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Condition: Diabetes Type 2
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Total 116 results found since Jan 2013.

Sodium-glucose cotransporter-2 inhibition for the reduction of cardiovascular events in high-risk patients with diabetes mellitus.
Abstract Patients with type 2 diabetes mellitus (T2DM) exhibit an increased risk for cardiovascular (CV) events. Hyperglycemia itself contributes to the pathogenesis of atherosclerosis and heart failure (HF) in these patients, but glucose-lowering strategies studied to date have had little or no impact on reducing CV risk, especially in patients with a long duration of T2DM and prevalent CV disease (CVD). Sodium-glucose cotransporter-2 (SGLT2) inhibitors are the new class of glucose-lowering medications that increase urinary glucose excretion, thus improving glycemic control, independent of insulin. The recently p...
Source: Indian Heart J - November 1, 2018 Category: Cardiology Authors: Pancholia AK Tags: Indian Heart J Source Type: research

Bariatric surgery and diabetes remission: how far have we progressed?
This article will review the effectiveness of bariatric procedures on the remission and improvement of diabetes and its implicated mechanisms. PMID: 30298760 [PubMed]
Source: Expert Review of Endocrinology and Metabolism - October 12, 2018 Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research

Sodium-glucose cotransporter-2 inhibition for the reduction of cardiovascular events in high-risk patients with diabetes mellitus
Publication date: Available online 1 September 2018Source: Indian Heart JournalAuthor(s): A.K. PancholiaAbstractPatients with type 2 diabetes mellitus (T2DM) exhibit an increased risk for cardiovascular (CV) events. Hyperglycemia itself contributes to the pathogenesis of atherosclerosis and heart failure (HF) in these patients, but glucose-lowering strategies studied to date have had little or no impact on reducing CV risk, especially in patients with a long duration of T2DM and prevalent CV disease (CVD). Sodium glucose cotransporter-2 (SGLT2)-inhibitors are the new class of glucose lowering medications that increase urin...
Source: Indian Heart Journal - September 1, 2018 Category: Cardiology Source Type: research

Mayo Clinic Researchers Find Some Bacteria Derail Weight Loss, Suggest Analysis of Individuals ’ Microbiomes; a Clinical Lab Test Could Help Millions Fight Obesity
CDC reports more than 93-million US adults are obese, and health issues related to obesity include heart disease, stroke, type 2 diabetes, and cancers In recent years, the role of the human microbiome in weight loss or weight gain has been studied by different research groups. There is keen interest in this subject because of […]
Source: Dark Daily - August 24, 2018 Category: Laboratory Medicine Authors: Jude Tags: Instruments & Equipment Laboratory Instruments & Laboratory Equipment Laboratory Management and Operations Laboratory News Laboratory Operations Laboratory Pathology Laboratory Testing anatomic pathology calories cancer carbohydrates Source Type: news

Diabetes type 2: Removing THIS type of oil from your diet could ease condition symptoms
DIABETES type 2 symptoms include increased thirst and hunger, unexplained weight loss and frequent urination. You should get the condition diagnosed quickly with the diabetes test, as it can lead to greater risk of stroke and heart disease. You should dump this food to help treat the condition.
Source: Daily Express - Health - May 16, 2018 Category: Consumer Health News Source Type: news

The design and rationale for the Dapagliflozin Effect on Cardiovascular Events (DECLARE) –TIMI 58 Trial
Conclusion The DECLARE–TIMI 58 trial is testing the hypotheses that dapagliflozin is safe (does not increase) and may reduce the occurrence of major CV events. DECLARE–TIMI 58 is the largest study to address this question with an SGLT-2 inhibitor in patients with T2DM and with established CV disease and without CV disease but with multiple risk factors.
Source: American Heart Journal - May 8, 2018 Category: Cardiology Source Type: research

A nonrestrictive, weight loss diet focused on fiber and lean protein increase
According to the World Health Organization, more than 1.9 billion adults age ≥18 year were overweight and more than 600 million adults obese worldwide in 2014 [1]. Excess weight significantly increases the risk for morbidity including hypertension, stroke, cardiovascular disease, type 2 diabetes, osteoarthritis, and some types of cancers [2,3]. In the United States, obesit y remains a leading public health problem with 34.9% of adults and 16.9% of children who were obese between 2011 and 2012 [4].
Source: Nutrition - March 22, 2018 Category: Nutrition Authors: Lijuan Zhang, Sherry Pagoto, Barbara Olendzki, Gioia Persuitte, Linda Churchill, Jessica Oleski, Yunsheng Ma Tags: Applied nutritional investigation Source Type: research

Sodium-glucose cotransporter 2 inhibitors and ischemic stroke.
CONCLUSION: Despite the multiple pleiotropic effects of SGLT-2 inhibitors, these agents do not appear to affect stroke risk. Ongoing large trials with longer follow-up will evaluate whether the pleiotropic effects of this class will translate into benefits in ischemic stroke prevention. PMID: 29412119 [PubMed - as supplied by publisher]
Source: Cardiovascular and Hematological Disorders Drug Targets - February 9, 2018 Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

