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Association of Initial Potassium Levels with the Type of Stroke in the Emergency Department
Early differentiation of hemorrhagic stroke from ischemic stroke in patients with suspected stroke is essential for subsequent management of the patient. While serum potassium level has been suggested as a marker of acute hemorrhagic conditions,1, 2 little is known about whether the initial serum potassium levels differ based on the type of stroke. If serum potassium levels can help differentiate hemorrhagic stroke from ischemic stroke, this information can be applied in deciding subsequent treatment procedures (e.g., catheter intervention, tissue plasminogen activator administration, and antihypertensive therapy) in setti...
Source: Journal of Stroke and Cerebrovascular Diseases - May 30, 2021 Category: Neurology Authors: Kiyomitsu Fukaguchi, Hiroshi Yamagami, Shoko Soeno, Konan Hara, Toru Shirakawa, Tomohiro Sonoo, Kensuke Nakamura, Tadahiro Goto Source Type: research

Seaweed Intake and Risk of Cardiovascular Disease: The Circulatory Risk in Communities Study (CIRCS).
CONCLUSIONS: We found an inverse association between seaweed intake and risk of total stroke, especially that from cerebral infarction, among Japanese men. PMID: 33597328 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - February 21, 2021 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

Urinary Sodium and Potassium, and Risk of Ischaemic and Haemorrhagic Stroke (INTERSTROKE): a case-control study.
CONCLUSION: The association of sodium intake and stroke is J-shaped, with high sodium intake a stronger risk factor for intracerebral haemorrhage than ischemic stroke. Our data suggest that moderate sodium intake - rather than low sodium intake - combined with high potassium intake may be associated with the lowest risk of stroke and expected to be a more feasible combined dietary target. PMID: 33197265 [PubMed - as supplied by publisher]
Source: American Journal of Hypertension - November 17, 2020 Category: Cardiology Authors: Judge C, O'Donnell MJ, Hankey GJ, Rangarajan S, Chin SL, Rao-Melacini P, Ferguson J, Smyth A, Xavier D, Lisheng L, Zhang H, Lopez-Jaramillo P, Damasceno A, Langhorne P, Rosengren A, Dans AL, Elsayed A, Avezum A, Mondo C, Ryglewicz D, Czlonkowska A, Pogoso Tags: Am J Hypertens Source Type: research

Serum Glucose and Potassium Ratio as Risk Factors for Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage
Objective: Cerebral vasospasm is associated with poor prognosis in patients with aneurysmal subarachnoid hemorrhage (SAH), and biomarkers for predicting poor prognosis have not yet been established. We attempted to clarify the relationship between serum glucose/potassium ratio and cerebral vasospasm in patients with aneurysmal SAH. Methods: We studied 333 of 535 aneurysmal SAH patients treated between 2006 and 2016 (123 males, 210 females; mean age 59.7 years; range 24-93). We retrospectively analyzed the relationship between cerebral vasospasm grade and clinical risk factors, including serum glucose/potassium ratio.
Source: Journal of Stroke and Cerebrovascular Diseases - May 2, 2019 Category: Neurology Authors: Fumihiro Matano, Yu Fujiki, Takayuki Mizunari, Kenta Koketsu, Tomonori Tamaki, Yasuo Murai, Hiroyuki Yokota, Akio Morita Source Type: research

Using Dental Pulp Stem Cells for Stroke Therapy
Conclusion and Future Perspectives Stem cell-based therapy is a promising alternative for stroke treatment. While stem cells from different sources, including induced PSC, ESC, MSC, and NSC, have been investigated, using NSC and enhancing the natural mechanisms is most appropriate for brain repair. In preclinical models of stroke, stem cell transplantation has led to positive outcomes through a variety of cellular and molecular mechanisms, many being mediated by the array of beneficial factors produced by the cells. Recent advances in cellular reprogramming have provided alternative sources of NSC to be investigated, allo...
Source: Frontiers in Neurology - April 28, 2019 Category: Neurology Source Type: research

Susceptibility of the cerebral cortex to spreading depolarization in neurological disease states: The impact of aging
Publication date: Available online 15 October 2018Source: Neurochemistry InternationalAuthor(s): Péter Hertelendy, Dániel P. Varga, Ákos Menyhárt, Ferenc Bari, Eszter FarkasAbstractSecondary injury following acute brain insults significantly contributes to poorer neurological outcome. The spontaneous, recurrent occurrence of spreading depolarization events (SD) has been recognized as a potent secondary injury mechanism in subarachnoid hemorrhage, malignant ischemic stroke and traumatic brain injury. In addition, SD is the underlying mechanism of the aura symptoms of migraineurs. The susceptibility of the nervous tissue...
Source: Neurochemistry International - October 16, 2018 Category: Neuroscience Source Type: research

Control of spreading depression with electrical fields - Whalen AJ, Xiao Y, Kadji H, Dahlem MA, Gluckman BJ, Schiff SJ.
Spreading depression or depolarization is a large-scale pathological brain phenomenon related to migraine, stroke, hemorrhage and traumatic brain injury. Once initiated, spreading depression propagates across gray matter extruding potassium and other activ...
Source: SafetyLit - June 12, 2018 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

