Filtered By:
Nutrition: Potassium
This page shows you your search results in order of date. This is page number 5.
Order by Relevance | Date
Total 378 results found since Jan 2013.
Repurposing the KCa3.1 Blocker Senicapoc for Ischemic Stroke
AbstractSenicapoc, a small molecule inhibitor of the calcium-activated potassium channel KCa3.1, was safe and well-tolerated in clinical trials for sickle cell anemia. We previously reported proof-of-concept data suggesting that both pharmacological inhibition and genetic deletion of KCa3.1 reduces infarction and improves neurologic recovery in rodents by attenuating neuroinflammation. Here we evaluated the potential of repurposing senicapoc for ischemic stroke. In cultured microglia, senicapoc inhibited KCa3.1 currents with an IC50 of 7 nM, reduced Ca2+ signaling induced by the purinergic agonist ATP, suppressed express...
Source: Translational Stroke Research - April 24, 2023 Category: Neurology Source Type: research
Discovery of a brain-sparing GIRK1/4 inhibitor for pharmacological cardioversion of atrial fibrillation
Bioorg Med Chem Lett. 2023 Mar 15;85:129237. doi: 10.1016/j.bmcl.2023.129237. Online ahead of print.ABSTRACTAtrial fibrillation (AF) is the most common cardiac arrhythmia, and a significant risk factor for ischemic stroke and heart failure. Marketed anti-arrhythmic drugs can restore sinus rhythm, but with limited efficacy and significant toxicities, including potential to induce ventricular arrhythmia. Atrial-selective ion channel drugs are expected to restore and maintain sinus rhythm without risk of ventricular arrhythmia. One such atrial-selective channel target is GIRK1/4 (G-protein regulated inwardly rectifying potass...
Source: Bioorganic and Medicinal Chemistry Letters - March 16, 2023 Category: Chemistry Authors: Stefan Peukert Hatice Belgin Gulgeze Efthymiou Ruowei Mo Yunshan Peng Fupeng Ma Guillaume Barbe Gregory Bebernitz Cary Fridrich Chiara Buono Eric T Williams Thomas Daniels Lisha Li Xia Zhang Yuichiro Adachi Mie Abe Andrew K P Taggart Source Type: research
Epigenetics and stroke: role of DNA methylation and effect of aging on blood –brain barrier recovery
This study aimed to evaluate the epigenetic and transcriptiona l profile of cerebral microvessels after thromboembolic (TE) stroke to define potential causes of limited BBB recovery. RNA-sequencing and reduced representation bisulfite sequencing (RRBS) analyses were performed using microvessels isolated from young (6 months) and old (18 months) mice seven day s poststroke compared to age-matched sham controls. DNA methylation profiling of poststroke brain microvessels revealed 11,287 differentially methylated regions (DMR) in old and 9818 DMR in young mice, corresponding to annotated genes. These DMR were enriched in gen...
Source: Fluids and Barriers of the CNS - February 28, 2023 Category: Neuroscience Source Type: research
Electrolyte Imbalance and Neurologic Injury
CNS Neurol Disord Drug Targets. 2023 Feb 15. doi: 10.2174/1871527322666230215144649. Online ahead of print.ABSTRACTNeurologic injury continues to be a debilitating worldwide disease with high morbidity and mortality. The systemic sequelae of a neural insult often lead to prolonged hospital stays and challenging nutritional demands that contribute to poorer prognoses. Clinical management of a given condition should prioritize preserving the homeostatic parameters disrupted by inflammatory response cascades following the primary insult. This focused review examines the reciprocal relationship between electrolyte disturbance ...
Source: CNS and Neurological Disorders Drug Targets - February 15, 2023 Category: Drugs & Pharmacology Authors: Jordan Poe Sai Sriram Yusuf Mehkri Brandon Lucke-Wold Source Type: research
The bean that could lower blood pressure and reduce stroke risk - high in potassium
One study showed that a potassium-rich diet could not only reduce blood pressure but lower the risk of stroke by 24 percent.
