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Source: Journal of the Neurological Sciences
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Total 856 results found since Jan 2013.
Ischemic stroke in patients with atrial fibrillation receiving oral anticoagulation
Abstract: Background: Atrial fibrillation is the most common cause of embolic stroke associated to heart disease. Oral anticoagulation with vitamin K antagonists substantially reduces this risk.Aims: We assessed a group of patients with prior diagnosis of atrial fibrillation who sustained an ischemic stroke while receiving an adequate regime of oral anticoagulation.Methods: We evaluated consecutive patients with ischemic stroke and prior diagnosis of atrial fibrillation. We determined demographics, clinical characteristics, TOAST stroke subtypes, CHADS2 scores, and prior or concomitant use of oral anticoagulants.Results: W...
Source: Journal of the Neurological Sciences - September 20, 2013 Category: Neurology Authors: Virginia A. Pujol Lereis, Sebastian Ameriso, Guillermo P. Povedano, Sebastián F. Ameriso Tags: Original Articles Source Type: research
A systematic review of closure versus medical therapy for preventing recurrent stroke in patients with patent foramen ovale and cryptogenic stroke or transient ischemic attack
Abstract: The optimal treatment for secondary prevention in patients who have a patent foramen ovale (PFO) and history of cryptogenic stroke is still uncertain and controversial. In view of this, we performed a systematic review of randomized controlled trials (RCTs) to investigate whether PFO closure was superior to medical therapy for prevention of recurrent stroke or transient ischemic attack (TIA) in patients with PFO after cryptogenic stroke. We searched the Cochrane Central Register of Controlled Trials, Embase, PubMed, Web of Science, and ClinicalTrials.gov. Three randomized controlled trials with a total of 2303 pa...
Source: Journal of the Neurological Sciences - December 2, 2013 Category: Neurology Authors: Linkun Chen, Shuguang Luo, Lingwan Yan, Weijia Zhao Tags: Review Source Type: research
Autonomic dysfunction in different subtypes of post-acute ischemic stroke
This study sought to investigate cardiovascular autonomic function in patients with different subtypes of post-acute ischemic stroke.Methods: 77 ischemic stroke patients [50 patients with large-artery atherosclerosis (LAA) and 27 patients with small-vessel occlusion (SVO), average 6months after stroke onset] and 37 elderly controls were recruited. All performed Ewing's battery autonomic function tests and power spectral analysis of heart rate variability (HRV).Results: Stroke patients with both LAA and SVO had significantly lower low frequency power spectral density than controls. The prevalence of autonomic dysfunction in...
Source: Journal of the Neurological Sciences - December 9, 2013 Category: Neurology Authors: L. Xiong, H.W. Leung, X.Y. Chen, W.H. Leung, O.Y. Soo, K.S. Wong Tags: Original Articles Source Type: research
Asymmetric dimethylarginine is related to the predicted stroke risk in middle-aged Japanese men
Conclusion: Elevated ADMA levels were significantly associated with an increased predicted stroke risk, suggesting that measuring ADMA levels may be useful for identifying middle-aged Japanese men with a high risk of stroke.
Source: Journal of the Neurological Sciences - December 30, 2013 Category: Neurology Authors: Yasuhiro Nishiyama, Toshiaki Otsuka, Masayuki Ueda, Hirofumi Inagaki, Kanako Muraga, Arata Abe, Tomoyuki Kawada, Yasuo Katayama Tags: Original Articles Source Type: research
Plasma S100A12 is associated with functional outcome after ischemic stroke: Research for Biomarkers in Ischemic Stroke
Abstract: Background: Ischemic stroke is accompanied by an inflammatory response, which exacerbates brain injury and deteriorates functional outcome. S100A12 is expressed abundantly in granulocytes, and has been implicated to play an important role on inflammatory reactions in various disease states. We aimed to determine the association between plasma S100A12 levels and a functional outcome in patients with acute ischemic stroke.Methods: We prospectively included 171 patients with acute ischemic stroke within 24h after onset in this study. Plasma samples were collected for the measurement of S100A12 levels. Poor functiona...
