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Condition: Multiple Sclerosis

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Total 1656 results found since Jan 2013.

Similar barriers and facilitators to physical activity across different clinical groups experiencing lower limb spasticity.
Conclusions In this population, participation in physical activity includes activities such as housework which are different than what is typically considered as physical activity. Further, the presence of similar barriers and facilitators across the groups suggests that support and services to promote valued forms of physical activity could be organised and delivered based on limitations in mobility and functioning rather than clinical diagnosis. Implications for rehabilitation Physical activity is of utmost importance in maintaining health and wellness in clinical populations. This research highlights the desired and act...
Source: Disability and Rehabilitation - January 4, 2016 Category: Rehabilitation Authors: Hundza S, Quartly C, Kim JM, Dunnett J, Dobrinsky J, Loots I, Choy K, Chow B, Hampshire A, Temple VA Tags: Disabil Rehabil Source Type: research

Systematic review of the influence of spasticity on quality of life in adults with chronic neurological conditions.
CONCLUSIONS: Spasticity is associated with worse health status, however its relationship with overall QOL is not established. The relationship between spasticity and QOL is confounded by other impairments and requires multivariate analysis. Implications for Rehabilitation Effective management of spasticity may result in significant improvements in HRQOL. It is important to address multiple factors in the management of spasticity including pain, bladder problems, fatigue and sleep, as the interplay of these may have significant negative effects on HRQOL. Clinician-administered methods for measuring spasticity, such as the A...
Source: Disability and Rehabilitation - December 29, 2015 Category: Rehabilitation Authors: Milinis K, Young CA, Trajectories of Outcome in Neurological Conditions (TONiC) study Tags: Disabil Rehabil Source Type: research

Fumaric acid esters promote neuronal survival upon ischemic stress through activation of the Nrf2 but not HIF-1 signaling pathway.
Abstract Oxidative stress is a hallmark of ischemic stroke pathogenesis causing neuronal malfunction and cell death. Up-regulation of anti-oxidative genes through activation of the NF-E2-related transcription factor 2 (Nrf2) is one of the key mechanisms in cellular defense against oxidative stress. Fumaric acid esters (FAEs) represent a class of anti-oxidative and anti-inflammatory molecules that are already in clinical use for multiple sclerosis therapy. Purpose of this study was to investigate whether FAEs promote neuronal survival upon ischemia, and analyze putative underlying molecular mechanisms in neurons. M...
Source: Neuropharmacology - January 19, 2016 Category: Drugs & Pharmacology Authors: Lin-Holderer J, Li L, Gruneberg D, Marti HH, Kuznets R Tags: Neuropharmacology Source Type: research

Neurologist ambulatory care, health care utilization, and costs in a large commercial dataset
Conclusion: Neurologist involvement with care is associated with greater unadjusted allowed payments, but fewer adverse events and less acute care utilization.
Source: Neurology - January 25, 2016 Category: Neurology Authors: Ney, J. P., Johnson, B., Knabel, T., Craft, K., Kaufman, J. Tags: Cost effectiveness/economic, Outcome research, Medical care, Billing, Insurance ARTICLE Source Type: research

Erectile Dysfunction in Individuals with Neurologic Disability: A Hospital-based Cross-sectional Study
Conclusion: The occurence of erectile dysfunction is significantly more prevalent among neurologically disabled men, particularly those with lesions below S2–S4, than among men without neurologic disability. Considering the prevalence of erectile dysfunction among neurologically disabled men, sexual functioning should be regularly evaluated during acute and long-term rehabilitation, and any existing sexual dysfunction should be addressed in the treatment plan. Introduction Penile erection is a neurovascular event characterized by the dilation of arteries that cause the corpora cavernosa and corpora spongiosum of the peni...
Source: Innovations in Clinical Neuroscience - February 22, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Medical Issues Neurologic Systems and Symptoms Neurology Neuromuscular Disease Original Research Neurogenic SD; Erectile Dysfunction; sexual health; Quality of life Source Type: research

Erectile Dysfunction in Individuals with Neurologic Disability: A Hospital-based, Cross-sectional Study
Conclusion: The occurence of erectile dysfunction is significantly more prevalent among neurologically disabled men, particularly those with lesions below S2–S4, than among men without neurologic disability. Considering the prevalence of erectile dysfunction among neurologically disabled men, sexual functioning should be regularly evaluated during acute and long-term rehabilitation, and any existing sexual dysfunction should be addressed in the treatment plan. Introduction Penile erection is a neurovascular event characterized by the dilation of arteries that cause the corpora cavernosa and corpora spongiosum of the peni...
Source: Innovations in Clinical Neuroscience - February 1, 2016 Category: Neuroscience Authors: ICN Online Editor Tags: Current Issue Medical Issues Neurologic Systems and Symptoms Neurology Neuromuscular Disease Original Research Neurogenic SD; Erectile Dysfunction; sexual health; Quality of life Source Type: research

