Filtered By:
Drug: Aspirin

This page shows you your search results in order of relevance. This is page number 7.

Order by Relevance | Date

Total 3663 results found since Jan 2013.

Safety of Ticagrelor in Moderate and Severe Acute Ischemic Stroke: A Single-Center Retrospective Review
Ticagrelor is a potent P2Y12 receptor antagonist that may have a role in acute ischemic stroke (AIS), particularly in patients with symptomatic atherosclerotic disease.1,2 Recently, a large randomized control trial demonstrated a significant reduction in stroke or death within 30 days following minor stroke or TIA with ticagrelor plus aspirin versus aspirin alone.3 Studies of ticagrelor have focused on patients with minor stroke or TIA; however, safety of ticagrelor following more severe ischemic strokes is unknown.
Source: Journal of Stroke and Cerebrovascular Diseases - April 3, 2021 Category: Neurology Authors: Stephen W. English, David R. Landzberg, Nirav R. Bhatt, Michael R. Frankel, Digvijaya Navalkele Source Type: research

Factors affecting self-reported bleeding acceptance in acute ischemic stroke survivors on various types of antithrombotic therapy
Stroke causes long-term serious disability with global prevalence of 101 million people in 2019.1 Antithrombotic therapy is recommended for stroke secondary prevention depending on the acute ischemic stroke (AIS) subtype.2 One of the major causes of non-cardioembolic AIS is intracranial atherosclerosis, which requires single antiplatelet therapy (SAPT), mostly with aspirin.3,4 Dual antiplatelet therapy (DAPT) may reduce the risk of non-cardioembolic stroke by 29% in AIS attributable to severe intracranial stenosis when used for a limited period of time.
Source: Journal of Stroke and Cerebrovascular Diseases - November 16, 2022 Category: Neurology Authors: Gabriela Rusin, Jadwiga Kubica, Krzysztof Piotr Malinowski, Agnieszka S łowik, Anetta Undas Source Type: research

Predictors for Recurrent Primary Intracerebral Hemorrhage: A Retrospective Population-based Study Clinical Sciences
Conclusions— Previous ischemic stroke independent of confounding factors may increase the risk for PICH recurrence.
Source: Stroke - February 25, 2013 Category: Neurology Authors: Huhtakangas, J., Lopponen, P., Tetri, S., Juvela, S., Saloheimo, P., Bode, M. K., Hillbom, M. Tags: Health policy and outcome research, Acute Cerebral Hemorrhage, Intracerebral Hemorrhage, Risk Factors for Stroke Clinical Sciences Source Type: research

Prevalence of Ex Vivo High On-treatment Platelet Reactivity on Antiplatelet Therapy after Transient Ischemic Attack or Ischemic Stroke on the PFA-100® and VerifyNow®
Background: The prevalence of ex vivo high on-treatment platelet reactivity (HTPR) to commonly prescribed antiplatelet regimens after transient ischemic attack (TIA) or ischemic stroke is uncertain.Methods: Platelet function inhibition was simultaneously assessed with modified light transmission aggregometry (VerifyNow; Accumetrics Inc, San Diego, CA) and with a moderately high shear stress platelet function analyzer (PFA-100; Siemens Medical Solutions USA, Inc, Malvern, PA) in a pilot, cross-sectional study of TIA or ischemic stroke patients. Patients were assessed on aspirin–dipyridamole combination therapy (n = 51) o...
Source: Journal of Stroke and Cerebrovascular Diseases - September 14, 2012 Category: Neurology Authors: Justin A. Kinsella, W. Oliver Tobin, Dermot Cox, Tara Coughlan, Ronan Collins, Desmond O’Neill, Raymond P. Murphy, Dominick J.H. McCabe Tags: Original Articles Source Type: research