Source: Journal of the Neurological Sciences - March 14, 2014 Category: Neurology Authors: Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Jyunya Kuroda, Ryu Matsuo, Jun Hata, Seiji Gotoh, Tetsu Isomura, Hideto Awano, Kazuo Suzuki, Kenji Fukuda, Yasushi Okada, Yutaka Kiyohara, Hiroaki Ooboshi, Takanari Kitazono, on behalf of the REBIOS Inve Tags: Original Articles Source Type: research
Towards evidence-based policies to strengthen acute stroke care in low-middle-income countries
Stroke is a major public health issue in many low- and middle-income countries (LMICs). Despite the emergence of new effective interventions for acute stroke care, uptake remains slow and largely inaccessible to patients in LMICs, where health systems response has been inadequate. In this paper, we propose a policy framework to optimise access to acute stroke care in LMICs. We draw on evidence from relevant primary studies, such as availability of evidence-based acute stroke care interventions, barriers to uptake of interventions for stroke care and insights on stroke mortality and morbidity burden in LMICs.
Source: Journal of the Neurological Sciences - September 2, 2020 Category: Neurology Authors: Leonard Baatiema, Seye Abimbola, Ama de-Graft Aikins, Albertino Damasceno, Andre Pascal Kengne, Fred S. Sarfo, Augustina Charway Felli, Shawn Somerset Tags: Editorial Source Type: research
Diffusion weighted imaging in acute ischemic stroke: A review of its interpretation pitfalls and advanced diffusion imaging application
Diffusion weighted imaging (DWI) is a widely used imaging technique to evaluate patients with stroke. It can detect brain ischemia within minutes of stroke onset. However, DWI has few potential pitfalls that should be recognized during interpretation. DWI lesion could be reversible in the early hours of stroke and the entire lesion may not represent ischemic core. False negative DWI could lead to diagnosis of DWI negative stroke or to a missed stroke diagnosis. Ischemic stroke mimics can occur on DWI with non-cerebrovascular neurological conditions.
Source: Journal of the Neurological Sciences - April 3, 2021 Category: Neurology Authors: Nandakumar Nagaraja Tags: Review Article Source Type: research
Reservations against new oral anticoagulants after stroke and cerebral bleeding
Abstract: Dabigatran, rivaroxaban, and apixaban are the new oral anticoagulants (NOAC) which have been investigated in patients with atrial fibrillation (AF) for primary and secondary prevention of stroke and thromboembolism. In these trials NOAC had a similar efficacy and safety profile compared to traditional vitamin-K-antagonists such as warfarin. We advise caution in the use of NOAC in patients with stroke or cerebral hemorrhage because of the following reasons:1) Patients with cerebral bleeding were excluded from the trials. 2) Stroke within 14days and severe stroke within 6months before screening were exclusion crite...
Source: Journal of the Neurological Sciences - April 29, 2013 Category: Neurology Authors: Claudia Stöllberger, Josef Finsterer Tags: Opinion Source Type: research
Brain control of volitional ankle tasks in people with chronic stroke and in healthy individuals
This study explored the relationships between motor cortical control of ankle dorsiflexors and clinical impairments of volitional ankle dorsiflexion in people with chronic stroke. Eighteen persons with stroke and 14 controls were evaluated. Clinical tools were used to assess ankle dorsiflexion amplitude and isometric strength. Transcranial magnetic stimulation (TMS) of the primary motor cortex (M1) tested the functional integrity of cortical circuits controlling the tibialis anterior (TA). All clinical scores and most TMS outcomes were impaired in people with chronic stroke. The lower clinical scores were related to the re...
