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Condition: Diabetes Type 2
Nutrition: Weight Loss

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Total 116 results found since Jan 2013.

The extra‐pancreatic effects of GLP‐1 receptor agonists: a focus on the cardiovascular, gastrointestinal and central nervous systems
Abstract The glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) exenatide and liraglutide have been shown to improve glycaemic control and beta‐cell function with a low risk of hypoglycaemia in people with type 2 diabetes. GLP‐1 receptors are also expressed in extra‐pancreatic tissues and trial data suggest GLP‐1RAs also have effects beyond their glycaemic actions. Preclinical studies using native GLP‐1 or GLP‐1RAs provide substantial evidence for cardioprotective effects, while clinical trial data have demonstrated beneficial actions on hypertension and dyslipidaemia in people with type 2 diabetes. Sig...
Source: Diabetes, Obesity and Metabolism - December 24, 2013 Category: Endocrinology Authors: J Seufert, B Gallwitz Tags: Unsolicited Review Article Source Type: research

Improved sex drive after bariatric surgery
The health risks of obesity are well known, with increased risk of cardiovascular diseases, type 2 diabetes, stroke and certain cancers. But what is not so well known is how it affects women's sex drive and satisfaction, something researchers from the University of Pennsylvania set out to explore. In a study, published in JAMA Surgery this month, Prof. David B. Sarwer, of the University's Perelman School of Medicine, and colleagues conducted a study with women who underwent bariatric surgery...
Source: Health News from Medical News Today - November 5, 2013 Category: Consumer Health News Tags: Obesity / Weight Loss / Fitness Source Type: news

Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes
In this study, conducted in 16 centers in the United States, 5145 overweight or obese patients with type 2 diabetes were randomly assigned to participate in an intensive lifestyle intervention that promoted weight loss through decreased caloric intake and increased physical activity, the intervention group, or receive diabetes support and education only, the control group. The primary outcome was a composite of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for angina occurring over a maximum follow-up of 13.5 years. At a median follow-up of 9.6 years, the trial was st...
Source: Journal of Vascular Surgery - October 1, 2013 Category: Surgery Authors: The Look AHEAD Research Group Tags: Abstracts Source Type: research

Just a few extra pounds increases heart failure risk
Conclusion This large study uses an interesting genetic approach (Mendelian randomisation) to suggest obesity increases the risk of heart failure and adverse changes in liver enzymes. The combination of a very large sample, prospectively collected information, and a wide range of cardiometabolic measures lend credibility to the findings. The method the researchers used is also thought to reduce the chances of factors other than BMI influencing results, and the chance that the ‘outcome’ could be causing the ‘exposure’ (reverse causality). The main limitation of this kind of research is that assumptions need to be m...
Source: NHS News Feed - June 26, 2013 Category: Consumer Health News Tags: Obesity Lifestyle/exercise Source Type: news

Diabetes Lifestyle Intervention Does Not Reduce Heart Attack Or Stroke Risk
A long-term, intensive lifestyle intervention program for type 2 diabetes patients that focused on weight loss and exercise did not reduce the risk of stroke or heart attacks, researchers involved in the "Look AHEAD" trial explained at the American Diabetes Association's 73rd Scientific Sessions, Chicago, Illinois. However, the program improved patients' physical quality of life, reduced incidence and severity of depressive symptoms, lowered medical costs because of fewer hospitalizations, outpatient care and medications, and also reduced *microvascular complications...
Source: Health News from Medical News Today - June 25, 2013 Category: Consumer Health News Tags: Diabetes Source Type: news

If you could propose one idea to help improve health care delivery in the United States, what would it be?
Thumbnail: Tags: conversationsphrma conversationslarry hausnermyrl weinbergchris hansennancy brownContributors: 11621161115911631173Contributions: Read Larry Hausner's bio Despite the rapid development of innovative technologies in the health care field, we have yet to discover a panacea that will easily transform our health care system into one that provides high-quality and cost-effective care.  What we have discovered and come to agree on over the last decade is that our sick care system must be reconfigured to a health care system that emphasizes wellness and prevention.  For that reason, I offer ...
Source: PHRMA - June 24, 2013 Category: Pharmaceuticals Authors: rlowe Source Type: news

