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Total 528 results found since Jan 2013.

Clinical Evaluation of Lacunar Infarction and Branch Atheromatous Disease
Patients with branch atheromatous disease (BAD) are more likely to experience neurologic deficits compared with those with lacunar infarction (LI), although both disorders are forms of intracranial deep brain infarction. We clinically evaluated patients with BAD (n = 42) and LI (n = 57) to investigate why patients with BAD tend to experience progressing stroke. Patients presenting to our hospital with acute ischemic stroke between April 2008 and March 2009 were screened. LI was defined as an intracerebral lesion 2-point increase in the National Institutes of Health Stroke Scale within 48 hours of stroke onset. Progressing ...
Source: Journal of Stroke and Cerebrovascular Diseases - December 1, 2011 Category: Neurology Authors: Taizen Nakase, Shotaroh Yoshioka, Masahiro Sasaki, Akifumi Suzuki Tags: Original Articles Source Type: research

Acute ischemic stroke patients with diabetes should not be excluded from intravenous thrombolysis
Abstract The benefit of intravenous thrombolysis (IVT) has been questioned for patients with diabetes mellitus (DM) in cases of acute ischemic stroke (IS). Our objective was to analyze the differences in outcome according to prior diagnosis of DM and the use or not of IVT. Observational study with inclusion of consecutive IS patients admitted to an stroke unit. Demographic data, vascular risk factors, comorbidity, stroke severity and 3-month follow-up outcome (modified Rankin Scale) were compared according to prior diagnosis of DM and the use or not of IVT. A total of 1,139 IS patients were admitted; 283 (24.8 %...
Source: Journal of Thrombosis and Thrombolysis - October 2, 2014 Category: Hematology Source Type: research

Obstructive sleep apnea is independently associated with arterial stiffness in ischemic stroke patients
Abstract Obstructive sleep apnea (OSA) is a predictor of all-cause mortality and recurrent vascular events following stroke. However, few studies have investigated the pathophysiology of OSA in ischemic stroke patients. Whether OSA independently increases arterial stiffness in ischemic stroke patients is determined by measuring the carotid–femoral pulse wave velocity (PWV) and via the central augmentation index (AIx). This cross-sectional study consecutively recruited 127 subacute ischemic stroke patients who were admitted to a teaching hospital for inpatient rehabilitation (median age, 61.3 years; IQR 53.6–7...
Source: Journal of Neurology - March 20, 2015 Category: Neurology Source Type: research

Early neurological deterioration during the acute phase as a predictor of long-term outcome after first-ever ischemic stroke
Early neurological deterioration (END) is associated with increased risk of functional disability and mortality. However, data are limited regarding the long-term risk of poor functional outcomes. Thus we explored the association between END and long-term outcomes in patients with acute ischemic stroke. A total of 1064 patients were enrolled with acute ischemic stroke who were consecutively admitted to the 3 stroke units of Huai-He Hospital, Kaifeng, China. END was defined as an increment change of at least one point in motor power or total National Institute of Health Stroke Scale (NIHSS) score deterioration ≥2 points ...
Source: Medicine - December 1, 2017 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Embolic stroke of undetermined source (ESUS) cohort of Brazilian patients in a university hospital
ABSTRACT Embolic stroke of undetermined source (ESUS) is an important group of cryptogenic strokes that are in evidence due recent ongoing trials. We reviewed medical records at discharge from the stroke unit of all patients who met ESUS criteria and attended our institution between February 2016 and July 2017. Among 550 stroke patients, 51 had ESUS. We found that hypertension (60%), diabetes mellitus (34%), and smoking (36%) were the most prevalent risk factors. The mean National Institutes of Health Stroke Scale (NIHSS) scores were 7 at admission and 4 at discharge, while median scores on the modified Rankin scale were 0...
Source: Arquivos de Neuro-Psiquiatria - June 10, 2019 Category: Neurology Source Type: research

Lacunar stroke syndromes as predictors of lacunar and non-lacunar infarcts on neuroimaging: a hospital-based study
AbstractLacunar syndromes are usually caused by small ischemic lesions called lacunar infarcts. However, non-lacunar infarcts account for about 20% of lacunar syndromes. The aim of this study was to identify clinical predictors of lacunar syndromes led by non-lacunar infarcts. The following single centre, observational study was conducted on an analysis of the “Perugia hospital-based Stroke Registry” database enrolling consecutive patients admitted with ischemic stroke during the period 2010–2017. We evaluated patient risk factors and clinical features linked to stroke syndrome (lacunar/non-lacunar) and to cerebral i...
Source: Internal and Emergency Medicine - September 17, 2019 Category: Emergency Medicine Source Type: research

Stroke Burden in Malaysia
Malaysia is located in the heart of South East Asia with two land masses, Peninsular Malaysia and East Malaysia which are separated by the South China Sea. Stroke or cerebrovascular disease is Malaysia ’s third leading cause of death. There were 47, 911 incident cases, 19,928 deaths, 443,995 prevalent cases, and 512,726 DALYs lost due to stroke in 2019. Successive national health and morbidity surveys from 2006 demonstrated a continuous rise in the prevalence of risk factor such as diabetes, hyp erlipidaemia and obesity. These risk factors are implicated in an increase in stroke incidence in those under 65 years of age, ...
Source: Cerebrovascular Diseases Extra - March 24, 2022 Category: Neurology Source Type: research

