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Pharmacologic Approaches to Weight Management: Recent Gains and Shortfalls in Combating Obesity
This article reviews recent literature in the field of Obesity Medicine and highlights important findings from clinical trials. Future directions in the pharmacologic management of obesity are presented along with new diabetes medications that promote weight loss and reduce cardiovascular mortality.
Source: Current Atherosclerosis Reports - May 14, 2016 Category: Cardiology Source Type: research

Visceral Fat Triggers Heart Disease
I tell my patients to avoid drinking soda not just because they make you fat. Each sip of soda affects your health. Soda puts you at risk for health problems like metabolic syndrome. This is a collection of symptoms that can lead to diabetes, heart disease and other chronic diseases, like cancer. Soft drinks are the beverage of choice for millions of Americans. The latest research now reveals that sodas are a major cause of visceral fat — the deadliest kind of fat you can have, inflaming your tissues, rotting your blood vessels and upsetting your body chemistry. In a minute I’m going to tell you about a great healthy ...
Source: Al Sears, MD Natural Remedies - February 29, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Heart Health heart disease metabolic syndrome Visceral Fat Source Type: news

You Don't Need To Lose A Lot Of Weight To Start Seeing Health Benefits
This study clarifies conventional wisdom among obesity experts, who have traditionally advised patients to lose 5 to 10 percent of their body weight in order to improve blood pressure, cholesterol and blood sugar levels. But as anyone who has ever tried to lose weight can attest, there is a big difference between 5 percent and 10 percent.   "That’s a very vague, wide range," Klein said. "It’s much harder to achieve a 10 percent weight loss than it is to achieve a five percent weight loss." Klein said his study shows that even just a little bit of weight loss is enough to improve health, and that peopl...
Source: Science - The Huffington Post - February 23, 2016 Category: Science Source Type: news

Potential role of sodium glucose cotransporter 2 inhibitors in the treatment of hypertension
Purpose of review: The majority of patients with type 2 diabetes mellitus (T2DM) have hypertension requiring combination therapy. Sodium glucose cotransporter 2 (SGLT2) inhibitors are novel glucose-lowering drugs with shared and potentially unique beneficial effects on cardiovascular risk beyond glycemic control. This review focuses on the potential role of SGLT2 inhibitors in the treatment of hypertension associated with T2DM. Recent findings: SGLT2 inhibitors reduce office SBP by 3–5 mmHg and DBP by 2–3 mmHg across all class members. Corresponding clinically meaningful, significant blood pressure (BP) lowering e...
Source: Current Opinion in Nephrology and Hypertension - February 5, 2016 Category: Urology & Nephrology Tags: PATHOPHYSIOLOGY OF HYPERTENSION: Edited by Nancy J. Brown Source Type: research

Pediatric obesity: Causes, symptoms, prevention and treatment.
Authors: Xu S, Xue Y Abstract Pediatric or childhood obesity is the most prevalent nutritional disorder among children and adolescents worldwide. Approximately 43 million individuals are obese, 21-24% children and adolescents are overweight, and 16-18% of individuals have abdominal obesity. The prevalence of obesity is highest among specific ethnic groups. Obesity increases the risk of heart diseases in children and adults. Childhood obesity predisposes the individual to insulin resistance and type 2 diabetes, hypertension, hyperlipidemia, liver and kidney diseases and causes reproductive dysfunction in adults. Obe...
Source: Experimental and Therapeutic Medicine - February 4, 2016 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Sugary drinks linked to increased fat levels around vital organs
Conclusion This US cohort study found drinking sugar-sweetened beverages on a daily basis is associated with the highest increase in fat accumulation around the abdominal organs, compared with people who do not consume them. But there was an average increase in the amount of this fat in all people who took part in the study, although this was lowest in people who never consumed sugar-sweetened beverages. The study was prospective, which limits some sources of bias, but it has some limitations. For example, the food frequency questionnaire was only conducted once, at baseline. The results are therefore reliant on the p...
Source: NHS News Feed - January 12, 2016 Category: Consumer Health News Tags: Food/diet Diabetes Heart/lungs Obesity Source Type: news

Book Review: Body of Truth
My friend’s husband once said I’d be a great catch if I would just “lose a little more weight.” I was surprised by his comment, particularly since he carries around a spare tire and since I am healthy (and happy) in size. Unfortunately, he, like many others, believes that being a stick is a pre-requisite to being a “great catch.” Now, after reading Harriet Brown’s Body of Truth: How Science, History, and Culture Drive Our Obsession with Weight — and What We Can Do about It, I want us all to eradicate this kind of bizarre commentary and judgment. Body of Truth is hard to describe in a nutshell. At its best, ...
Source: Psych Central - December 24, 2015 Category: Psychiatry Authors: Stephanie Kotelnicki Tags: Anorexia Binge Eating Book Reviews Bulimia Diet & Nutrition General Healthy Living Personal Stories Policy and Advocacy Psychology Weight Loss Women's Issues americas diet industry anorexia in america being skinny isnt healthy Source Type: news

