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Nutrition: Potassium

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Total 378 results found since Jan 2013.

Salt substitution reduces the rate of cardiovascular events and death
Nature Reviews Cardiology, Published online: 13 September 2021; doi:10.1038/s41569-021-00615-3In the SSaSS trial, substituting regular table salt (100% sodium chloride) with an alternative containing 25% potassium chloride reduced the rate of stroke, major cardiovascular events and all-cause death.
Source: Nature Reviews Cardiology - September 13, 2021 Category: Cardiology Authors: Gregory B. Lim Source Type: research

Janssen Demonstrates Commitment to Advancing Science and Innovation in the Treatment of Solid Tumors at ESMO Annual Congress
September 8, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than ten data presentations from its lung cancer, bladder cancer and prostate cancer portfolio and pipeline will be featured during the European Society for Medical Oncology (ESMO) Annual Congress 2021 virtual meeting, September 16–21. Further details about these data and the science Janssen is advancing will be made available throughout ESMO via the Janssen Oncology Virtual Newsroom.“With a diverse oncology portfolio and pipeline spanning bladder cancer, lung cancer and prostate cancer, Janssen...
Source: Johnson and Johnson - September 8, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Neuronal Swelling: A Non-osmotic Consequence of Spreading Depolarization
AbstractAn acute reduction in plasma osmolality causes rapid uptake of water by astrocytes but not by neurons, whereas both cell types swell as a consequence of lost blood flow (ischemia). Either hypoosmolality or ischemia can displace the brain downwards, potentially causing death. However, these disorders are fundamentally different at the cellular level. Astrocytes osmotically swell or shrink because they express functional water channels (aquaporins), whereas neurons lack functional aquaporins and thus maintain their volume. Yet both neuronsand astrocytes immediately swell when blood flow to the brain is compromised (c...
Source: Neurocritical Care - September 8, 2021 Category: Neurology Source Type: research

Janssen Announces U.S. FDA Approval of INVEGA HAFYERA ™(6-month paliperidone palmitate), First and Only Twice-Yearly Treatment for Adults with Schizophrenia
TITUSVILLE, N.J., Sept. 1, 2021 – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the U.S. Food and Drug Administration (FDA) has approved long-acting atypical antipsychotic INVEGA HAFYERA™ (6-month paliperidone palmitate), the first-and-only twice-yearly injectable for the treatment of schizophrenia in adults. Before transitioning to INVEGA HAFYERA™, patients must be adequately treated with INVEGA SUSTENNA® (1-month paliperidone palmitate) for at least four months, or INVEGA TRINZA® (3-month paliperidone palmitate) for at least one 3-month injection cycle.1 The FDA approval of INVEGA ...
Source: Johnson and Johnson - September 1, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Astrocytic potassium and calcium channels as integrators of the inflammatory and ischemic CNS microenvironment
Biol Chem. 2021 Aug 30. doi: 10.1515/hsz-2021-0256. Online ahead of print.ABSTRACTAstrocytes are key regulators of their surroundings by receiving and integrating stimuli from their local microenvironment, thereby regulating glial and neuronal homeostasis. Cumulating evidence supports a plethora of heterogenic astrocyte subpopulations that differ morphologically and in their expression patterns of receptors, transporters and ion channels, as well as in their functional specialisation. Astrocytic heterogeneity is especially relevant under pathological conditions. In experimental autoimmune encephalomyelitis (EAE), a mouse m...
Source: Biological Chemistry - August 29, 2021 Category: Chemistry Authors: Samantha Schmaul Nicholas Hanuscheck Stefan Bittner Source Type: research

