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Total 365 results found since Jan 2013.

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Isolation of Antimicrobial Compounds From Cnestis ferruginea Vahl ex. DC (Connaraceae) Leaves Through Bioassay-Guided Fractionation
Conclusion In conclusion, aqueous extracts of C. ferruginea leaves showed antimicrobial activity due to the presence of hydroquinone and caffeic acid methyl ester. This supports its traditional use for infections and confirmed that the active molecules are water-soluble. Author Contributions KK, SP, LVP, and WL conceived and designed the experiments. SP, KK, M-RY, and J-GL performed the experiments. SP, LVP, WL, M-RY, J-GL, and Z-HJ analyzed the data. WL and Z-HJ contributed reagents, materials, and analysis tools. KK, SP, WL, M-RY, Z-HJ, and LVP contributed to the writing of the manuscript. All authors contributed to m...
Source: Frontiers in Microbiology - April 10, 2019 Category: Microbiology Source Type: research

6-Bromoindirubin-3 ′-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver
In this study, we aimed to investigate the anti-aging effect, and molecular mechanism, of the novel anti-aging drug 6BIO on naturally aged mouse liver. Rapamycin, a well-known promising anti-aging drug that delays aging through mTOR-dependent autophagy (Zhou and Ye, 2018), was used as the positive control in the study. To our knowledge, this is the first study to demonstrate the effects of 6BIO treatment in models of natural aging. Our results indicated that 6BIO ameliorates the decline of liver function with age, including lipid metabolism disorder, and attenuates hepatocyte senescence in aged mice, as revealed by altera...
Source: Frontiers in Pharmacology - April 9, 2019 Category: Drugs & Pharmacology Source Type: research

Mediterranean-style diet for the primary and secondary prevention of cardiovascular disease.
CONCLUSIONS: Despite the relatively large number of studies included in this review, there is still some uncertainty regarding the effects of a Mediterranean-style diet on clinical endpoints and CVD risk factors for both primary and secondary prevention. The quality of evidence for the modest benefits on CVD risk factors in primary prevention is low or moderate, with a small number of studies reporting minimal harms. There is a paucity of evidence for secondary prevention. The ongoing studies may provide more certainty in the future. PMID: 30864165 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - March 12, 2019 Category: General Medicine Authors: Rees K, Takeda A, Martin N, Ellis L, Wijesekara D, Vepa A, Das A, Hartley L, Stranges S Tags: Cochrane Database Syst Rev Source Type: research

Prevalence and Predictors of Current and Former Tobacco Use among Older Adults in Indonesia
Conclusions: A high rate of current tobacco use and low rate of former tobacco use was found, particularly among men. The identified risk factors may help to better target this vulnerable population with tobacco cessation programmes. PMID: 30803198 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - February 27, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Featured Review: Mediterranean-style diet for the prevention of cardiovascular disease
In this Q&A we asked the lead author Professor Saverio Stranges from Western University Canada to explain more about the mediterranean diet and its role in preventing cardiovascular disease following the publication of aCochrane Review on this topic. What makes a diet ‘Mediterranean’?Scientific interest in the traditional Mediterranean dietary pattern originated in the 1960s because of the observation that populations in countries of the Mediterranean region, such as Greece and Italy, had lower mortality from cardiovascular disease compared with northern European populations or the US, probably as a result of diff...
Source: Cochrane News and Events - February 27, 2019 Category: Information Technology Authors: Katie Abbotts Source Type: news

Molecules, Vol. 24, Pages 793: GC-MS-Based Metabolomics to Reveal the Protective Effect of Gross Saponins of Tribulus terrestris Fruit against Ischemic Stroke in Rat
In this study, the protective effect of GSTTF on ischemic stroke in a middle cerebral artery occlusion (MCAO) rat model was investigated by the GC-MS-based metabolomics approach. 2,3,5-triphenyltetrazolium chloride (TTC) staining of brain tissues showed that GSTTF significantly reduced the infarct area after MCAO surgery. Metabolomic profiling showed a series of metabolic perturbation occurs in ischemic stroke compared with sham group. GSTTF can reverse the MCAO-induced serum metabolic deviations by regulating multiple metabolic pathways including fatty acids metabolism, amino acids metabolism, and carbohydrates metabolism...
Source: Molecules - February 22, 2019 Category: Chemistry Authors: Yang Wang Hongyu Zhao Yue Liu Wenjun Guo Yanru Bao Manqi Zhang Tunhai Xu Shengxu Xie Xinyu Liu Yajuan Xu Tags: Article Source Type: research

