Filtered By:
Condition: Multiple Sclerosis

This page shows you your search results in order of relevance. This is page number 6.

Order by Relevance | Date

Total 1656 results found since Jan 2013.

Eagle Syndrome: A Rare Cause of Stroke in a Young Patient
We report the case of a 26-year-old man who presented to the emergency department because he noticed that his right hand had become clumsy. He first noticed this symptom five days before his presentation, but he noticed that his symptom had improved significantly since it began. He reported that he had episodes of neck pain and pain around the ear. He visited the family physician clinic several times for this complaint and was diagnosed as having a temporomandibular joint disorder. Neurological examination revealed decreased muscle strength in the right upper limb with a power of 4/5 along with a sensory deficit. The coord...
Source: Pain Physician - February 15, 2022 Category: Anesthesiology Authors: Hussain A Alobaidi Ali A Alfaran Hawa H Algazwi Fatimah I Alkhater Hussain M Alshooalah Abdulrahman K Alanzi Ibrahim A Almindil Abdullah K Alqasim Aisha A Faqeeh Amani A Almutairi Ghaida H Alnaqa Najla H Alnaqa Renad M Alasmari Razan M Almashouf Faisal Al Source Type: research

Experiences of individuals with multiple sclerosis and stroke using transcutaneous foot drop electrical stimulators: a systematic review and meta-synthesis of qualitative studies
CONCLUSIONS: We recommend that the outcomes to continued use of foot drop electrical stimulators are carefully considered against the barriers. Our conceptual model may be useful to guide clinical conversations around the possible use of FES for managing foot drop in people with multiple sclerosis and stroke.Implications for rehabilitationThe key outcomes to foot drop electrical stimulator use were enhanced walking ability, improved independence and confidence, and enhanced social participation.The main barriers to foot drop electrical stimulator use were device aesthetics, usability challenges, trustworthiness of device i...
Source: Disability and Rehabilitation - May 24, 2022 Category: Rehabilitation Authors: Felicity Burns Allyson Calder Hemakumar Devan Source Type: research

Sphingosine ‐1‐phosphate receptor modulators in stroke treatment
AbstractSphingosine-1-phosphate (S1P) is a bioactive lysophospholipid that can influence a broad range of biological processes through its binding to five distinct G protein-coupled receptors. S1P receptor modulators are a new group of immunosuppressive agents currently used in the immunotherapy of multiple sclerosis. Inflammation following stroke may exacerbate injury. Given that S1P signaling is linked to multiple immune processes, therapies targeting the S1P axis may be suitable for treating stroke. In this review, we outline S1P metabolism and S1P receptors, discuss the mechanisms of action of S1P receptor modulators i...
Source: Journal of Neurochemistry - August 9, 2022 Category: Neuroscience Authors: Wanzhou Zhang, Yudi Li, Fangming Li, Li Ling Tags: REVIEW Source Type: research

Outcomes of importance to people with multiple sclerosis, Parkinson's disease and stroke following a falls prevention intervention: a qualitative study to inform a core outcome set
Conclusions: This study presents new perspectives across patient groups regarding important outcomes upon completion of falls prevention interventions. Taken together with the findings of a literature review, this data will inform the development of a COS.Implications for rehabilitationPeople with multiple sclerosis, Parkinson's disease and stroke consider the success of a falls prevention intervention to be dependent on improvements across a wide range of outcomes.The design and implementation of falls prevention interventions should align with patient preferences.Clinicians and researchers should consider the use of mult...
Source: Disability and Rehabilitation - April 24, 2023 Category: Rehabilitation Authors: Nicola O'Malley Susan Coote Amanda M Clifford Source Type: research

Multiple Sclerosis And Stroke Findings In Rehabilitation Research
Kessler Foundation scientists and their colleagues will discuss their progress in rehabilitation research at the upcoming 65th Annual American Academy of Neurology Conference at the San Diego Convention Center in San Diego, CA, March 16 - 23. A.M. Barrett, MD, director of Stroke Rehabilitation at Kessler Foundation will present on Pharmacologic Enhancement of Stroke Rehabilitation on Friday March 22, 2013 as part of a Specialty in Focus session on Neurorehabilitation Enhancement Techniques...
Source: Health News from Medical News Today - March 19, 2013 Category: Consumer Health News Tags: Multiple Sclerosis Source Type: news

Dysphagia in Stroke, Neurodegenerative Disease, and Advanced Dementia
This article reviews stroke, muscular dystrophy, myasthenia gravis, multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and advanced dementia. Approaches to screening and evaluation, recognizing sentinel indicators of decline that increase aspiration risk, and options for managing global laryngeal dysfunction are also presented.
Source: Otolaryngologic clinics of North America - October 14, 2013 Category: ENT & OMF Authors: Kenneth W. Altman, Amanda Richards, Leanne Goldberg, Steven Frucht, Daniel J. McCabe Tags: Special Populations and Considerations Source Type: research

