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Drug: Carbidopa/Levodopa

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Total 49 results found since Jan 2013.

The efficacy and safety of pharmacological treatments for post-stroke aphasia.
Conclusions Current evidence suggests that drugs can improve the prognosis of post-stroke aphasia, such as donepezil, memantine. Donepezil has a significant effect in improving the ability of auditory comprehension, naming, repetition and oral expression. Memantine has a significant effect in improving the ability of naming, spontaneous speech and repetition. Bromocriptine showed no significant improvement in the treatment of aphasia after stroke. The trial for galantamine, amphetamine and levodopa in the treatment of aphasia after stroke is limited and inconclusive. PMID: 29984673 [PubMed - as supplied by publisher]
Source: CNS and Neurological Disorders Drug Targets - July 6, 2018 Category: Drugs & Pharmacology Authors: Zhang X, Shu B, Zhang D, Huang L, Fu Q, Du G Tags: CNS Neurol Disord Drug Targets Source Type: research

Safety and efficacy of co-careldopa as an add-on therapy to occupational and physical therapy in patients after stroke (DARS): a randomised, double-blind, placebo-controlled trial
Publication date: June 2019Source: The Lancet Neurology, Volume 18, Issue 6Author(s): Gary A Ford, Bipin B Bhakta, Alastair Cozens, Suzanne Hartley, Ivana Holloway, David Meads, John Pearn, Sharon Ruddock, Catherine M Sackley, Eirini-Christina Saloniki, Gillian Santorelli, Marion F Walker, Amanda J FarrinSummaryBackgroundDopamine is a key modulator of striatal function and learning and might improve motor recovery after stroke. Previous small trials of dopamine agonists after stroke provide equivocal evidence of effectiveness on improving motor recovery. We aimed to assess the safety and efficacy of co-careldopa plus routi...
Source: The Lancet Neurology - May 22, 2019 Category: Neurology Source Type: research

Pharmacological interventions and rehabilitation approach for enhancing brain self-repair and stroke recovery.
Abstract Neuroplasticity is a natural process occurring in the brain for entire life. Stroke is the leading cause of long term disability and huge medical and financial problem throughout the world. Research conducted over the past decade focused mainly on neuroprotection in the acute phase of stroke while very little studies targets chronic stage. Recovery after stroke depends on the ability of our brain to reestablish structural and functional organization of neurovascular networks. Combining adjuvant therapies and drugs may enhance the repair processes and restore impaired brain functions. Currently, there are ...
Source: Current Neuropharmacology - July 24, 2019 Category: Drugs & Pharmacology Authors: Szelenberger R, Kostka J, Saluk-Bijak J, Miller E Tags: Curr Neuropharmacol Source Type: research

Pharmacotherapy and motor recovery after stroke.
Authors: Viale L, Catoira NP, Di Girolamo G, González CD Abstract INTRODUCTION: Stroke is one of the most prevalent neurological diseases worldwide, especially among the elderly population. There are various mechanisms that enhance motor recovery after a stroke. In clinical practice, we have the opportunity to enhance plasticity by designing specific rehabilitation programs. Areas covered: There are a variety of drugs commonly administered to people after the acute phase of a stroke. These drugs may modify motor performance. Herein reviewed is the evidence concerning motor enhancement or decline in stroke patients, p...
Source: Expert Review of Neurotherapeutics - November 11, 2017 Category: Neurology Tags: Expert Rev Neurother Source Type: research

Serotonin syndrome in stroke patients.
Conclusion: Because a considerable number of stroke patients have some limitation in communication, and serotonin syndrome is a potentially life-threatening condition, clinicians should pay particular attention to the potential for development of serotonin syndrome when prescribing these drugs to stroke patients. PMID: 25483226 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - December 12, 2014 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