Source: Daily Express - Health - February 6, 2023 Category: Consumer Health News Source Type: news
Epigenetics and stroke: role of DNA methylation and effect of aging on blood-brain barrier recovery
This study aimed to evaluate the epigenetic and transcriptional profile of cerebral microvessels after thromboembolic (TE) stroke to define potential causes of limited BBB recovery. RNA-sequencing and reduced representation bisulfite sequencing (RRBS) analyses were performed using microvessels isolated from young (6 months) and old (18 months) mice seven days poststroke compared to age-matched sham controls. DNA methylation profiling of poststroke brain microvessels revealed 11287 differentially methylated regions (DMR) in old and 9818 DMR in young mice, corresponding to annotated genes. These DMR were enriched in genes en...
Source: Cell Research - January 30, 2023 Category: Cytology Authors: Chelsea Phillips Svetlana Stamatovic Richard Keep Anuska Andjelkovic Source Type: research
Unlucky numbers: Fighting murder convictions that rest on shoddy stats
LEIDEN, THE NETHERLANDS—
When a Dutch nurse named Lucia de Berk stood trial for serial murder in 2003, statistician Richard Gill was aware of the case. But he saw no reason to stick his nose into it.
De Berk was a pediatric nurse at Juliana Children’s Hospital in The Hague. In 2001, after a baby died while she was on duty, a colleague told superiors that De Berk had been present at a suspiciously high number of deaths and resuscitations. Hospital staff immediately informed the police. When investigators reexamined records from De Berk’s shifts, they found 10 suspicious incidents. Three other hospitals where D...
Source: Science of Aging Knowledge Environment - January 19, 2023 Category: Geriatrics Source Type: research
Pollutants In Your Salt!?
Your doctor, the media, and the medical establishment continue to warn that flavoring your food with salt will kill you. They link sodium consumption to a higher risk of high blood pressure, stroke – and of course, heart disease.
As usual, the powers that be are missing the real picture…
You see, salt has been part of human life for thousands of years – long before these chronic diseases became as common as they are today.
Humans started adding salt to their food for more than 5,000 years. It was the most effective way to preserve food.
Some historians even go as far as to credit salt for the development of human civ...
Source: Al Sears, MD Natural Remedies - December 23, 2022 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Health Source Type: news
Novel predictors and a predictive model of cerebrovascular atherosclerotic ischemic stroke based on clinical databases
CONCLUSION: The efficacy of the predictive model was acceptable as an aid in predicting cerebrovascular atherosclerotic ischemic stroke.PMID:36413433 | DOI:10.1080/01616412.2022.2149185
Source: Neurological Research - November 22, 2022 Category: Neurology Authors: He Li Pei Liu Hong-Yu Ma Wei-Long Hua Yong-Xin Zhang Lei Zhang Yong-Wei Zhang Bo Hong Peng-Fei Yang Jian-Min Liu Source Type: research
Severe Hyperkalemia Masquerading as Acute Ischemic Stroke: A Case Report
We report a case of a 63-year-old Caucasian woman, who was admitted to Namazi Hospital, affiliated with Shiraz University of Medical Sciences (Shiraz, Iran) in August 2019. The patient suffered from left-sided weakness and slurred speech for one hour prior to admission. Initially, the patient was treated for acute ischemic stroke, and an intravenous recombinant tissue plasminogen activator (IV-rTPA) was prescribed. However, further investigations showed severe hyperkalemia. Hemiparesis and slurred speech improved significantly with appropriate management of hyperkalemia. To the best of our knowledge, this is the first case...
Source: Atherosclerosis - November 16, 2022 Category: Cardiology Authors: Zahra Bahrami Marzieh Salimi Vahid Reza Ostovan Source Type: research
Detrimental effects of transient cerebral ischemia on middle cerebral artery mitochondria in female rats
Am J Physiol Heart Circ Physiol. 2022 Nov 11. doi: 10.1152/ajpheart.00346.2022. Online ahead of print.ABSTRACTMitochondrial numbers and dynamics in brain blood vessels differ between young male and female rats under physiological conditions, but how these differences are affected by stroke is unclear. In males, we found that mitochondrial numbers, possibly due to mitochondrial fission, in large middle cerebral arteries (MCAs) increased following transient middle cerebral artery occlusion (tMCAO). However, mitochondrial effects of stroke on MCAs of female rats have not been studied. To address this disparity, we conducted m...
Source: American Journal of Physiology. Heart and Circulatory Physiology - November 11, 2022 Category: Physiology Authors: Ibolya Rutkai Ivan Merdzo Sanjay Wunnava Catherine McNulty Partha K Chandra Prasad V Katakam David W Busija Source Type: research