Adolescent bariatric surgery is on the Rise: An analysis of utilization and procedure trends in New York State
Obesity constitutes a major public health issue affecting an increasing number of families. In the United States the percentage of adolescents aged 12-19 years with obesity has reached an alarming level of 21%.  Childhood obesity could lead to long term development of heart disease, type 2 diabetes, stroke, several types of cancer, and osteoarthritis. The bariatric surgical interventions have emerged as successful alternative to the behavioral and psychological interventions in weight loss for adolescents .
Source: Surgery for Obesity and Related Diseases - October 1, 2017 Category: Surgery Authors: Shabana Humayon, Maria Altieri, Jie Yang, Kristie Price, Konstantinos Spaniolas, Aurora Pryor Tags: Bariatric Surgery in Adolescents Source Type: research

Benefits of SGLT2 Inhibitors beyond glycemic control - A focus on metabolic, cardiovascular, and renal outcomes.
CONCLUSIONS: SGLT2 inhibitors demonstrate some positive metabolic effects. In addition, empagliflozin specifically has demonstrated reduction in cardiovascular events and delay in the progression of kidney disease in patients with T2DM and a history of cardiovascular disease. Further data is needed to assess if this is a class effect. PMID: 28814245 [PubMed - as supplied by publisher]
Source: Current Diabetes Reviews - August 16, 2017 Category: Endocrinology Authors: Minze MG, Will K, Terrell BT, Black RL, Irons BK Tags: Curr Diabetes Rev Source Type: research

Benefits of artificial sweeteners unclear
Conclusion The study authors suggest artificial sweeteners may not aid weight loss, despite marketing claims to the contrary, and could actually increase the risk of type 2 diabetes. However, the results need to be treated with caution, as this review had numerous limitations: The randomised controlled trials had great variability and few participants, increasing the possibility of the results occurring by chance. They were also judged to be at a high risk of bias – for example, the participants could not be blinded to the intervention, and adherence (drop-out) rates were not provided. We do not know whether there w...
Source: NHS News Feed - July 19, 2017 Category: Consumer Health News Tags: Food/diet Obesity Source Type: news

Science: Sugar substitute effects not so sweet
Not so sweet. Switching out sucralose or other artificial sweeteners for sugar won ’t help you lose weight and may cause future health problems, researchers who reviewed multiple scientific studies on the topic said. Researchers found a link between consuming artificial sweeteners and higher risks of weight gain, Type 2 diabetes, hypertension, stroke and heart disease, Live Sci ence reported, while weight loss results were minimal. The purpose of the review was to determine the effects of non-nutritive…
Source: bizjournals.com Health Care:Physician Practices headlines - July 17, 2017 Category: American Health Authors: Anne Stych Source Type: news

Hypoglycaemia seriousness and weight gain as determinants of cardiovascular disease outcomes among sulfonylurea users
ConclusionsThis study provides evidence of increased CVD risk associated with hypoglycaemia, especially serious hypoglycaemia events. While associations were attenuated with non‐serious hypoglycaemia, the results were suggestive of a potential increased risk.
Source: Diabetes, Obesity and Metabolism - May 1, 2017 Category: Endocrinology Authors: Anthony P. Nunes, Kristy Iglay, Larry Radican, Samuel S. Engel, Jing Yang, Michael C. Doherty, David D. Dore Tags: ORIGINAL ARTICLE Source Type: research

Regular activity may help some people stay 'fat and fit'
Conclusion As people often say, if exercise was a medicine, it would be hailed as a miracle cure. This study suggests that what we already know about the benefits of exercise may extend to reducing risk of cardiovascular disease for middle aged and older people, even if they are overweight or obese. But the study has some limitations. This type of study can't prove that one factor – exercise – is responsible for the lower risk of heart attack and stroke among overweight or obese people who exercise more. It's possible that other factors are important – for example people's income may be linked to their opportuniti...
Source: NHS News Feed - March 2, 2017 Category: Consumer Health News Tags: Obesity Lifestyle/exercise Heart/lungs Source Type: news

This Is Your Body On Spicy Foods
While some of us avoid restaurant meal descriptions including words like cayenne, chili, and habanero, others jump on board. And new research suggests there might be a heart-healthy benefit to eating spicy foods.  A large study recently published in the journal PLOS One looked at the connection between hot red chili pepper consumption and mortality. Researchers from the University of Vermont surveyed a nationally representative sample of 16,179 U.S. adults over the course of 6 years, finding that those who ate hot peppers at least once a month had a 13 percent reduced risk of dying from heart disease or stroke. The st...
Source: Healthy Living - The Huffington Post - January 23, 2017 Category: Consumer Health News Source Type: news