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Nutrition: Flavonoids

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Total 135 results found since Jan 2013.

Molecules, Vol. 27, Pages 7620: Quercetin & rsquo;s Effects on Glutamate Cytotoxicity
Molecules, Vol. 27, Pages 7620: Quercetin’s Effects on Glutamate Cytotoxicity Molecules doi: 10.3390/molecules27217620 Authors: Kade Riche Natalie R. Lenard The potentially therapeutic effects of the naturally abundant plant flavonoid quercetin have been extensively studied. An extensive body of literature suggests that quercetin’s powerful antioxidant effects may relate to its ability to treat disease. Glutamate excitotoxicity occurs when a neuron is overstimulated by the neurotransmitter glutamate and causes dysregulation of intracellular calcium concentrations. Quercetin has been shown ...
Source: Molecules - November 7, 2022 Category: Chemistry Authors: Kade Riche Natalie R. Lenard Tags: Review Source Type: research

Beneficial effects of natural flavonoids on neuroinflammation
Neuroinflammation is the fundamental immune response against multiple factors in the central nervous system and is characterized by the production of inflammatory mediators, activated microglia and astrocytes, and the recruitment of innate and adaptive immune cells to inflammatory sites, that contributes to the pathological process of related brain diseases, such as Alzheimer’s disease, Parkinson’s disease, depression, and stroke. Flavonoids, as a species of important natural compounds, have been widely revealed to alleviate neuroinflammation by inhibiting the production of pro-inflammatory mediators, elevating the sec...
Source: Frontiers in Immunology - October 24, 2022 Category: Allergy & Immunology Source Type: research

Natural products of traditional Chinese medicine treat atherosclerosis by regulating inflammatory and oxidative stress pathways
This study aimed to update and summarize progress in understanding how natural medicines treat AS via inflammatory and oxidative stress-related signaling pathways. We also planned to create an information base for the development of novel drugs for future AS treatment.PMID:36249778 | PMC:PMC9563010 | DOI:10.3389/fphar.2022.997598
Source: Atherosclerosis - October 17, 2022 Category: Cardiology Authors: Tianwei Meng Xinghua Li Chengjia Li Jiawen Liu Hong Chang Nan Jiang Jiarui Li Yabin Zhou Zhiping Liu Source Type: research

Molecules, Vol. 27, Pages 5783: Therapeutic Effect of Icaritin on Cerebral Ischemia-Reperfusion-Induced Senescence and Apoptosis in an Acute Ischemic Stroke Mouse Model
ing-Hwa Liu An ischemic stroke is brain damage caused by interruption of blood supply to the brain that can cause death and long-term disability. New medical strategies or therapies are urgently needed for ischemic stroke. Icaritin (ICT) is a metabolite of icariin (ICA), which are two active flavonoid components extracted from Herba epimedii and considered neuroprotective agents in animal models of Alzheimer’s disease and ischemic stroke. The therapeutic effect of ICT on ischemic still remains to be clarified. The aim of this study was to investigate the therapeutic effect of ICT on cerebral ischemia-repe...
Source: Molecules - September 7, 2022 Category: Chemistry Authors: Cheng-Tien Wu Ting-Hua Yang Man-Chih Chen Siao-Syun Guan Chang-Mu Chen Shing-Hwa Liu Tags: Article Source Type: research

The Potential Role of Naringin and Naringenin as Nutraceuticals against Metabolic Syndrome
Endocr Metab Immune Disord Drug Targets. 2022 Aug 27. doi: 10.2174/1871530322666220827141203. Online ahead of print.ABSTRACTMetabolic syndrome, an increasing problem in western society, is a cluster of conditions which affects cardiovascular health, lipid and glucose management, increasing the risk of heart diseases, stroke and diabetes. Bioactive flavonoids are a great resource of compounds with proved anti-inflammatory activities. Naringin, a natural flavanone found in citrus fruits, and its aglycone have demonstrated to ameliorate obesity, dyslipidemia, and insulin resistance in animal models. The principal mechanisms b...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - August 31, 2022 Category: Drugs & Pharmacology Authors: Luca Massaro Anna Raguzzini Paola Aiello D ébora Villaño Valencia Source Type: research

Platelet-activating factor receptor antagonists of natural origin for acute ischemic stroke: a systematic review of current evidence
Conclusions: This systematic review not only makes an important contribution to the existing body of current evidence but also lays a well-conducted basis for providing opinions and recommendation on the evaluation of PAFRA-based medicine, which could also highlight the need for well-designed clinical trials of PAFRA for AIS to increase the quality of available evidence. Further research is required, using standardized functional outcome measures for AIS, adequate blinding and suitable comparator groups reflecting current best practice.
Source: Frontiers in Pharmacology - August 31, 2022 Category: Drugs & Pharmacology Source Type: research

Drinking Black Tea May Lower Mortality Risk, Study Suggests
While green tea has a long-standing reputation for health benefits, research has been much more mixed on black tea. One problem, says Maki Inoue-Choi, an epidemiologist at the National Cancer Institute, is that large observational studies on tea and mortality have focused on countries like Japan or China—places where green tea is more popular. To fill this gap, Inoue-Choi and her colleagues analyzed data in the United Kingdom, where black tea drinking is common. After surveying about 500,000 people and following them for a median of 11 years, the results, published Aug. 29 in the journal Annals of Internal Medicine, ...
Source: TIME: Health - August 29, 2022 Category: Consumer Health News Authors: Tara Law Tags: Uncategorized Diet & Nutrition healthscienceclimate Source Type: news

Exploration of Lamiaceae in Cardio Vascular Diseases and Functional Foods: Medicine as Food and Food as Medicine
In the current scenario, cardiovascular disease (CVD) is one of the most life-threatening diseases that has caused high mortality worldwide. Several scientists, researchers, and doctors are now resorting to medicinal plants and their metabolites for the treatment of different diseases, including CVD. The present review focuses on one such family of medicinal plants, called Lamiaceae, which has relieving and preventive action on CVD. Lamiaceae has a cosmopolitan distribution and has great importance in the traditional system of medicine. Lamiaceae members exhibit a wide range of activities like antioxidant, antihyperlipidem...
Source: Frontiers in Pharmacology - June 14, 2022 Category: Drugs & Pharmacology Source Type: research

A Comprehensive Review on Therapeutic Potential of Chrysin in Brain Related Disorders
This study depicts the relationship of chrysin with different brain related disorders and discusses the mechanisms responsible for the potential role of chrysin as a pharmacological agent for the treatment and management of different brain disorders, based on the results of several preclinical studies and taking into account the therapeutic effects of the compound.PMID:35657041 | DOI:10.2174/1871527321666220602111935
Source: CNS and Neurological Disorders Drug Targets - June 3, 2022 Category: Drugs & Pharmacology Authors: Ahsas Goyal Geetanjali Singh Aanchal Verma Source Type: research