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Nutrition: Flavonoids

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Total 135 results found since Jan 2013.

Clinical benefits and pharmacology of scutellarin: A comprehensive review
Publication date: Available online 6 May 2018Source: Pharmacology & TherapeuticsAuthor(s): Liping Wang, Qiang MaAbstractStroke and myocardial infarction are among the most common causes of mortality and disability in the world. The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. The current drug therapy of choice is to timely resupply the blood to the ischemic tissu...
Source: Pharmacology and Therapeutics - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Clinical benefits and pharmacology of Scutellarin: A comprehensive review
Publication date: Available online 6 May 2018 Source:Pharmacology & Therapeutics Author(s): Liping Wang, Qiang Ma Stroke and myocardial infarction are among the most common causes of mortality and disability in the world. The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. The current drug therapy of choice is to timely resupply the blood to the ischemic ti...
Source: Pharmacology and Therapeutics - May 6, 2018 Category: Drugs & Pharmacology Source Type: research

Chemical composition, antioxidant activity, neuroprotective and anti-inflammatory effects of cip ó-pucá (Cissus sicyoides L.) extracts obtained from supercritical extraction
Publication date: August 2018 Source:The Journal of Supercritical Fluids, Volume 138 Author(s): M.A.R Salazar, Jonabeto Vasconcelos Costa, Glides Rafael Olivo Urbina, Vânia Maria Borges Cunha, M.P. Silva, Priscila do Nascimento Bezerra, W.B.S. Pinheiro, Walace Gomes-Leal, Alessandra Santos Lopes, R.N. Carvalho Junior Cissus sicyoides L. is a plant used in the treatment of stroke and abscesses in popular Brazilian medicine. The aim of this work was to determine the best operational condition of the supercritical fluid extraction (SFE) of C. sicyoides with CO2 and CO2 + EtOH using the Box–Behnken design based on glob...
Source: The Journal of Supercritical Fluids - April 7, 2018 Category: Chemistry Source Type: research

Research trends in flavonoids and health.
Abstract Herein we describe, based on some bibliometric data, how the field of research on flavonoids has evolved over the last 25 years. The number of papers on flavonoids has risen in an exponential manner over these years, much faster than other fields on food constituents. This increase appears to be related to the contemporary explosion of interest in healthy foods, supplements and nutraceuticals. It was also probably triggered by large epidemiological studies on fruits and vegetables, and particularly on flavonoids, consumption and incidence of cancer, stroke and coronary heart disease. The widely distribute...
Source: Archives of Biochemistry and Biophysics - March 23, 2018 Category: Biochemistry Authors: Perez-Vizcaino F, Fraga CG Tags: Arch Biochem Biophys Source Type: research

Rutin attenuates cerebral ischemia/reperfusion injury in ovariectomized rats via estrogen receptor-mediated BDNF-TrkB and NGF-TrkA signaling.
This study was performed to investigate whether rutin could protect against cerebral ischemia by modulating ER pathway. Ovariectomized (OVX) rats were given intraperitoneal injection of vehicle (DMSO), rutin (100 mg/kg) or 17β-estradiol (100 μg/kg) for 5 continuous days. Then, the rats were subjected to middle cerebral artery occlusion (MCAO) for 1 h followed by a 24-h reperfusion to establish the cerebral ischemia/reperfusion (I/R) injury. We found that rutin improved the sensorimotor performance and recognition memory of I/R rats, decreased the infarct size and attenuated the neuron loss. Rutin treatment also increased...
Source: Biochemistry and Cell Biology - February 8, 2018 Category: Biochemistry Authors: Liu H, Zhong L, Zhang Y, Liu X, Li J Tags: Biochem Cell Biol Source Type: research

A metabolic exposure-oriented network regulation strategy for the identification of effective combination in the extract of Ginkgo biloba L.
Publication date: 5 February 2018 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 149 Author(s): Xin-Guang Liu, Cai-Yi Cheng, Ji-Xin Wang, Hong Luo, Li-Fan Tu, Lin Lin, Bin Wu, Hui-Ying Wang, Ke Liu, Ping Li, Hua Yang Nowadays, network pharmacology-based methods were increasing proposed to screen synergistic or combinatorial compounds from herbal medicines (HMs), while these researches mainly focused on structural prediction or experiment-based interaction between single compound and target protein. The proportion of each chemical in the nature and their metabolic process was ignored, which might decide a...
Source: Journal of Pharmaceutical and Biomedical Analysis - November 8, 2017 Category: Drugs & Pharmacology Source Type: research

Chemical profiling and quantification of Dan-Deng-Tong-Nao-capsule using ultra high performance liquid chromatography coupled with high resolution hybrid quadruple-orbitrap mass spectrometry
Publication date: 30 January 2018 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 148 Author(s): Xiao-Jing Lv, Zhi Sun, Pei-Le Wang, Jing Yang, Tan-Ye Xu, Qing-Quan Jia, Da-Wei Li, Fang-Yi Su, Zhen-Feng Zhu, Jian Kang, Xiao-Jian Zhang Dan-Deng-Tong-Nao capsule (DDTN) was a traditional Chinese medicine (TCM) formula, and has been widely used for the treatment of stroke clinically which caused by blood stasis. However, the bioactive substances and mechanism are unclear because of the complex compositions in DDTN. In this research, An ultra high-performance liquid chromatography (UHPLC) coupled with hybrid q...
Source: Journal of Pharmaceutical and Biomedical Analysis - October 16, 2017 Category: Drugs & Pharmacology Source Type: research

