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Condition: Multiple Sclerosis
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Total 1656 results found since Jan 2013.
Janssen Announces U.S. FDA Approval of PONVORY ™ (ponesimod), an Oral Treatment for Adults with Relapsing Multiple Sclerosis Proven Superior to Aubagio® (teriflunomide) in Reducing Annual Relapses and Brain Lesions
TITUSVILLE, N.J. – (March 19, 2021) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced that the U.S. Food and Drug Administration (FDA) approved PONVORY™ (ponesimod), a once-daily oral selective sphingosine-1-phosphate receptor 1 (S1P1) modulator, to treat adults with relapsing forms of multiple sclerosis (MS), to include clinically isolated syndrome, relapsing-remitting disease and active secondary progressive disease.1,2,3 PONVORY™ offers MS patients superior efficacy in reducing annualized relapse rates compared to an established oral therapy and a proven safety profile backed by ove...
Source: Johnson and Johnson - March 19, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news
Combined brain/heart magnetic resonance imaging in antiphospholipid syndrome-two sides of the same coin
AbstractAntiphospholipid syndrome (APS) is an autoimmune disorder characterized by arterial, venous, and/or small vessel thrombosis, pregnancy morbidity, and persistently elevated levels of antiphospholipid antibodies (aPL). Cardiovascular disease (CVD) in APS can present as heart valvular disease (HVD), macro-micro-coronary artery disease (CAD), myocardial dysfunction, cardiac thrombi, or pulmonary hypertension. Brain disease presents as stroke or transient ischemic attack (TIA) and less frequently as cerebral venous thrombosis, seizures, cognitive dysfunction, multiple sclerosis (MS) −like syndrome, or chorea. Infarcts...
Source: Clinical Rheumatology - June 10, 2021 Category: Rheumatology Source Type: research
Vibration therapy role in neurological diseases rehabilitation: an umbrella review of systematic reviews
CONCLUSION: WBV and FMV appear to play a considerable role in reducing spasticity and improving gait, balance, and motor function in stroke patients. By contrast, vibration therapy seems to be unable to reduce spasticity in multiple sclerosis and cerebral palsy. Also, correct use parameters for this therapy could not be defined.IMPLICATIONS FOR REHABILITATIONBased on the growing number of systematic reviews, this umbrella review aimed to summarize the findings and evaluate the role of vibration therapy in the rehabilitation of neurological diseases.Whole-body vibration and focal muscle vibration appear to play a considerab...
Source: Disability and Rehabilitation - July 6, 2021 Category: Rehabilitation Authors: Lucrezia Moggio Alessandro de Sire Nicola Marotta Andrea Demeco Antonio Ammendolia Source Type: research
High risk of cardiovascular diseases after diagnosis of multiple sclerosis
Conclusion:
We recommend careful surveillance and preventive CVDs measures among MS patients, particularly among the women.
Source: Multiple Sclerosis - August 30, 2013 Category: Neurology Authors: Jadidi, E., Mohammadi, M., Moradi, T. Tags: Research Papers Source Type: research
Paraoxonase 1 in neurological disorders.
Abstract
Paroxonase 1 displays multiple physiological activities that position it as a putative player in the pathogenesis of neurological disorders. Here we reviewed the literature focusing on the role of paraoxonase 1 (PON1) as a factor in the risk of stroke and the major neurodegenerative diseases. PON1 activity is reduced in stroke patients, which significantly correlates inversely with carotid and cerebral atherosclerosis. The presence of the R allele of the Q192R PON1 polymorphism seems to potentiate this risk for stroke. PON1 exerts peroxidase activities that may be important in neurodegenerative disorders ...
Source: Redox Report : communications in free radical research - November 12, 2013 Category: Biochemistry Authors: Menini T, Gugliucci A Tags: Redox Rep Source Type: research
Management of faecal incontinence and constipation in adults with central neurological diseases.
CONCLUSIONS: There is still remarkably little research on this common and, to patients, very significant issue of bowel management. The available evidence is almost uniformly of low methodological quality. The clinical significance of some of the research findings presented here is difficult to interpret, not least because each intervention has only been addressed in individual trials, against control rather than compared against each other, and the interventions are very different from each other.There was very limited evidence from individual trials in favour of a bulk-forming laxative (psyllium), an isosmotic macrogol l...
Source: Cochrane Database of Systematic Reviews - December 18, 2013 Category: Journals (General) Authors: Coggrave M, Norton C Tags: Cochrane Database Syst Rev Source Type: research
Can the Fatigue Severity Scale 7-item version be used across different patient populations as a generic fatigue measure - a comparative study using a Rasch model approach
Conclusions:
Some items performed differently between the three samples but did not bias person measures, thereby indicating that fatigue interference in these illnesses might still be reliably compared using FSS-7 scores. However, caution is warranted when comparing fatigue raw sum scores directly across diagnostic groups using the FSS-7. Further studies of the scale are needed in other types of chronic illnesses.