A Rare Association between Ulcerative Colitis and Bilateral Thalamic Stroke (P6.270)
CONCLUSIONS:Cerebral sinus and vein thrombosis is a serious and often fatal complication of idiopathic inflammatory bowel disease if undiagnosed. It should be considered in any patient with little or no known vascular risk factors presenting with a severe headache and other focal or diffuse neurological signs.Disclosure: Dr. Misthal has nothing to disclose. Dr. Haitham has nothing to disclose. Dr. Bashir has nothing to disclose. Dr. Hussain has nothing to disclose. Dr. Moussavi has nothing to disclose. Dr. Kirmani has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Misthal, S., Haitham, D., Bashir, A., Hussain, M., Moussavi, M., Kirmani, J. Tags: Cerebrovascular Disease and Interventional Neurology: Case Reports Source Type: research

Effect of monomethyl-fumarate on experimental stroke
Activation of the cytoprotective Nrf2 pathway has been shown to be beneficial in experimental stroke. Dimethyl-fumarate (DMF) activates the Nrf2 pathway through its active metabolite monomethyl-fumarate (MMF). DMF has been recently registered as an oral treatment of multiple sclerosis. Considering that novel treatment acting through the Nrf2 pathway is already available in clinical practice, here we investigated if MMF given intravenously protects against experimental stroke.
Source: Journal of Neuroimmunology - October 15, 2014 Category: Allergy & Immunology Authors: , Bettina H. Clausen, Bente Finsen, Helle H. Nielsen, Louise Lundberg, Kate L. Lambertsen Tags: 333 Source Type: research

The subpopulation of microglia expressing functional muscarinic acetylcholine receptors expands in stroke and Alzheimer's disease.
Abstract Microglia undergo a process of activation in pathology which is controlled by many factors including neurotransmitters. We found that a subpopulation (11 %) of freshly isolated adult microglia respond to the muscarinic acetylcholine receptor agonist carbachol with a Ca(2+) increase and a subpopulation of similar size (16 %) was observed by FACS analysis using an antibody against the M3 receptor subtype. The carbachol-sensitive population increased in microglia/brain macrophages isolated from tissue of mouse models for stroke (60 %) and Alzheimer's disease (25 %), but not for glioma and multiple sclero...
Source: Brain Structure and Function - December 19, 2014 Category: Neuroscience Authors: Pannell M, Meier MA, Szulzewsky F, Matyash V, Endres M, Kronenberg G, Prinz V, Waiczies S, Wolf SA, Kettenmann H Tags: Brain Struct Funct Source Type: research

Neuregulin1-β Decreases IL-1β-Induced Neutrophil Adhesion to Human Brain Microvascular Endothelial Cells
Abstract Neuroinflammation contributes to the pathophysiology of diverse diseases including stroke, traumatic brain injury, Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis, resulting in neurodegeneration and loss of neurological function. The response of the microvascular endothelium often contributes to neuroinflammation. One such response is the upregulation of endothelial adhesion molecules which facilitate neutrophil adhesion to the endothelium and their migration from blood to tissue. Neuregulin-1 (NRG1) is an endogenous growth factor which has been reported to have anti-inflammatory eff...
Source: Translational Stroke Research - March 12, 2015 Category: Neurology Source Type: research

Protective features of peripheral monocytes/macrophages in stroke
This article is part of a Special Issue entitled: Neuro inflammation: A common denominator for stroke, multiple sclerosis and Alzheimer's disease, guest edited by Helga de Vries and Markus Swaninger.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - November 13, 2015 Category: Molecular Biology Source Type: research

Imaging of Neuroinflammation in Alzheimer’s Disease, Multiple Sclerosis and Stroke: Recent Developments in Positron Emission Tomography
This article is part of a Special Issue entitled: Neuro Inflammation edited by Helga E. de Vries and Markus Schwaninger.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - November 29, 2015 Category: Molecular Biology Source Type: research

Imaging of neuroinflammation in Alzheimer's disease, multiple sclerosis and stroke: Recent developments in positron emission tomography
This article is part of a Special Issue entitled: Neuro Inflammation edited by Helga E. de Vries and Markus Schwaninger.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - February 13, 2016 Category: Molecular Biology Source Type: research

Non-stroke Central Neurologic Manifestations in Antiphospholipid Syndrome
Abstract Thrombotic manifestations of antiphospholipid syndrome (APS) are well known, and various non-stroke neuro-psychiatric manifestations (NPMs) have also been consistently described, but their place in APS remains unclear. Some syndromes, such as migraine or cognitive dysfunction, are frequently described in APS, whereas others, like seizure, multiple sclerosis-like symptoms, transverse myelitis, movement disorders, or psychiatric symptoms, are rarely found. Overlap with other autoimmune diseases, in particular with systemic lupus erythematosus, the lack of large sample size prospective studies, and discrepa...
Source: Current Rheumatology Reports - February 29, 2016 Category: Rheumatology Source Type: research

Roles of NG2-glia in ischemic stroke.
Abstract Recent studies have shown that a widely distributed class of glial cells, termed NG2-glia, engages in rapid signaling with surrounding neurons through direct synaptic contacts in the developing and mature central nervous system (CNS). This unique glial cell group has a typical function of proliferating and differentiating into oligodendrocytes during early development of the brain, which is crucial to axon myelin formation. Therefore, NG2-glia are also called oligodendrocyte precursor cells (OPCs). In vitro and in vivo studies reveal that NG2-glia expressing receptors and ion channels demonstrate function...
Source: CNS Neuroscience and Therapeutics - March 18, 2017 Category: Neuroscience Authors: Song FE, Huang JL, Lin SH, Wang S, Ma GF, Tong XP Tags: CNS Neurosci Ther Source Type: research