Dietary flavonoid intake and incident coronary heart disease: the REasons for Geographic and Racial Differences in Stroke (REGARDS) study Cardiovascular disease risk
Conclusions: Reported anthocyanidin and proanthocyanidin intakes were inversely associated with incident CHD. There was no significant effect modification by age, sex, race, or region of residence.
Source: American Journal of Clinical Nutrition - October 31, 2016 Category: Nutrition Authors: Goetz, M. E., Judd, S. E., Safford, M. M., Hartman, T. J., McClellan, W. M., Vaccarino, V. Tags: Nutritional Epidemiology Research Articles Cardiovascular disease risk Source Type: research

Dietary flavonoid intake and incident coronary heart disease: the REasons for Geographic and Racial Differences in Stroke (REGARDS) study.
CONCLUSIONS: Reported anthocyanidin and proanthocyanidin intakes were inversely associated with incident CHD. There was no significant effect modification by age, sex, race, or region of residence. PMID: 27655439 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - September 20, 2016 Category: Nutrition Authors: Goetz ME, Judd SE, Safford MM, Hartman TJ, McClellan WM, Vaccarino V Tags: Am J Clin Nutr Source Type: research

Dietary flavonoid intake and the risk of stroke: a dose-response meta-analysis of prospective cohort studies
Conclusions Results from this meta-analysis suggest that higher dietary flavonoid intake may moderately lower the risk of stroke.
Source: BMJ Open - June 7, 2016 Category: Journals (General) Authors: Tang, Z., Li, M., Zhang, X., Hou, W. Tags: Open access, Cardiovascular medicine, Evidence based practice, Neurology, Nutrition and metabolism, Public health Research Source Type: research

The effect of Scutellaria baicalensis stem-leaf flavonoids on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats.
Abstract Flavonoids have been shown to improve cognitive function and delay the dementia progression. However, the underlying mechanisms remain elusive. In the present study, we examined the effect of Scutellaria baicalensis stem-leaf total flavonoids (SSTFs) extracted from S. baicalensis Georgi on spatial learning and memory in a vascular dementia (VaD) rat model and explored its molecular mechanisms. The VaD rats were developed by permanent bilateral occlusion of the common carotid artery. Seven days after recovery, the VaD rats were treated with either 50 or 100 mg/kg of SSTF for 60 days. The spatial learning a...
Source: Acta Biochimica et Biophysica Sinica - April 25, 2016 Category: Biochemistry Authors: Cao Y, Liang L, Xu J, Wu J, Yan Y, Lin P, Chen Q, Zheng F, Wang Q, Ren Q, Gou Z, Du Y Tags: Acta Biochim Biophys Sin (Shanghai) Source Type: research

Dietary Flavonoid Intake and Incident Coronary Heart Disease in the Reasons for Geographic and Racial Differences in Stroke Study (REGARDS)
Flavonoids are dietary polyphenolic compounds with a variety of proposed beneficial cardiovascular effects, but rigorous prospective data in representative samples are limited. We assessed the association between dietary flavonoid intake and incident coronary heart disease (CHD) in a biracial cohort.
Source: Annals of Epidemiology - August 21, 2015 Category: Epidemiology Authors: Margarethe Goetz, Suzanne Judd, Monica Safford, Terry Hartman, William M. McClellan, Viola Vaccarino Source Type: research

Flavonoids Isolated from Rumex aquaticus Exhibit Neuroprotective and Neurorestorative Properties by Enhancing Neurite Outgrowth and Synaptophysin.
In this study, the isolation of two flavonoids - quercetin-3-O-galactoside (1) and quercetin-3-O-arabinoside (2) - from Rumex aquaticus (western dock) and their neuroprotective effects were reported in the oxygen-glucose deprivation (OGD) model of in vitro ischemia using rat pheochromocytoma (PC12) cell line. Bioassay-guided fractionation of the ethyl-acetate extract of Rumex aquaticus L. afforded the isolation of compounds 1 and 2. The structures of compounds were established on the basis of spectroscopic analyses (UV, mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR). Both compounds were isolated f...
Source: CNS and Neurological Disorders Drug Targets - October 23, 2014 Category: Drugs & Pharmacology Authors: Orbán-Gyapai O, Raghavan A, Vasas A, Forgo P, Hohmann J, Shah ZA Tags: CNS Neurol Disord Drug Targets Source Type: research

Investigating Flavonoids as Molecular Templates for the Design of Small‐Molecule Inhibitors of Cell Signaling
Abstract Epidemiological and clinical trials reveal compelling evidence for the ability of dietary flavonoids to lower cardiovascular disease risk. The mechanisms of action of these polyphenolic compounds are diverse, and of particular interest is their ability to function as protein and lipid kinase inhibitors. We have previously described structure–activity studies that reinforce the possibility for using flavonoid structures as templates for drug design. In the present study, we aim to begin constructing rational screening strategies for exploiting these compounds as templates for the design of clinically relevant, an...
Source: Journal of Food Science - December 11, 2013 Category: Food Science Authors: Bernice Wright, Marcus J. Tindall, Julie A. Lovegrove, Jonathan M. Gibbins Tags: N: Nanoscale Food Science Source Type: research