Filtered By:
Drug: Carbidopa/Levodopa

This page shows you your search results in order of relevance. This is page number 3.

Order by Relevance | Date

Total 49 results found since Jan 2013.

Gender and Dopaminergic Medication Treatment in Early Parkinson Disease (P3.069)
CONCLUSIONS: Although we did not observe gender differences in the type and dose of dopaminergic treatment in LS-1 participants with early PD, further research is needed to evaluate gender influences on dopaminergic medication treatment in mid- and late-stage PD.Study Supported by: on behalf of the NET-PD LS1 investigators.Disclosure: Dr. Umeh has nothing to disclose. Dr. Pérez has nothing to disclose. Dr. Augustine has nothing to disclose. Dr. Dhall has received personal compensation for activities with UCP Pharma, Impax Pharmaceuticals, and Teva Neuroscience. Dr. Dewey has received personal compensation for activi...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Umeh, C., Perez, A., Augustine, E., Dhall, R., Dewey, R., Mari, Z., Simon, D., Wills, A. M., Christine, C., Schneider, J., Suchowersky, O. Tags: Movement Disorders: Clinical Features of Parkinson ' s Disease Source Type: research

Successful Management of Hemorrhage-associated Hemiballism after STN DBS with Pallidal Stimulation: A Case Report
Conclusion In our case pallidal DBS was effective in treating hemiballism that arose as a result of traumatic displacement of STN DBS electrodes. Medical management and changes in stimulation parameters failed to produce any significant change in the hemiballism. This report is only the third of its kind in the literature wherein hemiballism arising as a result of STN damage after DBS was successfully treated with pallidal stimulation.
Source: World Neurosurgery - July 10, 2015 Category: Neurosurgery Source Type: research

Parkinsonism, small vessel disease, and white matter disease: Is there a link?
Parkinsonian syndrome is primarily attributed to striato-nigral degeneration as idiopathic Parkinson disease (PD), although it can be caused by white matter (WM) disease as classically seen in vascular parkinsonism (VP). VP clinically manifests as predominant lower extremities involvement and gait impairment with poor response to levodopa and, radiologically, as WM hyperintensities (WMH) that disrupt the striato-nigral pathways. However, brain MRI vascular lesions correlate poorly with clinical manifestations and pathology findings.1
Source: Neurology - November 2, 2015 Category: Neurology Authors: Luca, C. C., Rundek, T. Tags: Parkinson's disease/Parkinsonism, All Cerebrovascular disease/Stroke EDITORIALS Source Type: research

FDA Drug Safety Communication: Ongoing Safety Review of Stalevo and possible increased cardiovascular risk
[08-20-2010] The U.S. Food and Drug Administration (FDA) is evaluating clinical trial data that suggest patients taking Stalevo (a combination of carbidopa/levodopa and entacapone) may be at an increased risk for cardiovascular events (heart attack, stroke, and cardiovascular death) compared to those taking carbidopa/levodopa (sold as the combination product, Sinemet).
Source: FDA Center for Drug Evaluation and Research - What's New - March 2, 2016 Category: Drugs & Pharmacology Source Type: news

Patient Preferences for Device-Aided Treatments Indicated for Advanced Parkinsons Disease (APD) (P6.391)
Conclusions: Our findings suggest that patients, on average, prefer device aided treatments over oral therapy to improve movement symptoms in advanced PD, and that a portable infusion pump is preferred to DBS. Patient preferences are important and should be considered for therapeutic and access choices in advanced PD.Disclosure: Dr. Marshall has received personal compensation for activities with AbbVie, Inc. as an employee. Dr. Hauber has received research support from AbbVie. Dr. Fairchild has received research support from AbbVie. Dr. Sail has received personal compensation from AbbVie as an employee of the organization.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Marshall, T., Hauber, A. B., Fairchild, A., Sail, K. Tags: Movement Disorders: Parkinson ' s Disease II Source Type: research

Early reperfusion therapy in acute ischemic stroke after recent myocardial infarction
ABSTRACT Most known by his literary ability, the words of the neurologist Oliver Sacks (1933-2015) also had an impact on scientific community about the role of levodopa on parkinsonisms. Different from the most authors and based on his experience described on the book “ Awakenings ” , he had a pessimistic opinion about levodopa, which was related on many articles written by himself and colleagues in early 1970s. We reviewed the scientific contribution of Oliver Sacks associated to levodopa therapy on parkinsonisms, and how he advised caution with its complications before the majority of physicians.RESUMO Mais conhecido...
Source: Arquivos de Neuro-Psiquiatria - August 22, 2016 Category: Neurology Source Type: research

Co-occurrence of cadasil and a parkinsonian syndrome: a report of two cases and review of the literature
Conclusions To our knowledge this represents the first autopsy-confirmed case of CADASIL with coexistent idiopathic Parkinson’s disease in a patient with a novel NOTCH3 mutation. We also report on a new genetically confirmed case of CADASIL presenting as progressive Parkinsonism.
Source: Journal of Neurology, Neurosurgery and Psychiatry - May 8, 2017 Category: Neurosurgery Authors: Murray, N., Pepper, E., Blackie, J., Ronan, A., Sugo, E. Tags: Abstracts Source Type: research

Blood-brain barrier permeability in association with levodopa-induced dyskinesia in Parkinson's disease: a rubidium-82 PET study
Conclusion: The findings do not support the presence of significant alterations in BBB permeability in PD patients with or without LID. Research Support: This work was supported by the National Institute of Neurological Disorders and Stroke Morris K. Udall Center of Excellence for Parkinson’s Disease Research at The Feinstein Institute for Medical Research (P50 NS071675 to the last author).
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Fujita, K., Dhawan, V., Peng, S., Ma, Y., Eidelberg, D. Tags: New Approaches to Image Parkinson Syndrome Source Type: research