Cytoprotective effects of the flavonoid quercetin by activating mitochondrial BK < sub > Ca < /sub > channels in endothelial cells
Biomed Pharmacother. 2021 Aug 12;142:112039. doi: 10.1016/j.biopha.2021.112039. Online ahead of print.ABSTRACTMitochondrial potassium channels have been implicated in cytoprotective mechanisms. Activation of the mitochondrial large-conductance Ca2+-regulated potassium (mitoBKCa) channel is important for protecting brain tissue against stroke damage as well as heart tissue against ischemia damage. In this paper, we examine the effect of the natural flavonoid quercetin as an activator of the mitoBKCa channel. Quercetin has a beneficial effect on many processes in the human body and interacts with many receptors and signaling...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - August 15, 2021 Category: Drugs & Pharmacology Authors: Rafa ł Paweł Kampa Aleksandra S ęk Adam Szewczyk Piotr Bednarczyk Source Type: research

Association of Dyskalemias with Ischemic Stroke in Advanced Chronic Kidney Disease Patients Transitioning to Dialysis
Conclusion: In patients with advanced CKD, hypokalemia (chronic exposure) was associated with a higher risk of ischemic stroke, whereas hyperkalemia (acute exposure) was associated with a lower risk of ischemic stroke. Further studies in this population are needed to explore the mechanisms underlying these associations.Am J Nephrol
Source: American Journal of Nephrology - July 21, 2021 Category: Neurology Source Type: research

Stopping mineralocorticoid receptor antagonists after hyperkalaemia: trial emulation in data from routine care
ConclusionsStopping MRA after an episode of hyperkalaemia was associated with reduced risk for recurrent hyperkalaemia, but higher risk of death or cardiovascular events. Recurrent hyperkalaemia was common in either strategy.
Source: European Journal of Heart Failure - July 19, 2021 Category: Cardiology Authors: Marco Trevisan, Edouard L. Fu, Yang Xu, Gianluigi Savarese, Friedo W. Dekker, Lars H. Lund, Catherine M. Clase, Arvid Sj ölander, Juan J. Carrero Tags: Research Article Source Type: research

Stopping mineralocorticoid receptor antagonists after hyperkalemia: trial emulation in data from routine care
ConclusionsStopping MRA after an episode of hyperkalemia was associated with reduced risk for recurrent hyperkalemia, but higher risk of death or cardiovascular events. Recurrent hyperkalemia was common in either strategy.
Source: European Journal of Heart Failure - July 1, 2021 Category: Cardiology Authors: Marco Trevisan, Biostat Edouard L. Fu, Yang Xu, Gianluigi Savarese, Friedo W Dekker, Lars H Lund, Catherine M Clase, Arvid Sj ölander Biostat, Juan Jesus Carrero Tags: Research Article Source Type: research

Early postoperative effects of kidney transplantation on the cardiovascular system in our clinical practice
CONCLUSION: After transplantation, the left atrial and the end-systolic diameter of the left ventricle regrediated, decreasing the frequency of arrhythmic episodes. The number of the middle grade mitral valve regurgitation decreased and the calcification among diabetic population increased significantly. Orv Hetil. 2021; 162(26): 1052-1062.PMID:34175832 | DOI:10.1556/650.2021.32269
Source: Orvosi Hetilap - June 27, 2021 Category: General Medicine Authors: Andrea Darag ó Gerda Schwegler Eszter Szab ó Dorina Bark ó R éka P Szabó Attila Csaba Nagy Gerg ő József Szőllősi Bal ázs Nemes Source Type: research

A vesetranszplant áció korai posztoperatív hatásai a szív- és érrendszeri betegségekre klinikai gyakorlatunkban
CONCLUSION: After transplantation, the left atrial and the end-systolic diameter of the left ventricle regrediated, decreasing the frequency of arrhythmic episodes. The number of the middle grade mitral valve regurgitation decreased and the calcification among diabetic population increased significantly. Orv Hetil. 2021; 162(26): 1052-1062.PMID:34175832 | DOI:10.1556/650.2021.32269
Source: Orvosi Hetilap - June 27, 2021 Category: General Medicine Authors: Andrea Darag ó Gerda Schwegler Eszter Szab ó Dorina Bark ó R éka P Szabó Attila Csaba Nagy Gerg ő József Szőllősi Bal ázs Nemes Source Type: research