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Source: Journal of the Neurological Sciences
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Total 856 results found since Jan 2013.
Intravenous Alteplase for acute ischemic stroke in patients with current malignant neoplasm
Conclusions: Our experience suggests that IV thrombolysis does not appear to increase the risk of hemorrhagic complications in current non-metastatic cancer patients in absence of additional risk factors of bleeding. In addition, these patients showed clinical improvement after IV thrombolysis, although replication of our findings in a randomized controlled trial is required to confirm our results.
Source: Journal of the Neurological Sciences - January 14, 2013 Category: Neurology Authors: Manuel Cappellari, Monica Carletti, Nicola Micheletti, Giampaolo Tomelleri, Domenico Ajena, Giuseppe Moretto, Paolo Bovi Tags: Original Articles Source Type: research
Clinical predictors and outcome of patients of acute stroke requiring ventilatory support: A prospective hospital based cohort study
Abstract: The purpose of this study was to identify clinical factors which may help in predicting the requirement of support of mechanical ventilation (MV) in patients with stroke. This was a prospective cohort study done at a tertiary referral center of India, from December 2008 to December 2009. All consecutive patients of acute stroke, who were admitted from emergency or through outpatient department, and were ≥18years and in whom written consent was available, were considered for the study. Of 193 patients included in the study, 60 (31.08%) patients were intubated due to various reasons. Multivariate analysis of stat...
Source: Journal of the Neurological Sciences - December 2, 2013 Category: Neurology Authors: Priya Gupta, Kameshwar Prasad, Amit Kumar, Pradeep Kumar, Rohit Bhatia, Manjari Tripathi Tags: Original Articles Source Type: research
Efficacy and safety of botulinum toxin type A (Dysport) for the treatment of post-stroke arm spasticity: Results of the German–Austrian open-label post-marketing surveillance prospective study
Abstract: The current practice in Germany and Austria, and the safety and efficacy of botulinum toxin type A (BoNT-A; Dysport) in the treatment of patients with post-stroke arm spasticity (with no fixed upper-limb contractures), were assessed in this observational prospective non-interventional study. One treatment cycle was documented with assessments at baseline, approximately week 4 (optional), and approximately week 12. Pattern of spasticity, treatment goal, safety and efficacy were recorded. Overall response and goal achievement was rated on a 4-point scale (‘no goal achievement’, ‘goal achievement’, ‘good g...
Source: Journal of the Neurological Sciences - December 23, 2013 Category: Neurology Authors: Wolfgang H. Jost, Harald Hefter, Andrea Reissig, Katja Kollewe, Joerg Wissel Tags: Original Articles Source Type: research
Predictors for cortical gray matter volume in stroke patients with confluent white matter changes
Abstract: Background and Purpose: Our previous study found that cortical gray matter (cGM) volume predicted vascular cognitive impairment independent of age-related white matter changes (WMC). We aimed to investigate predictors for cGM volume in ischemic stroke patients with confluent WMC.Methods: One-hundred post-stroke patients with confluent WMC were recruited into the study. All volumetric measures were standardized by intracranial volume as volume ratio. Univariate analyses and multivariate linear regression models were used to test relationship of cGM volume with basic demography, vascular risk factors, APOE status, ...
Source: Journal of the Neurological Sciences - January 27, 2014 Category: Neurology Authors: Yunyun Xiong, Adrian Wong, Kelvin Wong, Winnie C.W. Chu, Xintao Hu, Xiangyan Chen, Ka Sing Wong, Stephen T.C. Wong, Xinfeng Liu, Vincent Mok Tags: Original Articles Source Type: research
The salt stimulation property of serum paraoxonase (PON1) could be a valuable factor in evaluating the enzyme status in ischemic stroke: The role of activity-determined PON1 192Q/R phenotypes
In this study, we investigated the enzyme activity parameters, based on the 192Q/R polymorphism, using the salt stimulation property of PON1 as an important although neglected property. In total, 172 participants, including 90 control subjects and 82 patients with ischemic stroke were enrolled. Paraoxonase activity (para), arylesterase activity (aryl) and salt-stimulated paraoxonase activity (para-Na) were measured by spectrophotometric assays. The distribution of the 192Q/R phenotypes was determined using the dual substrate method. We observed that the para-percent (percentage stimulation of paraoxonase activity by NaCl) ...