Effects of monoaminergic drugs on training-induced motor cortex plasticity in older adults.
Abstract Primary motor cortex (M1) plasticity is involved in motor learning and stroke motor recovery, and enhanced by increasing monoaminergic transmission. Age impacts these processes but there is a paucity of systematic studies on the effects of monoaminergic drugs in older adults. Here, in ten older adults (age 61+ 4 years, 4 males), we determine the effects of a single oral dose of carbidopa/levodopa (DOPA), d-amphetamine (AMPH), methylphenidate (MEPH) and placebo (PLAC) on M1 excitability and motor training-induced M1 plasticity. M1 plasticity is defined as training related long lasting changes in M1 excitab...
Source: Brain Research - June 17, 2017 Category: Neurology Authors: Kesar TM, Belagaje SR, Pergami P, Haut MW, Hobbs G, Buetefisch CM Tags: Brain Res Source Type: research

Low Frequency repetitive Transcranial Magnetic Stimulation: Potential role in treatment of patients with hemispheric cerebellar strokes
Five years prior to TMS study, a 64 years old left-handed man with mild tremor-predominant Parkinson's disease that predominantly affected his right side experienced a large embolic left cerebellar infarct and subsequently required cerebellar hemispherectomy due to complications of cerebellar edema. He had no other evidence of brain lesions or stroke (Supplementary Figure). Patient was on Parkinson's medication Carbidopa/Levodopa 25 –100mg 3 times per day and denied having ON of OFF periods. Residual difficulties with coordination, speech, fine motor movements, spasticity and most prominently his balance led to the perma...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 22, 2018 Category: Neurology Authors: Isabelle Buard, Jean M. Berliner, Benzi M. Kluger Source Type: research

Vascular Parkinsonism sensitive to Rotigotine therapy is found in aged patients: a clinical case description.
Abstract Previous and recent papers have pointed out several discussions about the so called 'Vascular Parkinsonism' (VP), particularly about some distinctive characteristics with respect to the Idiopathic Parkinson Disease (IPD); differences commonly described are  sudden onset of extrapyramidal symptoms after a stroke, main involvement of lower limbs in diffuse brain microinfarcts (lower body parkinsonism), low, short in time or absent response to classic IPD therapy in all kinds of vascular brain pathologies. But few published studies have also emphasized some relationship linking brain morphological signs of ...
Source: Acta Bio-Medica : Atenei Parmensis - March 27, 2018 Category: General Medicine Authors: Zarola F Tags: Acta Biomed Source Type: research

Low Frequency repetitive Transcranial Magnetic Stimulation: Potential role in treatment of patients with hemispheric cerebellar strokes
Five years prior to TMS study, a 64 years old left-handed man with mild tremor-predominant Parkinson's disease that predominantly affected his right side experienced a large embolic left cerebellar infarct and subsequently required cerebellar hemispherectomy due to complications of cerebellar edema. He had no other evidence of brain lesions or stroke (Supplementary Figure). Patient was on Parkinson's medication Carbidopa/Levodopa 25 –100mg 3 times per day and denied having ON of OFF periods. Residual difficulties with coordination, speech, fine motor movements, spasticity and most prominently his balance led to the perma...
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 22, 2018 Category: Neurology Authors: Isabelle Buard, Jean M. Berliner, Benzi M. Kluger Source Type: research

Sensory Re-weighting for Postural Control in Parkinson ’s Disease
In this study, we focused primarily on the change of sensory weighting parameters when sensory conditions change. We also tested the additional hypothesis that levodopa medication would improve sensory weighting for postural control. Materials and Methods Subjects The Institutional Review Board at Oregon Health and Science University (OHSU) approved the protocol for this experiment, and all subjects gave informed consent prior to participating. Eight subjects with PD (three female) and eight healthy, age-matched controls (two female) were recruited from the Balance Disorders Laboratory database and the Parkinson’...
Source: Frontiers in Human Neuroscience - April 16, 2019 Category: Neuroscience Source Type: research

C-Reactive Protein and Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis
Conclusions: This meta-analysis revealed that PD is associated with an increase of CRP levels. CRP might be a risk factor for PD or PD leads to an inflammatory response. Introduction Parkinson's disease (PD) is one of the most complex neuro-degenerative disorders next to Alzheimer's disease. It is characterized by bradykinesia, tremor, rigidity, abnormal postural, and gait (1). PD has been recognized by the selective loss of dopaminergic neurons within the substantia nigra pars compacta, whereas the exact etiology remains elusive (2). Previously, multiple inferences have reviewed the environmental a...
Source: Frontiers in Neurology - April 16, 2019 Category: Neurology Source Type: research

Dystonia and levodopa-induced dyskinesias in Parkinson's disease: Is there a connection?
Abstract Dystonia and levodopa-induced dyskinesia (LID) are both hyperkinetic movement disorders. Dystonia arises most often spontaneously, although it may be seen after stroke, injury, or as a result of genetic causes. LID is associated with Parkinson's disease (PD), emerging as a consequence of chronic therapy with levodopa, and may be either dystonic or choreiform. LID and dystonia share important phenomenological properties and mechanisms. Both LID and dystonia are generated by an integrated circuit involving the cortex, basal ganglia, thalamus and cerebellum. They also share dysregulation of striatal choliner...
Source: Neurobiology of Disease - August 20, 2019 Category: Neurology Authors: Calabresi P, Standaert DG Tags: Neurobiol Dis Source Type: research