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Drug: Nicotine

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Total 216 results found since Jan 2013.

Tobacco-related cardiovascular risk in women: New issues and therapeutic perspectives
CONCLUSIONS: Stopping smoking must be a priority objective for women smokers, for primary and secondary prevention, and they should systematically be offered a validated method of cessation or even electronic cigarettes.PMID:34593343 | DOI:10.1016/j.acvd.2021.06.013
Source: Archives of Cardiovascular Diseases - October 1, 2021 Category: Cardiology Authors: Ingrid Allagb é Anne-Laurence Le Faou Daniel Thomas Guillaume Airagnes Fr édéric Limosin Fr édéric Chagué Marianne Zeller Source Type: research

An association between electronic nicotine delivery systems use and a history of stroke using the 2016 behavioral risk factor surveillance system
This study aims to assess, using a survey representative of the USA general population, if an association exists between a history of ENDS use and a history of stroke. This cross-sectional study was a secondary data analysis using the 2016 behavioral risk factor surveillance system survey. The main exposure variable of the study was a self-reported history of ENDS use. The main outcome was a self-reported history of stroke. Covariates included sex, race, traditional cigarette use, smokeless tobacco use, chronic kidney disease, diabetes, myocardial infarction, and coronary artery disease. Unadjusted and adjusted logistic...
Source: Medicine - September 10, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Nicotine Exposure Along with Oral Contraceptive Treatment in Female Rats Exacerbates Post-cerebral Ischemic Hypoperfusion Potentially via Altered Histamine Metabolism
AbstractSmoking-derived nicotine (N) and oral contraceptives (OCs) synergistically exacerbate ischemic brain damage in the female, and the underlying mechanisms remain elusive. Our published study showed that N toxicity is exacerbated by OC via altered mitochondrial electron transport chain function. Because mitochondria play an important role in cellular metabolism, we investigated the global metabolomic profile of brains of adolescent and adult female Sprague-Dawley rats exposed to N with or without OC (N+/ −OC). Rats were randomly exposed to saline or N+/−OC for 16–21 days followed by random allocation into two c...
Source: Translational Stroke Research - September 6, 2021 Category: Neurology Source Type: research

Non-linear dose-response relation between urinary levels of nicotine and its metabolites and cognitive impairment among an elderly population in China
CONCLUSIONS: Urinary levels of OHCotGluc, NNO or ∑Nic exhibited a non-linear dose-response relationship with cognitive function in the urban elderly.PMID:34461317 | DOI:10.1016/j.ecoenv.2021.112706
Source: Ecotoxicology and Environmental Safety - August 30, 2021 Category: Environmental Health Authors: Tian Li Wei Liu Ya-Jun Yue Shao-You Lu Lu-Lin Nie Xi-Fei Yang Qing-Qing Zhu Bo Zhu Lu Wang Fei-Qi Zhu Li Zhou Jia-Fei Zhang Er-Wei Gao Kai-Wu He Li Liu Fang Ye Jian-Jun Liu Jing Yuan Lin Wang Source Type: research

Temporal proteomic changes induced by nicotine in human cells: A quantitative proteomics approach
J Proteomics. 2021 Apr 22:104244. doi: 10.1016/j.jprot.2021.104244. Online ahead of print.ABSTRACTNicotine is a prominent active compound in tobacco and many smoking cessation products. Some of the biological effects of nicotine are well documented in in vitro and in vivo systems; however, nominal data are available concerning the time-dependent changes on protein and phosphorylation events in response to nicotine. Here, we profiled the proteomes of SH-SY5Y and A549 cell lines subjected to acute (15 min, 1 h and 4 h) or chronic (24 h, 48 h) nicotine exposures. We used sample multiplexing (TMTpro16) and quantified more than...
Source: Journal of Proteomics - April 25, 2021 Category: Biochemistry Authors: Jos é Navarrete-Perea Steven P Gygi Joao A Paulo Source Type: research

COVID-19 Associated Reversible Cerebral Vasoconstriction Syndrome Successfully Treated with Nimodipine and Aspirin
A 31-year-old sexually active, non-smoker female with a past medical history of spina-bifida and idiopathic thoracolumbar scoliosis status post hardware spinal fusion surgery five years ago presented with a one-day history of severe holocranial headaches associated with nausea and visual changes. A thorough neurological examination was intact. She complained of mild cough as well. She had a positive nasopharyngeal swab for SARS-CoV-2 on RT-PCR assay. A comprehensive drug screen including amphetamines, cocaine, nicotine, alcohol, and ecstasy as well as a pregnancy test were negative; coagulation profile was within normal limits.
Source: Journal of Stroke and Cerebrovascular Diseases - April 12, 2021 Category: Neurology Authors: Tarab Mansoor, Ali A. Alsarah, Hossein Mousavi, Javed Elyias, Tarun Girotra, Omar Hussein Tags: Case Report Source Type: research

Medical and Pharmacy Students Celebrate Match Day
The annual event – held online due the COVID-19 pandemic – marks a rite of passage for students as they start their careers after graduation. Thursday University of Arizona Health Sciencesmatch-day-2400x1350-2021-v2-01-hero-web.png On March 19, Health Sciences students at the Colleges of Medicine – Tucson and Phoenix participated in Match Day and learned the location of the residency training program where they will start their careers as physicians.HealthCollege of Medicine - PhoenixCollege of Medicine - TucsonCollege of Pharmacy Media contact(s)Stacy Pigott University of Arizona Health Sciencesspigott@arizon...
Source: The University of Arizona: Health - March 25, 2021 Category: Universities & Medical Training Authors: mittank Source Type: research

Antithrombotic Treatment for Peripheral Arterial Occlusive Disease
CONCLUSION: Antiplatelet therapy should only be intensified for a limited time, or if the risk of ischemia is high. Before and during intensified antiplatelet therapy, the risk of bleeding should be assessed and weighed against the risk of ischemia. No validated score is available to estimate the risk of hemorrhagic complications in patients with PAOD. New antithrombotic therapies should not be used indiscriminately, but should rather be reserved for selected groups of patients.PMID:33734081 | DOI:10.3238/arztebl.m2021.0157
Source: Deutsches Arzteblatt International - March 18, 2021 Category: General Medicine Authors: David Hardung Andrea Behne Mehmet Boral Carsten Giesche Ralf Langhoff Source Type: research

Blood Cholesterol and Outcome of Patients with Cancer under Regular Cardiological Surveillance
Curr Oncol. 2021 Feb 12;28(1):863-872. doi: 10.3390/curroncol28010085.ABSTRACTCardiovascular (CV) diseases and cancer share several similarities, including common risk factors. In the present investigation we assessed the relationship between cholesterol levels and mortality in a cardiooncological collective. In total, 551 patients receiving anticancer treatment were followed over a median of 41 (95% CI 40, 43) months and underwent regular cardiological surveillance. A total of 140 patients (25.4%) died during this period. Concomitant cardiac diseases were more common in patients who deceased (53 (37.9%) vs. 67 (16.3%), p ...
Source: Current Oncology - February 22, 2021 Category: Cancer & Oncology Authors: Anna Lena Hohneck Stephanie Rosenkaimer Ralf-Dieter Hofheinz Ibrahim Akin Martin Borggrefe Stefan Gerhards Source Type: research