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Source: Neurological Sciences

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Total 431 results found since Jan 2013.

Neurological reasons for consultation and hospitalization during the COVID-19 pandemic
ConclusionNeurological disturbances represent a significant and severe burden in COVID-19 patients, and they can be the presenting condition that leads to the diagnosis of the viral infection in a high percentage of patients. Evidence of direct viral mechanisms was scarce, but the pathogenesis of the diverse manifestations remains enigmatic.
Source: Neurological Sciences - October 16, 2020 Category: Neurology Source Type: research

Utility of Hounsfield unit in the diagnosis of tandem occlusion in acute ischemic stroke
ConclusionDespite a significant difference in thrombus attenuation in MCA occlusions with an additional extracranial ICA occlusion compared with isolated MCA occlusions, a relevant threshold of thrombus attenuation was not found.
Source: Neurological Sciences - October 14, 2020 Category: Neurology Source Type: research

Admission blood cell counts are predictive of stroke-associated infection in acute ischemic stroke patients treated with endovascular therapy
AbstractStroke-associated infection (SAI) is a major medical complication in acute ischemic stroke patients (AIS) treated with endovascular therapy (EVT). Three hundred thirty-three consecutive patients with AIS caused by a large vessel occlusion in the anterior circulation who received EVT (142 (42.6%) of them were given IV tPA as bridging therapy) and 337 AIS patients who received IV tPA only (non-EVT) were enrolled in the study and evaluated to determine the association of inflammatory factors on admission with SAI. Among the 333 AIS patients undergoing EVT, SAI occurred in 219 (65.8%) patients. Patients with SAI had hi...
Source: Neurological Sciences - October 14, 2020 Category: Neurology Source Type: research

Characteristic imaging features of neurovascular involvement in primary Sneddon ’s syndrome: an analysis of 12 cases
ConclusionSneddon ’s syndrome is characterized by highly typical clinico-radiological features. Brain MRI has diagnostic value. By knowing the characteristics of the syndrome, misdiagnosis and potentially harmful treatment can be prevented in this entity that might pose a diagnostic challenge.
Source: Neurological Sciences - October 13, 2020 Category: Neurology Source Type: research

Association of lipid profiles with severity and outcome of acute ischemic stroke in patients with and without chronic kidney disease
ConclusionLDL-C levels are positively associated with stroke severity in only patients with CKD, with an interactive impact of LDL-C and CKD on ischemic stroke in the acute phase.
Source: Neurological Sciences - October 13, 2020 Category: Neurology Source Type: research

Impact of carotid tortuosity on outcome after endovascular thrombectomy
ConclusionsCarotid tortuosity does not appear to impact the likelihood of favorable functional outcome but may influence recanalization.
Source: Neurological Sciences - October 12, 2020 Category: Neurology Source Type: research

Cumulative risk of stroke recurrence over the last 10  years: a systematic review and meta-analysis
ConclusionsThe risk of stroke recurrence varies greatly from 3  months to over 10 years and increases significantly over time in both young and old subgroup. The heterogeneity may be explained by follow-up time, regions, age, methodology differences, and stroke types, which was needed further exploration in future.
Source: Neurological Sciences - October 10, 2020 Category: Neurology Source Type: research

Reperfusion strategies in stroke due to isolated cervical internal carotid artery occlusion: systematic review and treatment comparison
ConclusionsOur systematic review highlights that, in acute ischemic stroke associated with isolated cervical ICA occlusion, bridging (IVT + EVT) might lead to higher rate of functional independence at follow-up, without increasing mortality. The low quality of available studies prevents from drawing firm conclusions, and randomized-controlled clinical trials are critically needed to define optimal treatment in this AIS subgroup.
Source: Neurological Sciences - October 10, 2020 Category: Neurology Source Type: research

The influence of statin withdrawal and adherence on stroke outcomes
ConclusionThe suboptimal use of statins is associated with significantly worse clinical outcomes in stroke patients.
Source: Neurological Sciences - October 10, 2020 Category: Neurology Source Type: research

Prediction of mTICI 3 recanalization and clinical outcomes in endovascular thrombectomy for acute ischemic stroke: a retrospective study in the Taiwan registry
ConclusionsPrediction of mTICI 3 recanalization and clinical outcomes offer valuable clinical information for treatment planning in EVT.
Source: Neurological Sciences - October 10, 2020 Category: Neurology Source Type: research

The stroke mothership model survived during COVID-19 era: an observational single-center study in Emilia-Romagna, Italy
ConclusionDuring COVID-19 pandemic, TIA and minor stroke consistently reduced compared to the same timeframe in 2019. Longer stroke-to-call and door-to-scan times, attributable to change in citizen behavior and screening at hospital arrival, did not impact on stroke-to-treatment time. Mothership model might have minimized the effects of the pandemic on the stroke care organization.
Source: Neurological Sciences - October 8, 2020 Category: Neurology Source Type: research

Impact of COVID-19 on stroke admissions, treatments, and outcomes at a comprehensive stroke centre in the United Kingdom
ConclusionsDuring the COVID-19 pandemic, the number of stroke admissions fell, and stroke severity increased. There was no statistically significant change in the delivery of thrombolysis and mechanical thrombectomy and no increase in mortality.
Source: Neurological Sciences - October 5, 2020 Category: Neurology Source Type: research

The role of peripheral monocytes and macrophages in ischemic stroke
AbstractAfter acute ischemic stroke (AIS), peripheral monocytes infiltrate into the lesion site within 24  h, peak at 3 to 7 days, and then differentiate into macrophages. Traditionally, monocytes/macrophages (MMs) are thought to play a deleterious role in AIS. Depletion of MMs in the acute phase can alleviate brain injury induced by ischemia. However, several studies have shown that MMs have anti-inf lammatory functions, participate in angiogenesis, phagocytose necrotic neurons, and promote neurovascular repair. Therefore, MMs play dual roles in ischemic stroke, depending mainly upon the MM microenvironment and the wind...
Source: Neurological Sciences - October 2, 2020 Category: Neurology Source Type: research

Effects of N-Pep-12 dietary supplementation on neurorecovery after ischemic stroke
ConclusionThis exploratory clinical trial indicates a signal for the benefit of dietary supplementation with N-Pep-12 for the enhancement of neurorecovery after supratentorial ischemic stroke.
Source: Neurological Sciences - October 1, 2020 Category: Neurology Source Type: research

Relationship between bone disorders and stroke
AbstractBone disorders are among the most uncommon causes of stroke, but they should be considered as stroke cause in particular clinical scenarios. On the other hand, osteoporosis/osteopenia and increased fracture risk are well documented post stroke complications. The relationship between stroke and bone health is complex. The current facts suggest that these two conditions share same risk factors, but also are risk factors for each other. However, the evidence shows more clear effect of stroke on the bone health, than in the opposite direction. This extensive review is aiming to fill the huge gap of evidence about this ...
Source: Neurological Sciences - October 1, 2020 Category: Neurology Source Type: research