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Source: Journal of the Neurological Sciences
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Total 856 results found since Jan 2013.
Reply to effect of CYP2C19*2 and *3 on clinical outcome in ischemic stroke patients treated with Clopidogrel
We read with great interest the recent publication of Wang et al. [1] evaluating the relationship between CYP2C19 genotypes with nonfatal ischemic stroke, myocardial infarction, or vascular death. The striking finding of this study was that the presence of CYP2C19 loss of function (LOF) alleles may increase the recurrent risk of ischemic events. The polymorphisms of CYP2C19 may be predictors of poor functional outcome of patients without stent and the effect may be weakened by time [1]. Similarly, the authors recently demonstrated that in patients with transient ischemic attack (TIA) or minor stroke who can be treated with...
Source: Journal of the Neurological Sciences - October 31, 2016 Category: Neurology Authors: Demetrios Moris, Chris Bakoyiannis, Georgios Karaolanis, Sotirios Georgopoulos Tags: Letter to the Editor Source Type: research
Albuminuria predicts early neurological deterioration in patients with acute ischemic stroke
Reduced glomerular filtration rate (GFR) and albuminuria have been independently associated with an increased risk of stroke and unfavorable long-term outcomes. However, the association between GFR, albuminuria, and early neurological deterioration (END) in patients with ischemic stroke has not been well studied to date. We therefore investigated the ability of estimated GFR (eGFR) and albuminuria to predict END in patients with acute ischemic stroke.
Source: Journal of the Neurological Sciences - November 4, 2016 Category: Neurology Authors: Takuya Kanamaru, Satoshi Suda, Kanako Muraga, Seiji Okubo, Yoko Watanabe, Syuichi Tsuruoka, Kazumi Kimura Source Type: research
MRI based thrombolysis for FLAIR-negative stroke patients within 4.5 –6h after symptom onset
To investigate the feasibility of DWI-FLAIR mismatch in identifying patients who might benefit from thrombolytic therapy within 4.5 –6h, we analyzed the data of 105 ischemic stroke patients with known time of symptom onset who underwent MRI within 6h of stroke and thrombolysis between December 2006 and December 2013. They were divided into three groups: symptom onset within 4.5h (n=66); 4.5–6h and FLAIR images negative (n=9) ; and 4.5–6h and FLAIR images positive (n=30). Outcome of thrombolysis was assessed for each group by recanalization rate, National Institutes of Health Stroke Scale (NIHSS) and modified Rankin Scale (mRS) scores.
Source: Journal of the Neurological Sciences - November 8, 2016 Category: Neurology Authors: Xiao-Er Wei, Jia Zhou, Wen-Bin Li, Yu-Wu Zhao, Ming-Hua Li, Yue-Hua Li Source Type: research
Stroke severity may predict causes of readmission within one year in patients with first ischemic stroke event
Readmissions after stroke are costly. Risk assessment using information available upon admission could identify high-risk patients for potential interventions to reduce readmissions. Baseline stroke severity has been suspected to be a factor in readmission; however, the exact nature of the impact has not been adequately understood.
Source: Journal of the Neurological Sciences - November 14, 2016 Category: Neurology Authors: Cheng-Yang Hsieh, Huey-Juan Lin, Ya-Han Hu, Sheng-Feng Sung Source Type: research
Addressing post-stroke care in rural areas with Peru as a case study. Placing emphasis on evidence-based pragmatism
Stroke is a major cause of death and disability, with most of its burden now affecting low- and middle-income countries (LMIC). People in rural areas of LMIC who have a stroke receive very little acute stroke care and local healthcare workers and family caregivers in these regions lack the necessary knowledge to assist them. Intriguingly, a recent rapid growth in cell-phone use and digital technology in rural areas has not yet been appropriately exploited for health care training and delivery purposes.
