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Source: Neurological Research
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Total 381 results found since Jan 2013.

Thrombolytic treatment decreases glutamate/GABA ratio in serum during acute ischaemic stroke: a pilot study.
Authors: Kurzepa J, Szpetnar M, Hordyjewska A, Wątroba S, Gołąb P, Boguszewska-Czubara A Abstract There is no information about possible effect of recombinant tissue plasminogen activator (rtPA) therapy on excitotoxic/neuroprotective amino acids during acute phase of ischaemic stroke (IS). Our purpose was to evaluate iv thrombolytic treatment on glutamate (Glu) and gamma-aminobutyric acid (GABA) serum levels during acute IS. Eleven thrombolytic (rtPA group) and 12 non-thrombolytic (non-rtPA group) patients with acute IS were enrolled. The serum samples were obtained at three time-points for rtPA group (time-poin...
Source: Neurological Research - May 26, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Association between interleukin-6 (G174C and C572G) promoter gene polymorphisms and risk of ischemic stroke in North Indian population: a case-control study.
CONCLUSION: Our results suggest that IL-6 (G174C) polymorphism is significantly associated with the risk of IS in North Indian population. However, IL-6 (C572G) polymorphism is found significantly associated with the risk of IS after adjusting the demographic and risk factors variables. Prospective studies with large sample size are required for independent validation. Our findings could be helpful in identifying individuals at increased risk for developing IS. PMID: 26883819 [PubMed - as supplied by publisher]
Source: Neurological Research - February 18, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Association between Endothelial nitric oxide synthase G894T gene polymorphism and risk of ischemic stroke in North Indian population: a case-control study.
CONCLUSION: The findings of the present study suggest that polymorphism in G894T position of eNOS gene might be a risk factor for IS mainly for LVD stroke subtype in North Indian population. Further large prospective studies are required to confirm these findings. PMID: 27168380 [PubMed - as supplied by publisher]
Source: Neurological Research - May 18, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Relationship of phosphodiesterase 4D (PDE4D) gene polymorphisms with risk of ischemic stroke: a hospital based case-control study.
CONCLUSION: SNP 83 of PDE4D gene may increase the risk for developing IS whereas SNP 87 and SNP45 of PDE4D may not be associated with the risk of IS in the North Indian population. Prospective cohort studies are required to corroborate these findings. PMID: 28562233 [PubMed - as supplied by publisher]
Source: Neurological Research - June 2, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Effects of different montages of transcranial direct current stimulation on the risk of falls and lower limb function after stroke.
CONCLUSIONS: This is the first trial with different setups of tDCS on acute stroke patients. tDCS presents as an effective treatment strategy in reducing the risk of falls and improving lower limb function after a stroke. ClinicalTrials.gov (NCT 02422173). PMID: 28885111 [PubMed - as supplied by publisher]
Source: Neurological Research - September 10, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Elevated CRP at admission predicts post-stroke cognitive impairment in Han Chinese patients with intracranial arterial stenosis.
CONCLUSIONS: To our knowledge, this is the first study to explore the effects of CRP on PSCI in Han Chinese with ICAS. Our findings indicate that higher CRP levels at admission are associated with subsequent cognitive decline in Han Chinese patients with ICAS following ischemic stroke. Further studies in other ethnic groups are needed to validate the use of CRP to predict dementia in ICAS patients. PMID: 29451096 [PubMed - as supplied by publisher]
Source: Neurological Research - February 18, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Development and validation of a risk score to predict 30-day mortality in patients with atrial fibrillation-related stroke: GPS-GF score.
Conclusion The GPS-GF score is a simple and valid tool for predicting 30-day mortality in patients with AF-related stroke. PMID: 29544401 [PubMed - as supplied by publisher]
Source: Neurological Research - March 20, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Prognosis of dolichoectasia in non-cardioembolic transient ischemic attack and minor stroke.
Conclusions Dolichoectasia was significantly associated with SAO. There was no relationship between dolichoectasia and 12-month prognosis of patients with non-cardioembolic TIA or minor stroke. PMID: 29600887 [PubMed - as supplied by publisher]
Source: Neurological Research - March 31, 2018 Category: Neurology Tags: Neurol Res Source Type: research

D-dimer > 2.785  μg/ml and multiple infarcts ≥3 vascular territories are two characteristics of identifying cancer-associated ischemic stroke patients.
CONCLUSIONS: D-dimer >2.785 μg/ml may be an effective cutoff value and a sensitive index for identifying CAIS patients. AMBIs in ≥3 vascular territories and AMBIs in both the anterior and posterior circulations are two imaging characteristics of CAIS. PMID: 30317943 [PubMed - in process]
Source: Neurological Research - October 17, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Association analysis of Glutathione S-transferase omega-1 and omega-2 genetic polymorphisms and ischemic stroke risk in a Turkish population.
CONCLUSION: No significant difference was observed between the stroke patients and controls in terms of genotypes and allele distributions. Double combine haplotype CCAA was found to be protective against ischemic stroke when compare to other haplotypes. However, different genotypes of GSTO1 and GSTO2 were observed to have effects on stroke risk in subgroups of diabetics and smokers. In conclusion, the current study is the first to report this finding. PMID: 30417762 [PubMed - as supplied by publisher]
Source: Neurological Research - November 14, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Increasing trimethylamine N-oxide levels as a predictor of early neurological deterioration in patients with acute ischemic stroke.
Conclusions: Our study indicated that increasing TMAO levels at admission might be associated with END after acute ischemic stroke. PMID: 31928326 [PubMed - as supplied by publisher]
Source: Neurological Research - January 14, 2020 Category: Neurology Tags: Neurol Res Source Type: research

The effect of intravenous ginkgolide on clinical improvement of patients with acute ischemic stroke.
Conclusion: Intravenous ginkgolide may improve the outcome of acute ischemic stroke. Differences in effect between pre-marketing and post-marketing studies may be associated with gender, time of onset to enrollment and severity of stroke. PMID: 32048567 [PubMed - as supplied by publisher]
Source: Neurological Research - February 13, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Health-related quality of life after ischemic stroke: impact of sociodemographic and clinical factors
CONCLUSION: Stroke survivors have significantly reduced HR-QoL. Multiple interacting factors are associated with an unfavorable outcome after IS. Early detection of these factors would help to improve the care for IS patients, to reduce disabilities and improve HR-QoL.PMID:33637026 | DOI:10.1080/01616412.2021.1893563
Source: Neurological Research - February 27, 2021 Category: Neurology Authors: M Tsalta-Mladenov S Andonova Source Type: research