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Fish, Cardiovascular Disease, and Mortality
Fish and shellfish (hereafter referred to as fish) are major sources of the dietary long-chain ω-3 fatty acids eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) and also contain other nutrients, such as vitamin D, riboflavin, iodine, calcium, phosphorus, magnesium, potassium, zinc, and iron. The summed results of observational studies of fish intake, randomized clinical tria ls of fish oil supplements, and associated mechanistic and experimental studies suggest that regular fish consumption may decrease the incidence of myocardial infarction (MI) and coronary heart disease (CHD), with more uncertain effec...
Source: JAMA Internal Medicine - March 8, 2021 Category: Internal Medicine Source Type: research
Baicalin Inhibits Ferroptosis in Intracerebral Hemorrhage
Intracerebral hemorrhage (ICH) is a subtype of stroke characterized by high mortality and disability rates. To date, the exact etiology of ICH-induced brain injury is still unclear. Moreover, there is no effective treatment to delay or prevent disease progression currently. Increasing evidence suggests that ferroptosis plays a dominant role in the pathogenesis of ICH injury. Baicalin is a main active ingredient of Chinese herbal medicine Scutellaria baicalensis. It has been reported to exhibit neuroprotective effects against ICH-induced brain injury as well as reduce iron deposition in multiple tissues. Therefore, in this ...
Source: Frontiers in Pharmacology - March 19, 2021 Category: Drugs & Pharmacology Source Type: research
Repurposing Vorinostat for the Treatment of Disorders Affecting Brain
AbstractBased on the findings in recent years, we summarize the therapeutic potential of vorinostat (VOR), the first approved histone deacetylase (HDAC) inhibitor, in disorders of brain, and strategies to improve drug efficacy and reduce side effects. Scientific evidences provide a strong case for the therapeutic utility of VOR in various disorders affecting brain, including stroke, Alzheimer ’s disease, frontotemporal dementia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, spinal muscular atrophy, X‐linked adrenoleukodystrophy, epilepsy, Niemann-Pick type C disease, and neuropsychiatric dis...
Source: NeuroMolecular Medicine - May 4, 2021 Category: Neurology Source Type: research
Mechanisms of Modulation of Ferroptosis and Its Role in Central Nervous System Diseases
Ferroptosis is a new form of programmed cell death characterized by intracellular iron-dependent accumulation of lipid peroxide and primarily associated with iron metabolism, glutathione-dependent pathway, and coenzyme Q10-dependent pathway. Recent studies demonstrate that ferroptosis is associated with central nervous system (CNS) diseases, such as stroke, Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease. This review summarizes the key regulatory mechanisms of ferroptosis and its role in CNS diseases. These updates may provide novel perspective for the development of therapeutical agents against CNS diseases.
Source: Frontiers in Pharmacology - June 4, 2021 Category: Drugs & Pharmacology Source Type: research
The Impact of Intravenous Iron Supplementation on Hematinic Parameters and Erythropoietin Requirements in Hemodialysis Patients
ConclusionHigh-dose intravenous iron (400 mg/week) can reduce the mean dose of rhEPO requirements and increase the TSAT index over a period of 6 months in hemodialysis patients. High-dose IV iron administration can decrease cardiovascular events in hemodialysis patients with iron deficiency anemia.
Source: Advances in Therapy - July 12, 2021 Category: Drugs & Pharmacology Source Type: research
Iron chelation suppresses secondary bleeding after intracerebral hemorrhage in angiotensin II-infused mice
CONCLUSION: Iron overload plays a key role in secondary bleeding after ICH in Ang II-induced hypertensive mice. Iron chelation during the process of Ang II-induced hypertension suppresses secondary bleeding after ICH.PMID:34346561 | DOI:10.1111/cns.13706
Source: CNS Neuroscience and Therapeutics - August 4, 2021 Category: Neuroscience Authors: Jie Wang Xiao-Qin Tang Min Xia Cheng-Cheng Li Chao Guo Hong-Fei Ge Yi Yin Bo Wang Wei-Xiang Chen Hua Feng Source Type: research
Dauricine alleviated secondary brain injury after intracerebral hemorrhage by upregulating GPX4 expression and inhibiting ferroptosis of nerve cells
In this study, we used the STRING protein database to predict the proteins that may be co-expressed with GPX4, and studied the ability of Dauricine(Dau) to up-regulate the expression of GPX4 against ferroptosis and neuroprotection after intracerebral hemorrhage in normal cells in vitro, glutathione peroxidase 4 (GPX4) knockdown cells and collagenase injection in vivo in mouse models of intracerebral hemorrhage. The results showed that glutathione reductase (GSR) was a possible co-expression protein with GPX4. Dau could up-regulate the expression of glutathione peroxidase 4 (GPX4) in intracerebral hemorrhage(ICH) model, nor...
