Thrombolytic treatment decreases glutamate/GABA ratio in serum during acute ischaemic stroke: a pilot study.

Thrombolytic treatment decreases glutamate/GABA ratio in serum during acute ischaemic stroke: a pilot study. Neurol Res. 2015 May 24;:1743132815Y0000000049 Authors: Kurzepa J, Szpetnar M, Hordyjewska A, Wątroba S, Gołąb P, Boguszewska-Czubara A Abstract There is no information about possible effect of recombinant tissue plasminogen activator (rtPA) therapy on excitotoxic/neuroprotective amino acids during acute phase of ischaemic stroke (IS). Our purpose was to evaluate iv thrombolytic treatment on glutamate (Glu) and gamma-aminobutyric acid (GABA) serum levels during acute IS. Eleven thrombolytic (rtPA group) and 12 non-thrombolytic (non-rtPA group) patients with acute IS were enrolled. The serum samples were obtained at three time-points for rtPA group (time-point 0: first to fourth hour of stroke; time-point 1: immediately after rtPA administration; time-point 3: on days 5-7 from stroke onset). The remaining patients had blood collection at two time-points: time-point 1: 5(th)-10(th) hour of stroke and time-point 2: on days 5-7 of stroke. Glutamate and GABA were determined by the automated ion-exchange chromatography using Amino Acids Analyser (AAA 400) by INGOS Corp., Praha, Czech Republic. The statistically significant elevation of GABA serum level was noticed directly after thrombolysis (time-point 1) in comparison to the corresponding time-point in non-rtPA group [0.016 (0.002-0.032) μM/ml vs 0.001 (0.001-0.004) μM/ml for...
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research