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Nutrition: Calcium

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Total 1249 results found since Jan 2013.

Iptakalim improves cerebral microcirculation in mice after ischemic stroke by inhibiting pericyte contraction
In this study we investigated the impacts of iptakalim on pericytes contraction in stroke. Mice were subjected to cerebral artery occlusion (MCAO), then administered iptakalim (10 mg/kg, ip). We showed that iptakalim administration significantly promoted recovery of cerebral blood flow after cerebral ischemia and reperfusion. Furthermore, we found that iptakalim significantly inhibited pericytes contraction, decreased the number of obstructed capillaries, and improved cerebral microcirculation. Using a collagen gel contraction assay, we demonstrated that cultured pericytes subjected to oxygen-glucose deprivation (OGD) cons...
Source: Acta Pharmacologica Sinica - October 26, 2021 Category: Drugs & Pharmacology Authors: Ruo-Bing Guo Yin-Feng Dong Zhi Yin Zhen-Yu Cai Jin Yang Juan Ji Yu-Qin Sun Xin-Xin Huang Teng-Fei Xue Hong Cheng Xi-Qiao Zhou Xiu-Lan Sun Source Type: research

Exosomal microRNAs as Potential Biomarkers and Therapeutic Agents for Acute Ischemic Stroke: New Expectations
The morbidity and mortality rates of ischemic stroke (IS) are very high, and IS constitutes one of the main causes of disability and death worldwide. The pathogenesis of ischemic stroke includes excitotoxicity, calcium overload, oxygen radical injury, inflammatory reactions, necrosis/apoptosis, destruction of the blood-brain barrier (BBB), and other pathologic processes. Recent studies have shown that exosomes are critical to the pathogenesis, diagnosis, and treatment of cerebral infarctions resulting from ischemic stroke; and there is growing interest in the role of exosomes and exosomal miRNAs in the diagnosis and treatm...
Source: Frontiers in Neurology - January 24, 2022 Category: Neurology Source Type: research

Integrating serum proteomics and metabolomics to compare the common and distinct features between acute aggressive ischemic stroke (APIS) and acute non-aggressive ischemic stroke (ANPIS)
In this study, we integrated serum proteomics and metabolomics to explore the similarities and differences in pathophysiological processes between APIS and ANPIS. The global metabolic networks have been constructed, and the crucial common pathophysiological processes and the key distinct pathophysiological features between APIS and ANPIS were investigated based on the differentially expressed proteins and metabolites (DEPs/DEMs). Furthermore, pivotal serum proteins (SAA1 and S100A9) were detected in a dependent set to validate the key pathophysiological characteristics, as well as to assess the possibility of them being us...
Source: Journal of Proteomics - April 14, 2022 Category: Biochemistry Authors: Minchao Lai Xiaojun Zhang Danya Zhou Xiaojuan Zhang Mengting Zhu Qingxian Liu Ye Zhang Dian Wang Source Type: research

The association of admission ionized calcium with outcomes of thrombolysed patients with anterior circulation ischemic stroke
ConclusionThe current results found that ionized calcium might be associated with early neurological improvement, but had no association with 3 months' outcome in anterior circulation AIS patients after IVT.
Source: Brain and Behavior - December 7, 2022 Category: Neurology Authors: Yan ‐Li Qi, Qiong Wu, Xiao‐Qiu Li, Zhong‐He Zhou, Cheng Xia, Xin‐Hong Wang, Hui‐Sheng Chen Tags: ORIGINAL ARTICLE Source Type: research

Mitral annular calcification as a predictor of stroke in the multiethnic study of atherosclerosis
CONCLUSION: MAC is an independent predictor of long-term stroke risk in a racially diverse population beyond conventional cardiovascular risk factors and atrial fibrillation.PMID:37409651 | DOI:10.2459/JCM.0000000000001524
Source: Atherosclerosis - July 6, 2023 Category: Cardiology Authors: Afiachukwu Onuegbu Francesca Calicchio April Kinninger Rine Nakanishi John J Carr Khurram Nasir Rebecca Gottesman Matthew Budoff Source Type: research

Distinguishing features of microglia- and monocyte-derived macrophages after stroke
AbstractAfter stroke, macrophages in the ischemic brain may be derived from either resident microglia or infiltrating monocytes. Using bone marrow (BM)-chimerism and dual-reporter transgenic fate mapping, we here set out to delimit the responses of either cell type to mild brain ischemia in a mouse model of 30  min transient middle cerebral artery occlusion (MCAo). A discriminatory analysis of gene expression at 7 days post-event yielded 472 transcripts predominantly or exclusively expressed in blood-derived macrophages as well as 970 transcripts for microglia. The differentially regulated genes were fu rther collated wi...
Source: Acta Neuropathologica - December 16, 2017 Category: Neurology Source Type: research