Fruit and vegetable consumption and health outcomes: an umbrella review of observational studies.
Authors: Angelino D, Godos J, Ghelfi F, Tieri M, Titta L, Lafranconi A, Marventano S, Alonzo E, Gambera A, Sciacca S, Buscemi S, Ray S, Galvano F, Del Rio D, Grosso G Abstract The aim of this study was to provide a comprehensive evaluation of current evidence on fruit and vegetable consumption and health outcomes. A systematic search for quantitative syntheses was performed. Several criteria, including study design, dose-response relationship, heterogeneity and agreement of results over time, and identification of potential confounding factors, were used to assess the level of evidence. The strongest (probable) evi...
Source: International Journal of Food Sciences and Nutrition - February 17, 2019 Category: Nutrition Tags: Int J Food Sci Nutr Source Type: research

Could diet soda raise a woman's stroke risk?
New research looks at the possible connection between diet sodas ​ or artificially sweetened fruit juices and heart health
Source: Health News: CBSNews.com - February 14, 2019 Category: Consumer Health News Source Type: news

Diet Sodas and Juices Are Linked to Higher Stroke Risk, Study Says
Diet drinks may seem like healthier options than sugary sodas and fruit drinks, but studies haven’t all backed up their health benefits. In the latest look at the popular beverages, researchers found that older women who drank more diet drinks had a higher risk of stroke and heart disease, as well as a higher risk of dying early from any cause, compared to women who drank fewer of the drinks. In a study published in the journal Stroke, researchers studied data from more than 81,000 post-menopausal women enrolled in the large population-based Women’s Health Initiative. Three years into the study, the women answe...
Source: TIME: Health - February 14, 2019 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized healthytime Heart Disease Source Type: news

Could Diet Sodas Raise an Older Woman ' s Stroke Risk?
THURSDAY, Feb. 14, 2019 -- Older women, beware: New research warns that drinking a lot of diet sodas or artificially sweetened fruit juices may increase your risk for stroke. In a study that tracked nearly 82,000 postmenopausal women, those who...
Source: Drugs.com - Daily MedNews - February 14, 2019 Category: General Medicine Source Type: news

Is Brexit a Health Hazard?
FRIDAY, Feb. 1, 2019 -- Thousands more deaths from heart disease and stroke could occur in England if Brexit goes ahead, researchers warn. Fruits and vegetables play an important role in heart health, and the United Kingdom is highly dependent on...
Source: Drugs.com - Daily MedNews - February 1, 2019 Category: General Medicine Source Type: news

Nearly Half of Americans Have Some Form of Heart Disease
About 48% of adults in the U.S. have some type of heart or blood vessel disease, according to a new annual report from the American Heart Association published in the journal Circulation. The finding, based on data collected from 2016, means that almost half of Americans have had a heart attack, stroke, angina, abnormal heart rhythms, or narrowing of the arteries. The new report also shows that deaths from heart disease, after declining in recent years, rose from 2015 to 2016, from 836,546 to 840,678. Dr. Mariell Jessup, chief science and medical officer at the American Heart Association, said much of the increase in the p...
Source: TIME: Health - January 31, 2019 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Heart Disease Source Type: news

‘ Planetary Health Diet ’ : Scientists Say Cutting Red Meat, Sugar Can Save Lives And The Planet
(CNN) — An international team of scientists has developed a diet it says can improve health while ensuring sustainable food production to reduce further damage to the planet. The “planetary health diet” is based on cutting red meat and sugar consumption in half and upping intake of fruits, vegetables and nuts. And it can prevent up to 11.6 million premature deaths without harming the planet, says the report published Wednesday in the medical journal The Lancet. The authors warn that a global change in diet and food production is needed as 3 billion people across the world are malnourished — which in...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - January 18, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News Source Type: news

Association of vegetable, fruit, and Okinawan vegetable consumption with incident stroke and coronary heart disease.
CONCLUSIONS: This study demonstrated that consumption of total vegetable and fruit, total Okinawan vegetables, and specific Okinawan vegetables in Japanese residents of Okinawa was not associated with risk of incident stroke and coronary heart disease. PMID: 30643101 [PubMed - as supplied by publisher]
Source: Journal of Epidemiology - January 16, 2019 Category: Epidemiology Tags: J Epidemiol Source Type: research