Filtered By:
Drug: Lithium

This page shows you your search results in order of date. This is page number 3.

Order by Relevance | Date

Total 72 results found since Jan 2013.

In the Kingdom of Triphasic Waves, White Matter Is the Eminence Grise
Conclusions: This is the first series to demonstrate convincingly the presence of TWs in patients with WMD in the absence of commonly cited risk factors. The authors hypothesize that less recognized risk factors of WMD and mild metabolic or infectious abnormalities may be drivers of TWs. With a growing elderly population, the presence of WMD will increase, and treating physicians need to look beyond the common causes of TWs.
Source: Journal of Clinical Neurophysiology - November 1, 2021 Category: Neurology Tags: Original Research Source Type: research

Short-term lithium treatment protects the brain against ischemia-reperfusion injury by enhancing the neuroplasticity of cortical neurons
CONCLUSION: Our study confirmed that neuroplasticity in cortical neurons is crucial for lithium-induced brain function 50 recovery after brain ischemia.PMID:34396932 | DOI:10.1080/01616412.2021.1965427
Source: Cell Research - August 16, 2021 Category: Cytology Authors: Shih-Huang Tai Liang-Chun Chao Tung-Yi Huang Che-Chao Chang Sheng-Yang Huang Tian-Shung Wu E-Jian Lee Source Type: research

Potential Disease-Modifying Effects of Lithium Carbonate in Niemann-Pick Disease, Type C1
Conclusion: Lithium is a potential therapeutic option for NP-C1 patients. Larger randomized and double-blind clinical trials are needed to further support this finding.Clinical Trial Registration:ClinicalTrials.gov, NCT03201627.
Source: Frontiers in Pharmacology - June 9, 2021 Category: Drugs & Pharmacology Source Type: research

Lithium alleviates blood-brain barrier breakdown after cerebral ischemia and reperfusion by upregulating endothelial Wnt/ β-catenin signaling in mice.
Lithium alleviates blood-brain barrier breakdown after cerebral ischemia and reperfusion by upregulating endothelial Wnt/β-catenin signaling in mice. Neuropharmacology. 2021 Jan 29;:108474 Authors: Ji YB, Gao Q, Tan XX, Huang XW, Ma YZ, Fang C, Wang SN, Qiu LH, Cheng YX, Guo FY, Chang J Abstract Although upregulation of endothelial Wnt/β-catenin signaling may be used to treat blood-brain barrier (BBB) breakdown caused by cerebral ischemia/reperfusion injury, no agents based on this mechanism are available clinically. Lithium, a medication used for treating bipolar mood disorders, upregulates Wnt/β-...
Source: Neuropharmacology - January 29, 2021 Category: Drugs & Pharmacology Authors: Ji YB, Gao Q, Tan XX, Huang XW, Ma YZ, Fang C, Wang SN, Qiu LH, Cheng YX, Guo FY, Chang J Tags: Neuropharmacology Source Type: research

Lithium enhances post-stroke blood-brain barrier integrity, activates the MAPK/ERK1/2 pathway and alters immune cell migration in mice.
In conclusion, we demonstrate for the first time that lithium is able to enhance post-stroke BBB integrity. Importantly, our work delivers novel insights into the exact mechanism of lithium-induced acute neuroprotection, providing critical information for future clinical trials involving lithium treatment in stroke patients. PMID: 33065166 [PubMed - as supplied by publisher]
Source: Neuropharmacology - October 13, 2020 Category: Drugs & Pharmacology Authors: Haupt M, Zechmeister B, Bosche B, Lieschke S, Zheng X, Zhang L, Venkataramani V, Jin F, Hein K, Weber MS, Hermann DM, Bähr M, Doeppner TR Tags: Neuropharmacology Source Type: research

The association between carotid atherosclerosis and treatment with lithium and antipsychotics in patients with bipolar disorder.
CONCLUSION: Lithium treatment may be associated with less progression in carotid intima-media thickness and the reduced risk for atherosclerosis in adults with bipolar disorder, including those with high cardiovascular disease risk. In addition to age and body mass index, antipsychotics may increase carotid intima-media thickness even in the low cardiovascular disease-risk patients. PMID: 32900219 [PubMed - as supplied by publisher]
Source: The Australian and New Zealand Journal of Psychiatry - September 7, 2020 Category: Psychiatry Authors: Tsai SY, Shen RS, Kuo CJ, Chen PH, Chung KH, Hsiao CY, Huang SH Tags: Aust N Z J Psychiatry Source Type: research