Hemorrhagic Risk of Emergent Endovascular Treatment Plus Stenting in Patients with Acute Ischemic Stroke
Conclusions: Our findings suggest that emergent stenting in endovascular treatment of AIS is associated with SICH.
Source: Journal of Stroke and Cerebrovascular Diseases - January 24, 2013 Category: Neurology Authors: Laura Dorado, Carlos Castaño, Mònica Millán, Aitziber Aleu, Natàlia Pérez de la Ossa, Meritxell Gomis, Elena López-Cancio, Elio Vivas, Ana Rodriguez-Campello, Mar Castellanos, Antoni Dávalos Tags: Original Articles Source Type: research

Protocol for Cilostazol Stroke Prevention Study for Antiplatelet Combination (CSPS.com): a randomized, open‐label, parallel‐group trial
DiscussionThe CSPS.com is expected to provide evidence indicating whether secondary IS prevention in high‐risk patients can be improved by using DAPT involving cilostazol.
Source: International Journal of Stroke - December 8, 2014 Category: Neurology Authors: Kazunori Toyoda, Shinichiro Uchiyama, Haruhiko Hoshino, Kazumi Kimura, Hideki Origasa, Hiroaki Naritomi, Kazuo Minematsu, Takenori Yamaguchi, Tags: Protocols Source Type: research

The Effect of Different Doses and Different Routes of Acetylsalicylic Acid Administration on Platelet Aggregation in Healthy Volunteers and Ischemic Stroke Patients
Abstract The purpose was to assess the effect of different doses and different routes of acetylsalicylic acid (ASA) administration on platelet aggregation and the comparison between platelet aggregation after the single and the repetitive administration of ASA in healthy individuals and in patients after ischemic stroke. The study group consists of 22 healthy individuals and 30 patients with documented ischemic stroke. Platelet aggregation was measured in healthy individuals: (a) twice before ASA and (b) 2 h after different single doses and different routes of ASA administration—(b1) 500 mg orally, (b2) 500 m...
Source: Translational Stroke Research - December 19, 2014 Category: Neurology Source Type: research

The Interplay between Stroke Severity, Antiplatelet Use, and Aspirin Resistance in Ischemic Stroke
In this study, we evaluated the effect of antiplatelet use on clinical stroke severity and ischemic lesion volume, and assessed the confounding effect of laboratory-defined aspirin resistance on this relationship.
Source: Journal of Stroke and Cerebrovascular Diseases - November 11, 2015 Category: Neurology Authors: Nergiz Agayeva, Mehmet Akif Topcuoglu, Ethem Murat Arsava Source Type: research

Comparative Effectiveness of Interventions for Stroke Prevention in Atrial Fibrillation: A Network Meta-Analysis Arrhythmia and Electrophysiology
Conclusions The entire spectrum of therapy to prevent thromboembolism in nonvalvular AF significantly reduced stroke/systemic embolism events and mortality.
Source: JAHA:Journal of the American Heart Association - May 19, 2016 Category: Cardiology Authors: Tereshchenko, L. G., Henrikson, C. A., Cigarroa, J., Steinberg, J. S. Tags: Atrial Fibrillation, Anticoagulants, Treatment, Meta Analysis, Cerebrovascular Disease/Stroke Arrhythmia and Electrophysiology Source Type: research

Antecedent Aspirin Use Is Associated with Less Severe Symptoms on Admission for Ischemic Stroke
Aspirin is known to reduce stroke risk; however, its role in reducing severity of ischemic syndrome is not clear. We sought to investigate the relationship between antecedent aspirin use and stroke severity in patients presenting with acute ischemic stroke (AIS).
Source: Journal of Stroke and Cerebrovascular Diseases - July 17, 2016 Category: Neurology Authors: Sarah Nelson, Lisa Cloonan, Allison S. Kanakis, Kaitlin M. Fitzpatrick, Kelsey I. Shideler, Adriana S. Perilla, Karen L. Furie, Natalia S. Rost Source Type: research

