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Nutrition: Calcium

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Total 1249 results found since Jan 2013.

Effect of Intensive Blood Pressure Control on Carotid Morphology and Hemodynamics in Chinese Patients with Hyperhomocysteinemia-Type Hypertension and High Risk of Stroke.
CONCLUSIONS Intensive blood pressure management could be beneficial for Chinese patients with hyperhomocysteinemia-type hypertension and high risk of stroke. PMID: 31369520 [PubMed - in process]
Source: Medical Science Monitor - August 3, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Pre-clinical to clinical translational failures and current status of clinical trials in stroke therapy: a brief review.
This article highlights the various agents which have tried in the past but failed to translate into stroke therapy along with key points that are responsible for lagging of experimental success to translational failure in stroke treatment. PMID: 31934841 [PubMed - as supplied by publisher]
Source: Current Neuropharmacology - January 13, 2020 Category: Drugs & Pharmacology Authors: Dhir N, Medhi B, Prakash A, Goyal MK, Modi M, Mohindra S Tags: Curr Neuropharmacol Source Type: research

Coronary Calcium Score for the Prediction of Asymptomatic Coronary Artery Disease in Patients With Ischemic Stroke
Conclusion: The necessity for CAC evaluation could be determined based on the presence of risk factors and significant stenosis of the cervicocephalic arteries. CAC evaluation may be useful for screening for severe CAD in stroke patients.
Source: Frontiers in Neurology - March 26, 2020 Category: Neurology Source Type: research

An Overview on Stroke: Mechanism, in vivo Experimental Models Thereof and Neuroprotective Agents.
CONCLUSION: The injury mechanism, available encouraging medicaments thereof, and outcomes of natural and modern medicines for ischemia have been summarised. In spite of available therapeutic agents (thrombolytics, calcium channel blockers, NMDA receptor antagonists and antioxidants), there is a need of an ideal drug for stroke. PMID: 32552641 [PubMed - as supplied by publisher]
Source: Current Protein and Peptide Science - June 16, 2020 Category: Biochemistry Authors: Khan MM, Badruddeen, Mujahid M, Akhtar J, Khan MI, Ahmad U Tags: Curr Protein Pept Sci Source Type: research

Association between the high risk for obstructive sleep apnea and intracranial carotid artery calcification in patients with acute ischemic stroke.
CONCLUSIONS: This study showed that the presence of calcium in symptomatic intracranial ICA was related to high risk for OSA in patients with acute ischemic stroke. PMID: 32562170 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - June 18, 2020 Category: Sleep Medicine Authors: Woo HG, Song TJ, Jung JS, Oh SW, Lee SC, Seok JM, Yang KI Tags: Sleep Breath Source Type: research

The Multifaceted Role of Astrocyte Connexin 43 in Ischemic Stroke Through Forming Hemichannels and Gap Junctions
In this study, we review the changes in astrocytic Cx43 expression and distribution as well as the influence of these changes on the function of astrocytes and other cells in the CNS, providing new insight into the pathology of ischemic stroke injury; we also discuss the potential of astrocytic Cx43 as a target for the treatment of ischemic stroke.
Source: Frontiers in Neurology - July 30, 2020 Category: Neurology Source Type: research

Blood Pressure Variability during Angiography in Patients with Ischemic Stroke and Intracranial Artery Stenosis.
Authors: Pan H, Zhao R, Liu FD, Wu YL, Li GF, Shi YH, Liu YS, Zhao Y, Zhuang MT, Hou TY, Zhang QT, Yao Q, Qiao Y, Huang RJ, Chen LN, Zhu YM, Shu L, Su JJ, Fang J, Tang XM, Wang S, Cui GH, Wang DZ, Liu JR Abstract Our aim was to investigate factors predicting blood pressure (BP) variability during diagnostic cerebral angiography and associations between BP variability and clinical outcomes in patients with acute and subacute ischemic stroke and intracranial artery stenosis. 114 patients with ischemic stroke and intracranial artery stenosis (stenosis rate >50%) were recruited. Patients who underwent cerebral angio...
Source: International Journal of Hypertension - September 22, 2020 Category: Cardiology Tags: Int J Hypertens Source Type: research

Lithium enhances post-stroke blood-brain barrier integrity, activates the MAPK/ERK1/2 pathway and alters immune cell migration in mice.
In conclusion, we demonstrate for the first time that lithium is able to enhance post-stroke BBB integrity. Importantly, our work delivers novel insights into the exact mechanism of lithium-induced acute neuroprotection, providing critical information for future clinical trials involving lithium treatment in stroke patients. PMID: 33065166 [PubMed - as supplied by publisher]
Source: Neuropharmacology - October 13, 2020 Category: Drugs & Pharmacology Authors: Haupt M, Zechmeister B, Bosche B, Lieschke S, Zheng X, Zhang L, Venkataramani V, Jin F, Hein K, Weber MS, Hermann DM, Bähr M, Doeppner TR Tags: Neuropharmacology Source Type: research