Combining levodopa and virtual reality-based therapy for the rehabilitation of upper limb after acute stroke: pilot study part II.
CONCLUSION: Our results suggest that VR-based therapy and pharmacotherapy may be combined for acute stroke rehabilitation. The bedside acquisition of kinematic measurements allows for an accurate assessment of the quality of limb movement, offering a sensitive clinical tool for quantifying motor recovery during the rehabilitation process after acute stroke. PMID: 27311739 [PubMed - as supplied by publisher]
Source: Singapore Medical Journal - June 16, 2016 Category: Journals (General) Authors: Samuel GS, Oey NE, Choo M, Ju H, Chan WY, Kok S, Ge Y, Van Dongen AM, Ng YS Tags: Singapore Med J Source Type: research

Safety and efficacy of recovery-promoting drugs for motor function after stroke: A systematic review of randomised controlled trials.
CONCLUSION: Candidate drug interventions promoting motor recovery post-stroke were identified, specifically selective serotonin reuptake inhibitors and levodopa; however, the high risk of bias in many trials is concerning. Drugs to improve motor function remain an important area of enquiry. Future research must focus on establishing the correct drug intervention to be administered at an optimal dose and time, combined with the most effective adjuvant physical therapy to drive stroke recovery. PMID: 30805655 [PubMed - as supplied by publisher]
Source: Journal of Rehabilitation Medicine - February 27, 2019 Category: Rehabilitation Tags: J Rehabil Med Source Type: research

Dopamine receptor activation increases glial cell line-derived neurotrophic factor in experimental stroke.
Abstract Treatment with levodopa enhances functional recovery after experimental stroke but its mechanisms of action are elusive. Reactive astrocytes in the ischemic hemisphere are involved in mechanisms promoting recovery and also express dopamine 1 (D1) and dopamine 2 (D2) receptors. Here we investigated if the activation of astrocytic dopamine receptors (D1 and D2) regulates the expression of glial cell line-derived neurotrophic factor (GDNF) after combined in vitro hypoxia/aglycemia (H/A) and studied the expression of GDNF in the ischemic brain after treatment with levodopa/benserazide following transient occl...
Source: Experimental Neurology - May 9, 2013 Category: Neurology Authors: Kuric E, Wieloch T, Ruscher K Tags: Exp Neurol Source Type: research

Role, indications and controversies of levodopa administration in chronic stroke patients.
Abstract Stroke leaves many patients disabled even after rehabilitative training, representing a major cause of disability. Several approaches to improve outcomes have been attempted in recent years, with only relative benefit. Emerging evidences show a potential role of pharmacological intervention to enhance motor recovery after stroke. Contrasting evidence are coming from experimental and clinical studies, so far, and pharmacological intervention during rehabilitation represents a major controversial in neurorehabilitation. Dopaminergic stimulation appears as one of the most promising way to improve motor recov...
Source: European Journal of Physical and Rehabilitation Medicine - April 5, 2013 Category: Rehabilitation Authors: Acler M, Manganotti P Tags: Eur J Phys Rehabil Med Source Type: research

Combining Dopaminergic Facilitation with Robot-Assisted Upper Limb Therapy in Stroke Survivors: A Focused Review
ABSTRACT: Despite aggressive conventional therapy, lasting hemiplegia persists in a large percentage of stroke survivors. The aim of this article is to critically review the rationale behind targeting multiple sites along the motor learning network by combining robotic therapy with pharmacotherapy and virtual reality–based reward learning to alleviate upper extremity impairment in stroke survivors. Methods for personalizing pharmacologic facilitation to each individual’s unique biology are also reviewed. At the molecular level, treatment with levodopa was shown to induce long-term potentiation-like and practice-depende...
Source: American Journal of Physical Medicine and Rehabilitation - May 21, 2016 Category: Rehabilitation Tags: Literature Review Source Type: research