Prospective Association of GLUL rs10911021 With Cardiovascular Morbidity and Mortality Among Individuals With Type 2 Diabetes: The Look AHEAD Study
Genetic studies have identified a glutamate-ammonia ligase gene (GLUL) polymorphism associated with cardiovascular disease morbidity and mortality among people with type 2 diabetes (T2D). We sought to determine whether GLUL rs10911021 is associated prospectively with adjudicated cardiovascular composite end points among overweight/obese individuals with T2D and whether a lifestyle intervention resulting in weight loss could diminish this association. Look AHEAD is a randomized, controlled trial to determine the effects of intensive lifestyle intervention (ILI), including weight loss and physical activity, relative to diabe...
Source: Diabetes - December 22, 2015 Category: Endocrinology Authors: The Look AHEAD Research Group Tags: Genetics/Genomes/Proteomics/Metabolomics Source Type: research

Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care
Conclusions Bariatric surgery as delivered in the UK healthcare system is associated with dramatic weight loss, sustained at least 4 y after surgery. This weight loss is accompanied by substantial improvements in pre-existing T2DM and hypertension, as well as a reduced risk of incident T2DM, hypertension, angina, MI, and obstructive sleep apnoea. Widening the availability of bariatric surgery could lead to substantial health benefits for many people who are morbidly obese.
Source: PLoS Medicine - December 22, 2015 Category: Internal Medicine Authors: Ian J. Douglas et al. Source Type: research

The idea you can be fat but fit is 'a myth' study argues
ConclusionThis was a large prospective cohort study from Sweden, which was carried out in young adult males who were then followed for a period of around 29 years. The study found that lower levels of aerobic fitness were associated with risk of early death, but that this risk of death was greater for those with a high BMI, even if they had a high level of aerobic fitness. This study has a number of strengths and limitations. The limitations are that a large number of participants had missing smoking data and therefore it was not possible to control for the confounding effect of smoking. The lower fitness level group with...
Source: NHS News Feed - December 21, 2015 Category: Consumer Health News Tags: Food/diet Obesity Source Type: news

Empagliflozin: a new treatment option for patients with type 2 diabetes mellitus.
Authors: Dailey GE Abstract Empagliflozin is an oral sodium-glucose cotransporter 2 (SGLT2) inhibitor that reduces hyperglycemia in type 2 diabetes mellitus (T2DM) by decreasing renal glucose reabsorption and promoting urinary glucose excretion. In clinical trials, empagliflozin demonstrated significant improvements in glycemic control, as monotherapy and in combination regimens. In addition, empagliflozin was associated with weight loss and moderate reductions in blood pressure. In the EMPA-REG OUTCOME study, empagliflozin significantly reduced the risk of the composite primary endpoint of cardiovascular death, no...
Source: Drugs of Today - October 23, 2015 Category: Drugs & Pharmacology Tags: Drugs Today (Barc) Source Type: research

Warning about middle-aged drinking and dementia
"Middle-aged people should curb their drinking to reduce their risk of developing dementia, new guidance suggests," reports the Daily Mirror. The new guidance highlights that people aged 40 to 64 who regularly drink alcohol have an increased risk of dementia. Who produced the guidance?The guidance was produced by the National Institute for Health and Care Excellence (NICE). NICE is a government body that provides national guidance and advice to improve health and social care. What issues does the guidance look at?The guidance is based on the well-established principle that positive lifestyle changes tha...
Source: NHS News Feed - October 21, 2015 Category: Consumer Health News Tags: Food/diet QA articles Older people Neurology Source Type: news

Two Great Things Exercise Is Guaranteed to Do For You
Everyone knows that exercise is good for your heart. That's not one of the two things I was talking about, but it's good to remember. Stroke and heart disease are two of the leading causes of death in the U.S. and no one wants to die sooner than necessary! The Centers for Disease Control and Prevention as of last month were telling us two and a half hours of exercise could lower your risk for these diseases. You don't need to run a marathon or climb Half-Dome at Yosemite. You just need to do some moderate intensity aerobic activity. For any of you who don't know it, weight-bearing workouts (cables, weights etc.) are defi...
Source: Healthy Living - The Huffington Post - August 5, 2015 Category: Consumer Health News Source Type: news

Prevalence and determinants of excessive daytime sleepiness in hypertensive patients: a cross-sectional study in Douala, Cameroon
Conclusions A significant proportion of hypertensive patients suffer from EDS and present a high risk of sleep apnoea. Preventive measures targeted on weight loss, type 2 diabetes and snoring should be considered among these patients.
Source: BMJ Open - July 29, 2015 Category: Journals (General) Authors: Mbatchou Ngahane, B. H., Nganda, M. M., Dzudie, A., Luma, H., Kamdem, F., Ngote, H. R., Monkam, Y., Kuaban, C. Tags: Open access, Cardiovascular medicine, Respiratory medicine Research Source Type: research

Study finds obese people may struggle to reach a healthy weight
ConclusionThis research makes use of a general practice database providing just under 10 years of BMI observations for a large, nationally representative UK sample. It demonstrates that low proportions of people in the obese categories were able to achieve a normal BMI over a year of follow-up, and the common problem of weight cycling. However, there are points to consider when interpreting these results: The probability of obtaining a normal BMI over a year was very low: only 1 in 210 for men and 1 in 124 for women in the "simple obese" category of 30 to 35kg/m2, and much lower than that for the higher categor...
Source: NHS News Feed - July 20, 2015 Category: Consumer Health News Tags: Food/diet Obesity Source Type: news

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