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Source: Neurological Research
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Total 381 results found since Jan 2013.
Transesophageal echocardiography in patients less than 60 years of age without obvious cardiac source of embolism.
Authors: Nighoghossian N, Perinetti M, Barthelet M, Adeleine P, Trouillas P
Abstract
Minor potential cardioembolic sources of stroke such as atrial septal aneurysms (ASA) or patent foramen ovale (PFO) are important risk factors for cryptogenic stroke. We aim to determine the prevalence of these abnormalities through an exhaustive etiological workup including transesophageal echocardiography and cervical arteries assessment in stroke patients younger than 60 years of age who had no evidence of a significant source of embolism. We classified 118 stroke patients into four groups according to transesophageal echocardio...
Source: Neurological Research - November 10, 2016 Category: Neurology Tags: Neurol Res Source Type: research
The role of extracranial carotid duplex in predicting functional outcome in first time lacunae strokes
CONCLUSION: In the current study, the most suitable length of stay in hospital for lacunae stroke patients to fully recuperate is ten days. Additionally, CCA EDV might be the key determinant, with baseline diabetes mellitus acting in a medium role, capable of altering long-term outcome functionality and recovery.PMID:36376279 | DOI:10.1080/01616412.2022.2140542
Source: Neurological Research - November 14, 2022 Category: Neurology Authors: Ting-Wei Jiang Ying-Lin Hsu Ju-Lan Yang Yin-Tzer Shih Chih-Ming Lin Source Type: research
The role of microRNA in neuronal inflammation and survival in the post ischemic brain: a review.
Authors: Li WA, Efendizade A, Ding Y
Abstract
Each year, more than 790 000 people in the United States suffer from a stroke. Although progress has been made in diagnosis and treatment of ischemic stroke (IS), new therapeutic interventions to protect the brain during an ischemic insult is highly needed. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression post-transcriptionally. Growing evidence suggests that miRNAs have a profound impact on ischemic stroke progression and are potential targets of novel treatments. Notably, inflammatory pathways play an important role in the pathogenesis of i...
Source: Neurological Research - May 31, 2017 Category: Neurology Tags: Neurol Res Source Type: research
Genistein attenuates brain damage induced by transient cerebral ischemia through up-regulation of Nrf2 expression in ovariectomized rats.
In this study, ovariectomized rats were treated with genistein (10 mg/kg) or vehicle daily for two weeks before they received middle cerebral artery occlusion (MCAO) and reperfusion. After 72 hours of reperfusion, the neurological function was evaluated by Garcia test, infarct volume was detected by 2,3,5-triphenyltetrazolium chloride staining, and neuronal damage was detected by Nissl staining. In addition, ROS production and the expression of Nrf2, NQO1 and cleaved-Caspase3 in the ischemic penumbra were detected.
RESULTS: The results showed that genistein treatment significantly improved the neurological outcome, red...
Source: Neurological Research - April 26, 2018 Category: Neurology Tags: Neurol Res Source Type: research
Ligustilide provides neuroprotection by promoting angiogenesis after cerebral ischemia.
CONCLUSION: LGSL promoted focal angiogenesis and attenuated ischemia-induced brain injury, suggesting that LGSL is a potential agent that improves angiogenesis and promotes recovery from ischemic stroke.
PMID: 32584207 [PubMed - as supplied by publisher]
Source: Neurological Research - June 26, 2020 Category: Neurology Tags: Neurol Res Source Type: research
Predictors of neurological deterioration during hospitalization: results from the Chinese Intracranial Atherosclerosis (CICAS) Study.
DISCUSSION: Patients with watershed infarcts and MCA or BA stenosis or occlusion should be monitored closely, and various therapeutic strategies should be administered simultaneously to prevent pneumonia during hospitalisation.
PMID: 25917464 [PubMed - as supplied by publisher]
Source: Neurological Research - April 29, 2015 Category: Neurology Tags: Neurol Res Source Type: research
Transorbital Doppler with carotid siphon monitoring detects right-to-left shunt effectively.
Conclusion TOD with CS monitoring is able to detect RLS effectively in different populations including healthy subjects, cryptogenic stroke, transient ischemia attack, and migraine patients. In comparing to the TTD with MCA approach, TOD with CS monitoring could detect comparable rate of RLS, but more high grades of RLS.
PMID: 29350100 [PubMed - as supplied by publisher]
Source: Neurological Research - January 20, 2018 Category: Neurology Tags: Neurol Res Source Type: research
Low-dose rt-PA may not decrease the incidence of symptomatic intracranial haemorrhage in patients with high risk of symptomatic intracranial haemorrhage.
CONCLUSIONS: Our study suggests that low-dose intravenous rt-PA for high-risk sICH stroke in Chinese patients may not decrease the incidence of sICH, and concomitant with a poor outcome compared to standard-dose rt-PA.
ABBREVIATIONS: rt-PA: recombinant tissue plasminogen activator; AIS: acute ischemic stroke; sICH: symptomatic intracranial haemorrhage.
PMID: 30822264 [PubMed - as supplied by publisher]
Source: Neurological Research - March 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research
Cerebral ischaemia/reperfusion injury could be managed by using tramadol.
DISCUSSION: Tramadol can ameliorate the histopathological structure of ischaemic tissue in both periods of I/R injury in rat. We suggest further research investigating various dosages with different administration methods of tramadol in stroke should be conducted by adopting different explorative techniques.
PMID: 29792388 [PubMed - as supplied by publisher]
Source: Neurological Research - May 26, 2018 Category: Neurology Tags: Neurol Res Source Type: research
Matrix metallopeptidase 9 and placental growth factor may correlate with collateral status based on whole-brain perfusion combined with multiphase computed tomography angiography
DISCUSSION: Serum PGF and MMP-9 levels may correlate with collateral status based on MP-CTA in acute ischemic stroke patients with cerebral large artery atherosclerosis. Higher PGF and MMP-9 concentration associated with good collateral status.PMID:34107864 | DOI:10.1080/01616412.2021.1939238
Source: Neurological Research - June 10, 2021 Category: Neurology Authors: Bo Yang Yarong Ding Xin Liu Yuan Cai Xinxuan Yang Qixuan Lu Weibin Gu Liping Liu Yuehua Pu Source Type: research
The Shh/Gli1 signaling pathway regulates regeneration via transcription factor Olig1 expression after focal cerebral ischemia in rats
CONCLUSION: That blockade of Shh signaling concurrently with the creation of a lesion aggravated ischemic myelin damage, probably via its downstream effects on Olig1 transcription. Shh plays a contributory role during regeneration in the CNS, thereby providing promising new therapeutic strategies to assist in recovery from ischemic stroke.PMID:34592910 | DOI:10.1080/01616412.2021.1981106
Source: Neurological Research - October 1, 2021 Category: Neurology Authors: Hong Zhao Xiao-Yu Gao Xiao-Jun Wu Yong-Bo Zhang Xun-Fen Wang Source Type: research
