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Nutrition: Potassium

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Total 378 results found since Jan 2013.

BIIB093 (intravenous glibenclamide) for the prevention of severe cerebral edema
CONCLUSION: Studies analyzing the GAMES-Pilot and GAMES-PR trials suggest that glibenclamide has a moderate, however, measurable effect on intermediate biomarkers and clinical endpoints. Meaningful conclusions are limited by the small sample size of patients studied.PMID:33767884 | PMC:PMC7982107 | DOI:10.25259/SNI_933_2020
Source: Surgical Neurology International - March 26, 2021 Category: Neurosurgery Authors: Daniel W Griepp Jason Lee Christina M Moawad Cyrus Davati Juliana Runnels Brian Fiani Source Type: research

Predictors of Survival in Chronic Hemodialysis Patients: A 10-Year Longitudinal Follow-Up Analysis
CONCLUSION: In chronic hemodialysis patients, targets to improve the short-term prognosis and long-term prognosis are not equivalent. Hyperphosphatemia was a significant risk factor for the all-cause mortality among patients with normal serum albumin levels but not among patients with compromised albumin levels.PMID:33756478 | DOI:10.1159/000513951
Source: American Journal of Nephrology - March 23, 2021 Category: Urology & Nephrology Authors: Takuhiro Moromizato Kentaro Kohagura Kiyoyuki Tokuyama Yoshiki Shiohira Shigeki Toma Hajime Uehara Hisatomi Arima Shinichiro Ueda Kunitoshi Iseki Source Type: research

Network meta-analysis of efficacy and safety of chlorthalidone and hydrochlorothiazide in hypertensive patients
Hypertension is a chronic condition leading to increased stress on the heart and blood vessels, a critical risk factor for clinically significant events such as myocardial infarction heart failure, stroke and death. Chlorthalidone and hydrochlorothiazide are first-line antihypertensive agents for most patients with hypertension. The aim of our meta-analysis was to compare the efficacy and safety of both therapies in patients with hypertension. Searches of electronic databases PubMed, MEDLINE, Scopus, PsycInfo and eLIBRARY.ru, were performed. We used network meta-analysis to combine direct and indirect evidence. Forest plot...
Source: Blood Pressure Monitoring - March 11, 2021 Category: Cardiology Tags: Review Article Source Type: research

The cost-effectiveness of government actions to reduce sodium intake through salt substitutes in Vietnam
ConclusionThis research shows that all three modelled salt substitution strategies would be good value for money relative to no intervention in Vietnam. The subsidised alternative would require the highest level of government investment; however the implementation costs will be exceeded by healthcare savings assuming a reasonable time horizon is considered.
Source: Archives of Public Health - March 11, 2021 Category: International Medicine & Public Health Source Type: research

Genetic predisposition and bioinformatics analysis of ATP-sensitive potassium channels polymorphisms with the risks of elevated apolipoprotein B serum levels and its related arteriosclerosis cardiovascular disease
Aging (Albany NY). 2021 Mar 3;13. doi: 10.18632/aging.202628. Online ahead of print.ABSTRACTSerum concentration of apolipoprotein B (Apo B) is causally associated with arteriosclerosis cardiovascular disease (ASCVD) risk. Whether ATP-sensitive potassium channels (KATP) variants predict the risk of increased Apo B concentration (≥ 80 mg/dL) and related ASCVD remain less clear. We recruited 522 subjects with elevated Apo B concentration (≥ 80 mg/dL) and 522 counterpart subjects (< 80 mg/dL) from South China to assess the associations of KATP variants (rs11046182, rs78148713, rs145456027 and rs147265929) with the risks...
Source: Aging - March 9, 2021 Category: Biomedical Science Authors: Cheng Liu Tianwang Guan Yanxian Lai Junfang Zhan Yan Shen Source Type: research