TRPM2 in ischemic stroke: Structure, molecular mechanisms, and drug intervention.
Authors: Wang Q, Liu N, Ni YS, Yang JM, Ma L, Lan XB, Wu J, Niu JG, Yu JQ Abstract Ischemic stroke has a high lethality rate worldwide, and novel treatments are limited. Calcium overload is considered to be one of the mechanisms of cerebral ischemia. Transient receptor potential melastatin 2 (TRPM2) is a reactive oxygen species (ROS)-sensitive calcium channel. Cerebral ischemia-induced TRPM2 activation triggers abnormal intracellular Ca2+ accumulation and cell death, which in turn causes irreversible brain damage. Thus, TRPM2 has emerged as a new therapeutic target for ischemic stroke. This review provides data on ...
Source: Channels - January 21, 2021 Category: Molecular Biology Tags: Channels (Austin) Source Type: research

Role of Calcium Homeostasis in Ischemic Stroke: A Review.
Abstract Stroke is the second most common cause of death worldwide. It occurs due to the insufficient supply of oxygen-rich blood to the brain. It is a complex disease with multiple associated risk factors including smoking, alcoholism, age, sex, ethnicity, etc. Calcium ions are known to play a vital role in cell death pathways, which is a ubiquitous intracellular messenger during and immediately after an ischemic period. Disruption in normal calcium hemostasis is known to be a major initiator and activator of the ischemic cell death pathway. Under Ischemic stroke conditions, glutamate is released from the neurons...
Source: CNS and Neurological Disorders Drug Targets - February 12, 2021 Category: Drugs & Pharmacology Authors: Ludhiadch A, Sharma R, Muriki A, Munshi A Tags: CNS Neurol Disord Drug Targets Source Type: research

Olive oil consumption is associated with a lower risk of cardiovascular disease and stroke
CONCLUSIONS: Olive oil is associated with lower risk of CVD and stroke. The maximum benefit could be obtained with a consumption between 20 and 30 g/day. The association could be stronger for virgin olive oil and might operate from the early stages of the disease.PMID:34872046 | DOI:10.1016/j.clnu.2021.11.002
Source: Atherosclerosis - December 6, 2021 Category: Cardiology Authors: Carolina Donat-Vargas Helena Sandoval-Insausti Jos é L Peñalvo Maria Concepci ón Moreno Iribas Pilar Amiano Maira Bes-Rastrollo Esther Molina-Montes Bel én Moreno-Franco Antonio Agudo Cristina Lasheras Mayo Mart ín Laclaustra Carmen De La Fuente Arri Source Type: research

Association between Fok1 and TaqI polymorphisms of vitamin D receptor gene with the severity of stenosis and calcification in carotid bulb in patients with ischemic stroke
CONCLUSIONS: There may be a biological association between the FokI VDR gene and carotid bulb calcification.PMID:35091316 | DOI:10.1016/j.jocn.2022.01.009
Source: Atherosclerosis - January 29, 2022 Category: Cardiology Authors: Farzaneh Foroughinia Najmeh Morovati Anahid Safari Mehdi Dianatpour Iman Jamhiri Seyed Taghi Heydari Sedighe Hooshmandi Afshin Borhani-Haghighi Source Type: research

Molecules, Vol. 27, Pages 5488: The Effect of a New N-hetero Cycle Derivative on Behavior and Inflammation against the Background of Ischemic Stroke
Kiseleva Vadim V. Negrebetsky Yuri I. Baukov Ischemic stroke triggers a whole cascade of pathological changes in the brain, one of which is postischemic inflammation. Since in such cases thrombolytic therapy is often not possible, methods that modulate inflammation and affect microglia become particularly interesting. We synthesized 3-(2-oxo-4-phenylpyrrolidin-1-yl)propane-1-sulfonate calcium(II) (Compound 4) and studied its anti-inflammatory activity in in vitro and in vivo models of inflammation and ischemia. Macrophage cell line RAW 264.7 was treated with lipopolysaccharides (LPS) and Compound 4 at various dosa...
Source: Molecules - August 26, 2022 Category: Chemistry Authors: Denis A. Borozdenko Tatiana A. Shmigol Aiarpi A. Ezdoglian Darya I. Gonchar Natalia. Y. Karpechenko Dmitri N. Lyakhmun Anastasia D. Shagina Elvira A. Cherkashova Daria D. Namestnikova Ilya L. Gubskiy Anastasia A. Chernysheva Nina M. Kiseleva Vadim V. Negr Tags: Article Source Type: research

Transient receptor potential ion channels and cerebral stroke
ConclusionsAlthough the precise mechanism of transient receptor potential ion channels in cerebral stroke is still unclear, it has the potential to be a therapeutic target for patients with stroke if developed appropriately. Hence, more research is needed to prove its efficacy in this context.
Source: Brain and Behavior - December 17, 2022 Category: Neurology Authors: Qin'yi Xu, Yan Zou, Zeng'li Miao, Lei Jiang, Xu'dong Zhao Tags: REVIEW Source Type: research