Source: Journal of the Neurological Sciences - January 16, 2014 Category: Neurology Authors: Abdolkarim Mahrooz, Ahad Alizadeh, Ghorban Gohari Tags: Original Articles Source Type: research
Acute vertigo due to hemispheric stroke: A case report and comprehensive review of the literature
We report a 51-year-old patient presenting with an acute vestibular syndrome including spontaneous vertigo and nystagmus, lateropulsion and nausea due to middle cerebral artery infarction. The central origin of the acute vestibular syndrome was revealed by a normal head impulse test. A comprehensive literature review on patients with hemispheric stroke manifesting with acute vertigo is provided. Typically, patients with an acute vestibular syndrome due to cortical stroke have involvement of the temporoparietal junction.Highlights:
Source: Journal of the Neurological Sciences - March 3, 2014 Category: Neurology Authors: Michael von Brevern, Sina Süßmilch, Daniel Zeise Tags: Original Articles Source Type: research
Long-term prognosis for hearing recovery in stroke patients presenting vertigo and acute hearing loss
Abstract: Background and purpose: Vertebrobasilar ischemic stroke (VBIS) can cause acute hearing loss (AHL) because the vertebrobasilar system supplies most of the auditory system including the inner ear. The aim of this study was to assess the long-term prognosis of AHL associated with VBIS.Methods: Over 12.5years, 62 patients with AHL of a vascular cause who were followed for at least 1year (mean, 49.2months; SD, 24.4months) were enrolled in this study. Quantitative audiovestibular function testing was performed during the acute (mostly within 10days after symptom onset) and last follow-up periods in all patients.Results...
Source: Journal of the Neurological Sciences - March 3, 2014 Category: Neurology Authors: Hyun-Ah Kim, Byung-Chan Lee, Jeong-Ho Hong, Chang-Ki Yeo, Hyon-Ah Yi, Hyung Lee Tags: Original Articles Source Type: research
A raging fire in acute lacunar stroke: Inflammation, blood–brain barrier dysfunction and the origin of cerebral microbleeds
Cerebral microbleeds (CMBs) detected on T2*-weighted gradient-recalled echo or susceptibility-weighted MRI sequences have sparked scientific and clinical interest over the past 15years . Extensive research has provided compelling evidence that CMBs are an important marker of bleeding-prone microangiopathies, including hypertensive arteriopathy and cerebral amyloid angiopathy, and might thus be associated with a higher risk for stroke, cognitive impairment, and mortality. The exact pathophysiological mechanisms of CMBs formation, however, are still poorly understood. Histopathological studies indicate that radiologically-de...
Source: Journal of the Neurological Sciences - March 21, 2014 Category: Neurology Authors: Andreas Charidimou, David J. Werring Tags: Editorials Source Type: research
CTP infarct core may predict poor outcome in stroke patients treated with IV t-PA
Conclusion: CTP parameters derived from commercially available software and published thresholds yield little predictive value for good clinical outcomes for AIS patients treated with IV t-PA but may be useful in predicting poor clinical outcome especially if the area of non-viable tissue is greater than 30cm2.Highlights:
Source: Journal of the Neurological Sciences - April 1, 2014 Category: Neurology Authors: Tzu-Ching Wu, Clark Sitton, Andrew Potter, Ritvij Bowry, Preeti Sahota, Chunyan Cai, Peng Hui, Zhongxue Chen, Nicole Gonzales, Andrew Barreto, George Lopez, James C. Grotta, Sean I. Savitz Tags: Original Articles Source Type: research
Correlation between cerebral microbleeds and S100B/RAGE in acute lacunar stroke patients
Conclusions: Higher levels of S100B and lower levels of sRAGE are independently associated with presence and number of CMBs in patients with first-ever acute lacunar stroke, particularly in those with deep CMBs.Highlights:
Source: Journal of the Neurological Sciences - March 21, 2014 Category: Neurology Authors: Lulu Xiao, Wen Sun, Wenya Lan, Yunyun Xiong, Zuowei Duan, Zongjun Zhang, Wenping Fan, Lili Xu, Xia Xie, Nan Ma, Ruidong Ye, Gelin Xu, Xinfeng Liu, Wusheng Zhu Tags: Original Articles Source Type: research
Spontaneous sternocleidomastoid muscle hematoma following thrombolysis for acute ischemic stroke
We report the case of an 83y.o. woman with right facio-brachio-crural hemiparesis, left deviation of the head and aphasia who developed, after thrombolytic therapy, a spontaneous sternocleidomastoid muscle hematoma that regressed few days later. To our knowledge, this is the first case reported in the literature of asymptomatic and spontaneous skeletal muscle hematoma following thrombolysis for the treatment of acute ischemic stroke. The occurrence of lateral cervical tuberculosis lymphadenitis ipsilateral to sternocleidomastoid muscle hematoma may suggest a causal relationship between local chronic inflammation of active ...