Source: Journal of the Neurological Sciences - January 15, 2014 Category: Neurology Authors: L.D. Beaulieu, H. Massé-Alarie, B. Brouwer, C. Schneider Tags: Original Articles Source Type: research
Arterial spin-labeling magnetic resonance imaging for diagnosis of late seizure after stroke
Conclusions: ASL was able to reveal hyperperfusion and was of great diagnostic value in the peri-ictal phase of late seizure after stroke.
Source: Journal of the Neurological Sciences - February 10, 2014 Category: Neurology Authors: Yosuke Miyaji, Mutsumi Yokoyama, Yuichi Kawabata, Hideto Joki, Yuji Kushi, Yasutaka Yokoi, Jo Sasame, Shunsuke Seki, Kentaro Mori, Tomoya Kamide, Akira Tamase, Hiroshi Shima, Motohiro Nomura, Yoshihisa Kitamura, Fumiaki Tanaka Tags: Original Articles Source Type: research
Intravenous thrombolysis with rt-PA for acute ischemic stroke within 24h of a transient ischemic attack
Conclusion: TIA within 24h prior to ischemic stroke can portend severe intracerebral bleeding in patients qualified to iv-thrombolysis with the use of rt-PA.
Source: Journal of the Neurological Sciences - March 13, 2014 Category: Neurology Authors: Piotr Sobolewski, Waldemar Brola, Małgorzata Wiszniewska, Wiktor Szczuchniak, Małgorzata Fudala, Mariusz Domagalski, Monika Śledzińska-Dźwigał Tags: Original Articles Source Type: research
Prevalence of genetic polymorphisms of CYP2C9 and VKORC1 — Implications for warfarin management and outcome in Croatian patients with acute stroke
Conclusion: Our data indicated rapid and safe anticoagulation achieved by using pharmacogenetically-predicted warfarin dose in high-risk acute stroke patients without increasing the risk of warfarin dosage complications in an elderly population.Highlights:
Source: Journal of the Neurological Sciences - May 6, 2014 Category: Neurology Authors: Svjetlana Šupe, Nada Božina, Vesna Matijević, Antonela Bazina, Antonija Mišmaš, Josip Ljevak, Domagoj Alvir, Mario Habek, Zdravka Poljaković Tags: Original Articles Source Type: research
Association of heme oxygenase-1 gene rs2071746 polymorphism with vascular outcomes in patients with atherosclerotic stroke
In conclusion, HO-1 gene rs2071746 A allele carrier might be a protective factor for patients with atherosclerotic stroke.Highlights:
Source: Journal of the Neurological Sciences - July 1, 2014 Category: Neurology Authors: Liping Cao, Zhizhong Zhang, Biyang Cai, Wen Bai, Yumeng Zhang, Wenshan Sun, Xia Xie, Wen Sun, Qiankun Cai, Zhuangli Li, Dezhi Liu, Yunyun Xiong, Minmin Ma, Xinfeng Liu, Gelin Xu Tags: Original Articles Source Type: research
Association between 12p13 SNP rs11833579 and ischemic stroke in Asian population: An updated meta-analysis
Conclusions: Our meta-analysis shows that SNP rs11833579 is not related to ischemic stroke in the Asian population.Highlights:
Source: Journal of the Neurological Sciences - July 30, 2014 Category: Neurology Authors: Ling Wang, Chi Zhao, Qing-xin Xia, Si-jie Qiao Tags: Original Articles Source Type: research
Stroke and Sexual Dysfunction – A Narrative Review
Sexual function is an essential part of quality of life in adults. However, sexual dysfunction (SD) in stroke survivors is a common but under-recognized complication after stroke. It is frequently neglected by patients and clinicians. The etiology of post-stroke SD, which is multifactorial includes anatomical, physical and psychological factors. Complete return of sexual function is an important target for functional recovery after stroke, so clinicians need to be aware of this issue and take a lead role in addressing this challenge in stroke survivors.
Source: Journal of the Neurological Sciences - February 5, 2015 Category: Neurology Authors: Jong-Ho Park, Bruce Ovbiagele, Wuwei (Wayne) Feng Tags: Review Article Source Type: research