The Relation between Plasma Gelsolin Levels and Prognosis in Patients with Acute İschemic Stroke upon Admission to Emergency Department
To compare serum gelsolin levels and Glasgow Coma Scale (GCS) scores in patients with acute ischemic stroke and to compare with healthy control subjects. Included in this study were patients with onset of symptoms in the first 3 h after acute ischemic stroke. Healthy volunteers were included as the control group. Patients with chronic obstructive pulmonary disease, diabetes mellitus, acute coronary syndromes, renal failure, heart failure, trauma, hepatic failure, infection, sepsis, and hematologic and oncologic disease were excluded from study. Venous blood samples were obtained from the patients and the control group upo...
Source: The Journal of Emergency Medicine - January 23, 2014 Category: Emergency Medicine Authors: A. Bayir, N. Tufekci, H. Vatansev, H. Baran, H. Kara, S.A. Kayis Source Type: research

Association of Hispanic ethnicity with acute ischemic stroke care processes and outcomes.
DISCUSSION: Hispanic AIS patients in this study were less likely to arrive at the hospital by ambulance, and experienced half the odds of a favorable outcome compared to others. Strategies to boost ambulance utilization among Hispanic AIS patients and identify contributors to this worrisome outcome disparity are needed. PMID: 25812247 [PubMed - indexed for MEDLINE]
Source: Ethnicity and Disease - June 3, 2015 Category: Global & Universal Tags: Ethn Dis Source Type: research

Diagnosed diabetes mellitus and in-hospital stroke mortality in a major sub-Saharan African urban medical unit
Stroke and diabetes are common disorders affecting 33 million and 415 million individuals worldwide respectively [1,2]. Mortality associated with both conditions is high [1,3]. Globally, 6% of deaths are caused by high blood glucose, and stroke accounts for 11.1% of deaths worldwide [1,3]. Stroke is one of the leading complications of diabetes. It is estimated that 12% of strokes are attributable to diabetes [4]. People with diabetes mellitus have more than double the risk of ischemic stroke after correcting for other factors.
Source: Primary Care Diabetes - July 30, 2016 Category: Primary Care Authors: Alain Lekoubou, Nkoke Clovis, Anastase Dudzie, Andre Pascal Kengne Tags: Original research Source Type: research

Cerebral microbleeds and intracranial haemorrhage risk in patients anticoagulated for atrial fibrillation after acute ischaemic stroke or transient ischaemic attack (CROMIS-2): a multicentre observational cohort study
This study is registered with ClinicalTrials.gov, number NCT02513316. Findings Between Aug 4, 2011, and July 31, 2015, we recruited 1490 participants of whom follow-up data were available for 1447 (97%), over a mean period of 850 days (SD 373; 3366 patient-years). The symptomatic intracranial haemorrhage rate in patients with cerebral microbleeds was 9·8 per 1000 patient-years (95% CI 4·0–20·3) compared with 2·6 per 1000 patient-years (95% CI 1·1–5·4) in those without cerebral microbleeds (adjusted hazard ratio 3·67, 95% CI 1·27–10·60). Compared with the HAS-BLED score alone (C-index 0·41, 95% CI 0·29–0...
Source: The Lancet Neurology - May 16, 2018 Category: Neurology Source Type: research

Earlier Acupuncture Enhancing Long-Term Effects on Motor Dysfunction in Acute Ischemic Stroke: Retrospective Cohort Study.
Abstract Stroke is the leading fatal disease in China. This retrospective study aimed to explore the optimal acupuncture intervention time for long-term efficacy on motor dysfunction in patients suffering from acute ischemic stroke through 1-year of follow-up. Three hundred and nine patients collected at Longhua Hospital from January 2016 to December 2017 were classified into 3 groups based on the acupuncture intervention time, including groups A (within 2 days), B (within 3-7 days) and C (within 8-14 days). All patients had received standard treatment combined with acupuncture therapy. Specifically, acupuncture w...
Source: The American Journal of Chinese Medicine - December 10, 2020 Category: Complementary Medicine Authors: Xu J, Pei J, Fu QH, Wang LY, Zhan YJ, Tao L Tags: Am J Chin Med Source Type: research

Common genetic variants on chromosome 9p21 confers risk of ischemic stroke: A large-scale genetic association study
The objective of this experiment was to observe the allele frequency and genotype distribution of some 9p21 SNPs in the Anhui Han population, and to study its relationship with the susceptibility to ischemic stroke. For this purpose, a collection of 992 patients with ischemic stroke confirmed and hospitalized in our hospital from October 2017 to October 2020 were used as the IS case group, and 951 normal people who had a healthy physical examination in the physical examination center of our hospital during the same period were selected as the control group. After informed consent, cubital venous blood of all subjects was c...
Source: Cellular and Molecular Biology - November 24, 2021 Category: Molecular Biology Authors: Rongyao Li Xinyue Zhang Wei Yin Yuzhuo Wang Ying Liu Source Type: research