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Condition: Multiple Sclerosis
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Total 1656 results found since Jan 2013.
Safety and Clinical Efficacy of Mesenchymal Stem Cell Treatment in Traumatic Spinal Cord Injury, Multiple Sclerosis and Ischemic Stroke – A Systematic Review and Meta-Analysis
BackgroundMesenchymal stem cells (MSCs) is an attractive candidate in regenerative research and clinical trials have assessed their therapeutic potential in different neurological conditions with disparate etiologies. In this systematic review, we aimed to assess safety and clinical effect of MSC treatment in traumatic spinal cord injury (TSCI), multiple sclerosis (MS) and ischemic stroke (IS).MethodsA systematic search was performed 2021-12-10 in MEDLINE, EMBASE, Web of Science and Cochrane where clinical studies assessing MSC treatment in TSCI, MS or IS were included. Studies without control group were excluded for effic...
Source: Frontiers in Neurology - May 30, 2022 Category: Neurology Source Type: research
Protocol for the development of a core outcome set for evaluating mixed-diagnosis falls prevention interventions for people with multiple sclerosis, Parkinson's disease and stroke - O'Malley N, Coote S, Clifford AM.
BACKGROUND: Given the high incidence of falls and their associated negative effects, the development of effective falls prevention interventions for people with Multiple Sclerosis (MS), Parkinson's Disease (PD) and stroke is a priority. Currently the imple...
Source: SafetyLit - June 6, 2022 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
The role of IL-23/IL-17 axis in ischemic stroke from the perspective of gut-brain axis
Neuropharmacology. 2023 Mar 14:109505. doi: 10.1016/j.neuropharm.2023.109505. Online ahead of print.ABSTRACTBidirectional communication between central nervous system (CNS) and intestine is mediated by nerve, endocrine, immune and other pathways in gut-brain axis. Many diseases of CNS disturb the homeostasis of intestine and gut microbiota. Similarly, the dysbiosis of intestinal and gut microbiota also promotes the progression and deterioration of CNS diseases. IL-23/IL-17 axis is an important inflammatory axis which is widely involved in CNS diseases such as experimental autoimmune encephalomyelitis (EAE), multiple sclero...
Source: Neuropharmacology - March 16, 2023 Category: Drugs & Pharmacology Authors: Yang Jiang Yajie Dai Zhenquan Liu Yan Liao Shuyong Sun Xianghe Kong Jingjing Hu Yibo Tang Source Type: research
Analysis of heat stroke and heat exhaustion cases in EudraVigilance pharmacovigilance database
ConclusionsThe majority of implicated drugs belong to therapeutic groups that are already mentioned in different heat-illness prevention plans. But we also show that drugs aimed to treat multiple sclerosis and several cytokines were also associated with heat-related adverse effects.
Source: European Journal of Clinical Pharmacology - April 3, 2023 Category: Drugs & Pharmacology Source Type: research
Microbiota, diet and the gut-brain axis in multiple sclerosis and acute stroke
This article is protected by copyright. All rights reserved.PMID:37470461 | DOI:10.1002/eji.202250229
Source: European Journal of Immunology - July 20, 2023 Category: Allergy & Immunology Authors: Laura Diaz-Marugan Johan B Kantsj ö Andrina Rutsch Francesca Ronchi Source Type: research
Stem Cells Attenuate the Inflammation Crosstalk Between Ischemic Stroke and Multiple Sclerosis: A Review
Cell Transplant. 2023 Jan-Dec;32:9636897231184596. doi: 10.1177/09636897231184596.ABSTRACTThe immense neuroinflammation induced by multiple sclerosis (MS) promotes a favorable environment for ischemic stroke (IS) development, making IS a deadly complication of MS. The overlapping inflammation in MS and IS is a prelude to the vascular pathology, and an inherent cell death mechanism that exacerbates neurovascular unit (NVU) impairment in the disease progression. Despite this consequence, no therapies focus on reducing IS incidence in patients with MS. To this end, the preclinical and clinical evidence we review here argues f...
Source: Cell Transplantation - July 29, 2023 Category: Cytology Authors: Molly Monsour Jonah Gordon Gavin Lockard Cesar V Borlongan Source Type: research
Associations between multiple sclerosis and in-hospital outcomes of patients with hemorrhagic stroke
To determine the influence of multiple sclerosis (MS) on in-hospital outcomes of patients with hemorrhagic strokes using a large, nationally representative database.
Source: Journal of Stroke and Cerebrovascular Diseases - July 29, 2023 Category: Neurology Authors: Weiguang Xu, Dajun Yan, Zeqian Ning Source Type: research
