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Drug: Aspirin
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Total 3663 results found since Jan 2013.
Effects of aspirin on risk and severity of early recurrent stroke after transient ischaemic attack and ischaemic stroke: time-course analysis of randomised trials
Publication date: Available online 18 May 2016 Source:The Lancet Author(s): Peter M Rothwell, Ale Algra, Zhengming Chen, Hans-Christoph Diener, Bo Norrving, Ziyah Mehta Background Aspirin is recommended for secondary prevention after transient ischaemic attack (TIA) or ischaemic stroke on the basis of trials showing a 13% reduction in long-term risk of recurrent stroke. However, the risk of major stroke is very high for only the first few days after TIA and minor ischaemic stroke, and observational studies show substantially greater benefits of early medical treatment in the acute phase than do longer-term trials. ...
Source: The Lancet - May 19, 2016 Category: Journals (General) Source Type: research
Stroke prevention.
Abstract
Patients who have had a stroke are at high risk for recurrent stroke, myocardial infarction, and vascular death. Prevention of these events should be initiated promptly after stroke, because many recurrent events occur early, and should be tailored to the precise cause of stroke, which may require specific treatment. Lifestyle advice including abstinence from smoking, regular exercise, Mediterranean-style diet, and reduction of salt intake and alcohol consumption are recommended for all patients with stroke. For most patients with ischemic stroke or TIA, control of risk factors, including lowering blood p...
Source: Presse Medicale - November 1, 2016 Category: Journals (General) Authors: Isabel C, Calvet D, Mas JL Tags: Presse Med Source Type: research
8 ways to prevent a stroke
This year, nearly half a million women will have a stroke. The June 2013 Harvard Women's Health Watch offers eight steps women can take to limit the chances a stroke will strike.
Women can't do anything about two leading contributors to stroke—age and family history. But there are many other stroke risk factors they can control. Becoming aware of them is the first step. "Knowledge is power," says Dr. Natalia Rost, associate professor of neurology at Harvard Medical School and associate director of the Acute Stroke Service at Massachusetts General Hospital. "If you know that a particular risk factor is sabotaging your...
Source: New Harvard Health Information - May 31, 2013 Category: Consumer Health News Source Type: news
Aspirin for Acute Stroke of Undetermined Etiology in Resource-Limited Settings: A Decision Analysis (P4.296)
CONCLUSIONS: Aspirin initiation after acute stroke of unknown etiology in resource-limited settings is predicted to decrease acute stroke-related mortality and stroke recurrence. The assumption that aspirin cannot be safely administered to patients with acute stroke of unknown etiology without neuroimaging to assess for ICH is not supported by our model. In the absence of a clinical trial to test this approach empirically, clinical decisions still require patient-specific scrutiny.Disclosure: Dr. Berkowitz has received royalty payments from Medmaster and Oxford University Press. Dr. Westover has received personal compensat...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Berkowitz, A., Westover, M., Bianchi, M., Chou, S. Tags: Global Health and Infection Source Type: research
Comparative Effectiveness of Pre‐stroke Aspirin on Stroke Severity and Outcome
This article is protected by copyright. All rights reserved.
Source: Annals of Neurology - December 1, 2015 Category: Neurology Authors: Jong‐Moo Park, Kyusik Kang, Yong‐Jin Cho, Keun‐Sik Hong, Kyung Bok Lee, Tai Hwan Park, Soo Joo Lee, Youngchai Ko, Moon‐Ku Han, Jun Lee, Jae‐Kwan Cha, Dae‐Hyun Kim, Dong‐Eog Kim, Joon‐Tae Kim, Jay Chol Choi, Kyung‐Ho Yu, Byung‐Chul Lee, Tags: Research Article Source Type: research
Treatment with Clopidogrel Prior to Acute Non-Cardioembolic Ischemic Stroke Attenuates Stroke Severity
Background: Clopidogrel reduces the risk of non-cardioembolic ischemic stroke, but it is unclear whether it affects the severity and outcome of stroke. We aimed at evaluating the effect of prior treatment with clopidogrel on acute non-cardioembolic ischemic stroke severity and in-hospital outcome. Methods: We prospectively studied 608 consecutive patients (39.5% males, age 79.1 ± 6.6 years) who were admitted with acute ischemic stroke. The severity of stroke was assessed at admission with the National Institutes of Health Stroke Scale (NIHSS). Severe stroke was defined as NIHSS ≥21. The outcome was assessed using the de...
Source: Cerebrovascular Diseases - January 22, 2016 Category: Neurology Source Type: research
Stroke recurrence among 30 days survivors of ischemic stroke in a prospective community-based study.
Authors: Ryglewicz D, Baranska-Gieruszczak M, Czlonkowska A, Lechowicz W, Hier D
Abstract
A cohort of 209 patients (105 men and 104 women), who survived 30 days after "first ever-in-lifetime ischemic stroke' were followed for one year. Predictors ofsurvival were examined by log-rank test and Cox proportional hazards method. Twenty-four patients had a stroke recurr~nce (11.4%). Thirteen of the patients with recurrent stroke (54%) died because of the sequelae of the second stroke. Stroke recurred in 16% of patients with stoke due to atherosclerosis, in 12.5% of patients with cardioembolic stroke, and in 4.4% of patie...
Source: Neurological Research - November 10, 2016 Category: Neurology Tags: Neurol Res Source Type: research
Cryptogenic Stroke: Diagnostic Workup and Management
AbstractPurpose of reviewCryptogenic stroke describes a subset of ischemic stroke for which no cause can be found despite a structured investigation. There are a number of putative mechanisms of cryptogenic ischemic stroke including a covert structural cardiac lesion, paroxysmal atrial fibrillation, hypercoagulable state or undiagnosed malignancy. Because many of these proposed mechanisms are embolic – and based on studies of thrombus history showing commonalities between thrombus composition between cardioembolic and cryptogenic strokes – the concept of embolic stroke of undetermined source (ESUS) (Hart et al. Lancet ...