The pathophysiological role of astrocytic endothelin-1
Publication date: Available online 28 April 2016 Source:Progress in Neurobiology Author(s): Stéphanie Hostenbach, Miguel D’haeseleer, Ron Kooijman, Jacques De Keyser In the normal central nervous system, endothelin-1 (ET-1) is found in some types of neurons, epithelial cells of the choroid plexus, and endothelial cells of microvessels, but it is usually not detectable in glial cells. However, in different pathological conditions, astrocytes adapting a reactive phenotype express high levels of ET-1 and its receptors, mainly the ETB receptor. ET-1 released by reactive astrocytes appears mainly to have neurodeleterio...
Source: Progress in Neurobiology - April 28, 2016 Category: Neuroscience Source Type: research

ReWalk inks collab deal with Harvard to develop “soft” exosuit
ReWalk Robotics (NSDQ:RWLK) said today it inked a collaborative research with Harvard’s Wyss Institute to develop a lightweight “soft suit” exoskeleton system for lower limb disabilities. The collaboration looks to design a suit to treat stroke, multiple sclerosis and mobility limitations for the elderly as well as other applications. Through the agreement, ReWalk will pay Harvard in quarterly installment payments to fund the research, with reports from the research being relayed between the groups on a regular basis. ReWalk Robotics will be able to negotiate with Harvard to license new inventions create...
Source: Mass Device - May 17, 2016 Category: Medical Equipment Authors: Fink Densford Tags: Business/Financial News Prosthetics Harvard University ReWalk Robotics Wyss Institute Source Type: news

Facial expressions are key to first impressions. What does that mean for people with facial paralysis?
This article was originally published on The Conversation. Read the original article. -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.
Source: Science - The Huffington Post - May 30, 2016 Category: Science Source Type: news

Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation
Abstract Sphingosine-1-phosphate (S1P) and S1P receptors (S1PR) are ubiquitously expressed. S1P-S1PR signaling has been well characterized in immune trafficking and activation in innate and adaptive immune systems. However, the full extent of its involvement in the pathogenesis of autoimmune diseases is not well understood. FTY720 (fingolimod), a non-selective S1PR modulator, significantly decreased annualized relapse rates in relapsing-remitting multiple sclerosis (MS). FTY720, which primarily targets S1P receptor 1 as a functional antagonist, arrests lymphocyte egress from secondary lymphoid tissues and reduce...
Source: Drugs - June 17, 2016 Category: Drugs & Pharmacology Source Type: research

Vitamin d intake and its protective role in multiple sclerosis: the checkmate to survivin?
Vitamin D has long been speculated to reduce the risk of multiple sclerosis (MS). However, its role in development and modulating the course of MS has yet to be clarified. To date, there is no scientific evidence for the use of vitamin D as monotherapy for MS in clinical practice and perplexities still exist on potential disadvantages of Vitamin D intake. We hypothesize that vitamin D may be effective against MS inhibiting survivin gene expression and thereby affecting the development and progression of the disease. However, decreased levels of survivin may lead to worse outcomes during the acute phase of cardiovascular co...
Source: Iranian Journal of Pharmaceutical Research - May 31, 2016 Category: Drugs & Pharmacology Source Type: research

Pharmacological targeting of the PDGF-CC signaling pathway for blood –brain barrier restoration in neurological disorders
Publication date: Available online 12 August 2016 Source:Pharmacology & Therapeutics Author(s): Sebastian A. Lewandowski, Linda Fredriksson, Daniel A. Lawrence, Ulf Eriksson Neurological disorders account for a majority of non-malignant disability in humans and are often associated with dysfunction of the blood–brain barrier (BBB). Recent evidence shows that despite apparent variation in the origin of neural damage, the central nervous system has a common injury response mechanism involving platelet-derived growth factor (PDGF)-CC activation in the neurovascular unit and subsequent dysfunction of BBB integrity. ...
Source: Pharmacology and Therapeutics - August 11, 2016 Category: Drugs & Pharmacology Source Type: research

A comparison between the pathophysiology of multiple sclerosis and normal pressure hydrocephalus: is pulse wave encephalopathy a component of MS?
ConclusionsThere are blood flow and pulsation propagation changes in MS patients which are similar to those of NPH patients. The findings would be consistent with an underlying pulse wave encephalopathy component in MS.
Source: Fluids and Barriers of the CNS - September 21, 2016 Category: Neuroscience Source Type: research

7 Foot Problems That Can Be Serious
If you want to know the state of your health, try looking down. “There’s no question it’s extremely important that people pay attention to their feet,” says Terry Philbin, D.O., spokesperson for the American Academy of Orthopedic Surgeons (AAOS) and a foot and ankle specialist at the Orthopedic Foot and Ankle Center in Westerville, Ohio. The condition of your feet can give you clues to a host of medical issues, such as diabetes, arthritis, and even heart disease. Read on to find out what to look for and what it may mean. 1. Pain “There’s no pain that should be ignored,” says Jane ...
Source: Healthy Living - The Huffington Post - November 12, 2016 Category: Consumer Health News Source Type: news

The Valuation of Informal Care in Cost-of-Illness Studies: A Systematic Review
ConclusionThis paper identifies several aspects that should be enhanced to promote comparability between studies and countries, and it sends key messages for incorporating informal care costs to adequately measure the economic impact of diseases.
Source: PharmacoEconomics - November 14, 2016 Category: Health Management Source Type: research