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Drug: Aspirin

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Total 3663 results found since Jan 2013.

Effect of Estimated Glomerular Filtration Rate Decline on the Efficacy and Safety of Clopidogrel With Aspirin in Minor Stroke or Transient Ischemic Attack Clinical Sciences
Background and Purpose—Patients with chronic kidney disease (CKD) are at a particularly high risk for ischemic and bleeding events. Limited data exist as to the efficacy and safety of clopidogrel in stroke patients with renal dysfunction. Therefore, we sought to assess the impact of decreased kidney function on clinical outcomes for stroke patients on clopidogrel–aspirin treatment.Methods—Patients in the CHANCE trial (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events) were randomized to clopidogrel–aspirin or aspirin-alone treatment. The primary efficacy outcome was new stroke during ...
Source: Stroke - October 23, 2016 Category: Neurology Authors: Zhou, Y., Pan, Y., Wu, Y., Zhao, X., Li, H., Wang, D., Johnston, S. C., Liu, L., Wang, C., Meng, X., Wang, Y., , on behalf of the CHANCE Investigators Tags: Nephrology and Kidney, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research

Impact of Glycemic Control on Efficacy of Clopidogrel in Transient Ischemic Attack or Minor Stroke Patients With CYP2C19 Genetic Variants Clinical Sciences
Background and Purpose—Dysglycemia may influence the predictive value of CYP2C19 loss-of-function allele for clinical efficacy of antiplatelet drug, but the role of glycated albumin (GA) remains unclear in patients with stroke on antiplatelet drugs.Methods—The CHANCE trial (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events) included 2933 patients who had GA levels and CYP2C19 genotyping. Cox proportional hazards model was used to assess the interaction between CYP2C19 loss-of-function allele (*2, *3) carrier status and the effect of antiplatelet therapy based on their GA levels.Results—...
Source: Stroke - March 27, 2017 Category: Neurology Authors: Yi Lin, Anxin Wang, Jiejie Li, Jinxi Lin, David Wang, Xia Meng, Lixian Ou, Weiqi Chen, Xingquan Zhao, Liping Liu, Yilong Wang, Yongjun Wang Tags: Biomarkers, Secondary Prevention, Genetics, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research

Better outcomes for hospitalized patients with TIA when in stroke units: An observational study
Conclusions: Hospitalized patients with TIA managed in SUs had better survival at 180 days than those treated in alternate wards, potentially through better management, but further research is needed.
Source: Neurology - May 29, 2016 Category: Neurology Authors: Cadilhac, D. A., Kim, J., Lannin, N. A., Levi, C. R., Dewey, H. M., Hill, K., Faux, S., Andrew, N. E., Kilkenny, M. F., Grimley, R., Thrift, A. G., Grabsch, B., Middleton, S., Anderson, C. S., Donnan, G. A., On behalf of the Australian Stroke Clinical Reg Tags: Outcome research, All Cerebrovascular disease/Stroke, Models of care, Cohort studies ARTICLE Source Type: research

Ticagrelor in Acute Stroke or Transient Ischemic Attack in Asian Patients Clinical Sciences
Background and Purpose—In the SOCRATES trial (Acute Stroke or Transient Ischemic Attack Treated With Aspirin or Ticagrelor and Patient Outcomes), ticagrelor was not superior to aspirin. Because of differences in patient demographics and stroke disease pattern in Asia, outcomes of ticagrelor versus aspirin were assessed among Asian patients in a prespecified exploratory analysis.Methods—Baseline demographics, treatment effects, and safety of ticagrelor and aspirin were assessed among Asian patients. Differences in outcomes between groups were assessed using Cox proportional hazard model.Results—A total of 3858 (29.2%)...
Source: Stroke - December 22, 2016 Category: Neurology Authors: Yongjun Wang, Kazuo Minematsu, Ka Sing Lawrence Wong, Pierre Amarenco, Gregory W. Albers, Hans Denison, J. Donald Easton, Scott R. Evans, Peter Held, Jenny Jonasson, Carlos A. Molina, S. Claiborne Johnston Tags: Treatment, Cerebrovascular Disease/Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research

