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Drug: Lithium

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Total 72 results found since Jan 2013.

What Is Life?
Zombies and the walking dead make for good copy, but do little to advance our understanding of life and death. Unfortunately, neither did the National Geographic with a cover article entitled, "The Science of Death: Coming Back from the Beyond." The article issues forth just about every misconception of life that permeates our national discussion. Sam Parnia, a critical care physician and author of the book Erasing Death, is quoted as saying that death "is a process, not a moment." So far so good. But then he makes a common but critical error in thinking, which gets to the heart of our problem. In discussing a victim of a ...
Source: Science - The Huffington Post - April 7, 2016 Category: Science Source Type: news

A differential impact of lithium on endothelium-dependent but not on endothelium-independent vessel relaxation
Publication date: 3 June 2016 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry, Volume 67 Author(s): Bert Bosche, Marek Molcanyi, Thomas Noll, Soham Rej, Birgit Zatschler, Thorsten R. Doeppner, Jürgen Hescheler, Daniel J. Müller, R. Loch Macdonald, Frauke V. Härtel Lithium is drug for bipolar disorders with a narrow therapeutic window. Lithium was recently reported to prevent stroke and protect vascular endothelium but tends to accumulate particularly in the brain and kidney. Here, adverse effects are common; however mechanisms are still vaguely understood. If lithium could also negative...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 17, 2016 Category: Psychiatry Source Type: research

A differential impact of lithium on endothelium–dependent but not on endothelium–independent vessel relaxation
Publication date: Available online 10 February 2016 Source:Progress in Neuro-Psychopharmacology and Biological Psychiatry Author(s): Bert Bosche, Marek Molcanyi, Thomas Noll, Soham Rej, Birgit Zatschler, Thorsten R. Doeppner, Jürgen Hescheler, Daniel J. Müller, R. Loch Macdonald, Frauke V. Härtel Lithium is drug for bipolar disorders with a narrow therapeutic window. Lithium was recently reported to prevent stroke and protect vascular endothelium but tends to accumulate particularly in the brain and kidney. Here, adverse effects are common; however mechanisms are still vaguely understood. If lithium could al...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - February 12, 2016 Category: Psychiatry Source Type: research

Novel combinations of phenotypic biomarkers predict development of epilepsy in the lithium-pilocarpine model of temporal lobe epilepsy in rats.
Abstract The discovery and validation of biomarkers in neurological and neurodegenerative diseases is an important challenge for early diagnosis of disease and for the development of therapeutics. Epilepsy is often a consequence of brain insults such as traumatic brain injury or stroke, but as yet no biomarker exists to predict the development of epilepsy in patients at risk. Given the complexity of epilepsy, it is unlikely that a single biomarker is sufficient for this purpose, but a combinatorial approach may be needed to overcome the challenge of individual variability and disease heterogeneity. The goal of the...
Source: Epilepsy and Behaviour - November 2, 2015 Category: Neurology Authors: Bröer S, Löscher W Tags: Epilepsy Behav Source Type: research

A reduced risk of stroke with lithium exposure in bipolar disorder: a population‐based retrospective cohort study
ConclusionsLithium use was significantly related to a reduced risk of stroke in patients with bipolar disorder.
Source: Bipolar Disorders - September 23, 2015 Category: Psychiatry Authors: Chen‐Chia Lan, Chia‐Chien Liu, Ching‐Heng Lin, Tzuo‐Yun Lan, Melvin G McInnis, Chin‐Hong Chan, Tsuo‐Hung Lan Tags: Original Article Source Type: research

Magnetic resonance spectroscopy of the ischemic brain under lithium treatment. Link to mitochondrial disorders under stroke
In this study we evaluated partial metabolic pathways under the simulation of a stroke by using the occlusion of the middle cerebral artery in rats. The analysis shows that the induced switch to a non-oxidative energy metabolism (glycolysis) due to the block of tissue oxygen supply does not ensure the adequate supply of the tissue with ATP. Moreover, the well-known acidification of the ischemic tissue is not associated with the so-called traditionally and incorrectly considered “lactic acidosis” (the generation of lactate from glucose by itself does not lead to excessive generation of protons), but occurs because of th...
Source: Chemico Biological Interactions - June 24, 2015 Category: Biochemistry Source Type: research

Magnetic resonance spectroscopy of the ischemic brain under lithium treatment. Link to mitochondrial disorders under stroke.
In this study we evaluated partial metabolic pathways under the simulation of a stroke by using the occlusion of the middle cerebral artery in rats. The analysis shows that the induced switch to a non-oxidative energy metabolism (glycolysis) due to the block of tissue oxygen supply does not ensure the adequate supply of the tissue with ATP. Moreover, the well-known acidification of the ischemic tissue is not associated with the so-called traditionally and incorrectly considered "lactic acidosis" (the generation of lactate from glucose by itself does not lead to excessive generation of protons), but occurs because of the co...
Source: Chemico-Biological Interactions - June 12, 2015 Category: Molecular Biology Authors: Silachev DN, Gulyaev MV, Zorova LD, Khailova LS, Gubsky LV, Pirogov YA, Plotnikov EY, Sukhikh GT, Zorov DB Tags: Chem Biol Interact Source Type: research

