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Condition: Inflammatory Bowel Disease

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Total 222 results found since Jan 2013.

Epigenetic Aspects of Systemic Lupus Erythematosus
Abstract Autoimmune diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis, multiple sclerosis, autoimmune hepatitis, and inflammatory bowel disease have complex pathogeneses and the courses of events leading to these diseases are not well understood. The immune surveillance is a delicate balance between self and foreign as well as between tolerance and immune response. Exposure to certain environmental factors may impair this equilibrium, leading to autoimmune diseases, cancer, and the so-called “lifestyle diseases” such as atherosclerosis, heart attack, stroke, and obesity, among others. T...
Source: Rheumatology and Therapy - June 15, 2015 Category: Rheumatology Source Type: research

Mortality and comorbidities in patients with multiple sclerosis compared with a population without multiple sclerosis: An observational study using the US department of defense administrative claims database
Conclusions Rates of mortality and several comorbidities are higher in the MS versus non-MS cohort. Early recognition and management of comorbidities may reduce premature mortality and improve quality of life in patients with MS.
Source: Multiple Sclerosis and Related Disorders - August 19, 2015 Category: Neurology Source Type: research

Cardiovascular involvement in inflammatory bowel disease: Dangerous liaisons.
Abstract Increasing evidence of a link between inflammatory bowel disease (IBD) and adverse cardiovascular events has emerged during the last decade. In 2014, an important number of meta-analyses and cohort studies clarified the subtle dangerous liaisons between gut inflammation and cardiovascular pathology. The evidence suggests that patients with IBD have a significantly increased risk of myocardial infarction, stroke, and cardiovascular mortality, especially during periods of IBD activity. Some populations (e.g., women, young patients) may have an even greater risk. Current effective treatment of IBD is aimed a...
Source: World Journal of Gastroenterology : WJG - September 7, 2015 Category: Gastroenterology Authors: Filimon AM, Negreanu L, Doca M, Ciobanu A, Preda CM, Vinereanu D Tags: World J Gastroenterol Source Type: research

Smoking behaviour and knowledge of the health effects of smoking in patients with inflammatory bowel disease
ConclusionAlthough patients with Crohn's disease were better informed on the detrimental effects of smoking, the awareness rate was still low.
Source: Alimentary Pharmacology and Therapeutics - October 5, 2015 Category: Drugs & Pharmacology Authors: C. De Bie, V. Ballet, N. Hendriks, S. Coenen, E. Weyts, G. Van Assche, S. Vermeire, M. Ferrante Tags: Original Scientific Paper Source Type: research

No, Omega 3-Enriched Beef Is Not Necessarily Heart Healthy
Feeding cattle flaxseed or marine algae can raise the omega-3 fatty acid levels in ground beef from 30 milligrams per serving to 200 milligrams per serving, as Kansas State University researchers have found. But do higher levels of omega-3s make red meat significantly healthier?   Not according to Kim Larson, a registered dietitian nutritionist and spokesperson for the Academy of Nutrition and Dietetics. The attempt to make beef look like an important source of omega-3s is essentially a marketing ploy, she said. And despite the fatty acid's reputation as a health ...
Source: Science - The Huffington Post - October 14, 2015 Category: Science Source Type: news

Potential clinical applications of adult human mesenchymal stem cell (Prochymal®) therapy.
Authors: Patel AN, Genovese J Abstract In vitro, in vivo animal, and human clinical data show a broad field of application for mesenchymal stem cells (MSCs). There is overwhelming evidence of the usefulness of MSCs in regenerative medicine, tissue engineering, and immune therapy. At present, there are a significant number of clinical trials exploring the use of MSCs for the treatment of various diseases, including myocardial infarction and stroke, in which oxygen suppression causes widespread cell death, and others with clear involvement of the immune system, such as graft-versus-host disease, Crohn's disease, and ...
Source: Stem Cells and Cloning: Advances and Applications - December 1, 2015 Category: Stem Cells Tags: Stem Cells Cloning Source Type: research

Thalidomide Analogs that Inhibit Inflammation and Angiogenesis
Thalidomide and its close analogs (lenalidomide and pomalidomide) are widely used to treat a variety of diseases, such as multiple myeloma and other cancers as well as the symptoms of several inflammatory disorders. However, thalidomide is known for its teratogenic adverse effects when first clinically introduced in the 1950s, and is associated with drowsiness and peripheral neuropathy. Hence, there is intense interest to synthesize, identify and develop safer analogs.Researchers at the National Institute on Aging’s Drug Design and Development Section synthesized novel thalidomide analogs that demonstrate clinical potent...
Source: NIH OTT Licensing Opportunities - December 23, 2015 Category: Research Authors: admin Source Type: research

Association Between Long-Term Lipid Profiles and Disease Severity in a Large Cohort of Patients with Inflammatory Bowel Disease
Conclusions Low total cholesterol and high triglyceride levels are more frequent in IBD patients (in particular CD) compared to healthy controls and are independently associated with more severe disease.
Source: Digestive Diseases and Sciences - February 20, 2016 Category: Gastroenterology Source Type: research