Source: Current Treatment Options in Cardiovascular Medicine - December 2, 2019 Category: Cardiology Source Type: research
UCLA, partners get $11M to develop stroke-prevention programs for minority populations
UCLA researchers and their partners across Los Angeles County have been awarded an $11 million federal grant to fund research on community-based interventions aimed at reducing the higher rates of stroke and death from stroke among disadvantaged Hispanics, African Americans and Asian Americans.
Research has shown that stroke risk can be substantially lowered by increasing physical activity, controlling blood pressure, adopting a healthy diet, quitting smoking, lowering cholesterol and, for certain individuals, taking medication like aspirin.
However, the underserved populations targeted by this research progr...
Source: UCLA Newsroom: Health Sciences - May 1, 2013 Category: Universities & Medical Training Source Type: news
Abstract 10: Pre-stroke Antithrombotic Therapy and Stroke Severity in Acute Ischemic Stroke Patients with Atrial Fibrillation Session Title: Abstract Oral Session: Outcomes
Conclusions: A majority of AF patients presenting with AIS are not on guideline recommended anticoagulation or are not therapeutic on their anticoagulation. Even when strokes occurred on therapeutic warfarin or a NOAC, the strokes were less severe. These findings highlight the huge opportunities to further improve proper use of oral anticoagulants in eligible AF patients.
Source: Circulation: Cardiovascular Quality and Outcomes - February 26, 2016 Category: Cardiology Authors: Xian, Y., OBrien, E. C., Liang, L., Pencina, M. J., Schwamm, L. H., Fonarow, G. C., Bhatt, D. L., Smith, E. E., Maisch, L., Hannah, D., Lindholm, B., Lytle, B. L., Hernandez, A. F., Peterson, E. D. Tags: Session Title: Abstract Oral Session: Outcomes Source Type: research
Secondary Stroke Prevention in Cryptogenic Stroke and Embolic Stroke of Undetermined Source (ESUS)
AbstractPurpose of the ReviewThe purpose of the study was to review the literature on cryptogenic stroke and embolic stroke of undetermined stroke (ESUS). Cryptogenic stroke according to TOAST criteria is a stroke which is not due to cardiogenic embolism, small vessel disease with lacunes or large vessel disease of brain supplying arteries. In the context of secondary stroke prevention studies, cryptogenic stroke is not operationally defined.Recent FindingsThe new concept of “embolic stroke of undetermined source” (ESUS) provides an operational definition. ESUS is diagnosed as a non-lacunar stroke on cerebral imaging a...
Source: Current Neurology and Neuroscience Reports - July 13, 2017 Category: Neuroscience Source Type: research
Aspirin resistance are associated with long-term recurrent stroke events after ischaemic stroke.
CONCLUSION: In conclusion, AR is not uncommon in Chinese stroke patients who receive anti-platelet medications. Patients with AR may have a greater risk of suffering stroke recurrence events.
PMID: 28842303 [PubMed - as supplied by publisher]
Source: Brain Research Bulletin - August 22, 2017 Category: Neurology Authors: Zhang N, Wang Z, Zhou L Tags: Brain Res Bull Source Type: research
Prestroke Aspirin Use is Associated with Clinical Outcomes in Ischemic Stroke Patients with Atherothrombosis, Small Artery Disease, and Cardioembolic Stroke.
CONCLUSIONS: PA use may reduce initial stroke severity in AT stroke and the risk of END, and can improve functional outcome at three months irrespective of stroke subtypes.
PMID: 30429408 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - November 16, 2018 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
Stroke Outcomes in the Cardiovascular OutcoMes for People using Anticoagulation StrategieS (COMPASS) Trial.
CONCLUSIONS: Low-dose rivaroxaban plus aspirin is an important new antithrombotic option for primary and secondary stroke prevention in patients with clinical atherosclerosis.
CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov Unique Identifier: NCT01776424.
PMID: 30667279 [PubMed - as supplied by publisher]
Source: Circulation - January 22, 2019 Category: Cardiology Authors: Sharma M, Hart RG, Connolly SJ, Bosch J, Shestakovska O, Ng KKH, Catanese L, Keltai K, Aboyans V, Alings M, Ha JW, Varigos J, Tonkin A, O'Donnell M, Bhatt DL, Fox K, Maggioni A, Berkowitz SD, Cook Bruns N, Yusuf S, Eikelboom JW Tags: Circulation Source Type: research
Contemporary Antiplatelet and Anticoagulant Therapies for Secondary Stroke Prevention: A Narrative Review of Current Literature and Guidelines
Curr Neurol Neurosci Rep. 2023 Apr 11. doi: 10.1007/s11910-023-01266-2. Online ahead of print.ABSTRACTPURPOSE OF REVIEW: Stroke is a leading cause of death and disability worldwide. The annual incidence of new or recurrent stroke is approximately 795,000 cases per year in the United States, of which 87% are ischemic in nature. In addition to the management of modifiable high-risk factors to reduce the risk of recurrent stroke, antithrombotic agents (antiplatelets and anticoagulants) play an important role in secondary stroke prevention. This review will discuss the published literature on the use of antiplatelets and antic...
Source: Atherosclerosis - April 10, 2023 Category: Cardiology Authors: Kunal Bhatia Lindsey M Ladd Kelsey H Carr Mario Di Napoli Jeffrey L Saver Louise D McCullough Maryam Hosseini Farahabadi Diana L Alsbrook Archana Hinduja Jorge G Ortiz Garcia Sara Y Sabbagh Alibay Jafarli Afshin A Divani Source Type: research