Source: Journal of the Neurological Sciences - April 28, 2014 Category: Neurology Authors: Nadia Mariagrazia Giannantoni, Giacomo Della Marca, Aldobrando Broccolini, Fabio Pilato, Paolo Profice, Roberta Morosetti, Pietro Caliandro, Giovanni Frisullo Tags: Letters to the Editor Source Type: research
Neuroprotective effect of cathodal transcranial direct current stimulation in a rat stroke model
Abstract: Experimental focal brain ischemia generates in the penumbra recurrent depolarizations which spread across the injured cortex inducing infarct growth. Transcranial direct current stimulation can induce a lasting, polarity-specific, modulation of cortical excitability. To verify whether cathodal transcranial direct current stimulation could reduce the infarct size and the number of depolarizations, focal ischemia was induced in the rat by the 3 vessels occlusion technique. In the first experiment 12 ischemic rats received cathodal stimulation (alternating 15min on and 15min off) starting 45min after middle cerebral...
Source: Journal of the Neurological Sciences - May 19, 2014 Category: Neurology Authors: Francesca Notturno, Marta Pace, Filippo Zappasodi, Etrugul Cam, Claudio L. Bassetti, Antonino Uncini Tags: Original Articles Source Type: research
Interplay between polymorphisms in the endothelial nitric oxide synthase (eNOS) gene and metabolic syndrome in determining the risk of ischemic stroke in Koreans
Abstract: Background: Endothelial nitric oxide synthase (eNOS) gene variants are known to play a role in atherosclerotic development. However, whether interplay between eNOS polymorphisms and metabolic syndrome (MetS) affects ischemic stroke (IS) risk has yet to be discovered. We investigated whether the combined effects of eNOS polymorphisms and MetS influence ischemic stroke risk in Koreans.Methods: We genotyped the eNOS −922A>G, −786T>C, 4a4b, and 894G>T polymorphisms in 531 IS cases and 502 controls using polymerase chain reaction-amplified DNA. We then investigated whether the presence of MetS and the number of Me...
Source: Journal of the Neurological Sciences - June 20, 2014 Category: Neurology Authors: Min Kyu Kang, Ok Joon Kim, Young Joo Jeon, Hyun Sook Kim, Seung Hun Oh, Jin Kwon Kim, Eo Jin Kim, Tae Sun Hwang, Nam Keun Kim Tags: Original Articles Source Type: research
Responses to: Misconceptions surrounding the genetic susceptibility to ischemic stroke
We thank Dr. Sand PG for the comments on our paper titled: Three polymorphisms of ALOX5AP and risk of ischemic stroke in Chinese: Evidence from a meta-analysis . For first question raised by Dr. Sand PG, we acknowledged that T carriers (AT+TT) of LOX5AP SG13S114A/T and A carries (AA+AT) overlapped, but we could confirm that A allele was associated with increased risk of ischemic stroke (IS), as combined odds ratio (OR) and 95% confidence interval (95% CI) for AA vs. TT was 1.47 (1.13–1.91), P=0.005; and OR (95% CI) for A carries vs. TT for atherothrombotic-IS (AHS) was 1.17 (1.06–1.30), P=0.002.
Source: Journal of the Neurological Sciences - June 19, 2014 Category: Neurology Authors: Fei Ye, Nan-Nuan Liu, Yong-Qiang Zheng, Wen-Jun Zhang Tags: Letters to the Editor Source Type: research
A dose–response study of thymosin β4 for the treatment of acute stroke
Abstract: Background: Thymosin β4 (Tβ4) is a 5K actin binding peptide. Tβ4 improves neurological outcome in a rat model of embolic stroke and research is now focused on optimizing its dose for clinical trials. The purpose of this study was to perform a dose–response study of Tβ4 to determine the optimal dose of neurological improvement in a rat model of embolic stroke.Methods: Male Wistar rats were subjected to embolic middle cerebral artery occlusion (MCAo). Rats were divided into 4 groups of 10 animals/group: control, 2, 12 and 18mg/kg. Tβ4 was administered intraperitoneally 24h after MCAo and then every 3days for...
Source: Journal of the Neurological Sciences - July 14, 2014 Category: Neurology Authors: D.C. Morris, Y. Cui, W.L. Cheung, M. Lu, L. Zhang, Z.G. Zhang, M. Chopp Tags: Original Articles Source Type: research