Source: Journal of the Neurological Sciences - February 13, 2017 Category: Neurology Authors: J. Jaime Miranda, Miguel G. Moscoso, Lijing L. Yan, Francisco Diez-Canseco, Germ án Málaga, Hector H. Garcia, Bruce Ovbiagele Tags: Review Article Source Type: research
A systematic comparison of key features of ischemic stroke prevention guidelines in low- and middle-income vs. high-income countries
Implementation of contextually appropriate, evidence-based, expert-recommended stroke prevention guideline is particularly important in Low-Income Countries (LMICs), which bear disproportional larger burden of stroke while possessing fewer resources. However, key quality characteristics of guidelines issued in LMICs compared with those in High-Income Countries (HICs) have not been systematically studied. We aimed to compare important features of stroke prevention guidelines issued in these groups.
Source: Journal of the Neurological Sciences - February 18, 2017 Category: Neurology Authors: Hern án Bayona, Mayowa Owolabi, Wuwei Feng, Paul Olowoyo, Joseph Yaria, Rufus Akinyemi, James R Sawers, Bruce Ovbiagele Tags: Review Article Source Type: research
Duration of paroxysmal atrial fibrillation in cryptogenic stroke is not associated with stroke severity and early outcomes
The current definition of paroxysmal atrial fibrillation (PAF) requires an arbitrary cut-off of>30s, but in clinical practice cryptogenic stroke (CS) patients with PAF duration of ≤30s are not usually excluded from anticoagulation therapy. We sought to evaluate the clinical relevance of short-duration (≤30s) PAF in CS. Consecutive CS patients with no prior AF history and sinus-rhythm on baseline electrocardiography (ECG) were prospectively evaluated over a three-year peri od. Baseline stroke severity was assessed by NIHSS-scores.
Source: Journal of the Neurological Sciences - March 23, 2017 Category: Neurology Authors: Chrissoula Liantinioti, Konstantinos Tympas, Aristeidis H. Katsanos, John Parissis, Maria Chondrogianni, Christina Zompola, Georgios Papadimitropoulos, Michael Ioakeimidis, Sokratis Triantafyllou, Andromaxi Roussopoulou, Konstantinos Voumvourakis, John Le Source Type: research
Short-term pilot feasibility study of a nurse-led intervention to improve blood pressure control after stroke in Nigeria
Given the paucity of neurologists in Sub-Saharan Africa (SSA), task-shifting post-stroke care to nurses could be a viable avenue for enhancing post-stroke outcomes. This pilot study assessed the feasibility and short-term impact of a nurse-led intervention to manage blood pressure (BP) control in recent stroke survivors in Nigeria.
Source: Journal of the Neurological Sciences - April 6, 2017 Category: Neurology Authors: Kolawole Wasiu Wahab, Mayowa Owolabi, Rufus Akinyemi, Carolyn Jenkins, Oyedunni Arulogun, Onoja Akpa, Mulugeta Gebregziabher, Ezinne Uvere, Raelle Saulson, Bruce Ovbiagele Tags: Clinical Short Communication Source Type: research
Assessment of the general public's knowledge of stroke: A cross-sectional study in Yaound é, Cameroon
Stroke knowledge and awareness in the general public is important to improve stroke prevention and ensure prompt response to disease onset. Addressing the dearth of data in Africa, this study aimed to determine the level of knowledge on stroke definition, symptoms, risk factors and complications in the general population living in Yaound é, Cameroon.
Source: Journal of the Neurological Sciences - May 2, 2017 Category: Neurology Authors: Jobert Richie Nansseu, Cedric Paterson Atangana, Saint-Just N. Petnga, Joseph Kamtchum-Tatuene, Jean Jacques Noubiap Source Type: research
Common and specific risk factors for ischemic stroke in elderly: Differences based on type of ischemic stroke and aging
The risk factors among the types of ischemic stroke (atherothrombotic cerebral infarction: ATI, cardio-embolic infarction: CEI, lacunar infarction: LI) in aged stroke patients have rarely been compared to each other.
