechanism of natural pharmacological active components
Biomed Pharmacother. 2022 Sep 5;154:113611. doi: 10.1016/j.biopha.2022.113611. Online ahead of print.ABSTRACTCerebrovascular diseases, such as ischemic stroke, pose serious medical challenges worldwide due to their high morbidity and mortality and limitations in clinical treatment strategies. Studies have shown that reactive oxygen species (ROS)-mediated inflammation, excitotoxicity, and programmed cell death of each neurovascular unit during post-stroke hypoxia and reperfusion play an important role in the pathological cascade. Ferroptosis, a programmed cell death characterized by iron-regulated accumulation of lipid pero...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 9, 2022 Category: Drugs & Pharmacology Authors: Kailin Yang Liuting Zeng Xiao Yuan Shanshan Wang Anqi Ge Hao Xu Jinsong Zeng Jinwen Ge Source Type: research

Susceptibility-weighted imaging predicts infarct size and early-stage clinical prognosis in acute ischemic stroke
AbstractSusceptibility-weighted imaging (SWI) is a non-invasive technique that can reveal venous structures and iron in the brain. This retrospective study evaluated SWI, relative to other imaging techniques, for determining cerebral infarct size and early-stage clinical prognosis in patients with acute ischemic stroke. Within 3  days after onset, 22 patients with acute ischemic stroke underwent SWI, diffusion-weighted imaging (DWI), perfusion-weighted imaging (PWI), fluid-attenuated inversion recovery (FLAIR), and magnetic resonance angiography (MRA). At least 7 days after onset, the patients also underwent cranial FLAI...
Source: Neurological Sciences - March 20, 2018 Category: Neurology Source Type: research

Improvement of a novel proposal for antioxidant treatment against brain damage occurring in ischemic stroke patients.
Abstract The underlying mechanism of cerebral injury occurring in patients with acute ischemic stroke involves a key pathophysiological role of oxidative stress. Thus, reactive oxygen species are related to the development of brain edema, calcium overload, mitochondrial dysfunction, excitotoxicity, iron release and inflammation. Nevertheless, although experimental studies have tested the use of antioxidants as an adjuvant therapy in this setting, clinical data and randomized trials are still lacking. Current approved pharmacological therapy is aimed at reperfusion strategies; however, the therapeutic window is lim...
Source: CNS and Neurological Disorders Drug Targets - September 9, 2020 Category: Drugs & Pharmacology Authors: Orellana-Urzúa S, Claps G, Rodrigo R Tags: CNS Neurol Disord Drug Targets Source Type: research

Recent advances in iron homeostasis and regulation -A focus on epigenetic regulation and stroke.
Authors: Shi H, Almutairi M, Moskovitz J, Xu YG Abstract Iron is an element with redox properties. It is active sites of many enzymes and plays an important role in various cellular and biological functions including ATP production and DNA synthesis. However, as a redox element, iron promotes free radical generation and lipid peroxidation, causing oxidative damage and cell death. Iron-mediated oxidation is a central player in ferroptosis, a type of cell death process that is different from apoptosis and necrosis. Thus, iron metabolism and homeostasis are sophisticatedly regulated. There has been exciting progress i...
Source: Free Radical Research - December 23, 2020 Category: Research Tags: Free Radic Res Source Type: research

SATB1/SLC7A11/HO-1 Axis Ameliorates Ferroptosis in Neuron Cells After Ischemic Stroke by Danhong Injection
AbstractNeuronal damage after ischemic stroke (IS) is frequently due to ferroptosis, contributing significantly to ischemic injury. However, the mechanism against ferroptosis in IS remained unclear. The aim of this study was to investigate the potential mechanism of Danhong injection (DHI) and the critical transcription factor SATB1 in preventing neuronal ferroptosis after ischemic stroke in vivo and in vitro. The results showed that DHI treatment significantly reduced the infarct area and associated damage in the brains of the pMCAO mice, and enhanced the viability of OGD-injured neurons. And several characteristic indica...
Source: Molecular Neurobiology - December 17, 2022 Category: Neurology Source Type: research

MRI measurements of iron content show impact of stroke
French researchers have taken a basic MR imaging technique to break new ground...Read more on AuntMinnie.comRelated Reading: Deep-learning MRI algorithm aids in neurological diagnoses CT matches MRI for late-window stroke evaluation Women less likely to receive poststroke imaging Is CCTA, MRI, or transthoracic echo best for predicting stroke? Study reveals steep cost of delaying stroke treatment
Source: AuntMinnie.com Headlines - March 12, 2019 Category: Radiology Source Type: news