Fish, Cardiovascular Disease, and Mortality
Fish and shellfish (hereafter referred to as fish) are major sources of the dietary long-chain ω-3 fatty acids eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3) and also contain other nutrients, such as vitamin D, riboflavin, iodine, calcium, phosphorus, magnesium, potassium, zinc, and iron. The summed results of observational studies of fish intake, randomized clinical tria ls of fish oil supplements, and associated mechanistic and experimental studies suggest that regular fish consumption may decrease the incidence of myocardial infarction (MI) and coronary heart disease (CHD), with more uncertain effec...
Source: JAMA Internal Medicine - March 8, 2021 Category: Internal Medicine Source Type: research

Seaweed Intake and Risk of Cardiovascular Disease: The Circulatory Risk in Communities Study (CIRCS).
CONCLUSIONS: We found an inverse association between seaweed intake and risk of total stroke, especially that from cerebral infarction, among Japanese men. PMID: 33597328 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - February 21, 2021 Category: Cardiology Tags: J Atheroscler Thromb Source Type: research

The KATP channel opener, nicorandil, ameliorates brain damage by modulating synaptogenesis after ischemic stroke
by Yuanzheng Zhao, Zhuoying Yang, Yuanhong He, Ruonan Sun, Heping Yuan With population growth and aging, more and more patients with cerebral infarction have varying degrees of disability. ATP-sensitive potassium (KATP) channels regulate many cellular functions by coupling metabolic status with cell membrane electrical activity. Nicorandil (N-(2-hydroxyethyl)-nicotin amide nitrate) is the first KATP channel opener approved for clinical use. It has been reported that it might exert protective effects on the cerebral infarction by increasing cerebral blood flow and reducing inflammation. However, only a few studies explored...
Source: PLoS One - January 26, 2021 Category: Biomedical Science Authors: Yuanzheng Zhao Source Type: research

Association of KATP Gene Polymorphisms with Dyslipidemia and Ischemic Stroke Risks Among Hypertensive Patients in South China
This study investigates the potential association between KATP polymorphisms and hypertension (HTN), dyslipidemia, and consequently ischemic stroke (IS). Nine hundred and fourteen (914) patients genotyped for KATP polymorphisms (rs2285676, rs1799858, rs4148671, rs61928479, and rs141294036) were analyzed. KATP rs141294036 (CC, adjusted OR  = 1.59, 95%CI: 1.17–2.14,P = 0.003) was related to higher HTN risk. Meanwhile, rs2285676 (AA + GA, adjusted OR = 1.53, 95%CI: 1.08–2.19,P = 0.018) was associated with increased triglyceride level (≥ 1.7 mmol/L). rs2285676 (AA + GA, adjusted OR = 1.80, 95% CI: 1.24–...
Source: Journal of Molecular Neuroscience - January 5, 2021 Category: Neuroscience Source Type: research

Kv1.3 inhibition attenuates neuroinflammation through disruption of microglial calcium signaling.
Authors: Fomina AF, Nguyen HM, Wulff H Abstract In the last 5 years inhibitors of the potassium channel KV1.3 have been shown to reduce neuroinflammation in rodent models of ischemic stroke, Alzheimer's disease, Parkinson's disease and traumatic brain injury. At the systemic level these beneficial actions are mediated by a reduction in microglia activation and a suppression of pro-inflammatory cytokine and nitric oxide production. However, the molecular mechanisms for the suppressive action of KV1.3 blockers on pro-inflammatory microglia functions was not known until our group recently demonstrated that KV1.3 chan...
Source: Channels - December 29, 2020 Category: Molecular Biology Tags: Channels (Austin) Source Type: research

Network Pharmacology-Based Analysis of Xiao-Xu-Ming Decoction on the Treatment of Alzheimer ’s Disease
In conclusion, XXMD was found to have the potential to treat AD by targeting multiple AD-related targets and canonical pathways. Fangchinoline and dauricine might be the potential lead compounds in XXMD for the treatment of AD.
Source: Frontiers in Pharmacology - December 4, 2020 Category: Drugs & Pharmacology Source Type: research