Source: Journal of the Neurological Sciences - July 4, 2017 Category: Neurology Authors: Sayato Fukui, Ryoko Imazeki, Yu Amano, Yousuke Kudo, Kazumitsu Amari, Masahiro Yamamoto, Kikue Todoroki, Yoshimori Ikeya, Takashi Okazaki, Noriharu Yanagimachi, Toru Shizuma, Naoto Fukuyama, Ken Johkura, Hidezo Mori Source Type: research
Embolic stroke of undetermined source: The role of the nonstenotic carotid plaque
Cryptogenic stroke, or stroke of undetermined cause, presents a remarkably challenging dilemma for the treating physician as there are limited therapeutic options to prevent recurrence. Roughly one third of transient ischemic attacks (TIAs) and ischemic strokes are classified as cryptogenic, with an even greater proportion in young patients. While classification systems have been successfully used in trials to refine therapeutic approaches specific to subtype, there has been little progress made in secondary prevention of cryptogenic stroke.
Source: Journal of the Neurological Sciences - September 20, 2017 Category: Neurology Authors: Zachary Bulwa, Ajay Gupta Tags: Clinical Short Communication Source Type: research
Impact of anaemia on acute stroke outcomes depends on the type of anaemia: Evidence from a UK stroke register
This study aimed to assess the impact of anaemia on stroke by anaemia subtype.
Source: Journal of the Neurological Sciences - September 30, 2017 Category: Neurology Authors: Raphae S. Barlas, Stephen J. McCall, Joao H. Bettencourt-Silva, Allan B. Clark, Kristian M. Bowles, Anthony K. Metcalf, Mamas A. Mamas, John F. Potter, Phyo K. Myint Source Type: research
Association between increased N-terminal pro-brain natriuretic peptide level and poor clinical outcomes after acute ischemic stroke
N-terminal pro-brain natriuretic peptide (NT-proBNP) has been shown to be associated with the prognosis of cardiovascular diseases and NT-proBNP level is elevated in patients with acute ischemic stroke. However, the association between NT-proBNP and poor prognosis after ischemic stroke is still uncertain. The aim of this study was to examine whether serum NT-proBNP is associated with global clinical outcomes in a large cohort of patients with acute ischemic stroke.
Source: Journal of the Neurological Sciences - October 10, 2017 Category: Neurology Authors: Jingyuan Yang, Chongke Zhong, Aili Wang, Tan Xu, Xiaoqing Bu, Yanbo Peng, Jinchao Wang, Hao Peng, Qunwei Li, Zhong Ju, Deqin Geng, Yonghong Zhang, Jiang He, on behalf for the CATIS Investigation Groups Source Type: research
Comparative effects of low-dose versus standard-dose alteplase in ischemic patients with prior stroke and/or diabetes mellitus: The ENCHANTED trial
History of prior stroke (PS) and diabetes mellitus (DM) are considered relative contraindications to the use of intravenous alteplase in patients with acute ischemic stroke (AIS). We aimed to assess whether a history of PS and DM modified the comparative effects of low- versus standard-dose alteplase in patients who participated in the alteplase-dose arm of the Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED).
Source: Journal of the Neurological Sciences - January 11, 2018 Category: Neurology Authors: Guofang Chen, Xia Wang, Thompson G. Robinson, Richard I. Lindley, Shengkui Zhou, Lei Ping, Weiwei Liu, Leijing Liu, John Chalmers, Craig S. Anderson, for the ENCHANTED Investigators Source Type: research
Characteristics of the ischemic stroke patients whose seizures occur at stroke presentation at a single institution in Eastern China
We compared clinical characteristics and outcomes of the early-onset seizure post-stroke patients who had seizures occurring at stroke presentation (SSP) with other patients without SSP at a single institution in Eastern China.
Source: Journal of the Neurological Sciences - February 4, 2018 Category: Neurology Authors: Jian-Hua Cheng, Zheng Zhang, Qiang Ye, Zu-sen Ye, Nian-ge Xia Source Type: research