The Involvement of Canonical Wnt Signaling in Memory Impairment Induced by Chronic Cerebral Hypoperfusion in Mice
AbstractChronic cerebral hypoperfusion (CCH) has been proposed to contribute to the progression of memory loss, which is the main symptom of vascular cognitive impairment (VCI). Accumulating evidence indicates that underlying pathophysiology, such as neurodegeneration, may lead to memory loss. However, the underlying molecular basis of memory loss in CCH remains unclear. Here, we investigated the roles of canonical Wnt signaling, which modulates hippocampal function, in a CCH model. CCH was induced by unilateral common carotid artery occlusion (UCCAO). Mice were randomly divided into a sham-operated group or one of three U...
Source: Translational Stroke Research - January 19, 2020 Category: Neurology Source Type: research

Lithium treatment mitigates white matter injury after intracerebral hemorrhage through brain-derived neurotrophic factor signaling in mice.
Abstract Intracerebral hemorrhage (ICH), a subtype of stroke with high morbidity and mortality, occurs mainly in the basal ganglia and causes white matter injury (WMI), resulting in severe motor dysfunction and poor prognosis in patients. The preservation of the white matter around the hematoma is crucial for motor function recovery, but there is currently no effective treatment for WMI following ICH. Lithium has been widely used for the treatment of bipolar disorder for decades. Although the protective effects of lithium on neurodegenerative diseases and cerebral trauma have been studied in recent years, whether ...
Source: Translational Research : the journal of laboratory and clinical medicine - December 26, 2019 Category: Laboratory Medicine Authors: Li M, Xia M, Chen W, Wang J, Yin Y, Guo C, Li C, Tang X, Zhao H, Tan Q, Chen Y, Jia Z, Liu X, Feng H Tags: Transl Res Source Type: research

Lithium treatment mitigates white matter injury after intracerebral hemorrhage through brain-derived neurotrophic factor signalling in mice
Intracerebral hemorrhage (ICH), a subtype of stroke with high morbidity and mortality, occurs mainly in the basal ganglia and causes white matter injury (WMI), resulting in severe motor dysfunction and poor prognosis in patients. The preservation of the white matter around the hematoma is crucial for motor function recovery, but there is currently no effective treatment for WMI following ICH. Lithium has been widely used for the treatment of bipolar disorder for decades. Although the protective effects of lithium on neurodegenerative diseases and cerebral trauma have been studied in recent years, whether it can be used to ...
Source: Translational Research - December 26, 2019 Category: Research Authors: MINGXI LI, MIN XIA, WEIXIANG CHEN, JIE WANG, YI YIN, CHAO GUO, CHENGCHENG LI, XIAOQIN TANG, HENGLI ZHAO, QIANG TAN, YUJIE CHEN, ZHENGCAI JIA, XIN LIU, HUA FENG Source Type: research

This Under-Utilized Drug Is Actually Critical for Treatment-Resistant Depression
Many people with clinical depression have tried an array of medication and still feel sick. Maybe they’ve tried different selective serotonin reuptake inhibitors (SSRIs) or selective norepinephrine reuptake inhibitors (SNRIs). Maybe they’ve taken these antidepressants along with an antipsychotic (a common strategy to boost effectiveness). Either way, the lack of improvement can make individuals feel even more hopeless and fear the darkness will never lift. If this sounds all-too familiar, you’re definitely not alone. In fact, up to 30 percent of people with depression don’t respond to the first few antidepressants ...
Source: Psych Central - November 27, 2019 Category: Psychiatry Authors: Margarita Tartakovsky, M.S. Tags: Antidepressants Depression Disorders ECT General Medications Treatment Atypical Depression difficult to treat depression Managing Depression MAOIs medication for depression Monoamine Oxidase Inhibitors Severe Depression Treatin Source Type: news

Lithium intoxication in the pre-hospital care with stroke symptoms - Case report.
Authors: Peran D, Pukovcova K, Pekara J, Nesvadba M, Nedved V, Christian Cmorej P, Cmorej PC, Bohm P, Mamova A Abstract Lithium is widely used in psychiatry to treat bipolar affective disorders since 1970 but little is known about the incidence, clinical course and associated factors of acute lithium intoxication. Moderate and severe cases of lithium intoxication are rare. This case reports a patient with acute lithium intoxication (serum level of 3.7 mmol/L) with neurological symptoms imitating stroke, which affects the differential diagnosis in the pre-hospital and hospital care. Patient was treated with forced d...
Source: Neuroendocrinology Letters - June 13, 2019 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

1H NMR-Based Metabolomics Reveals Refined-Huang-Lian-Jie-Du-Decoction (BBG) as a Potential Ischemic Stroke Treatment Drug With Efficacy and a Favorable Therapeutic Window
This study was carried out in accordance with the recommendations of Animal Ethics Committee of China Pharmaceutical University. The protocol was approved by Animal Ethics Committee of China Pharmaceutical University. Author Contributions JW, MY, and LK conceived the experiments and helped to coordinate support and funding. XF performed the research and drafted the manuscript. SL, YL, and DX participated in the experiments. JW analyzed the data and edited the paper. All authors read and approved the final manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of an...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research