A Preliminary Study of Alterations in Iron Disposal and Neural Activity in Ischemic Stroke
CONCLUSION: This preliminary study demonstrates that the magnetic susceptibility may decrease at some ipsilesional DGM nuclei after tDCS, NMES, and occupational therapy for patients with ischemic stroke, suggesting a drop in the level of iron deposition, which may be associated with an increase in the level of activity in motor cortex after rehabilitation.PMID:35971446 | PMC:PMC9375706 | DOI:10.1155/2022/4552568
Source: Biomed Res - August 16, 2022 Category: Research Authors: Abolfazl Mahmoudi Aqeel-Abadi Hamid-Reza Fateh Saeed Masoudnia Niloufar Shirzad Milad Seyfi Tayyebeh Ebrahimi Mohammad-Reza Nazem-Zadeh Source Type: research

Design of the DREPAGREFFE trial: A prospective controlled multicenter study evaluating the benefit of genoidentical hematopoietic stem cell transplantation over chronic transfusion in sickle cell anemia children detected to be at risk of stroke by transcranial Doppler (NCT 01340404)
Children with sickle cell anemia (SCA) have an 11% risk of stroke by the age of 18. Chronic transfusion applied in patients detected to be at risk by transcranial Doppler allows a significant reduction of stroke risk. However, chronic transfusion exposes to several adverse events, including alloimmunization and iron overload, and is not curative. Hematopoietic stem cell transplantation allows termination of the transfusion program, but its benefit has not been demonstrated.
Source: Contemporary Clinical Trials - August 15, 2017 Category: Radiology Authors: Sylvie Chevret, Suzanne Verlhac, Elisabeth Ducros-Miralles, Jean-Hugues Dalle, Regis Peffault de Latour, Mariane de Montalembert, Malika Benkerrou, Corinne Pondarr é, Isabelle Thuret, Corinne Guitton, Emmanuelle Lesprit, Maryse Etienne-Julan, Gisèle Ela Source Type: research

Associations of multiple plasma metals with the risk of ischemic stroke: A case-control study.
CONCLUSIONS: Our study suggested that higher plasma concentrations of aluminum, arsenic, and cadmium, and lower concentrations of iron and selenium may increase the risk of IS. Further prospective studies in larger populations are warranted to confirm our findings. PMID: 30716572 [PubMed - as supplied by publisher]
Source: Environment International - February 1, 2019 Category: Environmental Health Authors: Wen Y, Huang S, Zhang Y, Zhang H, Zhou L, Li D, Xie C, Lv Z, Guo Y, Ke Y, Wu T, Cheng J Tags: Environ Int Source Type: research

Immune-inflammatory, oxidative stress and biochemical biomarkers predict short-term acute ischemic stroke death
In conclusion, activation of peripheral immune-inflammatory, oxidative and biochemical pathways is critically associated with mortality after AIS. Our results may contribute to identify new biomarker sets, which may predict post- stroke death, as well as suggest that IL-6 trans-signaling coupled with redox imbalances may be possible new targets in the prevention of short-term outcome AIS death.
Source: Metabolic Brain Disease - March 13, 2019 Category: Neurology Source Type: research

Intravenous Grafts of Human Amniotic Fluid-Derived Stem Cells Reduce Behavioral Deficits in Experimental Ischemic Stroke.
This study reports isolation of viable human amniotic fluid-derived stem cells, labeled with multimodal iron oxide nanoparticles, and its effect on focal cerebral ischemia-reperfusion injury in Wistar rats. Middle cerebral artery occlusion of 60 min followed by reperfusion for 1 h, 6 h, and 24 h was employed in the present study to produce ischemia and reperfusion-induced cerebral injury in rats. Tests were employed to assess the functional outcome of the sensorimotor center activity in the brain, through a set of modified neurological severity scores used to assess motor and exploratory capacity 24 h, 14, and 28 days afte...
Source: Cell Transplantation - June 3, 2019 Category: Cytology Authors: Sibov TT, Pavon LF, Cabral FR, Cunha IF, de Oliveira DM, de Souza JG, Marti LC, da Cruz EF, Malheiros JM, Paiva FF, Tannús A, de Oliveira SM, da Costa MDS, Dastoli PA, Mendonça JN, de Toledo SRC, Malheiros SMF, de Paiva Neto MA, Rego NBB, Moron AF, Cava Tags: Cell Transplant Source Type: research

Haptoglobin genotype 2-2 associated with atherosclerosis in patients with ischemic stroke.
CONCLUSION: This study has shown an association of the Hp2-2 genotype and atherosclerosis in patients with IS, indicating Hp2-2 genotype as a genetic biomarker for precision medicine and personalized healthcare. PMID: 32439379 [PubMed - as supplied by publisher]
Source: Gene - May 17, 2020 Category: Genetics & Stem Cells Authors: Merkler A, Sertić J, Martinović AB, Križ T, Miličić I, Šimić M, Caban D, Ljubić H, Markeljević J, Šimičević L, Kaštelan S, Pećin I, Reiner Ž Tags: Gene Source Type: research