Source: Health and Quality of Life Outcomes - February 22, 2014 Category: Global & Universal Authors: Sverker JohanssonAnders KottorpKathryn LeeCaryl GayAnners Lerdal Source Type: research
Walking Capacity WalkCap Measured by Six-Minute Walk (6MW) Does Not Demonstrate Fatigue in Patients with Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS),and Parkinson Disease (PD) (P3.071)
CONCLUSIONS:WalkCap of ambulatory ALS, MS, and PD during 6MW is not affected by motor fatigue. WalkCap was higher in ambulatory patients with stronger grip, faster in TUG and 25FW. WalkCap measured by 6MW can be used as a simple outcome measure to evaluate lower extremity impairments in various neurological diseases. Discordance between WalkCap and the UPDRS-motor scale in mildly affected PD patients indicates that 6MW may provide additional information regarding these patients in clinical practice and clinical research trials.Study Supported by:Carolinas ALS Research Fund, Pinstripes Fund, Carolinas Healthcare Foundation,...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Sanjak, M., Morgan, L., Simpson, A., Holsten, S., Hirsch, M., Englert, D., Iyer, S., Conway, J., Kaufman, M., Bravver, E., Desai, U., Russo, P., Brooks, B. Tags: Movement Disorders: Assessing Parkinson ' s Disease Source Type: research
Bridging the goal intention-action gap in rehabilitation: a study of if-then implementation intentions in neurorehabilitation.
Conclusion: If-then plans were feasible and acceptable in bridging the goal intention-action gap in rehabilitation with people with MS and stroke, who are experiencing difficulties with mobility. This approach can now be adapted and trialled further in a definitive study. Implications for Rehabilitation Goal planning in rehabilitation necessitates specific strategies that help people engage in goal-related tasks. If-then plans aim to support people to deal more effectively with self-regulatory problems that might undermine goal striving and have been found to be effective in health promotion and health behaviour change. Th...
Source: Disability and Rehabilitation - August 28, 2014 Category: Rehabilitation Authors: Kersten P, McPherson KM, Kayes NM, Theadom A, McCambridge A Tags: Disabil Rehabil Source Type: research
The role of IL-17 in CNS diseases
Abstract
Cytokines of the IL-17 family are uniquely placed on the border between immune cells and tissue. Although IL-17 was originally found to induce the activation and mobilization of neutrophils to sites of inflammation, its tissue-specific function is not yet fully understood. The best-studied IL-17 family members, IL-17A and IL-17F, are both typically produced by immune cells such as Th17, γδ T cells and innate lymphoid cells group 3. However, the cells that respond to these cytokines are mostly found in inflamed tissue. As seen in psoriatic skin lesions or in joints of rheumatoid arthritis patients, high ...
Source: Acta Neuropathologica - February 26, 2015 Category: Neurology Source Type: research
UCLA researchers provide first evidence of how obstructive sleep apnea damages the brain
Courtesy of Rajesh Kumar
Brains with obstructive sleep apnea (left) and without
UCLA researchers have reported the first evidence that obstructive sleep apnea contributes to a breakdown of the blood–brain barrier, which plays an important role in protecting brain tissue.
The discovery, reported in the Sept. 1 issue of the Journal of Neuroimaging, could lead to new approaches for treating obstructive sleep apnea, which affects an estimated 22 million American adults. The disorder causes frequent interruptions in breathing during sleep because the airways narrow or become blocked.
The blood–brain barrier limits harmful...
Source: UCLA Newsroom: Health Sciences - September 1, 2015 Category: Universities & Medical Training Source Type: news
Mania secondary to focal brain lesions: implications for understanding the functional neuroanatomy of bipolar disorder
ConclusionsSecondary mania should be suspected in patients with neurological deficits, histories atypical for classic bipolar disorder, and first manic episodes after the age of 40 years. Treatment with antimanic medications, along with specific treatment for the underlying neurologic condition, is typically required. Typical lesion locations fit with current models of bipolar disorder, which implicate hyperactivity of left‐hemisphere reward‐processing brain areas and hypoactivity of bilateral prefrontal emotion‐modulating regions. Lesion studies complement these models by suggesting that right‐hemisphere limbic‐...
Source: Bipolar Disorders - April 25, 2016 Category: Psychiatry Authors: David Satzer, David J Bond Tags: Review Article Source Type: research
Clinical implications for Translocator Protein (TSPO) imaging using 123ICLINDE SPECT: A feasible approach
Conclusions The preliminary results imply that [123I]CLINDE-SPECT is a feasible approach for TSPO imaging in neurological disorders associated with microglial activation and/or increased TSPO expression. The development of methods that do not need arterial blood sampling for quantification of TSPO will be important to ease implementation in a daily clinical setting. Further clinical studies are needed to determine the precise role of TSPO imaging in predicting clinical outcome and treatment response.
Source: Journal of Nuclear Medicine - May 23, 2016 Category: Nuclear Medicine Authors: Thomsen, G., Jensen, P., Feng, L., Knudsen, L., Knudsen, G., Pinborg, L. Tags: Neurosciences/Neurology. Miscellaneous Source Type: research