Source: European Journal of Pharmacology - September 1, 2021 Category: Drugs & Pharmacology Authors: Chiwei Peng Xiang Fu Kaixuan Wang Ling Chen Beijiao Luo Ni Huang Yunfeng Luo Wei Chen Source Type: research
Current Applications of Susceptibility Weighted Images in Pediatric Neurological Diseases
ConclusionIts high susceptibility for blood products, iron depositions, and calcifications makes susceptibility-weighted imaging an important additional sequence for the diagnostic workup of pediatric brain pathologic abnormalities that should be routinely added in our department. Compared with conventional MRI sequences, susceptibility-weighted imaging may show lesions with better detail and higher sensitivity. Familiarity with the pediatric susceptibility-weighted imaging signal variance is essential to prevent misdiagnosis.
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research
Evaluation of brain iron content in Egyptian Patients with Sickle cell disease and its impact on Neurocognitive functions
ConclusionThe results of our study showed that even in cases of iron overload which affects vital organs as the liver, cardiac and brain iron overload don't occur.
Source: QJM - October 1, 2021 Category: Internal Medicine Source Type: research
Ferrostatin-1 Alleviates White Matter Injury Via Decreasing Ferroptosis Following Spinal Cord Injury
AbstractSpinal cord injury (SCI), a devastating neurological impairment, usually imposes a long-term psychological stress and high socioeconomic burden for the sufferers and their family. Recent researchers have paid arousing attention to white matter injury and the underlying mechanism following SCI. Ferroptosis has been revealed to be associated with diverse diseases including stroke, cancer, and kidney degeneration. Ferrostatin-1, a potent inhibitor of ferroptosis, has been illustrated to curb ferroptosis in neurons, subsequently improving functional recovery after traumatic brain injury (TBI) and SCI. However, the role...
Source: Molecular Neurobiology - October 12, 2021 Category: Neurology Source Type: research
Repurposing Vorinostat for the Treatment of Disorders Affecting Brain
AbstractBased on the findings in recent years, we summarize the therapeutic potential of vorinostat (VOR), the first approved histone deacetylase (HDAC) inhibitor, in disorders of brain, and strategies to improve drug efficacy and reduce side effects. Scientific evidences provide a strong case for the therapeutic utility of VOR in various disorders affecting brain, including stroke, Alzheimer ’s disease, frontotemporal dementia, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, spinal muscular atrophy, X‐linked adrenoleukodystrophy, epilepsy, Niemann-Pick type C disease, and neuropsychiatric dis...
Source: NeuroMolecular Medicine - December 1, 2021 Category: Neurology Source Type: research
P-017 Evaluation of radiofrequency-induced heating in an X-ray and MR-visible interventional catheter at 3.0 T
ConclusionsInitial immersion tests suggest that the worst-case scenario for RF-induced heating of our guide catheter prototype occurs at 95 cm. During the period of our tests, our prototype remained safely under the maximum permitted temperature rise of +2°C/hr of exposure. This study suggests that our guide catheter may be retained during an intra-procedural MRI without the safety risk of RF-induced device heating over time to the patient.Disclosures B. Kilbride: None. J. Massachi: None. S. Ahn: None. K. Mueller: None. C. Jordan: None. A. Losey: None. A. Martin: None. T. Moore: None. M. Wilson: None. S. Hetts: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2021 Category: Neurosurgery Authors: Kilbride, B., Massachi, J., Ahn, S., Mueller, K., Jordan, C., Losey, A., Martin, A., Moore, T., Wilson, M., Hetts, S. Tags: Oral poster abstracts Source Type: research
Discovery of novel diphenylbutene derivative ferroptosis inhibitors as neuroprotective agents
Eur J Med Chem. 2022 Jan 28;231:114151. doi: 10.1016/j.ejmech.2022.114151. Online ahead of print.ABSTRACTFerroptosis is a regulated and iron-dependent cell death. Ferroptosis inhibitors are promising for treating many neurological diseases. Herein, with phenotypic assays, we discovered a new diphenylbutene derivative ferroptosis inhibitor, DPT. Based on this hit, we synthesized fourteen new diphenylbutene derivatives, evaluated their ferroptosis inhibitory activities in HT22 mouse hippocampal neuronal cells, and found that three compounds exhibited improved inhibitory activities compared with DPT. Among these active compou...
Source: European Journal of Medicinal Chemistry - February 5, 2022 Category: Chemistry Authors: Yuying Fang Qingyun Tan Huihao Zhou Qiong Gu Jun Xu Source Type: research
Dynamic Changes in Brain Iron Metabolism in Neonatal Rats after Hypoxia-Ischemia
The pathogenesis of hypoxic-ischemic white matter injury (WMI) in premature infants is still unclear, and the imbalance of cerebral iron metabolism may play an important role. Our study set out to investigate the changes in iron distribution, iron content and malondialdehyde (MDA) in disparate brain regions (parietal cortex, corpus callosum, hippocampus) within 84 days after hypoxia-ischemia (HI) in neonatal rats and to clarify the role of iron metabolism in WMI.
Source: Journal of Stroke and Cerebrovascular Diseases - February 10, 2022 Category: Neurology Authors: Ding-Wang Hu, Geng Zhang, Ling Lin, Xuan-Jing Yu, Feng Wang, Qing Lin Source Type: research