Pharmacological Prophylaxis for Venous Thromboembolism Among Hospitalized Patients With Acute Medical Illness: An Electronic Medical Records Study
The objectives of this study were to examine pharmacological prophylaxis against VTE among hospitalized medically ill patients and to assess demographic and clinical correlates related to VTE prophylaxis. A retrospective (1999–2010) electronic medical records study included patients aged 40 years and older hospitalized for at least 3 days, with significant medical illness or with a VTE hospitalization 30–365 days before admission. Each patient's first qualifying hospitalization was analyzed. Exclusions were if VTE treatment was started within 1 day of admission, or if warfarin (and not heparin or enoxaparin) was used. ...
Source: American Journal of Therapeutics - March 1, 2016 Category: Drugs & Pharmacology Tags: Original Articles Source Type: research

Vitamin D Deficiency Is As Dangerous As Smoking
The advice you’re getting from your doctor, the TV and even the Surgeon General is so wrong, it’s scary. They’re all busy telling you to stay out of the sun. But Swedish researchers recently discovered that nonsmokers who avoid the sun have a life expectancy similar to smokers who spend a lot of time in the sun. Staying out of the sun is as dangerous as smoking.1 It doesn’t surprise me. I tell all my patients sunlight exposure is essential to our health because it is the best source of vitamin D… possibly the most important nutrient we know of. Mainstream medicine still doesn’t recognize th...
Source: Al Sears, MD Natural Remedies - May 19, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Health Source Type: news

Comment on: "measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease"
ABSTRACT Herpes zoster (HZ) corresponds to the reactivation of varicella zoster virus (VZV). Among adults, the ophthalmic division of the trigeminal nerve is one of the most common sites of involvement. Vasculopathy caused by HZ is associated with significant morbidity and mortality, affecting structures such as the brain, which can lead to stroke. In this review, we analyzed the epidemiological and clinical aspects of the vascular involvement of VZV, focusing on the peculiarities of its association with ocular HZ. A review of the available literature indicated that ocular involvement of HZ was a risk factor for vasculopat...
Source: Arquivos Brasileiros de Oftalmologia - May 24, 2016 Category: Opthalmology Source Type: research

Health status of populations living in French overseas territories in 2012, compared with metropolitan France: An analysis of the national health insurance database.
CONCLUSION: This study highlights the utility of administrative database to compare and follow population health status considering healthcare use. Specific Public Health policies are justified for FOT, taking into account the specific context of each FOT, the necessity of prevention initiatives and screening to reduce the frequency of the chronic diseases. PMID: 27238162 [PubMed - as supplied by publisher]
Source: Revue d Epidemiologie et de Sante Publique - May 31, 2016 Category: Epidemiology Tags: Rev Epidemiol Sante Publique Source Type: research

Acute Stroke in a Girl with an Absent Radial Pulse
A 13 year-old right-handed girl woke with left-sided tinnitus, left facial burning, slurred speech, and confusion. Past medical history included poorly controlled ulcerative colitis, von Willebrand’s disease type 2, and anemia [hemoglobin 9.2 g/dL; normal 11.2-14.8 g/dL]. Medications included mercaptopurine, mesalamine, and ferrous sulfate.
Source: Pediatric Neurology - June 9, 2016 Category: Neurology Authors: Shivani Ghoshal, Richard A. Bronen, Paul L. McCarthy, Salley G. Pels, Lauren A. Beslow Tags: Visual Diagnosis Source Type: research

Acute Stroke in a Girl With an Absent Radial Pulse
This 13-year-old right-handed girl awoke with left tinnitus, left facial burning, slurred speech, and confusion. Her past medical history included poorly controlled ulcerative colitis, von Willebrand disease type 2, and anemia (hemoglobin 9.2  g/dL; normal 11.2 to 14.8 g/dL). Medications included mercaptopurine, mesalamine, and ferrous sulfate.
Source: Pediatric Neurology - June 9, 2016 Category: Neurology Authors: Shivani Ghoshal, Richard A. Bronen, Paul L. McCarthy, Salley G. Pels, Lauren A. Beslow Tags: Visual Diagnosis Source Type: research

Imparied retrobulbar blood flow and increased carotid IMT in patients with Crohn ’s disease
AbstractCrohn ’s Disease [CD] is one of the Inflammatory Bowel Diseases that are chronic relapsing inflammatory diseases. Despite the major affected organ is intestine in CD, extra intestinal organs and tissues including cardiovascular system are also affected. Several studies have demonstrated that CD patients may have a higher risk of advancing atherosclerosis. The microvascular endothelial dysfunction plays an essential role for developing coronary atherosclerosis. Microvascular structural abnormalities in the retinal circulation may predict macrovascular events such as stroke and coronary heart diseas e. In order to ...
Source: The International Journal of Cardiovascular Imaging - August 12, 2016 Category: Radiology Source Type: research