Ticagrelor Versus Aspirin in Acute Embolic Stroke of Undetermined Source Clinical Sciences
Background and Purpose—Ticagrelor is an effective antiplatelet therapy among patients with atherosclerotic disease and, therefore, could be more effective than aspirin in preventing recurrent stroke and cardiovascular events among patients with embolic stroke of unknown source (ESUS), which includes patients with ipsilateral stenosis
Source: Stroke - August 28, 2017 Category: Neurology Authors: Pierre Amarenco, Gregory W. Albers, Hans Denison, J. Donald Easton, Scott R. Evans, Peter Held, Michael D. Hill, Jenny Jonasson, Scott E. Kasner, Per Ladenvall, Kazuo Minematsu, Carlos A. Molina, Yongjun Wang, K.S. Lawrence Wong, S. Claiborne Johnston Tags: Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research

Statins and the Risk of Intracerebral Hemorrhage in Patients With Previous Ischemic Stroke or Transient Ischemic Attack Clinical Sciences
Conclusions—Statin use was not associated with an increased risk of ICH among patients with a previous history of IS/TIA.
Source: Stroke - November 27, 2017 Category: Neurology Authors: David Gaist, Larry B. Goldstein, Lucia Cea Soriano, Luis Alberto Garcia Rodriguez Tags: Secondary Prevention, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research

Types of stroke recurrence in patients with ischemic stroke: A substudy from the PRoFESS trial
ConclusionsRisk predictors for stroke recurrence and for brain hemorrhage differ by index ischemic stroke subtype, information that is important when initiating secondary prevention therapy.
Source: International Journal of Stroke - October 22, 2013 Category: Neurology Authors: Danilo Toni, Emanuele Di Angelantonio, Maria Teresa Di Mascio, Richard Vinisko, Philip MW Bath, Tags: Research Source Type: research

Efficacy of Antiplatelet Therapy in Secondary Prevention Following Lacunar Stroke: Pooled Analysis of Randomized Trials Clinical Sciences
Conclusions— Our results suggest that any of the single antiplatelet agents compared with placebo in the included trials is adequate for secondary stroke prevention after lacunar stroke. Dual antiplatelet therapy should not be used for long-term stroke prevention in this stroke subtype.
Source: Stroke - March 23, 2015 Category: Neurology Authors: Kwok, C. S., Shoamanesh, A., Copley, H. C., Myint, P. K., Loke, Y. K., Benavente, O. R. Tags: Antiplatelets Clinical Sciences Source Type: research

Prestroke antiplatelet agents in first-ever ischemic stroke: Clinical effects
Conclusions: PA use was associated with decreased first-ever stroke severity, suggesting that it has a beneficial effect. Classification of evidence: This study provides Class II evidence that prestroke use of antiplatelet agents reduces stroke severity in patients with first-ever acute ischemic stroke.
Source: Neurology - March 16, 2015 Category: Neurology Authors: Jung, J.-M., Choi, J., Eun, M.-Y., Seo, W.-K., Cho, K.-H., Yu, S., Oh, K., Hong, S., Park, K.-Y. Tags: MRI, All Cerebrovascular disease/Stroke, Class II, Case control studies, Natural history studies (prognosis) ARTICLE Source Type: research

Aspirin Treatment Failure and the Risk of Recurrent Stroke and Death Among Patients with Ischemic Stroke
Conclusions: In a post-hoc analysis of 2 randomized ischemic stroke trials, aspirin treatment failure was not found to be associated with an increased risk of recurrent stroke or death.
Source: Journal of Stroke and Cerebrovascular Diseases - August 11, 2011 Category: Neurology Authors: Alexandros L. Georgiadis, Steve M. Cordina, Gabriela Vazquez, Nauman Tariq, M. Fareed K. Suri, Kamakshi Lakshminarayan, Harold P. Adams, Adnan I. Qureshi Tags: Original Articles Source Type: research