Exogenous glutathione exerts a therapeutic effect in ischemic stroke rats by interacting with intrastriatal dopamine
Acta Pharmacol Sin. 2021 May 25. doi: 10.1038/s41401-021-00650-3. Online ahead of print.ABSTRACTWe previously showed that oral administration of exogenous glutathione (GSH) exerted a direct and/or indirect therapeutic effect on ischemic stroke rats, but the underlying mechanisms remain elusive. In the current study, we conducted a quantitative proteomic analysis to explore the pathways mediating the therapeutic effect of GSH in cerebral ischemia/reperfusion (I/R) model rats. Rats were subjected to middle cerebral artery occlusion (MCAO) for 2 h followed by reperfusion. The rats were treated with GSH (250 mg/kg, ig) or levo...
Source: Acta Pharmacologica Sinica - May 26, 2021 Category: Drugs & Pharmacology Authors: He Wang Yi-Sha Du Wen-Shuo Xu Chang-Jian Li Hong Sun Kang-Rui Hu Yuan-Zhuo Hu Teng-Jie Yu Hui-Min Guo Lin Xie Guang-Ji Wang Yan Liang Source Type: research

The effectiveness of dopamine agonists for treatment of neuropsychiatric symptoms post brain injury and stroke.
CONCLUSION: Our systematic review demonstrates an evolving evidence base to suggest some benefits in agitation and aggression, mood and attentional deficits. However, there are key limitations of the studies undertaken to date involving small numbers of participants, heterogeneous outcome measures, and variable study designs. There is a need for on-going large prospective double-blind RCTs in these medications using standardised criteria and outcomes to fully understand their effectiveness in this patient group. PMID: 25850757 [PubMed - as supplied by publisher]
Source: Acta Neuropsychiatrica - April 11, 2015 Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research

Takotsubo cardiomyopathy associated with serotonin syndrome in a patient with stroke: A case report
We describe a patient with stroke who presented with TC caused by serotonin syndrome (SS) following the administration of serotonergic and dopaminergic agents. Patient concerns: A 55-year-old man with stroke was administered venlafaxine, tianeptine, ropinirole, carbidopa/levodopa, bromocriptine, and methylphenidate during rehabilitation. The patient presented with clinical features of SS (mental confusion, agitation, hyperhidrosis, chills, rigidity, and tachycardia), which persisted over 24 hours. The day after his SS symptoms disappeared, the patient's blood pressure decreased, and he developed tachycardia. Diagnose...
Source: Medicine - March 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Enhanced functional recovery by levodopa is associated with decreased levels of synaptogyrin following stroke in aged mice.
This study investigates if dopamine might affect plasticity by having a direct effect on synaptic plasticity through alterations in neurotransmitter release and re-uptake. Synaptogyrin is a synaptic vesicle protein that has been suggested to be involved in dopamine re-uptake in the synaptic terminal. Therefore, we investigated if levodopa has an effect on the expression of synaptogyrin 1. Thy1-YFP mice were subjected to photothrombosis as an experimental model of stroke. Starting two days after surgery they were treated with either levodopa or a vehicle solution (saline) on a daily basis until day seven following surgery. ...
Source: Brain Research Bulletin - December 1, 2019 Category: Neurology Authors: Häggman Henrikson J, Pombo Antunes AR, Wieloch T, Ruscher K Tags: Brain Res Bull Source Type: research

Holmes’ tremor as a delayed complication of thalamic stroke
We present a 75-year-old man who developed a disabling tremor 1year after a posterolateral thalamic stroke. This tremor had low frequency (3–4Hz), did not disappear on focus and was exacerbated by maintaining a static posture and on target pursuit, which made it very difficult to perform basic functions. MRI demonstrated an old ischemic lesion at the left posterolateral thalamus. Treatment with levodopa led to symptom control. Lesions in the midbrain, cerebellum and thalamus may cause Holmes’ tremor. Delayed onset of symptoms is usually seen, sometimes appearing 2years after the original injury. This may be due to matu...
Source: Journal of Clinical Neuroscience - November 21, 2015 Category: Neuroscience Source Type: research