Secondary Stroke Prophylaxis with Clopidogrel Produces Sufficient Antiplatelet Response
Antiplatelet therapy is a cornerstone prevention strategy for secondary ischemic stroke (IS) and transient ischemic attack (TIA). Yet, a proportion of patients who receive antiplatelet therapy experience recurrent ischemic cerebrovascular events. A recent meta-analysis found an increased risk of recurrent stroke in clopidogrel- or aspirin-treated patients with ischemic stroke who had high on-treatment platelet reactivity (HTPR). Few studies have focused specifically on clopidogrel HTPR. Therefore, the aim of this study was to examine the relationship between clopidogrel HTPR and recurrent ischemic events in a population of...
Source: Journal of Stroke and Cerebrovascular Diseases - June 23, 2018 Category: Neurology Authors: Charlotte L ützhøft Rath, Niklas Rye Jørgensen, Troels Wienecke Source Type: research

Predictors of Recurrent Ischemic Stroke in Patients with Embolic Strokes of Undetermined Source and Effects of Rivaroxaban Versus Aspirin According to Risk Status: The NAVIGATE ESUS Trial
Background: Embolic stroke of undetermined source (ESUS) identifies patients with cryptogenic ischemic stroke presumed due to embolism from several unidentified sources. Among patients with recent ESUS, we sought to determine independent predictors of recurrent ischemic stroke during treatment with aspirin or rivaroxaban and to assess the relative effects of these treatments according to risk. Methods: Exploratory analyses of 7213 participants in the NAVIGATE ESUS international trial who were randomized to aspirin 100 mg/day or rivaroxaban 15 mg/day and followed for a median of 11 months, during which time there were 309 f...
Source: Journal of Stroke and Cerebrovascular Diseases - May 30, 2019 Category: Neurology Authors: Robert G. Hart, Roland C. Veltkamp, Patrick Sheridan, Mukul Sharma, Scott E. Kasner, Shrikant I. Bangdiwala, George Ntaios, Ashkan Shoamanesh, Sebastian F. Ameriso, Danilo Toni, Anna Czlonkowska, Arne Lindgren, Graeme J. Hankey, Kanjana. S. Perera, Ashfaq Source Type: research

Collagen-Induced Platelet Aggregates, Diabetes, and Aspirin Therapy Predict Clinical Outcomes in Acute Ischemic Stroke
This study aimed to identify factors that may affect platelet aggregability and their role in clinical outcomes in acute ischemic stroke. Methods: Consecutive acute ischemic stroke patients (n  = 352) who were transferred within 24 hours after its onset were enrolled. Peripheral venous blood was sampled to measure platelet aggregability and other parameters. Results: Mean values of spontaneous small-sized platelet aggregates and collagen- or adenosine diphosphate (ADP)-induced large-s ized aggregates were elevated in acute ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - June 3, 2019 Category: Neurology Authors: Kaho Harima, Sumika Honda, Kasumi Mikami, Maiko Kitajima, Mayumi Urushizaka, Toshiko Tomisawa, Joji Hagii, Hirofumi Metoki, Minoru Yasujima, Tomohiro Osanai Source Type: research

Cilostazol Versus Aspirin for Secondary Stroke Prevention: Systematic Review and Meta-Analysis
Cilostazol has promise as an alternative to aspirin for secondary stroke prevention given its vasodilatory and anti-inflammatory properties in addition to platelet aggregation inhibition. We aimed to conduct a systematic review and meta-analysis to estimate the efficacy and safety of cilostazol compared to aspirin for stroke prevention in patients with previous stroke or transient ischemic attack (TIA).
Source: Journal of Stroke and Cerebrovascular Diseases - December 31, 2020 Category: Neurology Authors: Michelle P. Lin, James F. Meschia, Neethu Gopal, Kevin M. Barrett, Owen A. Ross, Nil üfer Ertekin-Taner, Thomas G. Brott Source Type: research