Effect of Estimated Glomerular Filtration Rate Decline on the Efficacy and Safety of Clopidogrel With Aspirin in Minor Stroke or Transient Ischemic Attack [Clinical Sciences]

Background and Purpose—Patients with chronic kidney disease (CKD) are at a particularly high risk for ischemic and bleeding events. Limited data exist as to the efficacy and safety of clopidogrel in stroke patients with renal dysfunction. Therefore, we sought to assess the impact of decreased kidney function on clinical outcomes for stroke patients on clopidogrel–aspirin treatment.Methods—Patients in the CHANCE trial (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events) were randomized to clopidogrel–aspirin or aspirin-alone treatment. The primary efficacy outcome was new stroke during 90 days, whereas bleeding was the safety outcome. Patients were stratified according to estimated glomerular filtration rate.Results—Dual clopidogrel–aspirin therapy was associated with a marked reduction in new strokes compared with the therapy of aspirin alone in patients with normal renal function (hazard ratio, 0.77; 95% confidence interval, 0.60–0.98; P=0.02) and mild CKD (hazard ratio, 0.60; 95% confidence interval, 0.45–0.79; P

Source: Stroke - October 23, 2016 Category: Neurology Authors: Zhou, Y., Pan, Y., Wu, Y., Zhao, X., Li, H., Wang, D., Johnston, S. C., Liu, L., Wang, C., Meng, X., Wang, Y., , on behalf of the CHANCE Investigators Tags: Nephrology and Kidney, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research