Diabetes drugs may be linked to pancreatic cancer
Conclusion This article presents important concerns that glucagon-like peptide-1 (GLP-1) agonists and dipeptidylpeptidase-4 (DPP-4) inhibitors could potentially increase the risk of inflammation and cancerous changes in the pancreas. The agencies that regulate medicines in Europe and the USA are aware of these issues, and told the BMJ that their analyses show increased reporting of pancreatic cancer among people taking these types of drugs. However, the agencies note that it has not been established whether these drugs directly cause the adverse effects seen in the pancreas. Both agencies are reviewing emerging eviden...
Source: NHS News Feed - June 10, 2013 Category: Consumer Health News Tags: Medication Diabetes QA articles Source Type: news

Should visceral fat be reduced to increase longevity?
Abstract Several epidemiologic studies have implicated visceral fat as a major risk factor for insulin resistance, type 2 diabetes mellitus, cardiovascular disease, stroke, metabolic syndrome and death. Utilizing novel models of visceral obesity, numerous studies have demonstrated that the relationship between visceral fat and longevity is causal while the accrual of subcutaneous fat does not appear to play an important role in the etiology of disease risk. Specific recommended intake levels vary based on a number of factors, including current weight, activity levels, and weight loss goals. It is discussed the nee...
Source: Ageing Research Reviews - June 10, 2013 Category: Genetics & Stem Cells Authors: Finelli C, Sommella L, Gioia S, La Sala N, Tarantino G Tags: Ageing Res Rev Source Type: research

Hard times in Cuba linked to better national health
Conclusion This is an interesting study that appears to show that modest weight loss within a relatively short period across the whole population is associated with a downward trend in diabetes and reductions in death rates from both diabetes and heart disease. Similarly, weight regain was associated with an increase in diabetes incidence, prevalence and mortality as well as a slowing down in the decline of cardiovascular deaths. This type of study draws on many different data sources and, as such, there is a possibility of error. Also, as the authors point out, data was missing on diabetes incidence during the crisis year...
Source: NHS News Feed - April 10, 2013 Category: Consumer Health News Tags: Food/diet Heart/lungs Diabetes Source Type: news

Link Between TV Viewing, Sedentary Lifestyle In Teens And Disease Risk In Adulthood
A team of scientists at Umea University, in collaboration with colleagues in Melbourne, Australia, have found that television viewing and lack of exercise at age 16 is associated with the risk of developing metabolic syndrome at 43 years age. Metabolic syndrome is a name for the disorder of metabolism - a combination of abdominal obesity, elevated blood lipids, hypertension and impaired glucose tolerance - which provides for a significantly increased risk of developing type 2 diabetes, stroke and cardiovascular disease...
Source: Health News from Medical News Today - February 3, 2013 Category: Consumer Health News Tags: Obesity / Weight Loss / Fitness Source Type: news

Drug treatments to restore vascular function and diabesity.
Abstract Over the last decades, an escalating rate of type 2 diabetes has paralleled an epidemic rise in the prevalence of obesity. Both diabetes and obesity confer an increased risk of cardiovascular comorbidities, including hypertension, coronary artery disease and stroke. Vascular dysfunction, represented by impaired endothelial release of vasodilator substances or defective smooth muscle vasodilator reactivity, is the early stage of the process leading to atherosclerosis and a common finding in patients with diabesity. It is understandable, therefore, that effective treatments for diabesity should restore vasc...
Source: Annales Pharmaceutiques Francaises - January 1, 2013 Category: Drugs & Pharmacology Authors: Cardillo C Tags: Ann Pharm Fr Source Type: research