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Source: Neurological Research
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Total 381 results found since Jan 2013.
The Shh/Gli1 signaling pathway regulates regeneration via transcription factor Olig1 expression after focal cerebral ischemia in rats
CONCLUSION: That blockade of Shh signaling concurrently with the creation of a lesion aggravated ischemic myelin damage, probably via its downstream effects on Olig1 transcription. Shh plays a contributory role during regeneration in the CNS, thereby providing promising new therapeutic strategies to assist in recovery from ischemic stroke.PMID:34592910 | DOI:10.1080/01616412.2021.1981106
Source: Neurological Research - October 1, 2021 Category: Neurology Authors: Hong Zhao Xiao-Yu Gao Xiao-Jun Wu Yong-Bo Zhang Xun-Fen Wang Source Type: research
Loss of Kir6.1 facilitates peri-infarct depolarizations in focal cerebral ischemia
CONCLUSION: This study shows that loss of Kir6.1, not Kir6.2 facilitates the induction of PIDs in focal cerebral ischemia, indicating that Kir6.1-forming channels in the brain may provide protection against PIDs.PMID:35271426 | DOI:10.1080/01616412.2022.2051132
Source: Neurological Research - March 10, 2022 Category: Neurology Authors: Zelong Zheng Zhenyu Li Jianping Lv Source Type: research
Simplified classification of cavernous internal carotid artery tortuosity: a predictor of procedural complexity and clinical outcomes in mechanical thrombectomy
CONCLUSIONS: The study indicated that the grading of cICA tortuosity is highly correlated with procedural complexity and clinical outcome in mechanical thrombectomy. The proposed classification system may be helpful in pre-procedure prognostication complexity and clinical outcomes.Abbreviations:LVS: large vessel stroke; cICA: cavernous internal carotid artery; mRS: modified Rankin Scale; AIS: acute ischemic stroke; MCA: middle cerebral artery; M1: first division of middle cerebral artery; M2: second division of middle cerebral artery; M3: third division of middle cerebral artery; TICI: Thrombolysis In Cerebral Infarction; ...
Source: Neurological Research - April 27, 2022 Category: Neurology Authors: Zhongjun Chen Tieping Fan Xusheng Zhao Teng Hu Hengxu Qi Di Li Source Type: research
A comparison of rt-PA thrombolysis guidelines between China and the USA: are changes needed?
CONCLUSIONS: Onset to IV time is critical for reducing mortality and improving favorable outcomes. We suggest Chinese acute ischemic stroke treatment guidelines be revised to include an increase in the age limit of 80 years, removing contraindications such as a history of previous sever heart, liver, and kidney dysfunction, and placing more emphasis on physician expertise.
PMID: 24981554 [PubMed - in process]
Source: Neurological Research - December 2, 2014 Category: Neurology Tags: Neurol Res Source Type: research
The effect of recombinant tissue plasminogen activator on MMP-2 and MMP-9 activities in vitro.
In conclusion, this study showed that rtPA can increase the biological activity of MMP-2 and MMP-9 on posttranslational level.
PMID: 24963695 [PubMed - in process]
Source: Neurological Research - December 2, 2014 Category: Neurology Tags: Neurol Res Source Type: research
Trains of electrical stimulation of the trapezius muscles redistribute the frequencies of body oscillations during stance.
Authors: Nhouvannasak V, Clément S, Manto M
Abstract
We investigated the postural effects of trains of electrical stimulation (TES) applied unilaterally or bilaterally on the trapezius muscle in 20 healthy subjects (mean age: 23.1 ± 1.33 years; F/M: 8/12). The anterior-posterior (AP) displacements (AP axis), medio-lateral displacements (ML axis) and total travelled distances (TTW) of the centre of pressure (COP) remained unchanged with TES. However, detailed spectral analysis of COP oscillations revealed a marked decrease of the magnitudes of peak power spectral density (peak PSD) following application of T...
Source: Neurological Research - May 26, 2015 Category: Neurology Tags: Neurol Res Source Type: research
Aetiological diagnosis of middle-aged and elderly cryptogenic ischaemic cerebral vascular disease.
Authors: Dong J, Elmadhoun O, Ma X
Abstract
Although tremendous efforts have been made to explore the potential aetiologies of cryptogenic ischaemic cerebral vascular disease (CICVD), it remains a great challenge for neurologists to get a comprehensive picture of CICVD across the world. Part of the reason why is that the vast majority of studies have focussed on CICVD in young stroke patients while the underlying causes of CICVD in middle-aged or elderly stroke population have not been fully investigated. The focus of this paper has been dedicated to review the different studies that explore the aetiologies of CICV...
Source: Neurological Research - May 26, 2015 Category: Neurology Tags: Neurol Res Source Type: research
Normobaric hyperoxia retards the evolution of ischemic brain tissue toward infarction in a rat model of transient focal cerebral ischemia.
Conclusions： Our results demonstrate that NBO treatment given during cerebral ischemia retards the evolution of ischemic brain tissue toward infarction and NBO-preserved cortical tissue survives better than NBO-preserved striatal tissue during the phase of reperfusion.
PMID: 27078693 [PubMed - as supplied by publisher]
Source: Neurological Research - April 16, 2016 Category: Neurology Tags: Neurol Res Source Type: research
Internal maxillary artery to intracranial artery bypass: a case series of 31 patients with chronic internal carotid/middle cerebral arterial-sclerotic steno-occlusive disease.
CONCLUSIONS: By supplying an adequate flow to a larger flow territory of chronically stenotic/occlusive major cerebral arteries, IMA bypass surgery is efficient for restoring hemodynamics in selected patients and improving their neurological deficits.
PMID: 27122096 [PubMed - as supplied by publisher]
Source: Neurological Research - April 30, 2016 Category: Neurology Tags: Neurol Res Source Type: research
