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Source: Neurological Research
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The Shh/Gli1 signaling pathway regulates regeneration via transcription factor Olig1 expression after focal cerebral ischemia in rats
CONCLUSION: That blockade of Shh signaling concurrently with the creation of a lesion aggravated ischemic myelin damage, probably via its downstream effects on Olig1 transcription. Shh plays a contributory role during regeneration in the CNS, thereby providing promising new therapeutic strategies to assist in recovery from ischemic stroke.PMID:34592910 | DOI:10.1080/01616412.2021.1981106
Source: Neurological Research - October 1, 2021 Category: Neurology Authors: Hong Zhao Xiao-Yu Gao Xiao-Jun Wu Yong-Bo Zhang Xun-Fen Wang Source Type: research