Outcomes for people with atrial fibrillation in an Australian national audit of stroke care
ConclusionsHospital processes of care can influence outcomes in stroke patients with atrial fibrillation. The greater in‐hospital mortality experienced by stroke patients with atrial fibrillation may be attenuated by admission to a stroke unit, and for ischemic stroke, early administration of aspirin.
Source: International Journal of Stroke - July 9, 2013 Category: Neurology Authors: Nadine Andrew, Monique Kilkenny, Dawn Harris, Chris Price, Dominique A. Cadilhac Tags: Research Source Type: research

Aspirin for acute stroke of unknown etiology in resource-limited settings: A decision analysis
Conclusion: Aspirin treatment for the period of initial hospitalization after acute stroke of undetermined etiology is predicted to decrease acute stroke-related mortality and in-hospital stroke recurrence even at the highest reported proportion of acute strokes due to ICH. In the absence of clinical trials to test this approach empirically, clinical decisions require patient-specific evaluation of risks and benefits of aspirin in this context.
Source: Neurology - August 25, 2014 Category: Neurology Authors: Berkowitz, A. L., Westover, M. B., Bianchi, M. T., Chou, S. H.- Y. Tags: Decision analysis, All Cerebrovascular disease/Stroke, Intracerebral hemorrhage ARTICLE Source Type: research

Targeting aspirin in acute disabling ischemic stroke: an individual patient data meta‐analysis of three large randomized trials
ConclusionsUsing simple clinical variables to target aspirin to patients after acute disabling stroke by risk of thrombosis, haemorrhage or poor functional outcome does not lead to greater net clinical benefit. We suggest future risk stratification schemes include new risk factors for thrombosis and intracranial haemorrhage.
Source: International Journal of Stroke - April 12, 2015 Category: Neurology Authors: Douglas D. Thompson, Gordon D. Murray, Livia Candelise, Zhengming Chen, Peter A. G. Sandercock, William N. Whiteley Tags: Research Source Type: research

Michelle is moving ahead after experiencing a stroke
In fall of 2014, I was a senior, excited about finishing high school in New Hampshire and heading off to college. But I could never have guessed what the year would bring. I was an avid lacrosse player and competing in my fifth game of a tournament when I started to notice I was having trouble seeing out of my left eye. Soon, my hand felt weird and I couldn’t grip the stick properly. As I sat on the sidelines, onlookers recommended I be taken to a local hospital. Recovering from stroke I can’t remember a lot of what happened next, but I know that the emergency doctors believed I had a stroke. They sent me to the Stroke...
Source: Thrive, Children's Hospital Boston - October 2, 2017 Category: Pediatrics Authors: Michelle Ostaudelafont Tags: Diseases & Conditions Our Patients’ Stories Dr. Cameron Trenor Dr. Laura Lehman pediatric stroke Stroke and Cerebrovascular Center Source Type: news

Cerebrovascular Accidents During Mechanical Circulatory Support Clinical Sciences
Conclusions—Stroke is a major cause of morbidity and mortality in patients on LVAD support. Chronic obstructive pulmonary disease increases the risk of ischemic stroke, whereas dialysis may increase the risk of hemorrhagic stroke. Although any stroke increases mortality, post-LVAD hemorrhagic stroke was associated with higher mortality compared with ischemic stroke.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Saef Izzy, Daniel B. Rubin, Firas S. Ahmed, Feras Akbik, Simone Renault, Katelyn W. Sylvester, Henrikas Vaitkevicius, Jennifer A. Smallwood, Michael M. Givertz, Steven K. Feske Tags: Heart Failure, Complications, Quality and Outcomes, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research