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Condition: Inflammatory Bowel Disease
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Total 222 results found since Jan 2013.
Inhibitors of the NLRP3 inflammasome pathway as promising therapeutic candidates for inflammatory diseases (Review)
Int J Mol Med. 2023 Apr;51(4):35. doi: 10.3892/ijmm.2023.5238. Epub 2023 Mar 24.ABSTRACTThe inflammasome regulates innate immunity by serving as a signaling platform. The Nod‑like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor protein apoptosis‑associated speck‑like protein (ASC) and pro‑caspase‑1, is by far the most extensively studied and well‑characterized inflammasome. A variety of stimuli can activate the NLRP3 inflammasome. When activated, the NLRP3 protein recruits the adaptor ASC protein and activates pro‑caspase‑1, resulting in inflammatory cytokine maturation and secreti...
Source: Molecular Medicine - March 24, 2023 Category: Molecular Biology Authors: Xiaolu Zhang Ziyu Wang Yujia Zheng Qun Yu Miao Zeng Liding Bai Lin Yang Maojuan Guo Xijuan Jiang Jiali Gan Source Type: research
Varicella Zoster Vasculopathy Exacerbated by Tofacitinib in a Patient With Ulcerative Colitis
Stroke. 2023 Apr 6. doi: 10.1161/STROKEAHA.122.042228. Online ahead of print.NO ABSTRACTPMID:37021571 | DOI:10.1161/STROKEAHA.122.042228
Source: Herpes - April 6, 2023 Category: Infectious Diseases Authors: Kyle A Lyman Anirudh Sreekrishnan Prateek Thatikunta Ryan McConnell Maarten G Lansberg Christina M Mijalski Sells Source Type: research
Galangin as an inflammatory response modulator: An updated overview and therapeutic potential
Chem Biol Interact. 2023 Apr 10:110482. doi: 10.1016/j.cbi.2023.110482. Online ahead of print.ABSTRACTNumerous chronic diseases, such as cancer, diabetes, rheumatoid arthritis, cardiovascular disease, and gastrointestinal disorders, all have an inflammation-based etiology. In cellular and animal models of inflammation, flavonols were used to show potent anti-inflammatory activity. The flavonols enhanced the synthesis of the anti-inflammatory cytokines transforming growth factor and interleukin-10 (IL-10) and reduced the synthesis of the prostaglandins IL-6, tumor necrosis factor-alpha (TNF-α), and prostaglandin E2 (PGE2),...
Source: Chemico-Biological Interactions - April 12, 2023 Category: Molecular Biology Authors: Riya Thapa Obaid Afzal Abdulmalik Saleh Alfawaz Altamimi Ahsas Goyal Waleed Hassan Almalki Sami I Alzarea Imran Kazmi Vikash Jakhmola Sachin Kumar Singh Kamal Dua Ritu Gilhotra Gaurav Gupta Source Type: research
Atherosclerotic cardiovascular diseases in inflammatory bowel diseases: to the < em > heart < /em > of the issue
Front Cardiovasc Med. 2023 May 16;10:1143293. doi: 10.3389/fcvm.2023.1143293. eCollection 2023.ABSTRACTAtherosclerotic cardiovascular disease and stroke are the leading causes of morbidity and mortality worldwide. Along to the traditional risk factors for these diseases, chronic inflammation is known to be an important player in accelerating the process of atherosclerosis, which can result in an increased incidence of arterial thromboembolic events. As in other chronic inflammatory diseases, in the past few years, several studies suggested that subjects affected by inflammatory bowel diseases (IBD) may also be at an increm...
Source: Atherosclerosis - June 1, 2023 Category: Cardiology Authors: Roberto Gabbiadini Arianna Dal Buono Elisabetta Mastrorocco Virginia Solitano Alessandro Repici Antonino Spinelli Gianluigi Condorelli Alessandro Armuzzi Source Type: research
Diagnostic windows in non-neoplastic diseases: a systematic review
CONCLUSION: Evidence of changing healthcare use before diagnosis exists for many non-neoplastic conditions, establishing that early diagnosis is possible, in principle. In particular, some conditions may be detectable many years earlier than they are currently diagnosed. Further research is required to accurately estimate diagnostic windows and to determine how much earlier diagnosis may be possible, and how this might be achieved.PMID:37308303 | DOI:10.3399/BJGP.2023.0044
Source: Herpes - June 12, 2023 Category: Infectious Diseases Authors: Emma Whitfield Becky White Spiros Denaxas Georgios Lyratzopoulos Source Type: research