The yin and yang of KV channels in cerebral small vessel pathologies
This article is protected by copyright. All rights reserved.
Source: Microcirculation - December 15, 2017 Category: Research Authors: Masayo Koide, Arash Moshkforoush, Nikolaos M. Tsoukias, David C. Hill ‐Eubanks, George C. Wellman, Mark T. Nelson, Fabrice Dabertrand Tags: Invited Reviews Source Type: research

Associations of Biomarker-Calibrated Sodium and Potassium Intakes With Cardiovascular Disease Risk Among Postmenopausal Women
AbstractStudies of the associations of sodium and potassium intakes with cardiovascular disease incidence often rely on self-reported dietary data. In the present study, self-reported intakes from postmenopausal women at 40 participating US clinical centers are calibrated using 24-hour urinary excretion measures in cohorts from the Women's Health Initiative, with follow-up from 1993 to 2010. The incidence of hypertension was positively related to (calibrated) sodium intake and to the ratio of sodium to potassium. The sodium-to-potassium ratio was associated with cardiovascular disease incidence during an average follow-up ...
Source: American Journal of Epidemiology - June 14, 2017 Category: Epidemiology Source Type: research

Intakes of magnesium, potassium, and calcium and the risk of stroke among men
ConclusionsA diet rich in magnesium, potassium, and calcium may contribute to reduced risk of stroke among men. Because of significant collinearity, the independent contribution of each cation is difficult to define.
Source: International Journal of Stroke - June 4, 2015 Category: Neurology Authors: Sally N. Adebamowo, Donna Spiegelman, Alan J. Flint, Walter C. Willett, Kathryn M. Rexrode Tags: Research Source Type: research

Association between intakes of magnesium, potassium, and calcium and risk of stroke: 2 cohorts of US women and updated meta-analyses Nutritional epidemiology and public health
Conclusions: A combined mineral diet score was inversely associated with risk of stroke. High intakes of magnesium and potassium but not calcium were also significantly associated with reduced risk of stroke in women.
Source: American Journal of Clinical Nutrition - June 1, 2015 Category: Nutrition Authors: Adebamowo, S. N., Spiegelman, D., Willett, W. C., Rexrode, K. M. Tags: Nutritional Epidemiology Research Articles Nutritional epidemiology and public health Source Type: research

Association between intakes of magnesium, potassium, and calcium and risk of stroke: 2 cohorts of US women and updated meta-analyses.
CONCLUSIONS: A combined mineral diet score was inversely associated with risk of stroke. High intakes of magnesium and potassium but not calcium were also significantly associated with reduced risk of stroke in women. PMID: 25948665 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - May 6, 2015 Category: Nutrition Authors: Adebamowo SN, Spiegelman D, Willett WC, Rexrode KM Tags: Am J Clin Nutr Source Type: research

Calcium and potassium channels in experimental subarachnoid hemorrhage and transient global ischemia.
Authors: Kamp MA, Dibué M, Schneider T, Steiger HJ, Hänggi D Abstract Healthy cerebrovascular myocytes express members of several different ion channel families which regulate resting membrane potential, vascular diameter, and vascular tone and are involved in cerebral autoregulation. In animal models, in response to subarachnoid blood, a dynamic transition of ion channel expression and function is initiated, with acute and long-term effects differing from each other. Initial hypoperfusion after exposure of cerebral vessels to oxyhemoglobin correlates with a suppression of voltage-gated potassium channel activity...
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

Potassium Intake and Risk of Stroke in Women With Hypertension and Nonhypertension in the Women's Health Initiative Clinical Sciences
Conclusions— High potassium intake is associated with a lower risk of all stroke and ischemic stroke, as well as all-cause mortality in older women, particularly those who are not hypertensive.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Seth, A., Mossavar-Rahmani, Y., Kamensky, V., Silver, B., Lakshminarayan, K., Prentice, R., Van Horn, L., Wassertheil-Smoller, S. Tags: Cerebrovascular disease/stroke, Acute Cerebral Hemorrhage, Acute Cerebral Infarction, Epidemiology Clinical Sciences Source Type: research

Hemin inhibits the large conductance potassium channel in brain mitochondria: A putative novel mechanism of neurodegeneration.
Abstract Intracerebral hemorrhage (ICH) is a pathological condition that accompanies certain neurological diseases like hemorrhagic stroke or brain trauma. Its effects are severely destructive to the brain and can be fatal. There is an entire spectrum of harmful factors which are associated with the pathogenesis of ICH. One of them is a massive release of hemin from the decomposed erythrocytes. It has been previously shown, that hemin can inhibit the large-conductance Ca(2+)-regulated potassium channel in the plasma membrane. However, it remained unclear whether this phenomenon applies also to the mitochondrial la...
Source: Experimental Neurology - April 30, 2014 Category: Neurology Authors: Augustynek B, Kudin AP, Bednarczyk P, Szewczyk A, Kunz WS Tags: Exp Neurol Source Type: research