4-Phenylbutyric Acid (4-PBA) and Lithium Cooperatively Attenuate Cell Death during Oxygen-Glucose Deprivation (OGD) and Reoxygenation.
Abstract Hypoxia is an important cause of brain injury in ischemic stroke. It is known that endoplasmic reticulum (ER) stress is an important determinant of cell survival or death during hypoxia. However, the signaling pathways and molecular mechanisms involved remain to be studied in more detail. To investigate whether inhibition of ER stress promotes neuroprotection pathways, we applied an in vitro oxygen-glucose deprivation (OGD) followed by reoxygenation model of human SK-N-MC neuronal cell cultures in this study. Our results showed that neuronal cell death was induced in this model during the OGD reoxygenatio...
Source: Cellular and Molecular Neurobiology - March 17, 2015 Category: Cytology Authors: Tung WF, Chen WJ, Hung HC, Liu GY, Tung JN, Huang CC, Lin CL Tags: Cell Mol Neurobiol Source Type: research

Renal Extraction and Acute Effects of Glucagon-like peptide-1 on Central and Renal Hemodynamics in Healthy Men.
Abstract The present experiments were performed in order to elucidate the acute effects of intravenous infusion of glucagon-like peptide (GLP-1) on central and renal hemodynamics in healthy men. Seven healthy middle-aged men were examined on two different occasions in random order. During a 3-hour infusion of either GLP-1 (1.5 pmol kg-1 min-1) or saline, cardiac output was estimated non-invasively, and intra-arterial blood pressure and heart rate were measured continuously. Renal plasma flow, glomerular filtration rate, and uptake/release of hormones and ions were measured by Fick's Principle after catheterization...
Source: American Journal of Physiology. Endocrinology and Metabolism - February 10, 2015 Category: Physiology Authors: Asmar A, Simonsen L, Asmar M, Madsbad S, Holst JJ, Frandsen E, Moro C, Jonassen T, Bülow J Tags: Am J Physiol Endocrinol Metab Source Type: research

Evaluation of the Protective Potential of Brain Microvascular Endothelial Cell Autophagy on Blood–Brain Barrier Integrity During Experimental Cerebral Ischemia–Reperfusion Injury
Abstract Brain microvascular endothelial cell (BMVEC) injury induced by ischemia–reperfusion (I/R) is the initial phase of blood–brain barrier (BBB) disruption, which results in a poor prognosis for ischemic stroke patients. Autophagy occurs in ischemic brain and has been shown to exhibit protective effects on endothelial cell against stress. However, the potential effects of BMVEC autophagy on BBB permeability during I/R and the mechanisms underlying these effects have yet to be elucidated. In the current study, we answered these questions by using chemical modulators of autophagy, including rapamycin and li...
Source: Translational Stroke Research - October 1, 2014 Category: Neurology Source Type: research

Real-time monitoring of ischemic and contralateral brain pO2 during stroke by variable length multisite resonators
Conclusions: EPR oximetry with IRs can repeatedly assess temporal changes in the brain pO2 at four sites simultaneously during stroke. This oximetry approach can be used to test and develop interventions to rescue ischemic tissue by modulating cerebral pO2 during stroke.
Source: Magnetic Resonance Imaging - February 12, 2014 Category: Radiology Authors: Huagang Hou, Hongbin Li, Ruhong Dong, Nadeem Khan, Harold Swartz Tags: Original Contributions Source Type: research

Posttrauma cotreatment with lithium and valproate: reduction of lesion volume, attenuation of blood-brain barrier disruption, and improvement in motor coordination in mice with traumatic brain injury.
Conclusions Cotreatment with subeffective doses of lithium and VPA significantly attenuated TBI-induced brain lesion, BBB disruption, and neurodegeneration, and robustly improved long-term functional recovery. These findings suggest that potentiating histone acetylation by HDAC inhibition is probably part of the mechanism underlying the beneficial effects associated with this combined treatment for TBI. Because both lithium and VPA have a long history of safe clinical use, the results suggest that using a combination of these 2 agents at subtherapeutic doses to treat patients with TBI may also reduce side effects and enhan...
Source: Journal of Neurosurgery - July 12, 2013 Category: Neurosurgery Authors: Yu F, Wang Z, Tanaka M, Chiu CT, Leeds P, Zhang Y, Chuang DM Tags: J Neurosurg Source Type: research